GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Acyl_transf_1 - Acyl transferase domain
Pfam: PF00698 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0323
Length: 318
Sequences: 7425
Seq/Len: 23.35
HH_delta: -0.054 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
149_E194_P1.571994.012
247_R250_E1.333923.404
131_L172_V1.21393.098
33_D43_S1.121172.861
106_S109_D1.092952.789
169_E184_R1.08522.769
4_F75_A1.062122.710
123_E202_E0.985662.515
240_R244_S0.956162.440
19_Y30_D0.939122.397
76_R79_R0.931332.377
204_R236_E0.915722.337
249_R253_E0.90752.316
129_A168_L0.871532.224
116_E119_R0.854792.181
75_A101_A0.847622.163
164_E195_L0.828312.114
162_S193_S0.809422.066
31_R108_E0.806372.058
161_I171_L0.793642.025
46_E50_E0.792762.023
222_N251_A0.791872.021
197_E243_R0.789952.016
29_I69_A0.767121.958
79_R84_K0.75761.933
32_C107_L0.745411.902
68_F110_A0.73041.864
164_E167_A0.710051.812
26_R30_D0.705061.799
29_I48_L0.698491.782
236_E240_R0.694761.773
3_L276_V0.687521.755
10_Q14_M0.682631.742
172_V184_R0.68161.739
138_E142_L0.681371.739
35_I111_L0.666511.701
113_L207_L0.666011.700
1_V260_V0.662551.691
147_D164_E0.661091.687
33_D45_L0.659481.683
204_R239_A0.653371.667
131_L168_L0.645341.647
226_R254_A0.636451.624
172_V176_K0.630531.609
252_V276_V0.62021.583
207_L212_F0.617141.575
116_E206_A0.615341.570
165_R169_E0.610921.559
87_A260_V0.609441.555
28_T76_R0.60851.553
220_Y254_A0.60631.547
174_R178_E0.605661.546
256_Y280_L0.602391.537
71_Q97_A0.601121.534
104_A215_P0.59881.528
72_V100_V0.596481.522
43_S46_E0.594421.517
100_V110_A0.59441.517
129_A165_R0.594171.516
165_R184_R0.591691.510
136_E139_E0.589151.503
202_E205_E0.587561.499
172_V182_A0.578231.476
24_V80_S0.576741.472
59_D122_D0.575141.468
220_Y227_P0.567581.448
89_I251_A0.563071.437
27_E30_D0.562681.436
30_D45_L0.560711.431
137_E140_E0.560441.430
254_A258_D0.560391.430
151_A162_S0.552371.410
22_N77_L0.549831.403
15_G70_I0.548081.399
29_I73_A0.546751.395
204_R208_E0.542611.385
28_T31_R0.536871.370
252_V279_I0.536061.368
148_V171_L0.535921.368
61_E122_D0.535121.366
115_Y119_R0.528211.348
31_R76_R0.51031.302
88_V217_I0.505441.290
27_E31_R0.50411.286
134_R181_K0.500871.278
35_I108_E0.496171.266
56_D59_D0.49481.263
16_R20_E0.493111.258
2_F85_P0.491641.255
87_A255_L0.485411.239
153_I159_V0.485051.238
5_P71_Q0.48031.226
133_V175_L0.479891.225
131_L182_A0.479331.223
169_E172_V0.479021.222
89_I255_L0.477491.219
72_V97_A0.476431.216
153_I250_E0.472361.205
153_I249_R0.468611.196
220_Y258_D0.463281.182
200_A243_R0.462191.179
197_E200_A0.461831.179
140_E143_A0.461431.178
173_E176_K0.459461.173
4_F101_A0.456581.165
61_E118_A0.453851.158
174_R177_A0.452921.156
116_E120_L0.449211.146
120_L199_A0.447221.141
200_A204_R0.446711.140
1_V255_L0.445851.138
170_A173_E0.443881.133
136_E140_E0.443231.131
155_S275_L0.442011.128
263_F276_V0.440981.125
45_L49_F0.440741.125
205_E208_E0.440651.125
56_D62_Y0.437171.116
222_N241_Q0.434481.109
173_E177_A0.428961.095
169_E173_E0.426881.089
138_E141_K0.426061.087
199_A242_L0.425281.085
2_F75_A0.424161.082
218_P227_P0.423291.080
129_A184_R0.418111.067
153_I245_P0.416121.062
91_H154_N0.415721.061
120_L206_A0.414321.057
214_P231_P0.414121.057
137_E141_K0.41331.055
16_R49_F0.413291.055
96_Y114_V0.409721.046
220_Y251_A0.409011.044
24_V28_T0.409011.044
104_A212_F0.40851.042
3_L89_I0.406671.038
119_R123_E0.40611.036
112_R209_S0.406071.036
28_T73_A0.403931.031
32_C111_L0.402721.028
170_A174_R0.401231.024
120_L202_E0.400841.023
153_I247_R0.399531.020
78_L266_I0.399441.019
60_T191_F0.399361.019
201_D205_E0.398821.018
76_R100_V0.397861.015
77_L80_S0.395981.011
22_N81_W0.395461.009
19_Y49_F0.394231.006
230_D233_L0.39211.001
3_L263_F0.390280.996
2_F83_I0.389960.995
202_E206_A0.388670.992
2_F266_I0.388510.991
197_E201_D0.388390.991
87_A220_Y0.387730.989
206_A209_S0.385630.984
150_I153_I0.381380.973
131_L161_I0.379980.970
93_L114_V0.379830.969
133_V161_I0.379280.968
32_C69_A0.378580.966
67_I71_Q0.376720.961
23_P27_E0.374890.957
68_F72_V0.37460.956
175_L180_I0.374070.955
13_G16_R0.374040.955
253_E257_E0.373770.954
1_V263_F0.373230.952
88_V219_V0.370880.946
29_I45_L0.370020.944
191_F242_L0.36960.943
197_E239_A0.368420.940
168_L184_R0.368180.940
147_D167_A0.36810.939
150_I159_V0.367790.939
69_A111_L0.367450.938
17_D21_N0.367070.937
48_L70_I0.36460.930
25_F73_A0.364460.930
166_E169_E0.361310.922
99_L238_W0.359950.919
88_V101_A0.359690.918
219_V233_L0.358960.916
9_S67_I0.358570.915
155_S278_R0.354070.904
61_E65_P0.353680.903
200_A239_A0.353030.901
44_L69_A0.353010.901
68_F100_V0.352210.899
203_F242_L0.349840.893
250_E253_E0.34820.889
135_G180_I0.347090.886
109_D112_R0.347080.886
144_L174_R0.346460.884
107_L111_L0.34460.879
225_G251_A0.343460.876
63_A67_I0.340810.870
254_A257_E0.340220.868
225_G250_E0.33960.867
28_T32_C0.336930.860
131_L184_R0.336910.860
75_A79_R0.334480.854
7_Q187_V0.333770.852
256_Y263_F0.332720.849
161_I168_L0.332710.849
15_G25_F0.332610.849
227_P254_A0.331820.847
77_L81_W0.330140.842
139_E143_A0.330060.842
171_L175_L0.329940.842
100_V107_L0.326320.833
68_F114_V0.323860.826
133_V182_A0.323680.826
76_R107_L0.322910.824
228_Y233_L0.322110.822
42_F62_Y0.321980.822
223_V244_S0.320250.817
140_E144_L0.31980.816
2_F264_I0.319540.815
30_D34_E0.319250.815
221_S224_T0.316920.809
20_E49_F0.316910.809
58_N186_P0.316610.808
61_E119_R0.31620.807
127_P165_R0.315060.804
149_E193_S0.314690.803
274_S277_K0.314570.803
19_Y26_R0.314290.802
157_R278_R0.312710.798
72_V76_R0.310210.792
214_P230_D0.309640.790
156_P279_I0.308480.787
25_F28_T0.308450.787
91_H246_V0.307990.786
23_P26_R0.306250.782
148_V161_I0.304730.778
33_D44_L0.303020.773
96_Y207_L0.30140.769
25_F70_I0.300930.768
167_A170_A0.297860.760
229_D232_E0.297730.760
133_V138_E0.296710.757
47_L56_D0.296090.756
105_L113_L0.296090.756
105_L110_A0.295420.754
134_R157_R0.29470.752
87_A258_D0.293440.749
141_K178_E0.288850.737
103_G216_K0.288790.737
68_F111_L0.288040.735
72_V111_L0.287630.734
24_V27_E0.28580.729
248_F276_V0.284570.726
271_V275_L0.283660.724
44_L66_A0.282610.721
239_A243_R0.28250.721
113_L210_I0.281040.717
201_D204_R0.280730.716
114_V118_A0.279720.714
75_A78_L0.279530.713
89_I248_F0.279520.713
138_E143_A0.279480.713
1_V87_A0.278430.711
74_L266_I0.277980.709
252_V263_F0.27640.705
196_M242_L0.274940.702
224_T228_Y0.274290.700
147_D166_E0.273420.698
19_Y29_I0.272950.697
95_E221_S0.271330.692
205_E209_S0.271110.692
121_M196_M0.271080.692
72_V107_L0.270860.691
7_Q64_Q0.270630.691
171_L174_R0.269830.689
256_Y261_R0.269280.687
219_V228_Y0.26860.685
58_N63_A0.267510.683
225_G254_A0.266310.680
199_A203_F0.265040.676
5_P267_G0.265020.676
206_A210_I0.263720.673
221_S237_Y0.26240.670
160_V191_F0.261370.667
55_E58_N0.260620.665
100_V105_L0.260290.664
130_M160_V0.259490.662
139_E142_L0.258340.659
53_E58_N0.258250.659
35_I112_R0.258020.658
176_K182_A0.257370.657
24_V77_L0.256940.656
220_Y255_L0.256850.655
70_I74_L0.256780.655
253_E279_I0.255220.651
276_V280_L0.254870.650
249_R279_I0.254370.649
47_L50_E0.254260.649
147_D170_A0.253920.648
253_E256_Y0.253470.647
5_P269_G0.253420.647
85_P88_V0.253190.646
143_A178_E0.252590.645
156_P249_R0.252460.644
44_L65_P0.252350.644
199_A202_E0.251960.643
125_A190_A0.251280.641
26_R45_L0.251170.641
60_T93_L0.251030.641
148_V167_A0.250170.638
7_Q121_M0.249880.638
31_R35_I0.249450.637
99_L104_A0.249080.636
213_R216_K0.248820.635
190_A196_M0.247120.631
223_V240_R0.246950.630
112_R116_E0.246080.628
187_V191_F0.245410.626
130_M187_V0.24450.624
136_E143_A0.242390.619
75_A266_I0.241350.616
71_Q266_I0.240830.615
84_K216_K0.239770.612
7_Q191_F0.239690.612
124_A199_A0.239420.611
106_S213_R0.238880.610
75_A100_V0.238370.608
48_L66_A0.237940.607
208_E235_A0.236470.603
212_F235_A0.235840.602
11_Y269_G0.235320.601
5_P266_I0.234530.599
239_A242_L0.233440.596
224_T237_Y0.233130.595
195_L198_P0.232780.594
64_Q117_R0.23240.593
5_P9_S0.232120.592
276_V279_I0.232120.592
256_Y281_K0.232050.592
67_I268_P0.231970.592
227_P258_D0.23180.592
95_E222_N0.231030.590
73_A77_L0.230990.589
109_D210_I0.230840.589
1_V261_R0.230580.588
145_P167_A0.230460.588
132_A154_N0.230430.588
51_G55_E0.230060.587
28_T100_V0.230.587
263_F280_L0.228030.582
176_K179_G0.22780.581
62_Y65_P0.227560.581
87_A254_A0.227480.581
137_E247_R0.227410.580
93_L191_F0.226790.579
141_K175_L0.226740.579
251_A255_L0.226260.577
60_T121_M0.225950.577
60_T188_S0.225250.575
270_S274_S0.225230.575
106_S211_E0.225070.574
224_T240_R0.224990.574
27_E76_R0.224810.574
132_A158_Q0.224670.573
72_V101_A0.224440.573
168_L172_V0.224240.572
123_E199_A0.224170.572
99_L219_V0.223740.571
198_P201_D0.223420.570
68_F107_L0.220440.563
265_E272_L0.219850.561
124_A196_M0.217950.556
52_P55_E0.217790.556
118_A121_M0.217230.554
31_R107_L0.216690.553
154_N248_F0.216440.552
194_P197_E0.215970.551
226_R232_E0.21560.550
225_G247_R0.215510.550
20_E26_R0.214730.548
120_L123_E0.214650.548
200_A240_R0.214090.546
47_L62_Y0.212370.542
40_L111_L0.21220.542
141_K171_L0.212150.541
190_A195_L0.21190.541
117_R246_V0.211890.541
12_P51_G0.211640.540
93_L96_Y0.211260.539
63_A191_F0.210760.538
30_D33_D0.210340.537
274_S278_R0.210020.536
136_E142_L0.20870.533
97_A100_V0.208450.532
152_N160_V0.207950.531
130_M154_N0.207760.530
24_V76_R0.207530.530
130_M162_S0.206850.528
31_R34_E0.206230.526
105_L109_D0.205750.525
97_A101_A0.205220.524
25_F77_L0.204720.522
60_T63_A0.204650.522
203_F207_L0.204520.522
221_S228_Y0.204490.522
62_Y115_Y0.204410.522
129_A169_E0.204120.521
175_L182_A0.203760.520
191_F196_M0.203490.519
251_A254_A0.20280.518
88_V98_A0.20130.514
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3tzyA0.9906100-0.054
2qo3A0.9969100-0.033
2hg4A0.9874100-0.023
3ptwA0.96231000.006
2vz8A0.97171000.023
3hhdA0.97171000.024
3k89A0.93711000.038
3ezoA0.9341000.038
2h1yA0.9341000.043
3qatA0.93711000.046

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