GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Esterase - Putative esterase
Pfam: PF00756 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0028
Length: 251
Sequences: 21973
Seq/Len: 87.54
HH_delta: 0.198 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
118_A142_A2.515764.513
133_A143_V1.965983.526
145_A148_G1.434772.574
192_T232_P1.427452.560
105_Y109_N1.400812.513
119_I129_A1.345772.414
216_A220_K1.266232.271
213_R230_V1.252122.246
216_A228_Y1.240042.224
216_A226_H1.195712.145
113_D116_R1.190812.136
129_A143_V1.116632.003
209_L213_R1.10861.989
27_L120_A1.086951.950
48_R52_E1.027671.843
192_T230_V1.012711.817
29_L120_A0.983261.764
130_L145_A0.978561.755
143_V186_I0.964131.729
26_V112_T0.940151.686
26_V59_I0.933971.675
122_H147_S0.930621.669
217_Q221_A0.927181.663
218_L222_K0.890941.598
107_E117_R0.880681.580
120_A146_F0.854391.533
53_G58_M0.850771.526
107_E139_L0.817921.467
24_Y59_I0.810991.455
27_L58_M0.808041.449
12_V61_V0.804891.444
120_A144_I0.803841.442
14_L59_I0.781661.402
105_Y108_A0.774871.390
65_N68_N0.77361.388
12_V59_I0.772051.385
187_Y229_H0.768521.379
131_Y135_R0.766721.375
126_G148_G0.763431.369
32_G123_S0.757631.359
142_A185_R0.748581.343
190_V228_Y0.744841.336
49_L53_G0.744111.335
218_L221_A0.740961.329
145_A188_L0.736711.321
104_P107_E0.732071.313
190_V212_N0.725741.302
122_H146_F0.718661.289
30_L119_I0.712381.278
219_L224_I0.708191.270
209_L230_V0.706491.267
15_P24_Y0.693131.243
46_L50_I0.690911.239
220_K226_H0.687011.232
130_L215_L0.686951.232
144_I187_Y0.685161.229
10_V61_V0.681991.223
47_D51_A0.67811.216
104_P108_A0.673071.207
185_R225_P0.667811.198
100_E104_P0.661531.187
35_G38_R0.651021.168
104_P139_L0.650091.166
187_Y227_T0.648381.163
101_E104_P0.648251.163
190_V230_V0.645071.157
64_P69_S0.642841.153
188_L216_A0.641931.151
58_M64_P0.640871.150
217_Q220_K0.638171.145
190_V194_D0.63281.135
161_D164_A0.632311.134
213_R217_Q0.628181.127
103_I140_F0.626031.123
64_P67_D0.625281.122
214_E217_Q0.623961.119
163_E166_K0.623541.118
190_V209_L0.618751.110
119_I132_L0.608611.092
118_A144_I0.60371.083
189_D229_H0.603631.083
26_V61_V0.602921.081
97_F101_E0.595451.068
214_E218_L0.594131.066
103_I107_E0.584911.049
28_Y117_R0.579791.040
96_T100_E0.579651.040
88_S91_G0.57811.037
213_R216_A0.572061.026
107_E112_T0.565521.014
10_V102_L0.565371.014
219_L226_H0.564571.013
147_S194_D0.563761.011
127_Y131_Y0.561471.007
189_D231_F0.561021.006
144_I189_D0.560621.006
213_R228_Y0.560351.005
48_R51_A0.553790.993
26_V117_R0.553520.993
30_L129_A0.553510.993
119_I140_F0.553090.992
89_G93_A0.549120.985
116_R141_G0.549080.985
86_D89_G0.547540.982
147_S191_G0.54730.982
169_D172_D0.546160.980
210_A213_R0.546040.979
115_D141_G0.544810.977
87_D91_G0.544650.977
193_K233_G0.544480.977
163_E167_E0.538780.966
154_P158_G0.531490.953
146_F189_D0.52890.949
23_P113_D0.528290.948
126_G145_A0.527370.946
182_K185_R0.526790.945
50_I53_G0.523480.939
143_V184_L0.520460.934
62_V65_N0.520010.933
164_A167_E0.517520.928
150_L215_L0.517190.928
29_L122_H0.517190.928
89_G92_D0.515780.925
129_A133_A0.511750.918
103_I117_R0.511450.917
87_D90_G0.511030.917
211_N214_E0.510560.916
95_E135_R0.509810.914
136_H139_L0.509310.914
26_V106_I0.507430.910
66_G69_S0.507420.910
27_L118_A0.504920.906
107_E110_Y0.502570.901
188_L215_L0.501550.900
119_I143_V0.499950.897
181_K184_L0.496140.890
9_R64_P0.49060.880
123_S235_H0.488840.877
59_I112_T0.488460.876
13_Y62_V0.485780.871
166_K172_D0.485110.870
30_L128_G0.48410.868
118_A141_G0.482020.865
162_D166_K0.480670.862
212_N216_A0.480470.862
121_G126_G0.479780.861
192_T209_L0.479010.859
17_G24_Y0.478670.859
92_D95_E0.478610.859
215_L219_L0.472410.847
28_Y103_I0.470220.843
30_L63_I0.470140.843
21_S24_Y0.470050.843
15_P59_I0.469460.842
127_Y149_A0.468450.840
155_S159_P0.468310.840
124_M128_G0.464530.833
169_D173_L0.463150.831
25_P58_M0.458810.823
102_L105_Y0.455030.816
130_L150_L0.454450.815
124_M127_Y0.454370.815
130_L148_G0.453630.814
121_G125_G0.453620.814
106_I110_Y0.453550.814
165_W168_N0.450570.808
192_T233_G0.449170.806
46_L49_L0.44870.805
43_Q47_D0.445940.800
90_G95_E0.442110.793
31_D65_N0.439220.788
155_S158_G0.439040.788
160_S163_E0.435110.780
162_D165_W0.434080.779
147_S236_D0.432580.776
102_L106_I0.431730.774
180_K183_P0.431010.773
170_P173_L0.430040.771
211_N215_L0.429450.770
142_A187_Y0.429170.770
25_P113_D0.428950.769
91_G94_Y0.427580.767
131_Y134_L0.426980.766
129_A145_A0.426630.765
65_N69_S0.42350.760
130_L186_I0.422250.757
10_V105_Y0.416590.747
61_V64_P0.413870.742
25_P116_R0.413670.742
106_I109_N0.41360.742
36_W40_G0.411960.739
65_N124_M0.411770.739
132_L136_H0.411420.738
210_A214_E0.411280.738
44_E47_D0.411250.738
95_E98_L0.409860.735
29_L46_L0.408950.734
27_L49_L0.40520.727
86_D91_G0.404280.725
149_A152_P0.404280.725
14_L24_Y0.402340.722
90_G93_A0.400840.719
103_I139_L0.400220.718
113_D117_R0.399890.717
223_G226_H0.399330.716
126_G147_S0.399110.716
88_S92_D0.396970.712
120_A129_A0.396280.711
92_D96_T0.395990.710
34_S37_F0.395890.710
160_S165_W0.395710.710
29_L62_V0.393160.705
101_E105_Y0.390770.701
63_I66_G0.389170.698
216_A230_V0.386050.692
121_G129_A0.384440.690
188_L212_N0.382650.686
45_A49_L0.382260.686
188_L226_H0.376590.676
86_D90_G0.376550.675
44_E48_R0.375820.674
134_L215_L0.373890.671
137_P140_F0.373380.670
24_Y111_R0.373090.669
91_G95_E0.371060.666
90_G94_Y0.371020.666
36_W39_N0.369670.663
113_D141_G0.369390.663
112_T116_R0.369310.662
25_P118_A0.36890.662
132_L140_F0.365050.655
100_E136_H0.364460.654
192_T231_F0.363990.653
98_L103_I0.359140.644
147_S237_W0.358180.642
35_G39_N0.357570.641
26_V118_A0.357430.641
14_L111_R0.357320.641
186_I215_L0.35690.640
212_N215_L0.356250.639
42_A45_A0.356050.639
140_F143_V0.353790.635
101_E109_N0.352640.633
95_E101_E0.352340.632
64_P68_N0.352220.632
117_R140_F0.35080.629
112_T115_D0.35010.628
95_E100_E0.349650.627
161_D165_W0.346930.622
45_A48_R0.346250.621
142_A145_A0.34530.619
153_S166_K0.345280.619
133_A184_L0.344470.618
61_V106_I0.343870.617
29_L60_I0.342690.615
98_L101_E0.342170.614
104_P136_H0.341620.613
30_L97_F0.340960.612
38_R41_N0.340860.611
145_A150_L0.340110.610
107_E114_P0.338030.606
159_P162_D0.336830.604
31_D62_V0.333970.599
143_V148_G0.332920.597
13_Y60_I0.33240.596
180_K222_K0.331710.595
87_D93_A0.331270.594
98_L104_P0.330650.593
23_P111_R0.330280.592
94_Y97_F0.330240.592
47_D50_I0.329720.591
130_L143_V0.329610.591
60_I63_I0.327730.588
188_L219_L0.324920.583
147_S190_V0.324080.581
91_G97_F0.323890.581
13_Y47_D0.323680.581
11_W64_P0.32350.580
59_I62_V0.323250.580
126_G129_A0.322330.578
46_L62_V0.321250.576
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3e4dA0.932399.90.198
3fcxA0.940299.90.21
4hvtA0.892499.90.212
4a5sA0.892499.90.215
3ls2A0.928399.90.218
3i6yA0.928399.90.218
1xfdA0.888499.90.224
4hxfB0.880599.90.226
3o4hA0.876599.90.226
3azoA0.888499.90.227

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