GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Acetyltransf_1 - Acetyltransferase (GNAT) family
Pfam: PF00583 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0257
Length: 83
Sequences: 48226
Seq/Len: 581.04
HH_delta: -0.043 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
44_S80_L3.401672.512
51_E82_F3.343582.469
11_A50_A2.89192.136
64_L77_Y2.581341.906
9_G33_V2.313461.709
44_S79_K2.283971.687
8_V37_Y2.259351.669
49_A53_W2.241111.655
37_Y40_Q2.231851.648
49_A52_E2.227071.645
53_W57_R2.122361.567
13_L50_A2.118361.565
74_R78_E2.117991.564
48_Q80_L2.052971.516
75_R78_E2.012281.486
47_L80_L1.942741.435
11_A46_L1.937451.431
3_E8_V1.898341.402
3_E37_Y1.895621.400
66_V74_R1.872141.383
34_D37_Y1.857421.372
70_N73_A1.812361.339
73_A77_Y1.774721.311
44_S48_Q1.715131.267
45_K49_A1.692841.250
26_A59_I1.655961.223
43_G76_F1.616291.194
15_P59_I1.586941.172
10_F32_A1.583591.170
25_H61_R1.575231.163
53_W56_K1.563911.155
26_A54_A1.530191.130
47_L77_Y1.522571.124
14_R29_H1.519161.122
6_Q37_Y1.518961.122
47_L82_F1.507141.113
42_I45_K1.504241.111
51_E62_I1.468211.084
76_F80_L1.460051.078
66_V70_N1.423181.051
27_Y63_Y1.418231.047
71_P74_R1.407111.039
13_L54_A1.398661.033
12_S30_R1.381371.020
41_G44_S1.359311.004
52_E56_K1.35471.001
6_Q36_E1.349840.997
64_L82_F1.330940.983
71_P75_R1.31590.972
66_V77_Y1.309480.967
25_H63_Y1.306580.965
45_K48_Q1.271110.939
12_S29_H1.261330.932
51_E80_L1.238780.915
31_L47_L1.229280.908
54_A62_I1.220210.901
48_Q51_E1.205920.891
67_S70_N1.187470.877
33_V42_I1.179870.871
6_Q34_D1.175810.868
51_E55_R1.175430.868
31_L77_Y1.175010.868
13_L53_W1.172430.866
35_P38_R1.167430.862
38_R72_A1.158630.856
33_V38_R1.146170.846
3_E40_Q1.140530.842
66_V73_A1.129180.834
3_E6_Q1.106870.817
54_A59_I1.102890.815
31_L43_G1.067880.789
10_F30_R1.060670.783
48_Q52_E1.049520.775
75_R79_K1.044940.772
9_G42_I1.01370.749
39_G72_A1.004250.742
33_V43_G1.001930.740
72_A75_R0.999690.738
27_Y65_D0.993290.734
8_V42_I0.976940.722
62_I82_F0.966810.714
37_Y42_I0.964330.712
52_E55_R0.961590.710
27_Y30_R0.959120.708
77_Y82_F0.956550.706
15_P26_A0.950750.702
46_L49_A0.943370.697
13_L26_A0.939740.694
33_V46_L0.93170.688
16_P25_H0.921510.681
29_H65_D0.903630.667
47_L51_E0.868010.641
12_S32_A0.842510.622
3_E42_I0.83510.617
29_H32_A0.833450.616
28_I47_L0.827560.611
28_I31_L0.824850.609
16_P27_Y0.824490.609
44_S76_F0.822560.607
31_L76_F0.802970.593
73_A76_F0.800620.591
8_V34_D0.799410.590
54_A57_R0.781820.577
14_R30_R0.773240.571
25_H29_H0.766580.566
11_A31_L0.765090.565
64_L73_A0.756740.559
30_R65_D0.75450.557
15_P57_R0.753820.557
47_L76_F0.745970.551
7_I10_F0.739990.547
28_I77_Y0.731570.540
69_D74_R0.730870.540
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1tiqA199.2-0.043
4e2aA199.2-0.038
1u6mA199.2-0.034
2dxqA199.2-0.034
3fynA199.2-0.024
3i9sA199.2-0.023
1z4eA199.2-0.014
1bo4A199.2-0.013
2beiA0.98899.2-0.011
1wwzA0.98899.2-0.008

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