GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
SPRY - SPRY domain
Pfam: PF00622 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 124
Sequences: 4105
Seq/Len: 33.1
HH_delta: 0.06 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
5_Y71_G0.97353.768
3_K75_D0.65752.545
35_G40_S0.633482.452
7_E71_G0.553162.141
24_S102_E0.541872.097
71_G84_Y0.519422.010
91_G94_A0.475741.841
73_G82_S0.469591.818
20_V81_L0.448091.734
21_A107_A0.444291.720
50_K53_G0.434841.683
9_E69_V0.42981.664
76_L100_F0.419981.626
5_Y73_G0.408421.581
36_Y44_H0.408161.580
52_H55_T0.40591.571
10_V16_I0.401791.555
6_W74_L0.394611.527
6_W20_V0.394231.526
50_K55_T0.39011.510
23_S105_Y0.375191.452
73_G84_Y0.362481.403
83_F95_F0.357111.382
72_C83_F0.356351.379
75_D78_N0.355861.377
68_D86_N0.354181.371
17_S46_D0.352841.366
51_Y54_G0.352311.364
23_S103_P0.34891.350
17_S44_H0.345071.336
6_W106_P0.342241.325
85_K88_K0.331441.283
7_E69_V0.32981.277
79_G100_F0.32971.276
86_N89_F0.327661.268
6_W72_C0.325021.258
50_K54_G0.318961.235
41_W104_L0.313961.215
21_A25_A0.299791.160
31_E35_G0.296811.149
5_Y84_Y0.29341.136
22_T102_E0.292841.133
17_S42_G0.28741.112
30_D36_Y0.281611.090
2_G6_W0.278881.079
34_S109_S0.278321.077
21_A105_Y0.278041.076
53_G56_S0.277941.076
32_N37_D0.27711.073
82_S91_G0.275471.066
33_L36_Y0.270051.045
17_S109_S0.26961.044
93_Y96_T0.26261.016
43_F61_S0.260051.007
68_D87_G0.253930.983
41_W81_L0.253460.981
55_T59_T0.252720.978
5_Y86_N0.252570.978
34_S40_S0.25050.970
59_T90_L0.247620.958
82_S89_F0.243480.942
2_G74_L0.236250.914
81_L98_I0.235050.910
61_S85_K0.232830.901
20_V72_C0.232690.901
46_D49_K0.231250.895
72_C81_L0.229990.890
2_G77_D0.22760.881
52_H56_S0.22290.863
8_V11_D0.222840.863
70_I86_N0.222610.862
14_G46_D0.221520.857
8_V108_V0.219590.850
11_D68_D0.21640.838
58_E61_S0.216360.837
3_K73_G0.215170.833
44_H47_G0.214550.830
3_K82_S0.21430.829
100_F104_L0.213160.825
51_Y55_T0.211880.820
50_K60_G0.210550.815
100_F103_P0.209550.811
70_I85_K0.206480.799
19_G34_S0.205930.797
85_K90_L0.205170.794
24_S75_D0.203980.790
35_G41_W0.202940.786
25_A29_G0.202470.784
39_F43_F0.200850.777
35_G42_G0.200010.774
67_G85_K0.197620.765
31_E34_S0.197290.764
30_D111_G0.196530.761
29_G37_D0.196420.760
40_S107_A0.195350.756
37_D40_S0.195120.755
18_I72_C0.19440.752
31_E36_Y0.192330.744
22_T37_D0.192310.744
33_L37_D0.191710.742
81_L104_L0.191620.742
72_C84_Y0.190970.739
4_H74_L0.19040.737
4_H77_D0.188780.731
10_V45_G0.187720.727
8_V16_I0.186740.723
3_K77_D0.18650.722
15_S46_D0.185180.717
8_V106_P0.18460.715
20_V104_L0.183690.711
35_G39_F0.183310.710
41_W94_A0.181130.701
51_Y56_S0.18030.698
22_T103_P0.179220.694
50_K95_F0.179040.693
34_S37_D0.178690.692
25_A40_S0.178450.691
4_H20_V0.178080.689
79_G99_D0.177410.687
50_K58_E0.177170.686
11_D14_G0.17630.682
75_D80_E0.175770.680
73_G89_F0.175580.680
36_Y47_G0.174990.677
7_E86_N0.174880.677
10_V36_Y0.174610.676
86_N91_G0.174490.675
84_Y87_G0.174060.674
18_I96_T0.173370.671
96_T99_D0.172590.668
20_V98_I0.172160.666
14_G65_E0.171410.663
49_K52_H0.171360.663
35_G107_A0.171270.663
79_G98_I0.171130.662
71_G86_N0.170910.662
68_D85_K0.170670.661
74_L81_L0.16830.651
25_A31_E0.168070.651
33_L44_H0.167930.650
10_V19_G0.167860.650
73_G86_N0.166770.646
44_H51_Y0.166390.644
41_W45_G0.166380.644
17_S33_L0.166210.643
42_G107_A0.165940.642
79_G104_L0.165590.641
49_K68_D0.165030.639
69_V86_N0.164620.637
8_V93_Y0.164130.635
90_L94_A0.163830.634
33_L42_G0.163260.632
22_T105_Y0.163180.632
50_K56_S0.162820.630
69_V87_G0.162440.629
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3tojA0.943599.90.06
2yyoA0.951699.80.118
2jk9A0.975899.80.175
3emwA0.967799.80.178
2afjA0.975899.80.192
2fbeA0.991999.70.243
2vokA0.975899.70.25
2wl1A0.975899.70.267
4b3nA0.967799.70.272
3kb5A0.943599.70.283

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