GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DPPIV_N - Dipeptidyl peptidase IV (DPP IV) N-terminal region
Pfam: PF00930 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0186
Length: 353
Sequences: 22501
Seq/Len: 63.74
HH_delta: 0.132 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
243_L246_D1.130242.841
47_D60_V0.994892.501
216_D219_T0.987162.481
29_D32_T0.984822.475
58_A67_L0.968172.434
59_F68_R0.961212.416
51_S108_W0.947992.383
69_D72_T0.937112.356
105_A118_L0.922612.319
266_D269_G0.911322.291
58_A108_W0.904522.274
164_D167_S0.895632.251
65_L117_F0.868072.182
230_S233_W0.840292.112
49_K107_W0.82932.085
66_Y75_E0.82912.084
326_E330_H0.806592.027
190_G241_H0.755031.898
25_Y59_F0.753451.894
243_L288_W0.733931.845
311_R314_L0.728381.831
26_Y35_I0.715971.800
296_Y335_F0.706151.775
199_W214_L0.705361.773
182_Q200_V0.701621.764
117_F128_Y0.697421.753
308_H322_C0.695821.749
229_T233_W0.688191.730
58_A115_L0.673541.693
52_P112_S0.673241.692
160_L200_V0.673081.692
251_L288_W0.669111.682
287_G334_S0.663161.667
51_S55_K0.661961.664
27_I50_W0.655831.648
58_A106_V0.649711.633
197_R214_L0.645391.622
289_D335_F0.64231.614
129_P132_D0.638431.605
278_G282_V0.63471.595
56_Y67_L0.631221.587
192_S242_F0.631091.586
51_S56_Y0.628821.581
59_F66_Y0.621871.563
213_V225_V0.616131.549
109_S113_K0.616091.549
290_E335_F0.613871.543
200_V215_C0.613791.543
241_H287_G0.605811.523
41_P59_F0.600541.510
294_R311_R0.598081.503
257_D261_H0.596941.500
297_F301_G0.588451.479
297_F310_Y0.586991.475
117_F121_D0.577711.452
22_K26_Y0.576081.448
336_S339_G0.572591.439
192_S196_K0.557031.400
249_E264_L0.554351.393
107_W147_R0.552291.388
149_P191_W0.5511.385
213_V222_T0.550061.383
151_A154_P0.546831.375
245_P288_W0.545871.372
199_W242_F0.544521.369
212_L252_W0.542981.365
52_P108_W0.538361.353
182_Q186_L0.537831.352
290_E339_G0.537051.350
289_D293_N0.531591.336
133_Y136_P0.528091.327
79_T82_G0.527361.326
319_E322_C0.526551.324
296_Y333_A0.523981.317
243_L248_N0.518911.304
49_K106_V0.512191.287
116_A127_E0.509441.281
289_D294_R0.504011.267
50_W70_L0.5041.267
25_Y48_A0.502321.263
296_Y309_L0.501941.262
50_W57_I0.500561.258
252_W255_E0.498531.253
75_E78_L0.496191.247
149_P153_D0.493681.241
55_K71_A0.492841.239
67_L108_W0.491081.234
126_P135_P0.490081.232
41_P45_L0.489251.230
51_S54_G0.482641.213
251_L264_L0.482421.213
38_L41_P0.475161.194
287_G333_A0.472331.187
311_R321_K0.468571.178
190_G240_P0.465661.170
197_R200_V0.465451.170
26_Y38_L0.465341.170
298_T301_G0.464981.169
147_R190_G0.463191.164
251_L295_I0.461661.160
68_R75_E0.459311.155
289_D292_N0.457471.150
196_K218_S0.457351.150
314_L318_G0.456231.147
66_Y78_L0.45491.143
241_H286_L0.454791.143
162_V191_W0.454741.143
199_W240_P0.453931.141
191_W217_A0.452161.137
261_H274_Q0.449341.129
252_W265_Y0.448031.126
215_C222_T0.447341.124
109_S114_Y0.446691.123
152_G155_N0.444771.118
161_F170_T0.443921.116
275_L278_G0.443131.114
45_L48_A0.440751.108
132_D136_P0.440441.107
109_S112_S0.439551.105
249_E252_W0.437451.100
116_A148_Y0.437241.099
193_P242_F0.436831.098
119_R124_E0.43671.098
144_E156_P0.436681.098
239_P253_I0.436461.097
56_Y69_D0.434481.092
61_R64_N0.434041.091
151_A155_N0.43341.089
243_L249_E0.431251.084
55_K69_D0.430611.082
222_T225_V0.427841.075
192_S197_R0.426321.072
48_A59_F0.422641.062
49_K108_W0.421881.060
307_R311_R0.419831.055
254_S257_D0.418111.051
245_P292_N0.415891.045
285_I333_A0.415331.044
210_L214_L0.414341.041
56_Y59_F0.413731.040
193_P247_G0.412111.036
53_D56_Y0.411541.034
132_D135_P0.41081.033
65_L106_V0.40831.026
214_L242_F0.406951.023
209_R213_V0.406451.022
117_F126_P0.406451.022
279_D282_V0.405871.020
135_P138_S0.404941.018
111_D114_Y0.402931.013
182_Q209_R0.402881.013
26_Y37_P0.402751.012
291_D294_R0.40211.011
69_D76_T0.401861.010
243_L247_G0.401061.008
64_N77_Q0.401031.008
163_V170_T0.400191.006
264_L273_R0.396350.996
58_A65_L0.395880.995
82_G117_F0.393660.990
126_P138_S0.392310.986
69_D74_Q0.392010.985
297_F300_N0.3890.978
27_I36_T0.388330.976
167_S171_T0.387160.973
22_K28_Y0.386110.971
50_W54_G0.385510.969
35_I38_L0.38550.969
50_W288_W0.385470.969
37_P40_P0.382150.961
294_R309_L0.380540.957
200_V213_V0.379490.954
192_S195_G0.37870.952
103_R106_V0.377720.949
107_W116_A0.376370.946
106_V117_F0.374340.941
285_I298_T0.373020.938
251_L286_L0.37190.935
186_L189_V0.371720.934
60_V106_V0.371630.934
248_N268_D0.36960.929
104_S120_F0.36820.926
315_D318_G0.367660.924
47_D106_V0.36630.921
294_R297_F0.365920.920
147_R189_V0.365750.919
108_W115_L0.363120.913
299_A310_Y0.361570.909
29_D33_G0.36140.908
56_Y76_T0.358930.902
188_R239_P0.35720.898
109_S148_Y0.356330.896
149_P154_P0.355920.895
191_W242_F0.355430.893
28_Y35_I0.353030.887
119_R122_E0.351550.884
263_Y274_Q0.351150.883
31_E166_A0.350970.882
226_L229_T0.350790.882
249_E253_I0.347350.873
48_A57_I0.346150.870
241_H288_W0.342180.860
199_W250_F0.338480.851
293_N311_R0.338030.850
161_F172_E0.337290.848
30_I33_G0.336980.847
109_S116_A0.336760.846
212_L240_P0.33520.843
197_R216_D0.335140.842
198_L217_A0.334110.840
165_L168_G0.334070.840
246_D249_E0.333560.838
191_W198_L0.332670.836
285_I299_A0.332520.836
106_V115_L0.331390.833
278_G310_Y0.330890.832
41_P61_R0.330170.830
276_T279_D0.329580.828
322_C325_C0.32940.828
149_P155_N0.32790.824
50_W335_F0.327820.824
164_D168_G0.326140.820
278_G297_F0.322980.812
240_P252_W0.322820.811
263_Y272_P0.322410.810
49_K58_A0.322340.810
265_Y272_P0.320960.807
192_S199_W0.320050.804
188_R240_P0.31560.793
307_R310_Y0.313240.787
129_P136_P0.313170.787
274_Q277_S0.310670.781
250_F253_I0.310380.780
37_P41_P0.309240.777
168_G171_T0.309110.777
308_H319_E0.308850.776
257_D263_Y0.30740.773
285_I332_S0.306420.770
189_V200_V0.306130.769
70_L73_G0.306050.769
214_L223_R0.305440.768
29_D34_E0.305140.767
239_P286_L0.304050.764
45_L59_F0.303820.764
167_S170_T0.303130.762
53_D112_S0.302790.761
65_L115_L0.301620.758
289_D296_Y0.301620.758
62_D66_Y0.300690.756
217_A220_G0.299570.753
116_A191_W0.299480.753
108_W191_W0.299170.752
103_R119_R0.297610.748
220_G223_R0.297570.748
157_R160_L0.297380.747
160_L189_V0.297380.747
250_F267_L0.297350.747
194_D197_R0.297040.747
187_T208_N0.296940.746
150_K155_N0.296180.744
149_P152_G0.293710.738
35_I75_E0.293090.737
43_P62_D0.289810.728
239_P285_I0.289590.728
166_A218_S0.289520.728
125_V128_Y0.289270.727
130_L133_Y0.289070.727
196_K216_D0.288680.726
114_Y117_F0.288340.725
327_D330_H0.288070.724
114_Y136_P0.287760.723
46_Q104_S0.287660.723
46_Q102_R0.287610.723
121_D124_E0.286370.720
266_D270_G0.285960.719
143_V157_R0.285420.717
128_Y135_P0.285370.717
51_S58_A0.285350.717
295_I312_V0.285030.716
24_D37_P0.284650.715
267_L270_G0.284010.714
47_D105_A0.283740.713
286_L295_I0.282530.710
60_V103_R0.281010.706
310_Y319_E0.280260.704
284_S301_G0.279260.702
49_K105_A0.278290.700
242_F267_L0.278070.699
288_W312_V0.278070.699
252_W263_Y0.277370.697
34_E37_P0.276570.695
56_Y114_Y0.276160.694
182_Q213_V0.275950.694
243_L251_L0.275770.693
214_L224_V0.274880.691
306_E322_C0.274130.689
228_E232_G0.273660.688
144_E147_R0.273290.687
113_K131_P0.273110.686
182_Q215_C0.272940.686
64_N80_T0.272880.686
157_R161_F0.272770.686
49_K334_S0.272610.685
229_T232_G0.269430.677
318_G322_C0.269210.677
143_V146_I0.269050.676
57_I70_L0.26860.675
209_R212_L0.268580.675
109_S191_W0.268380.675
32_T36_T0.267850.673
293_N313_S0.267480.672
114_Y118_L0.267150.672
209_R215_C0.266740.670
216_D221_E0.266430.670
82_G103_R0.266240.669
287_G335_F0.266160.669
249_E288_W0.265290.667
69_D75_E0.265240.667
105_A146_I0.264660.665
254_S263_Y0.2640.664
35_I170_T0.263990.664
181_P215_C0.263910.663
104_S144_E0.263890.663
190_G242_F0.263020.661
186_L200_V0.262450.660
315_D319_E0.262420.660
311_R315_D0.261930.658
43_P63_N0.261190.657
294_R320_P0.260190.654
239_P254_S0.25930.652
230_S252_W0.259140.651
134_S137_D0.258220.649
250_F255_E0.257630.648
313_S319_E0.257220.647
264_L267_L0.255090.641
140_Y143_V0.254940.641
300_N308_H0.254410.639
253_I286_L0.254370.639
118_L146_I0.2540.638
150_K195_G0.253390.637
301_G308_H0.253010.636
107_W190_G0.252850.636
51_S112_S0.252740.635
63_N102_R0.252380.634
161_F173_L0.251960.633
269_G273_R0.251930.633
266_D271_K0.251860.633
76_T79_T0.251850.633
25_Y57_I0.251430.632
45_L61_R0.251150.631
58_A61_R0.250310.629
129_P134_S0.249380.627
35_I272_P0.249250.627
254_S261_H0.248720.625
118_L122_E0.24860.625
107_W146_I0.248590.625
69_D73_G0.248310.624
280_W301_G0.248080.624
60_V63_N0.247750.623
129_P133_Y0.247470.622
24_D38_L0.247280.622
66_Y77_Q0.247010.621
150_K191_W0.246230.619
287_G296_Y0.245910.618
189_V198_L0.245320.617
216_D220_G0.245110.616
301_G306_E0.244710.615
261_H264_L0.243910.613
29_D36_T0.242960.611
277_S310_Y0.242920.611
50_W108_W0.242350.609
261_H265_Y0.24230.609
225_V228_E0.241230.606
249_E266_D0.240950.606
72_T76_T0.239860.603
61_R66_Y0.239820.603
77_Q81_D0.239570.602
104_S118_L0.239560.602
197_R267_L0.239540.602
294_R335_F0.239280.601
46_Q144_E0.238990.601
103_R117_F0.238870.600
134_S138_S0.238830.600
36_T39_T0.23850.599
42_P64_N0.237910.598
218_S268_D0.23780.598
219_T223_R0.237340.597
325_C330_H0.237320.597
210_L213_V0.237130.596
262_L297_F0.236820.595
32_T35_I0.236290.594
73_G76_T0.236130.594
162_V171_T0.234640.590
276_T324_T0.234530.590
216_D223_R0.234140.589
170_T222_T0.234080.588
33_G36_T0.23380.588
294_R298_T0.233130.586
108_W242_F0.233080.586
131_P166_A0.23290.585
27_I70_L0.232530.584
330_H333_A0.232490.584
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1nr0A0.90081000.132
1nr0A0.89521000.137
2ymuA0.84421000.165
2ymuA0.84421000.191
3sfzA0.86971000.191
1xfdA0.98871000.192
1vyhC0.75921000.194
4jsnD0.84141000.203
4jspD0.84141000.203
3sfzA0.85271000.204

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