GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DAGK_acc - Diacylglycerol kinase accessory domain
Pfam: PF00609 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 161
Sequences: 2457
Seq/Len: 15.26
HH_delta: 0.271 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
62_E145_R0.879984.305
60_E147_E0.676023.307
141_G144_I0.607862.974
63_V141_G0.567442.776
113_K142_R0.532472.605
60_E69_D0.527482.580
115_E140_Q0.523532.561
7_S156_Q0.481842.357
116_V144_I0.458572.243
7_S11_D0.456442.233
62_E147_E0.454552.224
80_L92_W0.415932.035
113_K140_Q0.40291.971
64_D142_R0.397791.946
62_E67_E0.394651.931
60_E67_E0.393571.925
79_F114_L0.390661.911
65_G143_P0.377851.848
79_F144_I0.354491.734
74_L118_G0.351411.719
120_R137_R0.35121.718
17_G46_A0.340091.664
116_V141_G0.332711.628
11_D156_Q0.330911.619
81_N115_E0.326031.595
15_A156_Q0.313491.534
11_D85_Y0.298361.460
111_D115_E0.296611.451
93_G107_Q0.295881.447
85_Y91_L0.283021.385
10_V14_I0.276661.353
42_F45_K0.274031.341
16_L154_P0.272911.335
7_S78_V0.255711.251
154_P161_P0.252221.234
2_M6_F0.243671.192
5_Y78_V0.238321.166
148_T153_V0.237771.163
62_E65_G0.237451.162
16_L161_P0.235661.153
2_M114_L0.235121.150
4_N82_I0.233351.142
116_V139_A0.232611.138
63_V139_A0.229251.122
123_F126_G0.229011.120
4_N156_Q0.223031.091
92_W107_Q0.221321.083
124_H135_A0.221271.082
12_A156_Q0.219931.076
84_S90_D0.217651.065
11_D88_G0.21751.064
64_D141_G0.215331.053
39_Y87_G0.213491.044
118_G139_A0.212931.042
15_A19_H0.212271.038
66_K139_A0.208821.022
118_G137_R0.208411.020
115_E138_L0.208091.018
58_K71_P0.207651.016
18_F38_W0.207331.014
111_D140_Q0.200370.980
4_N7_S0.196230.960
8_I146_I0.191710.938
34_L41_F0.191140.935
7_S12_A0.189710.928
6_F155_F0.189470.927
13_Q46_A0.188390.922
35_N39_Y0.187230.916
64_D143_P0.1840.900
62_E149_K0.182830.894
34_L38_W0.182750.894
4_N160_E0.181320.887
59_I148_T0.181280.887
58_K69_D0.180980.885
79_F116_V0.180290.882
7_S88_G0.180050.881
5_Y156_Q0.179560.878
7_S10_V0.178240.872
17_G45_K0.177150.867
58_K149_K0.177020.866
11_D39_Y0.175430.858
63_V66_K0.17420.852
59_I74_L0.172770.845
12_A161_P0.172520.844
13_Q17_G0.172440.844
8_I77_I0.171360.838
57_K148_T0.170990.837
85_Y156_Q0.170920.836
79_F146_I0.169950.831
62_E143_P0.169570.830
126_G130_A0.169520.829
6_F157_V0.169520.829
108_S140_Q0.169080.827
63_V144_I0.168780.826
69_D147_E0.167420.819
4_N15_A0.1670.817
78_V85_Y0.165820.811
124_H127_Q0.165640.810
13_Q16_L0.165230.808
15_A86_G0.164730.806
126_G131_G0.164060.803
36_K82_I0.162950.797
5_Y11_D0.162360.794
77_I118_G0.160970.787
2_M5_Y0.160440.785
82_I111_D0.159660.781
2_M157_V0.159150.779
149_K152_K0.158790.777
120_R139_A0.157380.770
126_G129_Q0.157320.770
35_N38_W0.15730.770
45_K49_Q0.155480.761
47_L50_R0.155360.760
117_V138_L0.154460.756
14_I46_A0.153920.753
42_F46_A0.153640.752
107_Q115_E0.152750.747
70_L118_G0.151760.742
91_L117_V0.151180.740
121_G125_L0.150560.737
10_V85_Y0.149460.731
6_F146_I0.149440.731
11_D18_F0.14920.730
74_L77_I0.148580.727
67_E143_P0.148460.726
18_F36_K0.148410.726
130_A136_K0.147930.724
11_D14_I0.147750.723
5_Y82_I0.147530.722
4_N11_D0.146770.718
75_E157_V0.146650.717
123_F127_Q0.145850.714
8_I148_T0.145340.711
17_G42_F0.145010.709
150_E153_V0.143810.704
85_Y117_V0.1430.700
5_Y80_L0.140890.689
92_W117_V0.140490.687
56_P127_Q0.139410.682
5_Y38_W0.139170.681
86_G93_G0.139010.680
51_S150_E0.13880.679
75_E119_F0.137590.673
80_L138_L0.137550.673
51_S126_G0.137080.671
57_K153_V0.137040.670
60_E149_K0.136420.667
84_S87_G0.136340.667
11_D160_E0.136330.667
108_S115_E0.136310.667
67_E110_D0.136150.666
38_W42_F0.135880.665
82_I156_Q0.135870.665
129_Q132_L0.135040.661
8_I37_L0.134980.660
19_H156_Q0.134140.656
63_V146_I0.131970.646
19_H38_W0.130790.640
114_L144_I0.130780.640
35_N158_D0.130530.639
139_A144_I0.130310.637
4_N88_G0.130240.637
21_S38_W0.130170.637
59_I77_I0.129850.635
15_A87_G0.129530.634
61_L146_I0.129530.634
80_L115_E0.12930.633
81_N160_E0.12920.632
85_Y160_E0.128840.630
18_F39_Y0.128820.630
2_M41_F0.128570.629
71_P121_G0.128440.628
39_Y159_G0.128370.628
11_D87_G0.128360.628
47_L124_H0.128320.628
67_E70_L0.128030.626
44_F47_L0.127730.625
68_V147_E0.127550.624
127_Q130_A0.127490.624
75_E78_V0.127140.622
78_V156_Q0.127070.622
11_D82_I0.126470.619
18_F34_L0.126250.618
7_S82_I0.126240.618
36_K84_S0.126140.617
82_I86_G0.125960.616
119_F136_K0.125510.614
36_K135_A0.12540.613
114_L141_G0.125370.613
122_S135_A0.125110.612
10_V117_V0.124810.611
39_Y86_G0.124630.610
131_G134_S0.124150.607
62_E68_V0.123810.606
63_V118_G0.123780.606
156_Q159_G0.123230.603
4_N84_S0.122720.600
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3s40A0.832399.90.271
2bonA0.832399.80.328
2qv7A0.832399.80.353
3vzbA0.838599.80.372
3vzdA0.838599.80.373
2an1A0.850995.60.824
1yt5A0.8137930.846
1u0tA0.844790.40.857
2i2cA0.869689.20.861
2kafA0.335411.40.925

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