GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
WH1 - WH1 domain
Pfam: PF00568 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0266
Length: 111
Sequences: 1146
Seq/Len: 10.32
HH_delta: 0.177 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
104_Y108_Q0.48123.013
106_K109_E0.44832.807
38_V92_L0.387852.428
94_F103_F0.373352.337
73_Y81_H0.339452.125
42_K47_R0.328082.054
97_E101_D0.314131.967
54_Y61_V0.286091.791
15_V56_L0.274361.718
36_G53_L0.272411.705
43_D46_R0.270331.692
18_V53_L0.230021.440
55_D62_V0.227221.423
78_P97_E0.227011.421
17_Q31_P0.218581.368
50_F64_E0.204341.279
27_R30_S0.204021.277
105_K109_E0.203231.272
10_S13_T0.20271.269
17_Q93_N0.20121.260
41_V50_F0.201161.259
40_F49_Y0.200811.257
9_Q44_N0.200731.257
63_W107_V0.200341.254
11_I106_K0.197981.239
101_D105_K0.197921.239
96_S99_E0.197851.239
13_T37_V0.196421.230
39_C50_F0.191231.197
77_R80_F0.190641.194
53_L62_V0.187841.176
78_P81_H0.182851.145
54_Y64_E0.178961.120
55_D60_K0.177331.110
33_K36_G0.177291.110
80_F91_G0.172751.082
21_A26_K0.172641.081
31_P53_L0.17041.067
68_Y71_F0.170011.064
61_V64_E0.169351.060
73_Y104_Y0.168641.056
74_T105_K0.167141.046
15_V31_P0.162361.016
95_A99_E0.162121.015
29_W91_G0.161721.012
10_S39_C0.160991.008
79_F83_F0.160781.007
99_E102_Q0.160571.005
33_K55_D0.159070.996
10_S46_R0.156950.983
42_K49_Y0.155370.973
105_K108_Q0.15410.965
12_A92_L0.153660.962
33_K53_L0.152850.957
40_F67_L0.152830.957
75_K101_D0.151960.951
55_D58_D0.151510.949
29_W79_F0.15070.943
31_P91_G0.149640.937
39_C54_Y0.147870.926
34_G53_L0.147130.921
9_Q42_K0.146980.920
39_C64_E0.145710.912
51_I92_L0.144940.907
19_Y88_C0.144330.904
40_F51_I0.14430.903
102_Q105_K0.144080.902
70_G101_D0.143780.900
17_Q21_A0.143490.898
14_A99_E0.143290.897
35_T95_A0.141880.888
79_F82_Q0.141230.884
18_V85_D0.141150.884
40_F107_V0.140520.880
34_G54_Y0.138980.870
76_A93_N0.137710.862
40_F68_Y0.137130.859
80_F83_F0.134830.844
92_L99_E0.134350.841
76_A82_Q0.132890.832
98_E102_Q0.132790.831
24_D86_D0.131590.824
52_R64_E0.131360.822
80_F84_E0.130920.820
29_W70_G0.130660.818
20_Q85_D0.130620.818
30_S61_V0.129760.812
18_V31_P0.129760.812
11_I59_G0.129690.812
73_Y107_V0.129620.811
81_H100_A0.128590.805
102_Q106_K0.128570.805
42_K51_I0.128350.804
82_Q89_V0.128340.803
31_P34_G0.127680.799
78_P83_F0.127080.796
16_A53_L0.12680.794
43_D52_R0.126670.793
41_V64_E0.12640.791
10_S41_V0.125080.783
26_K66_E0.124930.782
14_A17_Q0.124140.777
38_V103_F0.123720.775
73_Y94_F0.123180.771
83_F94_F0.122890.769
16_A29_W0.122670.768
39_C57_Q0.121820.763
35_T91_G0.120850.757
66_E83_F0.120030.751
16_A82_Q0.120020.751
43_D61_V0.118680.743
89_V107_V0.118630.743
31_P93_N0.118510.742
19_Y53_L0.118440.741
17_Q36_G0.118360.741
16_A38_V0.117850.738
25_T70_G0.117790.737
38_V53_L0.117280.734
78_P82_Q0.117240.734
57_Q62_V0.117160.733
77_R82_Q0.117120.733
16_A19_Y0.116640.730
89_V93_N0.116320.728
15_V104_Y0.116130.727
40_F57_Q0.115930.726
75_K104_Y0.115570.724
14_A80_F0.115270.722
11_I69_P0.114570.717
17_Q56_L0.114260.715
48_S69_P0.114170.715
14_A29_W0.114110.714
30_S33_K0.1140.714
17_Q34_G0.113340.710
48_S64_E0.112440.704
35_T99_E0.112350.703
15_V34_G0.112340.703
67_L71_F0.112250.703
76_A80_F0.111990.701
11_I108_Q0.111530.698
82_Q88_C0.111510.698
24_D75_K0.110390.691
24_D27_R0.110350.691
67_L104_Y0.109770.687
29_W89_V0.109540.686
27_R89_V0.108830.681
31_P59_G0.107550.673
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4l6eA0.98299.90.177
1xkeA0.97399.80.19
1rrpB0.98299.80.196
3n7cA0.98299.80.197
3m1iB0.98299.80.201
1k5dB0.98299.80.202
4hatB0.98299.80.205
1qc6A0.936999.80.229
2ifsA0.97399.80.23
1egxA0.936999.80.233

Page generated in 0.0271 seconds.