GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Bax1-I - Inhibitor of apoptosis-promoting Bax1
Pfam: PF01027 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0453
Length: 205
Sequences: 2008
Seq/Len: 9.8
HH_delta: 0.925 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
8_Y169_T0.543323.376
110_T169_T0.456972.839
157_G200_R0.442942.752
40_W44_I0.374362.326
168_D193_D0.364222.263
138_G153_I0.359562.234
8_Y110_T0.356582.216
109_L162_S0.352232.189
101_L205_L0.321271.996
46_S79_E0.320761.993
124_G167_Y0.320641.992
158_I197_L0.298341.854
98_A204_L0.297091.846
18_T191_Y0.29591.839
110_T114_F0.292781.819
155_Y204_L0.288171.790
140_V144_L0.286281.779
46_S82_L0.28511.771
14_Q72_L0.284711.769
127_L167_Y0.283891.764
148_P152_L0.283071.759
132_I136_I0.281191.747
87_S95_V0.280721.744
74_I78_L0.270491.681
41_V44_I0.264071.641
134_L157_G0.257841.602
94_I205_L0.256941.596
168_D171_R0.256311.593
104_A136_I0.256211.592
152_L156_I0.256091.591
156_I160_L0.256061.591
199_L203_R0.255791.589
192_L196_N0.255631.588
131_L135_I0.252511.569
108_A132_I0.251361.562
165_L197_L0.249071.548
45_V78_L0.246741.533
44_I48_V0.243351.512
128_F132_I0.241171.498
116_T120_F0.241011.497
98_A201_I0.239981.491
127_L163_L0.238471.482
112_Y116_T0.236951.472
150_Y203_R0.235061.461
151_L204_L0.232461.444
155_Y159_L0.230561.433
101_L158_I0.229371.425
100_L104_A0.224881.397
171_R189_S0.223321.388
134_L160_L0.223171.387
69_L73_F0.220781.372
171_R193_D0.219231.362
201_I205_L0.21741.351
101_L201_I0.214941.335
135_I139_L0.210631.309
91_D94_I0.209991.305
161_F196_N0.209081.299
159_L163_L0.205771.279
12_A107_I0.202751.260
70_I74_I0.197921.230
131_L192_L0.195351.214
10_L69_L0.192631.197
97_Q205_L0.192351.195
189_S193_D0.191331.189
116_T170_Q0.190821.186
111_L115_F0.189621.178
139_L142_I0.18661.159
137_F153_I0.185831.155
106_F165_L0.185721.154
190_L193_D0.184761.148
109_L166_V0.18351.140
130_G160_L0.183041.137
161_F164_Y0.18261.135
168_D192_L0.181661.129
59_R62_R0.179971.118
37_P41_V0.178071.106
161_F168_D0.177721.104
39_S43_L0.177441.102
13_L17_I0.177011.100
21_G77_L0.175411.090
75_F79_E0.175291.089
170_Q174_R0.174791.086
86_I199_L0.17171.067
177_F186_A0.17141.065
106_F190_L0.170921.062
112_Y118_R0.170021.056
19_A100_L0.16991.056
90_Y199_L0.169791.055
162_S197_L0.168081.044
141_S144_L0.167751.042
98_A101_L0.166981.038
50_L75_F0.165631.029
161_F192_L0.164571.023
120_F166_V0.163141.014
131_L164_Y0.162931.012
49_L78_L0.162621.010
113_A170_Q0.162361.009
83_L199_L0.162151.007
34_Q37_P0.161431.003
144_L147_S0.161241.002
136_I140_V0.160730.999
157_G161_F0.160590.998
161_F193_D0.159510.991
106_F194_I0.158180.983
154_S203_R0.158070.982
164_Y168_D0.155130.964
105_I109_L0.154510.960
20_L24_L0.154360.959
154_S158_I0.154190.958
76_T80_G0.153810.956
9_G13_L0.152760.949
114_F173_I0.152160.945
86_I90_Y0.152010.944
16_A103_A0.150630.936
200_R204_L0.150490.935
17_I20_L0.149810.931
172_I190_L0.149550.929
59_R71_L0.149220.927
108_A128_F0.148610.923
105_I108_A0.147910.919
133_G137_F0.147370.916
122_R126_I0.14710.914
135_I138_G0.147090.914
149_L152_L0.146620.911
43_L47_L0.14610.908
141_S146_S0.145880.906
179_P182_Y0.14540.903
14_Q76_T0.145170.902
134_L200_R0.145110.902
149_L153_I0.144370.897
23_F27_A0.142960.888
113_A173_I0.142920.888
56_L71_L0.142590.886
21_G25_V0.141880.882
109_L122_R0.141730.881
126_I130_G0.141560.880
191_Y198_F0.14120.877
114_F169_T0.140860.875
200_R203_R0.140310.872
104_A128_F0.139170.865
132_I135_I0.139010.864
47_L50_L0.138530.861
3_F7_V0.137850.857
42_S46_S0.136710.849
164_Y193_D0.136290.847
118_R123_W0.135940.845
100_L132_I0.135810.844
101_L105_I0.135290.841
50_L188_L0.135270.840
115_F118_R0.13510.839
123_W127_L0.134870.838
17_I73_F0.134740.837
101_L140_V0.13440.835
40_W43_L0.134170.834
60_R71_L0.133470.829
46_S50_L0.132890.826
96_L100_L0.132620.824
3_F172_I0.130620.812
49_L75_F0.130120.808
154_S200_R0.129850.807
131_L138_G0.129760.806
127_L164_Y0.12930.803
36_F40_W0.128260.797
72_L164_Y0.128220.797
6_K66_N0.128050.796
158_I204_L0.127770.794
122_R162_S0.127660.793
49_L74_I0.126790.788
26_L29_P0.12640.785
137_F141_S0.126340.785
6_K197_L0.125560.780
14_Q18_T0.125440.779
36_F41_V0.125310.779
160_L164_Y0.125240.778
69_L184_I0.124510.774
8_Y11_L0.124070.771
121_T170_Q0.123580.768
113_A120_F0.123440.767
39_S81_L0.12340.767
154_S157_G0.122910.764
23_F96_L0.122870.763
66_N70_I0.122730.763
50_L72_L0.122590.762
6_K9_G0.122490.761
16_A20_L0.122360.760
127_L130_G0.1220.758
7_V172_I0.121020.752
122_R125_G0.120760.750
45_V48_V0.120750.750
177_F181_D0.119870.745
2_Q6_K0.119840.745
10_L184_I0.119170.740
137_F140_V0.118970.739
72_L172_I0.118690.737
13_L73_F0.117820.732
150_Y154_S0.116960.727
145_P149_L0.116670.725
66_N72_L0.116450.724
87_S165_L0.1160.721
141_S145_P0.115670.719
140_V145_P0.115010.715
37_P44_I0.114370.711
151_L154_S0.11420.710
145_P148_P0.114030.709
16_A125_G0.113870.708
75_F192_L0.113710.707
118_R122_R0.113340.704
167_Y171_R0.11310.703
60_R63_F0.113050.702
128_F164_Y0.112860.701
90_Y202_L0.11260.700
131_L197_L0.112570.699
182_Y186_A0.112290.698
147_S150_Y0.11180.695
157_G203_R0.111710.694
47_L160_L0.111340.692
40_W47_L0.111040.690
41_V46_S0.110860.689
109_L120_F0.110440.686
11_L194_I0.109980.683
82_L86_I0.109740.682
178_S181_D0.109670.681
82_L85_P0.109510.680
196_N200_R0.109270.679
19_A99_F0.109240.679
138_G142_I0.10910.678
56_L64_P0.108960.677
99_F194_I0.108790.676
111_L114_F0.108620.675
134_L156_I0.108480.674
157_G192_L0.108470.674
2_Q5_R0.107850.670
98_A205_L0.107850.670
139_L144_L0.107720.669
108_A137_F0.107660.669
92_P96_L0.107490.668
103_A107_I0.107340.667
9_G12_A0.10730.667
30_L34_Q0.107240.666
95_V98_A0.107230.666
131_L161_F0.107220.666
21_G81_L0.106590.662
161_F171_R0.106550.662
38_L44_I0.106160.660
106_F166_V0.106070.659
141_S156_I0.106050.659
10_L187_A0.105940.658
36_F39_S0.105610.656
160_L163_L0.105450.655
61_R66_N0.105320.654
41_V48_V0.105260.654
3_F186_A0.105210.654
112_Y115_F0.105080.653
109_L163_L0.104920.652
147_S203_R0.104450.649
17_I77_L0.104360.648
56_L63_F0.104210.647
120_F123_W0.103820.645
177_F184_I0.103440.643
79_E83_L0.10310.641
161_F191_Y0.102970.640
10_L18_T0.102790.639
120_F170_Q0.102710.638
92_P156_I0.102580.637
165_L194_I0.102480.637
26_L95_V0.10230.636
11_L190_L0.102180.635
14_Q77_L0.102150.635
79_E82_L0.102080.634
97_Q101_L0.101820.633
78_L180_D0.101780.632
153_I200_R0.101760.632
95_V202_L0.101650.632
29_P89_F0.101440.630
6_K69_L0.101280.629
94_I97_Q0.101180.629
97_Q126_I0.101110.628
135_I192_L0.101060.628
56_L59_R0.100820.626
151_L155_Y0.100670.625
73_F76_T0.099890.621
131_L160_L0.099860.620
124_G163_L0.099730.620
105_I201_I0.099710.620
94_I98_A0.099480.618
191_Y199_L0.099480.618
136_I153_I0.099090.616
178_S182_Y0.098990.615
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4ev6A0.307325.70.925
4i0uA0.307319.60.929
2iubA0.307316.40.931
3m73A0.9611.70.956
3b5dA0.53661.40.958
1wazA0.22441.20.959
3ewtE0.04391.20.959
1rklA0.17561.10.96
2latA0.18051.10.96
2ls2A0.12681.10.96
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