GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Asn_synthase - Asparagine synthase
Pfam: PF00733 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0039
Length: 255
Sequences: 2613
Seq/Len: 10.25
HH_delta: 0.176 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
46_K73_E0.672873.741
5_L219_F0.646073.592
32_A242_M0.628913.497
64_R76_E0.620353.449
65_K249_E0.585053.253
21_G121_I0.584033.247
240_E243_K0.509212.831
22_I34_A0.495372.754
7_E39_R0.471692.623
3_R244_D0.469532.611
200_S207_V0.444752.473
6_L36_L0.432332.404
8_E215_R0.428652.383
46_K75_H0.421862.346
248_P252_W0.405732.256
12_R215_R0.404712.250
115_L119_N0.400812.228
230_D236_Y0.39552.199
134_F220_C0.389692.167
47_T72_L0.385652.144
214_R218_E0.383322.131
64_R68_R0.381452.121
3_R241_A0.37982.112
47_T74_H0.379312.109
113_A200_S0.379282.109
9_A13_R0.379092.108
236_Y240_E0.376112.091
31_S66_V0.365582.033
5_L216_L0.358571.994
90_D114_R0.353811.967
123_V208_R0.340031.891
243_K252_W0.338871.884
244_D248_P0.330651.838
63_A67_A0.33061.838
34_A72_L0.325481.810
132_E137_Y0.323971.801
62_Y253_R0.315621.755
31_S246_L0.30941.720
2_L134_F0.307491.710
130_G211_F0.306741.705
243_K248_P0.306721.705
7_E36_L0.299261.664
197_D201_M0.296751.650
3_R245_L0.290011.612
215_R218_E0.289531.610
219_F223_L0.278181.547
82_E86_D0.274321.525
53_E78_E0.26931.497
154_S158_R0.268731.494
8_E12_R0.268351.492
117_R122_R0.26411.468
3_R7_E0.25841.437
80_D83_D0.257181.430
5_L215_R0.249491.387
48_F120_G0.248291.380
129_G212_L0.247761.378
33_I211_F0.246541.371
8_E11_A0.246151.369
60_R76_E0.244891.362
128_Q195_R0.244221.358
49_T63_A0.24141.342
112_L116_A0.238911.328
66_V250_I0.23461.304
83_D86_D0.234351.303
197_D206_E0.234031.301
37_A125_L0.232941.295
34_A70_L0.231031.285
2_L219_F0.230921.284
12_R15_R0.22841.270
20_I123_V0.228281.269
24_L47_T0.227451.265
14_L37_A0.22651.259
13_R209_S0.225941.256
37_A45_I0.22471.249
94_R202_A0.221651.232
65_K68_R0.219841.222
48_F119_N0.216791.205
216_L219_F0.216071.201
241_A244_D0.213091.185
6_L211_F0.212891.184
44_P73_E0.212581.182
4_E7_E0.210761.172
87_N111_L0.208281.158
51_G60_R0.206641.149
22_I37_A0.202811.128
5_L8_E0.201811.122
13_R213_D0.200041.112
181_Y185_W0.196031.090
201_M206_E0.195921.089
36_L245_L0.19421.080
237_L240_E0.192481.070
140_Y183_D0.191821.067
2_L220_C0.190031.057
196_S207_V0.189161.052
90_D93_W0.187791.044
38_A70_L0.186781.038
2_L238_L0.18651.037
10_V33_I0.186491.037
235_K238_L0.184911.028
35_A245_L0.184591.026
96_D198_R0.183151.018
62_Y65_K0.182761.016
83_D114_R0.182751.016
219_F222_S0.182161.013
95_L99_S0.18131.008
224_P227_Q0.181011.006
21_G48_F0.180131.002
6_L242_M0.179931.000
129_G132_E0.179911.000
2_L6_L0.178970.995
244_D251_L0.17880.994
9_A213_D0.178660.993
128_Q196_S0.1760.979
23_L116_A0.175540.976
18_K122_R0.174420.970
32_A241_A0.17350.965
21_G124_L0.172950.962
77_I115_L0.17280.961
18_K201_M0.172720.960
16_S20_I0.17270.960
69_H249_E0.170860.950
126_T207_V0.170440.948
6_L32_A0.168250.935
194_P198_R0.167170.929
110_Y203_Y0.167110.929
110_Y202_A0.166990.928
48_F121_I0.164750.916
53_E80_D0.164610.915
22_I33_I0.164250.913
137_Y206_E0.163640.910
135_G229_F0.163490.909
2_L216_L0.163340.908
218_E222_S0.161980.901
123_V206_E0.161280.897
211_F238_L0.159710.888
137_Y197_D0.159530.887
133_L217_V0.159150.885
22_I47_T0.159080.884
248_P251_L0.158920.884
87_N90_D0.157540.876
95_L199_A0.157050.873
123_V197_D0.156550.870
62_Y66_V0.156280.869
126_T209_S0.156110.868
149_L152_R0.155560.865
103_D195_R0.155450.864
197_D204_G0.154810.861
95_L106_S0.15470.860
197_D208_R0.154620.860
242_M245_L0.154410.859
28_L242_M0.154180.857
109_L196_S0.153930.856
8_E214_R0.153770.855
65_K69_H0.153680.854
17_D201_M0.153140.851
240_E252_W0.153040.851
86_D90_D0.152680.849
160_F165_L0.152410.847
31_S62_Y0.151940.845
87_N114_R0.151150.840
32_A244_D0.150750.838
132_E136_G0.150270.835
18_K206_E0.149680.832
64_R67_A0.149250.830
68_R71_G0.149150.829
23_L124_L0.148020.823
105_N195_R0.147690.821
242_M246_L0.14660.815
122_R206_E0.146330.814
31_S253_R0.145810.811
201_M208_R0.14570.810
25_S29_D0.1450.806
235_K255_K0.144640.804
124_L205_I0.144310.802
16_S19_P0.143350.797
131_D235_K0.143260.797
49_T60_R0.141670.788
67_A71_G0.141560.787
91_I110_Y0.141160.785
233_I239_R0.140610.782
2_L237_L0.14060.782
27_G30_S0.140240.780
4_E8_E0.139870.778
234_Y239_R0.139770.777
148_L152_R0.139140.774
108_P195_R0.138230.769
18_K123_V0.137780.766
51_G63_A0.137560.765
4_E11_A0.137140.762
33_I125_L0.137050.762
246_L251_L0.136710.760
87_N91_I0.136450.759
116_A124_L0.136270.758
7_E11_A0.136030.756
33_I126_T0.135860.755
10_V36_L0.135580.754
137_Y201_M0.135220.752
223_L237_L0.134680.749
75_H120_G0.13430.747
219_F224_P0.134240.746
61_E65_K0.134140.746
216_L220_C0.133760.744
142_P145_L0.133350.741
249_E252_W0.133280.741
34_A37_A0.133190.741
32_A134_F0.131280.730
17_D206_E0.13110.729
122_R208_R0.130820.727
24_L74_H0.130390.725
201_M204_G0.130350.725
75_H119_N0.129890.722
6_L33_I0.12980.722
9_A12_R0.12970.721
35_A246_L0.129570.720
48_F75_H0.129330.719
35_A70_L0.129130.718
63_A76_E0.128670.715
60_R78_E0.128640.715
136_G235_K0.128370.714
109_L199_A0.128330.714
180_E228_R0.12820.713
109_L128_Q0.127920.711
181_Y184_F0.127490.709
132_E212_L0.127310.708
90_D110_Y0.127080.707
137_Y235_K0.127010.706
111_L114_R0.127010.706
132_E197_D0.126760.705
23_L195_R0.126260.702
136_G208_R0.126170.702
87_N107_L0.1260.701
132_E201_M0.125880.700
34_A47_T0.125450.697
192_L195_R0.124990.695
2_L241_A0.12450.692
241_A245_L0.123840.689
59_E195_R0.123840.689
19_P122_R0.123390.686
239_R251_L0.123210.685
23_L113_A0.123110.684
247_P250_I0.12310.684
32_A238_L0.122980.684
219_F237_L0.122110.679
91_I111_L0.121330.675
16_S123_V0.12070.671
130_G133_L0.119950.667
6_L216_L0.119780.666
126_T199_A0.119680.665
161_I164_L0.119190.663
5_L217_V0.119180.663
154_S159_R0.119180.663
179_S183_D0.119160.663
180_E184_F0.119120.662
26_G66_V0.119050.662
120_G205_I0.118910.661
77_I121_I0.118750.660
158_R162_R0.118560.659
128_Q192_L0.118060.656
220_C237_L0.117970.656
158_R161_I0.117760.655
41_G45_I0.117740.655
99_S128_Q0.11750.653
150_L155_R0.117490.653
59_E104_P0.117330.652
133_L220_C0.117110.651
100_P103_D0.115880.644
143_A147_P0.115830.644
28_L31_S0.115640.643
105_N108_P0.115640.643
38_A45_I0.115160.640
17_D122_R0.115050.640
110_Y114_R0.115050.640
25_S30_S0.115050.640
151_G155_R0.114690.638
133_L212_L0.113960.634
128_Q198_R0.113950.634
18_K197_D0.113350.630
103_D128_Q0.113280.630
77_I111_L0.113020.628
65_K70_L0.11290.628
90_D94_R0.112840.627
54_D57_Y0.11280.627
122_R201_M0.112490.625
95_L128_Q0.112490.625
124_L207_V0.112250.624
193_L212_L0.112170.624
137_Y208_R0.112020.623
44_P114_R0.111960.622
131_D211_F0.111910.622
127_G131_D0.111140.618
112_L115_L0.111120.618
93_W96_D0.111020.617
94_R110_Y0.1110.617
47_T76_E0.110960.617
70_L74_H0.110320.613
233_I252_W0.110160.612
125_L208_R0.110040.612
153_L156_E0.110030.612
77_I83_D0.109430.608
17_D197_D0.109320.608
149_L156_E0.108850.605
193_L201_M0.108780.605
95_L104_P0.108570.604
109_L126_T0.108430.603
27_G127_G0.10790.600
66_V69_H0.107680.599
13_R212_L0.107380.597
26_G253_R0.107280.596
4_E86_D0.107190.596
79_L107_L0.1070.595
10_V125_L0.106910.594
48_F112_L0.106870.594
236_Y252_W0.106790.594
3_R242_M0.106520.592
19_P135_G0.10630.591
132_E198_R0.106160.590
46_K121_I0.105970.589
235_K239_R0.105510.587
4_E83_D0.105140.585
8_E13_R0.105110.584
51_G78_E0.105090.584
30_S247_P0.104820.583
226_E230_D0.104590.582
245_L252_W0.10450.581
50_I113_A0.104470.581
130_G235_K0.104430.581
23_L126_T0.104360.580
152_R164_L0.104340.580
17_D137_Y0.104320.580
71_G86_D0.104210.579
128_Q209_S0.104110.579
220_C223_L0.103960.578
24_L213_D0.103750.577
106_S195_R0.103570.576
150_L158_R0.103490.575
122_R137_Y0.103430.575
71_G222_S0.103410.575
29_D127_G0.103110.573
59_E63_A0.102930.572
160_F164_L0.102570.570
28_L246_L0.102480.570
161_I165_L0.102420.569
154_S165_L0.102270.569
50_I112_L0.102170.568
69_H244_D0.101960.567
38_A41_G0.101860.566
162_R165_L0.101670.565
193_L209_S0.101490.564
6_L134_F0.101470.564
224_P228_R0.101420.564
230_D240_E0.100990.562
132_E206_E0.100890.561
91_I95_L0.100850.561
99_S105_N0.100850.561
135_G180_E0.100780.560
3_R36_L0.100780.560
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1ct9A0.88241000.176
1q15A0.86271000.199
1jgtA0.84311000.199
3n05A0.721699.50.69
1xngA0.909899.30.719
3bl5A0.752999.20.729
2e18A0.882499.20.731
3fiuA0.894199.20.735
3p52A0.917699.20.736
1kqpA0.905999.20.737

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