GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
PMP22_Claudin - PMP-22EMPMP20Claudin family
Pfam: PF00822 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0375
Length: 166
Sequences: 1889
Seq/Len: 11.38
HH_delta: 0.925 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
46_C57_C0.453923.824
25_T148_S0.361733.047
20_I24_A0.302322.547
75_A79_L0.292912.467
150_Y154_V0.262082.208
22_A152_G0.223151.880
91_A107_A0.211231.779
78_I82_I0.204621.724
108_G115_G0.200921.692
30_V146_G0.200111.686
27_Y39_W0.19721.661
145_F153_W0.193091.626
21_V25_T0.189931.600
86_L89_I0.189221.594
23_T77_M0.189081.593
120_I124_W0.181941.533
123_S127_A0.181161.526
115_G160_L0.173291.460
121_A125_Y0.170561.437
116_L120_I0.169971.432
149_F153_W0.168691.421
132_E135_D0.167631.412
70_L94_G0.165591.395
25_T147_W0.15891.338
82_I89_I0.158671.337
119_L123_S0.155961.314
116_L123_S0.154341.300
28_W41_G0.147351.241
15_W84_G0.141851.195
77_M118_L0.141481.192
22_A155_A0.140791.186
108_G163_G0.140741.186
118_L122_V0.139351.174
110_L113_L0.139071.171
79_L86_L0.137721.160
122_V152_G0.136561.150
118_L155_A0.136231.148
27_Y147_W0.135971.145
90_L107_A0.135891.145
41_G57_C0.135261.139
145_F156_F0.13511.138
26_P41_G0.134961.137
132_E143_Y0.134591.134
85_F89_I0.131781.110
90_L118_L0.131681.109
126_T129_I0.131321.106
80_S114_A0.13131.106
50_S53_G0.131071.104
80_S84_G0.131051.104
43_W74_R0.130321.098
112_I163_G0.129981.095
57_C67_P0.129751.093
42_L82_I0.129511.091
74_R94_G0.128531.083
73_A80_S0.128471.082
25_T41_G0.127581.075
84_G87_G0.126921.069
17_A24_A0.126811.068
83_L117_C0.126541.066
31_S137_S0.126431.065
21_V24_A0.125591.058
112_I115_G0.124731.051
20_I99_K0.124011.045
68_G72_A0.121541.024
36_Q54_S0.12031.013
77_M121_A0.11961.007
107_A110_L0.119331.005
157_I161_L0.119121.003
20_I81_I0.11820.996
147_W151_L0.117690.991
149_F162_S0.117090.986
121_A124_W0.116430.981
58_D61_D0.115610.974
75_A82_I0.115390.972
77_M95_L0.114440.964
119_L156_F0.114270.963
147_W161_L0.11420.962
62_S65_S0.114140.961
15_W85_F0.113510.956
92_L101_G0.113070.952
19_L84_G0.112990.952
96_C114_A0.11290.951
43_W156_F0.112880.951
20_I26_P0.112630.949
126_T149_F0.112030.944
16_L20_I0.11170.941
31_S141_I0.111360.938
52_T57_C0.110920.934
89_I102_P0.110740.933
70_L74_R0.110710.933
15_W48_Q0.110540.931
79_L99_K0.110390.930
107_A111_F0.109580.923
45_E58_D0.109110.919
22_A148_S0.108960.918
89_I100_R0.108750.916
83_L123_S0.108690.916
84_G159_L0.108590.915
110_L114_A0.108520.914
121_A159_L0.108140.911
115_G164_I0.108080.910
91_A164_I0.106760.899
102_P105_K0.106580.898
111_F159_L0.106350.896
17_A21_V0.106210.895
127_A149_F0.105990.893
20_I137_S0.105140.886
150_Y153_W0.105050.885
93_F98_T0.104450.880
153_W163_G0.103560.872
72_A161_L0.10350.872
93_F97_C0.103370.871
30_V161_L0.103010.868
23_T60_Y0.102950.867
83_L93_F0.102730.865
107_A157_I0.102620.864
69_Y73_A0.102480.863
82_I106_V0.102460.863
38_R47_I0.102310.862
74_R119_L0.102110.860
93_F164_I0.102080.860
30_V112_I0.101630.856
23_T93_F0.101550.855
43_W70_L0.101240.853
87_G108_G0.101010.851
118_L156_F0.100860.850
21_V97_C0.100770.849
78_I99_K0.100760.849
19_L145_F0.100740.849
31_S143_Y0.100730.848
24_A41_G0.100710.848
140_N143_Y0.10050.847
22_A60_Y0.100450.846
85_F92_L0.100410.846
127_A160_L0.100120.843
130_V134_S0.099990.842
23_T126_T0.099960.842
94_G107_A0.099910.842
19_L116_L0.099780.840
81_I88_L0.099460.838
127_A148_S0.099150.835
28_W122_V0.099130.835
132_E136_P0.09860.831
104_P114_A0.09860.831
126_T133_F0.098340.828
67_P85_F0.09820.827
109_I112_I0.098140.827
33_V36_Q0.098130.827
72_A76_L0.098010.826
34_S143_Y0.097820.824
15_W39_W0.097740.823
48_Q99_K0.09770.823
118_L162_S0.097640.822
40_S45_E0.097620.822
85_F88_L0.097580.822
60_Y125_Y0.097580.822
82_I99_K0.097370.820
76_L79_L0.097270.819
144_E159_L0.097060.818
26_P44_R0.09680.815
48_Q55_T0.096720.815
56_Q59_S0.096520.813
123_S156_F0.096520.813
28_W152_G0.096430.812
89_I92_L0.096290.811
80_S119_L0.096140.810
42_L131_Q0.095810.807
82_I86_L0.095580.805
16_L68_G0.095230.802
92_L97_C0.095120.801
26_P148_S0.095110.801
71_Q74_R0.095080.801
126_T147_W0.095050.801
20_I161_L0.095040.801
90_L154_V0.094710.798
122_V126_T0.09460.797
82_I125_Y0.094540.796
123_S126_T0.094460.796
50_S54_S0.094310.794
72_A117_C0.094290.794
48_Q59_S0.094010.792
73_A124_W0.093980.792
110_L128_V0.093920.791
105_K158_L0.093880.791
24_A27_Y0.093770.790
122_V156_F0.093310.786
25_T92_L0.092620.780
14_G24_A0.09190.774
80_S116_L0.091630.772
116_L160_L0.091580.771
91_A94_G0.091550.771
26_P39_W0.091270.769
58_D65_S0.091260.769
41_G49_Q0.091220.768
19_L164_I0.090780.765
153_W157_I0.090760.765
14_G163_G0.090680.764
22_A25_T0.090680.764
109_I114_A0.090630.763
26_P57_C0.090460.762
106_V109_I0.090210.760
124_W128_V0.090020.758
97_C108_G0.089980.758
83_L87_G0.089930.758
55_T157_I0.089840.757
40_S60_Y0.089620.755
38_R80_S0.089540.754
41_G46_C0.08940.753
154_V163_G0.088810.748
70_L117_C0.088790.748
20_I33_V0.08850.745
95_L101_G0.088450.745
13_L151_L0.088380.744
71_Q75_A0.088250.743
12_S24_A0.088160.743
27_Y85_F0.088080.742
71_Q98_T0.088080.742
83_L100_R0.088080.742
21_V155_A0.088030.742
64_L68_G0.088020.741
13_L20_I0.087960.741
57_C163_G0.087910.741
64_L134_S0.087740.739
30_V55_T0.087710.739
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3ux4A0.53019.20.925
3rkoL0.53017.30.928
4he8L0.5066.60.929
4he8M0.4943.60.937
4b19A0.180730.939
3rhwA0.81932.50.942
3j2wE0.21082.20.943
1q8dA0.40962.20.944
4gc0A0.93371.90.945
2k9yA0.2411.90.945
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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