GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
CRAL_TRIO - CRALTRIO domain
Pfam: PF00650 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0512
Length: 159
Sequences: 2729
Seq/Len: 17.16
HH_delta: 0.076 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
15_D19_R0.695434.024
16_K148_D0.542923.142
150_E159_T0.515172.981
104_Y134_H0.49822.883
125_P129_E0.467972.708
144_K149_P0.464422.687
149_P159_T0.393922.279
112_F116_W0.380792.203
125_P128_R0.352722.041
142_K145_E0.349682.023
104_Y146_Y0.348382.016
13_G151_Q0.347652.012
19_R101_G0.34191.978
144_K152_L0.332751.925
154_V159_T0.332641.925
48_E96_Y0.328221.899
21_V147_I0.325821.885
25_R68_D0.320561.855
102_K132_V0.31241.808
126_K130_K0.307341.778
120_K128_R0.306651.774
124_S127_T0.278851.614
132_V146_Y0.276491.600
117_K120_K0.275481.594
15_D64_V0.26971.561
116_W120_K0.26321.523
10_Y153_P0.257531.490
117_K121_P0.253491.467
44_V48_E0.251671.456
25_R28_R0.250661.450
110_W114_V0.250271.448
100_L103_I0.249051.441
118_I121_P0.245741.422
37_E87_K0.243331.408
23_Y66_I0.242621.404
93_Q124_S0.241371.397
98_E127_T0.238551.380
132_V145_E0.238261.379
147_I151_Q0.236691.370
69_L105_I0.236211.367
98_E130_K0.231351.339
108_A112_F0.226491.311
51_L99_R0.2251.302
70_S107_N0.22431.298
64_V104_Y0.22271.289
153_P156_Y0.221781.283
15_D18_G0.22061.276
11_L50_M0.210631.219
69_L109_P0.207281.199
134_H142_K0.20721.199
83_S86_K0.199161.152
16_K149_P0.197561.143
100_L130_K0.196611.138
25_R155_E0.194371.125
77_F85_L0.19261.114
87_K90_Q0.188631.091
116_W123_L0.188291.090
21_V64_V0.18751.085
35_S38_D0.185581.074
116_W122_F0.184011.065
114_V117_K0.182641.057
7_G10_Y0.181891.052
86_K90_Q0.178421.032
149_P152_L0.177791.029
127_T130_K0.176511.021
45_Y49_R0.175881.018
43_F92_L0.175751.017
43_F47_L0.174991.013
20_P54_M0.174431.009
143_L147_I0.171060.990
123_L131_I0.170990.989
123_L133_F0.167950.972
65_V103_I0.167740.971
148_D151_Q0.166120.961
9_F22_I0.164940.954
106_I134_H0.163670.947
118_I135_S0.16290.943
109_P112_F0.162490.940
66_I106_I0.161540.935
82_I86_K0.160730.930
122_F128_R0.15830.916
66_I144_K0.15810.915
64_V102_K0.157980.914
116_W133_F0.155510.900
105_I131_I0.154590.895
132_V135_S0.154140.892
90_Q94_D0.151380.876
66_I77_F0.151260.875
144_K147_I0.150640.872
8_P24_I0.150460.871
69_L108_A0.146990.851
74_L78_D0.144610.837
24_I65_V0.144430.836
136_G142_K0.143480.830
12_H23_Y0.143440.830
24_I43_F0.142740.826
53_R56_E0.14250.825
84_F89_I0.142280.823
67_I103_I0.141530.819
23_Y153_P0.141370.818
7_G47_L0.14020.811
94_D124_S0.138530.802
113_R135_S0.138080.799
108_A131_I0.137770.797
64_V101_G0.137610.796
18_G97_P0.136130.788
27_G71_G0.135870.786
47_L85_L0.135060.782
16_K83_S0.134540.778
16_K150_E0.133090.770
25_R156_Y0.132690.768
17_D102_K0.132640.767
42_F46_L0.132280.765
91_L96_Y0.132170.765
87_K91_L0.131680.762
40_I88_I0.13130.760
111_F115_L0.131240.759
38_D41_R0.130860.757
20_P60_V0.13010.753
30_D33_K0.129970.752
112_F120_K0.129180.747
74_L115_L0.129010.746
8_P98_E0.12840.743
49_R52_K0.127870.740
16_K145_E0.127220.736
32_K73_S0.127160.736
17_D146_Y0.125860.728
155_E159_T0.125430.726
118_I125_P0.124640.721
123_L130_K0.124430.720
40_I87_K0.124350.720
17_D149_P0.124270.719
50_M85_L0.12360.715
10_Y23_Y0.123210.713
21_V65_V0.1230.712
62_G101_G0.122480.709
104_Y142_K0.122440.708
110_W113_R0.122370.708
108_A133_F0.121920.705
9_F46_L0.121720.704
94_D126_K0.121420.703
68_D156_Y0.121340.702
52_K72_F0.121120.701
43_F65_V0.121070.701
102_K120_K0.120930.700
144_K154_V0.120820.699
17_D22_I0.120650.698
151_Q159_T0.120230.696
123_L127_T0.119350.691
36_P40_I0.119030.689
59_Q62_G0.118930.688
45_Y48_E0.118560.686
29_F78_D0.11820.684
14_R151_Q0.117450.680
95_H99_R0.116890.676
132_V142_K0.116580.675
114_V132_V0.116210.672
98_E124_S0.116010.671
31_P76_N0.115530.668
55_P62_G0.11550.668
89_I123_L0.115010.665
53_R62_G0.114980.665
15_D21_V0.114630.663
67_I92_L0.114620.663
54_M63_I0.114360.662
64_V150_E0.114270.661
73_S77_F0.113990.660
100_L124_S0.113860.659
147_I158_G0.113640.658
64_V146_Y0.11350.657
21_V151_Q0.113440.656
48_E97_P0.11340.656
111_F114_V0.113320.656
73_S76_N0.113130.655
43_F84_F0.113080.654
101_G104_Y0.113030.654
21_V153_P0.112650.652
46_L50_M0.112610.652
37_E41_R0.112530.651
37_E40_I0.112510.651
113_R117_K0.112510.651
102_K146_Y0.111840.647
94_D121_P0.111350.644
130_K133_F0.110790.641
50_M63_I0.110770.641
64_V90_Q0.110770.641
39_V43_F0.110050.637
11_L22_I0.109420.633
91_L135_S0.109150.632
43_F88_I0.108880.630
68_D106_I0.108690.629
41_R109_P0.108490.628
13_G53_R0.108350.627
53_R69_L0.108330.627
116_W131_I0.10760.623
17_D148_D0.107560.622
72_F105_I0.106960.619
143_L157_G0.106950.619
118_I123_L0.106560.617
7_G11_L0.106490.616
23_Y26_L0.106180.614
54_M60_V0.106080.614
44_V91_L0.106030.614
22_I108_A0.105850.612
114_V122_F0.105740.612
66_I143_L0.105390.610
13_G147_I0.105310.609
26_L69_L0.105310.609
33_K38_D0.104910.607
26_L131_I0.104540.605
124_S129_E0.104490.605
101_G126_K0.10440.604
78_D82_I0.103950.601
129_E151_Q0.10380.601
115_L121_P0.103760.600
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3hx3A0.97481000.076
1r5lA0.97481000.087
1olmA0.99371000.087
1auaA0.98741000.1
3q8gA0.98741000.116
4fmmA0.937199.90.171
3pg7A0.918299.60.46
3pegA0.918299.50.493
2qi2A0.893127.50.91
3j15A0.9308160.919

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