GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DSPc - Dual specificity phosphatase catalytic domain
Pfam: PF00782 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0031
Length: 133
Sequences: 4860
Seq/Len: 36.54
HH_delta: 0.041 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
78_V91_A1.03532.979
102_S105_E0.938882.702
109_Y113_R0.875222.519
62_A90_V0.864142.487
20_T75_K0.756182.176
20_T74_G0.755522.174
24_N42_Y0.695932.003
88_G117_I0.655961.888
92_A110_V0.643481.852
67_E98_K0.639051.839
12_A16_N0.638341.837
21_H43_L0.635911.830
101_M109_Y0.605281.742
21_H69_A0.604751.740
25_L90_V0.591061.701
80_C87_S0.587681.691
92_A107_I0.585681.686
109_Y112_S0.550741.585
43_L61_Q0.545161.569
43_L65_F0.536351.544
18_G75_K0.534751.539
21_H74_G0.5151.482
49_D85_S0.484281.394
36_K39_G0.482011.387
13_F17_L0.467881.347
60_D64_E0.46071.326
22_V79_H0.445611.282
55_I58_H0.439131.264
63_V93_A0.43111.241
23_I62_A0.430591.239
66_I94_Y0.422681.216
59_L90_V0.411231.183
79_H86_R0.410841.182
104_E108_E0.40991.180
54_P57_E0.409571.179
60_D97_K0.407551.173
92_A103_L0.407241.172
24_N44_R0.405411.167
108_E112_S0.405061.166
82_A86_R0.400141.152
13_F16_N0.395121.137
45_I62_A0.394961.137
23_I43_L0.394041.134
88_G110_V0.393581.133
95_L106_A0.391721.127
79_H82_A0.387981.117
49_D82_A0.384491.107
21_H65_F0.378151.088
99_N109_Y0.373611.075
110_V117_I0.37331.074
11_I15_K0.367261.057
65_F69_A0.367151.057
85_S89_A0.36651.055
87_S91_A0.360611.038
34_F37_P0.359861.036
101_M105_E0.35791.030
80_C83_G0.355321.023
19_I75_K0.354971.022
67_E97_K0.348721.004
14_L40_I0.346290.997
31_N44_R0.343810.989
59_L63_V0.342940.987
67_E94_Y0.340550.980
69_A74_G0.338740.975
64_E68_N0.338480.974
25_L88_G0.334270.962
84_L118_N0.331770.955
62_A66_I0.330390.951
58_H61_Q0.32210.927
53_E58_H0.320690.923
111_R118_N0.320230.922
47_I53_E0.319270.919
84_L116_Q0.318510.917
45_I65_F0.315610.908
68_N72_E0.314310.905
51_P55_I0.313340.902
23_I76_V0.310980.895
96_M106_A0.308920.889
103_L107_I0.308480.888
62_A65_F0.305550.879
24_N79_H0.30460.877
96_M103_L0.304450.876
83_G87_S0.301660.868
55_I60_D0.300730.865
83_G86_R0.299620.862
67_E71_S0.298570.859
28_E44_R0.291630.839
19_I77_L0.291330.838
107_I118_N0.2890.832
94_Y98_K0.288490.830
63_V97_K0.28810.829
67_E70_I0.286550.825
21_H41_E0.285890.823
35_Y40_I0.285860.823
54_P58_H0.277520.799
85_S88_G0.277330.798
45_I58_H0.273510.787
56_L59_L0.273230.786
36_K42_Y0.271290.781
26_Q85_S0.270770.779
93_A96_M0.266410.767
88_G91_A0.262740.756
26_Q42_Y0.260940.751
51_P54_P0.258280.743
15_K38_E0.25460.733
59_L93_A0.254560.733
66_I76_V0.254450.732
105_E108_E0.253650.730
17_L75_K0.252170.726
115_P118_N0.249860.719
56_L60_D0.248060.714
85_S92_A0.245630.707
24_N31_N0.244820.705
27_E48_D0.242840.699
24_N81_K0.241950.696
25_L47_I0.241690.696
12_A15_K0.241520.695
21_H73_G0.240860.693
54_P59_L0.23790.685
93_A97_K0.236860.682
30_P44_R0.236780.681
79_H84_L0.234610.675
57_E61_Q0.233930.673
91_A95_L0.233870.673
23_I45_I0.232030.668
15_K40_I0.230140.662
19_I94_Y0.227760.655
25_L45_I0.227610.655
80_C86_R0.226370.651
89_A92_A0.225620.649
22_V40_I0.225160.648
83_G114_R0.224720.647
41_E68_N0.223240.642
11_I40_I0.221110.636
41_E72_E0.220690.635
49_D86_R0.219460.632
95_L110_V0.21840.629
81_K89_A0.21790.627
84_L88_G0.216580.623
25_L78_V0.215530.620
95_L109_Y0.214740.618
77_L85_S0.213540.615
29_C48_D0.213240.614
61_Q64_E0.213030.613
44_R51_P0.212970.613
49_D54_P0.212820.612
10_S15_K0.2120.610
49_D83_G0.210760.607
9_A77_L0.210610.606
77_L87_S0.210190.605
24_N27_E0.208650.600
25_L29_C0.208380.600
35_Y39_G0.207920.598
30_P82_A0.207850.598
94_Y106_A0.205920.593
15_K39_G0.204390.588
101_M106_A0.204330.588
71_S74_G0.203790.586
97_K100_G0.201380.580
21_H72_E0.201340.579
8_A13_F0.20050.577
88_G118_N0.199560.574
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3emuA0.977499.90.041
3s4eA0.977499.90.051
3ezzA0.977499.90.053
2g6zA0.977499.90.063
2esbA0.977499.90.065
3f81A0.992599.90.073
2nt2A0.977499.90.077
2oudA0.992599.90.087
1zzwA0.992599.90.089
2hcmA0.977499.90.089

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