GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
RGS - Regulator of G protein signaling domain
Pfam: PF00615 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0272
Length: 118
Sequences: 1786
Seq/Len: 15.14
HH_delta: -0.003 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
30_F34_V0.580353.018
33_E57_F0.512962.668
31_W94_Q0.444822.313
104_D108_K0.438492.281
65_E73_R0.403042.096
50_A90_F0.38942.025
18_F108_K0.382191.988
5_I106_F0.380951.981
26_E67_N0.376221.957
12_L32_L0.373311.942
22_E108_K0.370231.926
75_E92_E0.353961.841
23_N26_E0.340481.771
30_F93_A0.336051.748
16_K32_L0.328181.707
35_E94_Q0.314141.634
38_K94_Q0.308411.604
5_I11_G0.301571.568
2_F6_L0.298491.552
31_W98_Y0.295021.534
20_E25_E0.291561.516
38_K91_D0.290851.513
19_L105_W0.28921.504
37_F50_A0.285551.485
16_K29_Q0.283871.476
36_E49_L0.279431.453
24_C105_W0.269971.404
15_F109_F0.269631.402
19_L28_L0.268921.399
76_V93_A0.262421.365
37_F46_R0.257541.339
60_P73_R0.25431.323
69_P96_E0.254261.322
101_L105_W0.249131.296
72_I93_A0.247721.288
27_N100_M0.245531.277
19_L101_L0.242261.260
58_I66_L0.228641.189
11_G14_L0.228591.189
15_F19_L0.223951.165
34_V94_Q0.223461.162
27_N67_N0.219691.143
33_E56_K0.21711.129
78_D82_N0.214541.116
14_L109_F0.213961.113
29_Q64_N0.209281.088
59_S65_E0.204561.064
27_N104_D0.199351.037
35_E38_K0.197891.029
16_K25_E0.192931.003
34_V93_A0.192211.000
112_S115_Y0.191910.998
31_W101_L0.188870.982
69_P72_I0.187790.977
22_E105_W0.186650.971
8_D11_G0.186130.968
24_C27_N0.18580.966
27_N105_W0.185370.964
104_D107_P0.185010.962
71_K75_E0.184970.962
13_E17_E0.18450.960
26_E65_E0.18340.954
20_E29_Q0.180860.941
72_I96_E0.179580.934
2_F102_E0.17940.933
62_S66_L0.175320.912
46_R50_A0.173610.903
17_E20_E0.172910.899
46_R49_L0.169870.883
62_S67_N0.169090.879
31_W35_E0.168780.878
10_E14_L0.168590.877
74_K77_Q0.168020.874
42_S87_P0.16660.866
55_N59_S0.165740.862
23_N27_N0.165380.860
21_K114_E0.165190.859
100_M104_D0.164130.854
75_E78_D0.162040.843
46_R87_P0.160470.835
18_F31_W0.15940.829
2_F106_F0.157260.818
17_E89_L0.15710.817
46_R86_S0.156240.813
86_S89_L0.156090.812
59_S77_Q0.155760.810
24_C67_N0.155690.810
67_N104_D0.154690.805
19_L27_N0.153430.798
23_N67_N0.152720.794
2_F101_L0.152690.794
30_F66_L0.152380.793
62_S85_P0.151530.788
33_E36_E0.151410.787
58_I68_I0.151180.786
4_K7_E0.151140.786
40_S68_I0.150860.785
104_D111_K0.150720.784
54_Y77_Q0.150320.782
37_F90_F0.149770.779
30_F97_V0.149120.776
57_F65_E0.149110.776
7_E10_E0.14860.773
5_I75_E0.147250.766
67_N100_M0.146960.764
44_E47_K0.14670.763
17_E114_E0.146280.761
32_L57_F0.146240.761
29_Q95_E0.145450.756
49_L52_Q0.145160.755
37_F89_L0.145150.755
62_S65_E0.143990.749
10_E101_L0.143670.747
9_P12_L0.142310.740
15_F30_F0.141910.738
50_A89_L0.141720.737
50_A80_L0.141590.736
92_E113_E0.140530.731
66_L93_A0.140060.728
15_F105_W0.139170.724
21_K92_E0.138620.721
100_M106_F0.13810.718
50_A54_Y0.137880.717
19_L31_W0.137660.716
102_E106_F0.135660.706
66_L95_E0.135440.704
11_G106_F0.134380.699
6_L31_W0.134320.699
11_G27_N0.133570.695
3_E98_Y0.133530.694
5_I8_D0.133420.694
46_R85_P0.133040.692
88_D91_D0.133010.692
12_L90_F0.132350.688
79_A86_S0.131850.686
58_I69_P0.130780.680
23_N56_K0.130740.680
80_L89_L0.130610.679
58_I65_E0.130530.679
16_K28_L0.130310.678
38_K61_G0.130170.677
76_V79_A0.129910.676
33_E53_I0.129480.673
24_C104_D0.129410.673
25_E64_N0.129280.672
70_S73_R0.128440.668
26_E104_D0.128230.667
37_F40_S0.127670.664
77_Q80_L0.127350.662
45_Q52_Q0.12730.662
31_W38_K0.127230.662
100_M115_Y0.127090.661
113_E116_K0.127040.661
68_I72_I0.126160.656
58_I73_R0.125970.655
93_A100_M0.125820.654
105_W108_K0.124890.650
13_E114_E0.123930.645
99_E103_E0.123630.643
17_E49_L0.123380.642
54_Y98_Y0.123210.641
76_V89_L0.123070.640
61_G65_E0.122710.638
24_C72_I0.122460.637
100_M105_W0.122360.636
12_L101_L0.122080.635
42_S111_K0.122020.635
42_S48_K0.12190.634
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3c7lA0.983199.9-0.003
2ihdA0.983199.9-0.002
1dk8A199.9-0.002
1agrE0.983199.9-0.001
2pbiA0.974699.90
1zv4X0.983199.90
2dlvA0.983199.90
2jm5A0.983199.90.003
1cmzA0.983199.90.005
2oj4A0.983199.90.006

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