GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DAGK_cat - Diacylglycerol kinase catalytic domain
Pfam: PF00781 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0240
Length: 130
Sequences: 3315
Seq/Len: 25.5
HH_delta: 0.103 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
60_V70_V0.843723.240
61_V90_A0.72762.794
21_E25_R0.718342.758
38_S41_H0.687852.641
75_M124_V0.579522.225
23_A112_L0.508331.952
57_V84_P0.470841.808
41_H45_L0.470341.806
41_H44_A0.469851.804
2_V57_V0.464911.785
2_V59_V0.459171.763
68_N72_N0.435261.671
95_D99_S0.430681.654
96_F122_I0.426111.636
36_T42_A0.417681.604
11_G92_T0.408511.569
97_A102_I0.406431.561
6_I35_E0.404791.554
67_L87_I0.399671.535
95_D98_R0.397021.524
103_P113_L0.384941.478
69_E73_G0.383971.474
4_V59_V0.38111.463
79_R84_P0.375741.443
7_N10_S0.369651.419
3_L34_I0.36771.412
62_G66_T0.362661.392
22_P26_A0.361951.390
40_G69_E0.354241.360
36_T69_E0.353041.356
89_P94_N0.352481.353
3_L54_Y0.347391.334
36_T41_H0.333351.280
3_L32_E0.32991.267
6_I33_V0.327311.257
37_E41_H0.323431.242
51_L54_Y0.322881.240
19_K107_E0.321111.233
68_N71_V0.31941.226
27_A112_L0.319031.225
105_D108_A0.317971.221
84_P119_V0.317141.218
40_G43_E0.316831.217
60_V87_I0.305851.174
7_N66_T0.305531.173
60_V66_T0.303311.165
4_V31_Y0.293321.126
46_A50_A0.290041.114
50_A54_Y0.287541.104
42_A69_E0.287291.103
88_I106_P0.286751.101
49_L54_Y0.284381.092
112_L116_L0.27841.069
57_V86_G0.278351.069
114_I117_G0.278061.068
42_A46_A0.276571.062
7_N65_G0.275591.058
6_I15_A0.269871.036
49_L53_D0.26971.036
6_I61_V0.267941.029
96_F100_L0.266741.024
95_D123_D0.264051.014
17_W21_E0.261951.006
108_A112_L0.259990.998
23_A26_A0.259480.996
68_N95_D0.259210.995
46_A70_V0.256560.985
23_A27_A0.255630.982
92_T95_D0.253940.975
71_V85_L0.25390.975
34_I45_L0.253570.974
61_V88_I0.250870.963
103_P108_A0.247650.951
60_V85_L0.247180.949
113_L117_G0.246820.948
59_V86_G0.245510.943
2_V29_I0.243490.935
103_P110_A0.242830.932
40_G44_A0.242190.930
88_I110_A0.239740.921
25_R28_G0.233090.895
67_L96_F0.232370.892
25_R31_Y0.231940.891
44_A47_R0.229460.881
10_S13_G0.22890.879
38_S69_E0.227340.873
47_R51_L0.225410.865
97_A106_P0.223270.857
38_S44_A0.222660.855
47_R76_G0.222540.854
98_R104_S0.222060.853
64_D91_G0.221490.850
99_S123_D0.220270.846
5_I46_A0.220.845
5_I70_V0.219760.844
106_P111_A0.217060.833
19_K22_P0.216330.831
112_L115_I0.215930.829
58_I74_L0.215660.828
2_V31_Y0.214620.824
111_A115_I0.213420.819
87_I96_F0.213370.819
12_G93_G0.205550.789
23_A111_A0.204170.784
16_K52_D0.200140.768
60_V71_V0.199820.767
60_V67_L0.199340.765
6_I17_W0.198880.764
57_V114_I0.197850.760
16_K35_E0.197770.759
27_A115_I0.195170.749
121_K124_V0.194060.745
118_R121_K0.193160.742
17_W73_G0.191740.736
117_G120_R0.190520.732
18_K22_P0.190520.732
112_L120_R0.189840.729
93_G96_F0.18910.726
5_I36_T0.188970.726
102_I110_A0.188920.725
5_I42_A0.187730.721
28_G61_V0.187450.720
92_T125_G0.187370.719
74_L77_S0.187060.718
107_E118_R0.186630.717
61_V99_S0.186450.716
20_V88_I0.185470.712
24_L114_I0.184010.707
63_G94_N0.183850.706
30_D56_D0.181740.698
113_L118_R0.181410.697
39_A42_A0.178570.686
61_V93_G0.177480.681
46_A74_L0.177450.681
8_P36_T0.176770.679
120_R126_K0.176520.678
50_A77_S0.176110.676
43_E47_R0.174580.670
42_A73_G0.173880.668
43_E73_G0.173680.667
24_L29_I0.173050.664
21_E32_E0.172950.664
84_P87_I0.172350.662
112_L118_R0.172350.662
68_N93_G0.171180.657
21_E31_Y0.170950.656
111_A114_I0.170870.656
96_F124_V0.170340.654
105_D110_A0.17020.654
7_N12_G0.170080.653
17_W35_E0.16960.651
15_A95_D0.169310.650
87_I92_T0.169070.649
21_E35_E0.168960.649
36_T73_G0.167880.645
13_G17_W0.166640.640
114_I123_D0.165960.637
25_R47_R0.165370.635
60_V99_S0.164880.633
63_G91_G0.164830.633
36_T40_G0.164120.630
87_I102_I0.164050.630
97_A101_G0.163830.629
72_N95_D0.16320.627
23_A115_I0.16240.624
17_W31_Y0.162250.623
32_E54_Y0.162180.623
89_P102_I0.161550.620
24_L111_A0.159160.611
24_L115_I0.159040.611
7_N74_L0.158640.609
15_A20_V0.158310.608
110_A114_I0.157860.606
72_N124_V0.15780.606
110_A113_L0.156990.603
76_G79_R0.156980.603
59_V114_I0.156680.602
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3vzdA0.984699.90.103
3vzbA0.984699.90.105
3s40A0.961599.90.108
2qv7A0.969299.90.143
2bonA0.976999.90.149
2an1A0.938599.50.461
1u0tA0.938599.40.489
1yt5A0.823199.20.531
2i2cA0.807799.10.558
3afoA0.946298.90.591

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