GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Na_H_Exchanger - Sodiumhydrogen exchanger family
Pfam: PF00999 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0064
Length: 380
Sequences: 7691
Seq/Len: 20.24
HH_delta: 0.592 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
198_W202_R0.494093.288
311_Y321_W0.392012.609
329_L373_I0.381572.539
108_S111_E0.379672.527
93_L305_G0.378542.519
194_L198_W0.370782.468
299_L365_L0.362472.412
96_F100_F0.349712.327
320_P323_E0.322122.144
184_W188_I0.321082.137
202_R205_R0.308142.051
180_L184_W0.304232.025
99_S109_W0.303262.018
225_L243_A0.295951.970
73_R76_W0.289751.928
292_I296_L0.283951.890
338_S359_I0.283791.889
95_G99_S0.277781.849
116_G120_S0.273321.819
221_L243_A0.271781.809
183_L187_L0.271631.808
157_I341_L0.264971.763
202_R206_R0.256921.710
79_A147_S0.256861.709
289_P292_I0.256831.709
99_S112_A0.255391.700
293_I297_L0.252661.681
114_L345_A0.252491.680
359_I363_V0.24621.638
15_F25_G0.243421.620
307_F328_G0.242881.616
346_L356_F0.241361.606
311_Y328_G0.240461.600
87_F155_I0.240041.597
296_L300_I0.238541.587
189_G193_G0.23711.578
352_S355_M0.236031.571
295_V361_A0.234661.562
315_R321_W0.232921.550
148_E331_M0.231991.544
95_G116_G0.230051.531
305_G309_G0.22921.525
314_S324_A0.22871.522
179_L183_L0.227221.512
81_A317_F0.224461.494
61_F222_I0.224391.493
198_W201_R0.223381.487
176_G179_L0.223171.485
291_V295_V0.222611.481
193_G197_G0.221491.474
46_P49_E0.220541.468
226_Y236_G0.219351.460
34_G37_G0.219021.458
84_L88_L0.217541.448
309_G313_A0.212581.415
298_L362_A0.212211.412
342_A359_I0.211131.405
315_R324_A0.211061.405
321_W325_L0.210891.403
33_L40_L0.208841.390
302_I334_R0.208591.388
187_L191_V0.2081.384
96_F109_W0.207991.384
245_L248_S0.207861.383
92_I97_L0.207051.378
123_S126_I0.206391.374
187_L190_I0.206081.371
91_F117_A0.2061.371
118_I342_A0.2041.358
112_A116_G0.20351.354
139_S142_G0.202891.350
118_I359_I0.201721.342
68_D71_E0.20111.338
110_A163_L0.199131.325
145_L330_G0.198471.321
70_K74_R0.197971.317
197_G201_R0.197061.311
294_L297_L0.197051.311
191_V195_L0.196891.310
365_L369_I0.196751.309
188_I234_L0.196451.307
312_L316_L0.196141.305
301_A305_G0.195761.303
89_L93_L0.195491.301
188_I193_G0.194611.295
49_E53_E0.194451.294
176_G180_L0.193791.290
96_F99_S0.193371.287
230_E236_G0.193021.285
97_L100_F0.192491.281
343_L347_N0.190871.270
311_Y324_A0.190361.267
181_S184_W0.190341.267
339_L363_V0.189721.263
136_L141_L0.188971.258
78_R144_L0.188841.257
35_P39_G0.188791.256
88_L92_I0.187421.247
192_I196_F0.187321.247
273_F277_G0.18641.240
28_L32_V0.185481.234
194_L246_I0.185471.234
307_F325_L0.185291.233
324_A328_G0.185091.232
70_K73_R0.183911.224
91_F120_S0.183711.223
57_A226_Y0.183661.222
147_S150_V0.183341.220
26_Y270_P0.183251.220
177_Q180_L0.18321.219
184_W192_I0.183051.218
302_I362_A0.180911.204
284_S357_T0.180441.201
193_G196_F0.180431.201
141_L326_F0.180391.200
300_I304_L0.178811.190
35_P38_L0.178351.187
122_T149_S0.177161.179
174_S177_Q0.176611.175
292_I295_V0.176021.171
337_V340_A0.175731.169
175_L179_L0.175471.168
334_R338_S0.174641.162
111_E352_S0.173851.157
149_S152_N0.17381.157
299_L303_L0.173351.154
306_K331_M0.171881.144
131_L142_G0.17151.141
32_V35_P0.171331.140
84_L155_I0.171151.139
201_R205_R0.170941.138
76_W80_L0.170111.132
152_N331_M0.169891.131
30_G34_G0.169771.130
61_F244_G0.169741.130
140_R323_E0.169471.128
32_V37_G0.16941.127
121_A124_P0.169391.127
122_T152_N0.169371.127
227_G231_I0.168361.120
82_L310_V0.167441.114
190_I194_L0.167271.113
195_L198_W0.166891.111
47_S50_L0.166841.110
141_L327_I0.166441.108
148_E152_N0.165741.103
129_P133_E0.165631.102
121_A156_A0.165611.102
119_L362_A0.165411.101
25_G29_V0.165181.099
307_F311_Y0.165071.099
330_G374_L0.164841.097
122_T127_V0.16451.095
197_G204_I0.16341.087
295_V299_L0.163391.087
124_P149_S0.16261.082
289_P293_I0.162451.081
123_S152_N0.162411.081
115_L119_L0.162311.080
322_K325_L0.162211.080
311_Y315_R0.162111.079
320_P324_A0.16191.077
303_L307_F0.16121.073
346_L353_E0.161091.072
200_L204_I0.160541.068
34_G39_G0.160181.066
186_I190_I0.159021.058
131_L145_L0.159021.058
15_F24_I0.158651.056
358_I362_A0.158461.055
315_R318_G0.157891.051
229_A234_L0.157491.048
89_L309_G0.157291.047
69_I73_R0.155941.038
81_A316_L0.15551.035
344_I348_L0.155421.034
304_L307_F0.15521.033
224_L228_L0.153961.025
86_G90_P0.153591.022
196_F200_L0.152661.016
131_L137_L0.152591.015
225_L239_G0.152571.015
117_A159_L0.152421.014
144_L319_I0.151711.010
87_F152_N0.151341.007
141_L323_E0.150961.005
184_W187_L0.150211.000
123_S336_E0.149780.997
62_E66_E0.149630.996
252_F255_R0.149480.995
162_I178_L0.148990.992
183_L186_I0.148630.989
336_E340_A0.147860.984
229_A239_G0.147150.979
125_A156_A0.146740.977
36_S281_D0.146710.976
134_L375_S0.14660.976
121_A152_N0.146520.975
192_I225_L0.145520.968
191_V194_L0.145420.968
363_V367_I0.14530.967
299_L369_I0.145280.967
224_L227_G0.145160.966
127_V130_V0.144920.964
122_T331_M0.144220.960
308_I312_L0.144150.959
86_G306_K0.143510.955
156_A341_L0.143190.953
281_D284_S0.142220.946
75_N78_R0.142220.946
157_I235_S0.142220.946
222_I225_L0.142180.946
71_E143_R0.141810.944
192_I195_L0.141720.943
98_L300_I0.141620.942
148_E335_G0.141290.940
16_R19_G0.141280.940
69_I72_L0.140730.937
182_F186_I0.140670.936
188_I196_F0.14030.934
75_N79_A0.139870.931
293_I296_L0.139750.930
149_S154_I0.139470.928
319_I323_E0.139450.928
82_L148_E0.139440.928
225_L228_L0.139340.927
255_R259_K0.139280.927
220_A224_L0.138920.925
58_F268_F0.138890.924
91_F159_L0.138780.924
303_L369_I0.138740.923
194_L197_G0.138690.923
177_Q181_S0.138610.922
319_I324_A0.138320.921
356_F360_I0.138010.918
123_S331_M0.137790.917
199_L202_R0.137690.916
148_E310_V0.137560.915
155_I162_I0.13720.913
276_I336_E0.136780.910
304_L308_I0.136140.906
67_L241_F0.135920.905
95_G109_W0.135590.902
150_V241_F0.135580.902
34_G41_L0.135050.899
180_L183_L0.134990.898
332_L363_V0.134650.896
117_A120_S0.134530.895
353_E357_T0.134130.893
314_S319_I0.133870.891
321_W324_A0.133860.891
15_F22_S0.133730.890
86_G152_N0.133530.889
311_Y325_L0.133520.889
100_F109_W0.13350.888
92_I96_F0.133440.888
344_I347_N0.133270.887
330_G336_E0.133070.886
75_N140_R0.132840.884
60_L237_I0.132620.883
294_L358_I0.132580.882
98_L105_L0.132360.881
81_A85_V0.132320.881
57_A236_G0.132280.880
335_G367_I0.13210.879
98_L115_L0.131970.878
36_S39_G0.13160.876
336_E367_I0.131470.875
149_S367_I0.131120.873
260_L263_F0.131010.872
329_L370_A0.130850.871
61_F260_L0.130830.871
193_G204_I0.13010.866
97_L301_A0.129860.864
57_A223_L0.129850.864
48_F275_F0.129710.863
100_F112_A0.129410.861
75_N144_L0.129120.859
278_M282_F0.12850.855
121_A338_S0.128430.855
40_L43_P0.128210.853
351_I354_Q0.127890.851
343_L356_F0.127820.851
21_P83_G0.127810.851
145_L327_I0.127730.850
307_F312_L0.127720.850
84_L87_F0.127680.850
182_F185_I0.127670.850
367_I370_A0.127590.849
33_L278_M0.127430.848
350_I353_E0.127020.845
123_S363_V0.126870.844
81_A313_A0.126770.844
362_A366_T0.126630.843
225_L229_A0.125750.837
298_L358_I0.12550.835
297_L301_A0.125480.835
220_A227_G0.125390.834
235_S238_L0.125290.834
15_F19_G0.125270.834
354_Q358_I0.125160.833
368_I372_I0.125070.832
314_S327_I0.124970.832
89_L92_I0.124810.831
86_G148_E0.124630.829
326_F330_G0.124290.827
113_L163_L0.124210.827
172_Q177_Q0.123980.825
342_A356_F0.123860.824
107_L115_L0.123840.824
80_L84_L0.123820.824
334_R363_V0.123510.822
107_L112_A0.123480.822
123_S338_S0.123420.821
77_R81_A0.123090.819
123_S127_V0.123010.819
192_I234_L0.122810.817
251_P254_E0.122580.816
185_I201_R0.122390.815
188_I192_I0.121570.809
335_G338_S0.121510.809
110_A113_L0.121410.808
281_D357_T0.121390.808
332_L370_A0.121320.807
306_K370_A0.121120.806
338_S342_A0.121030.805
272_F336_E0.120810.804
122_T145_L0.12070.803
185_I189_G0.120480.802
184_W234_L0.120310.801
60_L310_V0.120190.800
37_G40_L0.120180.800
152_N336_E0.119860.798
299_L366_T0.119790.797
111_E350_I0.119540.796
228_L231_I0.119230.793
86_G334_R0.119210.793
97_L104_I0.119150.793
72_L79_A0.1190.792
123_S154_I0.118590.789
124_P337_V0.118570.789
121_A127_V0.118430.788
172_Q176_G0.118420.788
218_V247_L0.118290.787
25_G274_V0.118130.786
180_L187_L0.118110.786
216_L266_G0.117940.785
334_R337_V0.117850.784
59_L248_S0.117810.784
293_I298_L0.117760.784
52_A55_G0.117750.784
295_V298_L0.117720.783
235_S341_L0.117610.783
185_I197_G0.117450.782
308_I315_R0.117420.781
186_I189_G0.117390.781
332_L336_E0.11730.781
152_N156_A0.117190.780
109_W112_A0.116890.778
49_E279_S0.115330.768
275_F279_S0.115310.767
334_R366_T0.115270.767
336_E341_L0.115150.766
73_R245_L0.115140.766
19_G25_G0.115020.765
148_E156_A0.114980.765
191_V196_F0.114950.765
126_I129_P0.114840.764
71_E74_R0.11480.764
26_Y30_G0.114730.764
199_L203_L0.114470.762
97_L300_I0.114350.761
171_G183_L0.114290.761
37_G41_L0.114280.761
111_E115_L0.114010.759
125_A269_I0.113860.758
297_L300_I0.113830.758
36_S282_F0.113690.757
234_L239_G0.113530.756
36_S283_S0.113460.755
170_S175_L0.113430.755
157_I337_V0.113180.753
87_F127_V0.113170.753
313_A317_F0.113170.753
322_K326_F0.113150.753
78_R317_F0.113080.753
350_I355_M0.112590.749
34_G38_L0.112470.748
218_V256_L0.112350.748
127_V330_G0.112280.747
26_Y129_P0.112230.747
250_S254_E0.112180.747
175_L211_S0.112050.746
82_L331_M0.1120.745
120_S159_L0.111930.745
219_L222_I0.111780.744
100_F108_S0.11170.743
68_D328_G0.111630.743
335_G339_L0.111580.743
192_I200_L0.111520.742
196_F225_L0.111360.741
27_I364_L0.111360.741
106_G112_A0.111080.739
123_S149_S0.111010.739
211_S258_E0.110850.738
50_L222_I0.110770.737
291_V354_Q0.11060.736
345_A351_I0.110570.736
219_L223_L0.110410.735
22_S26_Y0.110350.734
55_G59_L0.110210.733
83_G90_P0.11020.733
238_L330_G0.110030.732
338_S363_V0.110020.732
83_G151_I0.110020.732
60_L121_A0.109860.731
153_D334_R0.109850.731
290_S294_L0.109830.731
331_M335_G0.109820.731
121_A337_V0.109630.730
226_Y240_A0.109560.729
26_Y274_V0.109410.728
48_F52_A0.109270.727
108_S112_A0.109260.727
63_A269_I0.109060.726
221_L224_L0.109050.726
61_F147_S0.108980.725
98_L112_A0.108880.725
189_G197_G0.108830.724
178_L182_F0.10880.724
133_E142_G0.108630.723
113_L116_G0.10860.723
120_S334_R0.108450.722
329_L371_G0.108330.721
38_L42_E0.108260.720
148_E327_I0.108180.720
196_F246_I0.108170.720
64_G245_L0.1080.719
131_L330_G0.107910.718
14_L70_K0.107720.717
170_S174_S0.107680.717
284_S354_Q0.107520.716
196_F221_L0.107520.716
125_A270_P0.10740.715
83_G149_S0.107380.715
96_F299_L0.107380.715
50_L54_I0.107370.715
173_S177_Q0.107330.714
331_M336_E0.107260.714
20_I25_G0.107230.714
61_F243_A0.107220.714
91_F116_G0.107070.713
88_L91_F0.106730.710
156_A337_V0.106610.709
87_F159_L0.106590.709
354_Q357_T0.106550.709
318_G324_A0.106430.708
50_L53_E0.106210.707
85_V88_L0.105990.705
223_L227_G0.105970.705
109_W113_L0.105840.704
172_Q175_L0.105670.703
310_V327_I0.105660.703
307_F329_L0.105570.703
26_Y124_P0.105470.702
290_S293_I0.105210.700
222_I226_Y0.105160.700
268_F272_F0.105010.699
211_S255_R0.104950.698
283_S289_P0.104930.698
76_W143_R0.104620.696
35_P41_L0.10460.696
92_I113_L0.104520.696
178_L245_L0.104450.695
61_F64_G0.104450.695
140_R143_R0.104420.695
121_A128_S0.104290.694
157_I229_A0.104250.694
194_L199_L0.10420.693
350_I354_Q0.104140.693
228_L320_P0.104050.692
16_R133_E0.103910.692
223_L244_G0.103860.691
190_I193_G0.10380.691
85_V313_A0.103780.691
115_L359_I0.103780.691
148_E306_K0.103680.690
349_G353_E0.103660.690
291_V294_L0.103480.689
294_L298_L0.103450.688
29_V274_V0.103420.688
52_A272_F0.103420.688
346_L349_G0.103350.688
95_G113_L0.103340.688
121_A125_A0.103210.687
175_L178_L0.103120.686
76_W222_I0.103120.686
240_A244_G0.103090.686
170_S191_V0.103020.686
306_K310_V0.103010.686
296_L299_L0.1030.685
302_I366_T0.102920.685
115_L358_I0.102860.685
35_P40_L0.102790.684
43_P200_L0.102730.684
338_S341_L0.102680.683
274_V367_I0.102630.683
105_L108_S0.102550.682
370_A373_I0.102530.682
150_V158_I0.102490.682
117_A122_T0.102480.682
306_K314_S0.102430.682
331_M337_V0.102270.681
95_G188_I0.102270.681
23_I123_S0.102250.680
152_N309_G0.102230.680
140_R319_I0.102210.680
125_A153_D0.102160.680
91_F163_L0.101990.679
227_G230_E0.101820.678
318_G321_W0.101720.677
218_V299_L0.101630.676
61_F218_V0.101550.676
60_L337_V0.101430.675
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1zcdA0.999.90.592
3zuxA0.797497.70.869
2k3cA0.086891.80.92
2htgA0.073786.20.928
2l0eA0.086885.80.929
2m7xA0.078985.40.929
2kbvA0.073724.40.953
3ne5A0.3519.50.955
1y4eA0.0711140.958
3w9iA0.37639.50.961
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