GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Sulfatase - Sulfatase
Pfam: PF00884 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0088
Length: 308
Sequences: 9410
Seq/Len: 30.55
HH_delta: 0.115 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
232_K237_Y1.651734.712
28_N225_G1.433354.089
229_E233_E1.244983.551
35_N279_Y1.20273.431
157_F178_T1.106873.157
42_A293_V1.09073.111
161_I230_Y1.059033.021
8_L11_L1.005162.867
17_S30_D0.933882.664
40_S290_D0.913332.605
90_K119_D0.89262.546
280_W283_G0.865522.469
159_Y162_D0.855842.441
3_V306_L0.846192.414
230_Y234_Q0.80952.309
4_V242_I0.806042.299
228_I242_I0.762612.175
28_N31_R0.754852.153
230_Y233_E0.739812.110
158_D226_R0.731222.086
38_R288_T0.727532.075
160_A174_L0.696511.987
2_N172_F0.68771.962
161_I226_R0.680011.940
165_L230_Y0.675381.927
8_L244_I0.667381.904
11_L244_I0.666371.901
191_Y222_D0.6591.880
160_A176_I0.653041.863
37_L289_I0.641561.830
157_F161_I0.637631.819
237_Y279_Y0.636941.817
95_R170_K0.630931.800
157_F227_F0.629221.795
83_P91_K0.626251.786
26_T30_D0.625331.784
37_L287_Q0.62321.778
241_I305_L0.61511.755
241_I278_I0.614551.753
228_I237_Y0.604911.725
31_R35_N0.604251.724
92_A308_I0.602741.719
40_S288_T0.598961.709
189_P193_E0.593371.693
3_V89_L0.590191.684
303_L308_I0.588881.680
18_C38_R0.585161.669
225_G229_E0.584011.666
6_I224_L0.571491.630
7_V245_T0.56971.625
4_V240_T0.56611.615
223_Q226_R0.561811.603
178_T223_Q0.560251.598
31_R232_K0.56011.598
5_L243_I0.559731.597
99_F174_L0.555541.585
194_K218_A0.553721.579
60_L82_F0.551051.572
231_L242_I0.54021.541
243_I278_I0.531751.517
19_Y38_R0.528631.508
5_L173_F0.520121.484
176_I227_F0.517451.476
49_T53_R0.517061.475
5_L245_T0.515261.470
61_Y296_I0.514691.468
4_V172_F0.50441.439
55_S65_S0.501671.431
39_F276_L0.501571.431
85_L173_F0.501151.430
243_I302_L0.499671.425
6_I227_F0.498581.422
8_L220_V0.495511.413
17_S26_T0.494091.409
2_N240_T0.491191.401
42_A276_L0.49041.399
218_A222_D0.488211.393
298_I302_L0.486171.387
181_P217_I0.48541.385
97_S163_F0.482661.377
98_F175_F0.480181.370
237_Y242_I0.474331.353
32_L224_L0.471671.345
89_L306_L0.467141.333
32_L277_I0.457531.305
35_N232_K0.456491.302
43_Y272_Y0.456321.302
28_N229_E0.448111.278
52_S295_H0.44711.275
153_D180_G0.431681.231
154_D219_Y0.427241.219
97_S120_Y0.423851.209
11_L181_P0.421791.203
226_R229_E0.416241.187
156_L176_I0.413341.179
7_V56_M0.411651.174
88_L91_K0.410821.172
280_W284_E0.409151.167
154_D223_Q0.408311.165
172_F236_L0.40491.155
241_I280_W0.401071.144
26_T29_L0.393951.124
37_L284_E0.391921.118
89_L302_L0.388071.107
4_V174_L0.386891.104
3_V241_I0.385671.100
36_G277_I0.384811.098
25_T218_A0.384781.098
222_D226_R0.383451.094
88_L299_A0.383091.093
83_P88_L0.38281.092
229_E232_K0.379671.083
11_L217_I0.375531.071
3_V302_L0.375071.070
165_L234_Q0.374091.067
220_V244_I0.374061.067
269_E273_H0.372171.062
29_L244_I0.365071.041
18_C30_D0.363061.036
29_L224_L0.362731.035
178_T220_V0.361131.030
32_L279_Y0.360621.029
27_P221_D0.360281.028
162_D166_N0.358731.023
13_A273_H0.358551.023
192_A215_N0.35781.021
97_S174_L0.357071.019
4_V231_L0.356871.018
157_F223_Q0.356561.017
94_Y306_L0.354141.010
224_L228_I0.354041.010
26_T217_I0.351081.001
33_A38_R0.348790.995
44_S274_V0.348350.994
28_N221_D0.348040.993
276_L298_I0.346950.990
280_W305_L0.345390.985
32_L36_G0.344010.981
276_L293_V0.343660.980
87_D116_H0.343630.980
88_L303_L0.343370.979
43_Y269_E0.342180.976
190_D222_D0.341540.974
10_S248_H0.337610.963
89_L173_F0.336280.959
28_N228_I0.336180.959
42_A295_H0.334460.954
10_S263_K0.333890.952
24_P218_A0.333530.951
232_K279_Y0.333360.951
182_H247_D0.33160.946
6_I242_I0.330280.942
60_L64_N0.329110.939
211_N215_N0.328490.937
88_L92_A0.328020.936
289_I293_V0.327180.933
235_G238_D0.324540.926
95_R119_D0.323550.923
188_P191_Y0.322630.920
219_Y223_Q0.322420.920
236_L239_N0.320950.916
31_R229_E0.319270.911
44_S52_S0.313940.896
84_S87_D0.313110.893
234_Q237_Y0.311880.890
157_F226_R0.311060.887
188_P219_Y0.310550.886
11_L16_L0.31040.885
98_F177_H0.310370.885
8_L181_P0.310130.885
2_N236_L0.309670.883
3_V173_F0.309450.883
56_M298_I0.307230.876
227_F230_Y0.306650.875
7_V175_F0.306280.874
15_D213_Y0.306090.873
31_R34_E0.305590.872
221_D225_G0.305430.871
30_D34_E0.305050.870
160_A164_L0.304240.868
6_I244_I0.303640.866
23_I214_L0.297640.849
58_T84_S0.297530.849
56_M245_T0.295260.842
7_V53_R0.294750.841
7_V177_H0.294150.839
241_I302_L0.293640.838
172_F240_T0.293520.837
21_Y214_L0.293470.837
288_T291_R0.292970.836
41_N273_H0.292440.834
215_N218_A0.291050.830
86_P89_L0.290630.829
151_Y219_Y0.290330.828
180_G219_Y0.289780.827
26_T221_D0.28910.825
21_Y24_P0.288890.824
49_T247_D0.28860.823
50_S67_V0.287710.821
187_Y192_A0.286410.817
231_L237_Y0.286410.817
5_L302_L0.284110.810
31_R228_I0.283630.809
57_L175_F0.283150.808
208_E211_N0.28310.808
189_P192_A0.282230.805
9_E181_P0.278440.794
60_L65_S0.277990.793
246_S274_V0.276820.790
95_R167_E0.275250.785
32_L228_I0.2750.784
5_L298_I0.274370.783
87_D91_K0.274150.782
5_L56_M0.273890.781
6_I176_I0.273640.781
89_L94_Y0.273330.780
99_F163_F0.272850.778
158_D161_I0.27210.776
13_A19_Y0.271770.775
55_S62_P0.271130.773
45_S294_S0.270590.772
155_A158_D0.270560.772
192_A212_N0.270330.771
283_G286_Q0.269640.769
191_Y219_Y0.268540.766
36_G279_Y0.267810.764
191_Y218_A0.26750.763
297_D301_T0.267390.763
55_S296_I0.266860.761
4_V227_F0.266230.759
42_A274_V0.266110.759
10_S250_E0.265720.758
297_D300_P0.2650.756
94_Y171_P0.26380.752
245_T295_H0.263120.751
190_D194_K0.262320.748
219_Y222_D0.261870.747
96_T173_F0.261860.747
118_F175_F0.26130.745
86_P118_F0.259550.740
299_A303_L0.257890.736
154_D158_D0.256120.731
3_V94_Y0.254460.726
289_I292_L0.254450.726
35_N237_Y0.253880.724
85_L89_L0.252770.721
280_W286_Q0.251240.717
167_E170_K0.250460.714
158_D162_D0.250260.714
193_E215_N0.249330.711
194_K222_D0.249260.711
187_Y215_N0.249240.711
93_G96_T0.247590.706
260_H268_Y0.247370.706
228_I232_K0.246270.702
15_D214_L0.245320.700
43_Y292_L0.24520.699
83_P87_D0.244820.698
49_T248_H0.24390.696
18_C277_I0.24380.695
99_F120_Y0.243460.694
238_D281_P0.243230.694
94_Y173_F0.242590.692
50_S70_N0.242360.691
89_L303_L0.241570.689
151_Y154_D0.240850.687
55_S295_H0.240070.685
54_F65_S0.239610.683
154_D226_R0.23940.683
153_D178_T0.239360.683
165_L233_E0.238270.680
78_L84_S0.23610.673
49_T177_H0.235540.672
45_S55_S0.235330.671
243_I276_L0.235190.671
16_L19_Y0.234580.669
162_D165_L0.233940.667
9_E249_G0.233080.665
65_S68_Y0.231950.662
9_E51_P0.230680.658
278_I284_E0.230430.657
20_G30_D0.230020.656
92_A303_L0.229180.654
44_S295_H0.22790.650
118_F122_L0.227780.650
237_Y240_T0.227160.648
181_P220_V0.227150.648
57_L173_F0.226690.647
85_L302_L0.226240.645
57_L86_P0.225960.645
152_S156_L0.225560.643
39_F289_I0.225510.643
10_S49_T0.225490.643
214_L218_A0.225140.642
21_Y25_T0.22510.642
3_V305_L0.22460.641
30_D33_A0.224420.640
242_I279_Y0.223590.638
211_N214_L0.223320.637
153_D223_Q0.222460.635
132_D135_R0.221370.631
42_A298_I0.219190.625
5_L175_F0.217030.619
2_N171_P0.216790.618
274_V295_H0.216650.618
85_L299_A0.216510.618
12_R271_S0.21640.617
245_T274_V0.21580.616
178_T224_L0.215430.615
190_D193_E0.215250.614
231_L236_L0.214990.613
29_L277_I0.214590.612
61_Y294_S0.213180.608
36_G280_W0.212240.605
24_P30_D0.210640.601
157_F230_Y0.209790.598
187_Y212_N0.209760.598
86_P90_K0.209620.598
67_V70_N0.209550.598
224_L244_I0.209140.597
37_L286_Q0.209120.597
90_K96_T0.20910.596
27_P32_L0.208720.595
250_E271_S0.208610.595
188_P192_A0.208420.595
31_R225_G0.208210.594
53_R100_G0.207460.592
228_I279_Y0.206870.590
104_A123_G0.20670.590
28_N222_D0.206040.588
161_I164_L0.205950.587
99_F156_L0.205770.587
180_G216_A0.205650.587
96_T119_D0.205270.586
47_P267_L0.205150.585
302_L306_L0.2050.585
275_P278_I0.20450.583
132_D136_I0.204420.583
98_F102_W0.204130.582
129_D132_D0.20330.580
27_P30_D0.202890.579
212_N216_A0.20260.578
213_Y217_I0.202520.578
220_V224_L0.20160.575
226_R230_Y0.200710.573
83_P86_P0.200550.572
208_E212_N0.200460.572
167_E234_Q0.200270.571
157_F176_I0.200250.571
95_R120_Y0.199730.570
164_L174_L0.199590.569
154_D188_P0.199580.569
133_N137_S0.199260.568
89_L92_A0.199230.568
49_T263_K0.198860.567
17_S25_T0.198780.567
27_P31_R0.197860.564
11_L15_D0.197710.564
16_L26_T0.19760.564
49_T101_P0.197340.563
12_R249_G0.197150.562
17_S24_P0.197120.562
261_G268_Y0.196480.560
185_Y250_E0.196370.560
59_G300_P0.195570.558
224_L227_F0.194820.556
216_A219_Y0.194690.555
99_F160_A0.194640.555
231_L235_G0.194560.555
222_D225_G0.194440.555
48_W51_P0.194320.554
12_R250_E0.19370.553
2_N239_N0.192880.550
245_T276_L0.192660.550
45_S295_H0.192250.548
94_Y241_I0.191940.548
10_S246_S0.191140.545
120_Y163_F0.190920.545
90_K117_G0.190770.544
263_K271_S0.190630.544
164_L231_L0.190140.542
57_L118_F0.189970.542
120_Y166_N0.189790.541
10_S177_H0.189770.541
223_Q227_F0.189450.540
54_F67_V0.189060.539
95_R169_D0.188850.539
251_S271_S0.188840.539
164_L230_Y0.187680.535
18_C29_L0.187640.535
159_Y163_F0.18720.534
39_F293_V0.18520.528
4_V164_L0.185160.528
40_S289_I0.185130.528
181_P216_A0.184410.526
57_L104_A0.184290.526
4_V7_V0.183930.525
79_P82_F0.183780.524
300_P304_D0.183530.524
38_R277_I0.183060.522
89_L308_I0.181850.519
220_V223_Q0.181510.518
134_P137_S0.181330.517
88_L308_I0.181240.517
87_D90_K0.181060.516
269_E272_Y0.180790.516
151_Y155_A0.179270.511
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2vqrA0.9741000.115
3ed4A0.99681000.117
2qzuA0.98381000.123
3b5qA0.93181000.131
1aukA0.95131000.134
1p49A0.95451000.134
1fsuA0.96751000.137
3lxqA0.87341000.138
4fdiA0.95131000.138
1hdhA0.9871000.146

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