GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Cation_ATPase_C - Cation transporting ATPase C-terminus
Pfam: PF00689 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 182
Sequences: 4750
Seq/Len: 26.1
HH_delta: 0.058 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
158_P161_Q0.631942.795
141_L145_V0.573252.535
177_E180_K0.57032.522
89_Q161_Q0.560622.480
149_N156_P0.495522.192
11_W139_Q0.487152.155
68_A93_M0.472762.091
68_A97_A0.46222.044
130_I134_I0.457042.021
163_L167_A0.439651.944
96_T139_Q0.431511.908
65_C94_A0.425421.882
27_E110_R0.405591.794
107_F132_I0.404031.787
16_T102_Q0.393341.740
142_I152_F0.373481.652
99_V139_Q0.363521.608
159_L163_L0.360781.596
146_P149_N0.359991.592
95_F142_I0.348431.541
67_F71_L0.345191.527
93_M161_Q0.342641.515
176_D179_R0.340761.507
129_L133_L0.340241.505
96_T143_V0.339191.500
93_M165_C0.33851.497
61_M101_S0.331081.464
72_G93_M0.325881.441
5_T8_Q0.319011.411
10_L13_N0.317831.406
149_N154_T0.316211.399
174_I178_I0.308551.365
66_F70_F0.305891.353
55_L59_L0.301391.333
5_T153_G0.300931.331
12_I98_L0.299411.324
121_G124_S0.297131.314
140_I162_W0.29541.307
105_N108_N0.294811.304
70_F74_Y0.294291.302
23_A131_A0.292781.295
58_G62_A0.291531.289
106_A128_L0.290231.284
100_L136_I0.288141.274
17_D95_F0.285381.262
144_Y156_P0.28231.249
140_I144_Y0.281821.246
160_W163_L0.280311.240
127_W130_I0.277961.229
89_Q155_A0.276031.221
46_I50_L0.2741.212
48_K52_R0.273621.210
115_S118_R0.272961.207
115_S177_E0.26831.187
21_A25_G0.266481.179
167_A171_L0.264921.172
170_L174_I0.264171.168
126_K130_I0.263461.165
69_F90_A0.260471.152
47_N51_L0.259611.148
14_L17_D0.259451.148
49_R52_R0.257351.138
114_R118_R0.25661.135
107_F129_L0.25631.134
130_I133_L0.256081.133
102_Q105_N0.255711.131
60_I171_L0.253921.123
100_L169_A0.253351.121
16_T98_L0.252091.115
64_A168_L0.251671.113
104_F169_A0.251391.112
16_T20_P0.250171.106
118_R121_G0.248841.101
90_A94_A0.248551.099
34_M38_P0.246041.088
161_Q165_C0.246031.088
165_C169_A0.244371.081
13_N17_D0.242381.072
17_D20_P0.240981.066
57_Q172_P0.240191.062
160_W164_I0.23791.052
44_P47_N0.237831.052
101_S172_P0.237741.051
9_I13_N0.23741.050
103_L136_I0.235261.041
96_T157_L0.234961.039
162_W165_C0.233331.032
143_V154_T0.229891.017
92_T157_L0.228281.010
131_A135_S0.226361.001
89_Q158_P0.225020.995
178_I181_L0.223370.988
170_L173_F0.223250.987
39_R43_E0.221610.980
97_A101_S0.220490.975
65_C97_A0.220440.975
65_C98_L0.220080.973
97_A165_C0.219320.970
173_F177_E0.217330.961
104_F170_L0.215890.955
2_L5_T0.21570.954
128_L131_A0.215130.951
11_W15_I0.215080.951
99_V135_S0.215030.951
16_T25_G0.21490.950
32_D35_K0.213480.944
176_D180_K0.212740.941
91_Q94_A0.211510.935
103_L135_S0.210630.932
73_L90_A0.210030.929
100_L140_I0.207860.919
145_V148_L0.207660.918
108_N173_F0.207440.917
28_P124_S0.206450.913
96_T165_C0.206390.913
8_Q13_N0.20580.910
113_R116_V0.204890.906
10_L14_L0.203970.902
22_L99_V0.203970.902
12_I152_F0.200870.888
72_G90_A0.200370.886
33_I38_P0.200070.885
92_T143_V0.198740.879
60_I175_V0.197360.873
173_F176_D0.19680.870
50_L54_I0.195910.866
110_R124_S0.195620.865
24_L34_M0.195250.864
92_T154_T0.194940.862
81_E91_Q0.194340.860
63_A67_F0.193920.858
29_P33_I0.192490.851
69_F94_A0.190750.844
64_A101_S0.189570.838
19_L135_S0.189310.837
9_I17_D0.188830.835
111_S114_R0.188510.834
20_P24_L0.188410.833
15_I139_Q0.188340.833
143_V162_W0.188180.832
22_L26_F0.186640.825
27_E30_D0.185920.822
25_G54_I0.185820.822
20_P135_S0.18520.819
105_N109_C0.183950.814
4_L9_I0.182470.807
111_S115_S0.182330.806
145_V149_N0.181130.801
62_A66_F0.180660.799
106_A177_E0.180510.798
57_Q105_N0.180270.797
123_F129_L0.179650.795
167_A170_L0.178960.792
106_A135_S0.178770.791
137_A141_L0.178510.790
67_F168_L0.177640.786
133_L137_A0.177540.785
141_L148_L0.177380.785
94_A98_L0.177340.784
46_I49_R0.176710.782
127_W131_A0.176620.781
30_D36_R0.175710.777
54_I58_G0.175320.775
20_P25_G0.174230.771
12_I21_A0.174110.770
144_Y162_W0.173960.769
14_L102_Q0.173850.769
6_P13_N0.17380.769
132_I135_S0.173050.765
126_K129_L0.172960.765
150_R160_W0.172880.765
71_L164_I0.172330.762
3_P6_P0.172320.762
21_A24_L0.170490.754
25_G106_A0.170460.754
11_W17_D0.170050.752
67_F70_F0.169680.750
157_L161_Q0.169420.749
144_Y154_T0.169130.748
177_E181_L0.168420.745
171_L178_I0.167870.742
14_L22_L0.167490.741
171_L174_I0.167380.740
16_T21_A0.16680.738
7_I12_I0.166360.736
68_A72_G0.166030.734
96_T100_L0.165870.734
64_A171_L0.164910.729
166_L170_L0.164610.728
2_L106_A0.164120.726
26_F127_W0.163190.722
35_K123_F0.16220.717
62_A65_C0.161990.716
23_A26_F0.161860.716
13_N18_L0.161770.715
132_I136_I0.161410.714
18_L152_F0.161270.713
125_N128_L0.160030.708
100_L104_F0.159370.705
164_I167_A0.159340.705
12_I95_F0.158860.703
56_I179_R0.158480.701
13_N105_N0.158450.701
18_L135_S0.158160.700
61_M105_N0.157690.697
72_G94_A0.157020.694
114_R117_F0.156940.694
150_R167_A0.156780.693
16_T131_A0.156390.692
163_L170_L0.156030.690
18_L21_A0.15570.689
7_I153_G0.155470.688
74_Y160_W0.154920.685
27_E125_N0.154780.685
103_L132_I0.154090.682
172_P176_D0.153830.680
71_L74_Y0.153810.680
137_A163_L0.153770.680
117_F124_S0.15330.678
53_R109_C0.152870.676
79_D89_Q0.152830.676
141_L160_W0.152710.675
169_A172_P0.152420.674
72_G76_F0.152250.673
9_I91_Q0.15210.673
61_M172_P0.151880.672
116_V121_G0.151640.671
18_L102_Q0.151560.670
16_T24_L0.151220.669
112_R176_D0.151080.668
12_I102_Q0.150940.668
7_I14_L0.150930.668
16_T95_F0.15070.667
12_I20_P0.150610.666
7_I135_S0.150340.665
93_M157_L0.150270.665
20_P103_L0.149790.662
157_L165_C0.149670.662
8_Q154_T0.149150.660
123_F127_W0.148770.658
5_T154_T0.148130.655
101_S169_A0.147770.654
153_G156_P0.147230.651
16_T99_V0.147230.651
37_P124_S0.146620.648
139_Q143_V0.14630.647
33_I36_R0.146040.646
167_A180_K0.145830.645
21_A135_S0.145720.644
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3ixzA0.99451000.058
2zxeA0.9891000.145
3ar4A0.99451000.171
1mhsA0.901199.80.405
3b8cA0.917699.60.496
4hygA0.67035.10.939
3dh4A0.45054.40.94
3w4tA0.77474.40.941
2lzrA0.15933.40.944
4dveA0.75823.40.944

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