GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
BTB - BTBPOZ domain
Pfam: PF00651 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0033
Length: 111
Sequences: 8137
Seq/Len: 73.31
HH_delta: -0.002 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
14_T22_T1.416482.641
26_H72_Y1.412542.634
17_V64_F1.401942.614
23_F61_P1.367092.549
67_F96_I1.246142.324
16_R22_T1.195262.229
16_R53_E1.128552.104
13_V25_V1.12782.103
92_D100_K1.082332.018
35_P95_Q1.016811.896
14_T24_Y1.01311.889
23_F65_E0.990391.847
21_K61_P0.943161.759
22_T53_E0.923221.721
21_K65_E0.901081.680
59_V90_L0.865861.615
33_R71_M0.857221.598
67_F90_L0.85321.591
38_R42_E0.731151.363
60_S63_A0.727111.356
25_V68_L0.717111.337
65_E69_E0.712331.328
15_I64_F0.69851.302
16_R55_S0.693991.294
60_S86_E0.692221.291
36_Y40_L0.69211.291
67_F99_L0.685251.278
59_V93_K0.675181.259
13_V41_F0.659011.229
59_V64_F0.655831.223
47_K51_V0.625411.166
66_A69_E0.617741.152
63_A86_E0.61741.151
37_F41_F0.615671.148
39_N95_Q0.615551.148
84_V106_F0.611961.141
70_Y99_L0.60721.132
58_D93_K0.605371.129
18_G60_S0.601721.122
63_A90_L0.595041.110
71_M96_I0.590621.101
84_V103_C0.585991.093
79_N83_N0.580711.083
66_A87_L0.574581.071
67_F94_L0.572961.068
27_K31_A0.563851.051
15_I25_V0.5631.050
90_L94_L0.555411.036
30_L37_F0.546561.019
23_F68_L0.540261.007
26_H29_I0.524950.979
52_P56_L0.514770.960
11_S24_Y0.511360.953
27_K41_F0.50820.948
83_N106_F0.505430.942
18_G61_P0.498880.930
13_V30_L0.496180.925
43_G46_F0.495940.925
31_A42_E0.495010.923
12_D28_N0.486270.907
16_R20_G0.485380.905
88_L104_E0.483560.902
39_N43_G0.483510.902
23_F64_F0.481280.897
88_L100_K0.479170.893
14_T53_E0.477620.891
97_P101_K0.476070.888
62_E83_N0.472640.881
63_A83_N0.471820.880
63_A87_L0.470790.878
102_A106_F0.455760.850
86_E89_E0.453960.846
98_E102_A0.453810.846
35_P38_R0.450820.841
11_S25_V0.449730.839
17_V23_F0.449550.838
36_Y94_L0.447720.835
29_I72_Y0.444730.829
100_K104_E0.4420.824
78_I106_F0.44010.821
91_A99_L0.430010.802
27_K52_P0.416570.777
59_V94_L0.415690.775
12_D26_H0.410670.766
87_L103_C0.409990.764
97_P100_K0.407960.761
15_I23_F0.406310.758
13_V54_I0.406110.757
33_R74_G0.399690.745
101_K104_E0.395010.737
48_E51_V0.38880.725
61_P65_E0.387670.723
70_Y98_E0.387420.722
88_L107_L0.38110.711
44_S49_S0.377210.703
87_L91_A0.376390.702
85_E107_L0.375170.700
12_D27_K0.37360.697
70_Y73_T0.372280.694
50_T53_E0.365590.682
64_F68_L0.365570.682
74_G98_E0.363930.679
82_E86_E0.361370.674
68_L72_Y0.359820.671
89_E97_P0.358660.669
81_D106_F0.358120.668
29_I32_A0.351910.656
66_A83_N0.35190.656
15_I30_L0.350980.654
73_T76_I0.350210.653
35_P97_P0.349290.651
66_A77_E0.347420.648
62_E66_A0.341820.637
88_L92_D0.340170.634
84_V107_L0.338880.632
69_E73_T0.338190.631
91_A103_C0.337560.629
69_E77_E0.33530.625
31_A41_F0.334980.625
96_I99_L0.334220.623
91_A100_K0.331770.619
88_L103_C0.330010.615
101_K105_K0.327960.612
92_D95_Q0.325640.607
29_I33_R0.325170.606
15_I68_L0.324390.605
51_V55_S0.32370.604
12_D72_Y0.323250.603
15_I94_L0.322420.601
25_V30_L0.321790.600
70_Y76_I0.320020.597
44_S47_K0.319530.596
31_A34_S0.31150.581
11_S69_E0.306920.572
28_N32_A0.30580.570
35_P39_N0.304170.567
92_D104_E0.295850.552
102_A105_K0.295760.551
100_K103_C0.292920.546
67_F71_M0.292110.545
55_S58_D0.288080.537
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4hxiA0.97399.7-0.002
1r29A0.96499.70.006
2ppiA0.945999.70.011
3i3nA0.98299.70.011
3hveA0.97399.70.014
2if5A0.945999.70.018
3hqiA0.97399.70.02
3htmA0.97399.70.032
2yy9A0.936999.70.039
3b84A0.936999.70.04

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