GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ABC2_membrane - ABC-2 type transporter
Pfam: PF01061 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0181
Length: 210
Sequences: 11472
Seq/Len: 54.63
HH_delta: 0.924 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
136_I204_A1.165434.527
8_R12_K1.161334.511
7_L106_L0.91363.549
140_S201_A0.851023.306
4_W8_R0.793863.084
3_I102_L0.735792.858
92_S95_A0.710182.759
187_S190_R0.637612.477
190_R194_Y0.633282.460
10_E100_K0.623442.422
6_L99_A0.600862.334
15_W18_P0.583832.268
187_S191_W0.550242.137
113_L134_L0.540392.099
7_L102_L0.532862.070
191_W195_L0.522472.029
3_I95_A0.495131.923
4_W7_L0.485261.885
191_W194_Y0.48111.869
3_I7_L0.472761.836
188_W191_W0.472381.835
117_I121_L0.462081.795
188_W192_I0.453891.763
5_A8_R0.443661.723
182_L193_S0.432361.679
109_L138_L0.430911.674
3_I99_A0.419351.629
99_A103_S0.418721.626
12_K15_W0.413181.605
7_L99_A0.410481.594
3_I98_L0.407161.582
132_L135_L0.396851.542
11_F15_W0.390081.515
54_G58_G0.389861.514
37_G122_L0.387781.506
196_N199_T0.383721.491
200_Y204_A0.380161.477
182_L194_Y0.377771.467
11_F103_S0.377751.467
202_V206_R0.373361.450
157_S160_D0.359741.397
193_S199_T0.358341.392
131_F135_L0.356931.386
194_Y200_Y0.356611.385
185_L189_L0.35061.362
38_F41_G0.348381.353
10_E13_R0.347361.349
190_R193_S0.34711.348
105_F142_L0.341761.328
46_S50_F0.337261.310
12_K16_R0.335281.302
46_S49_G0.334741.300
108_S111_I0.330251.283
140_S144_S0.330151.282
156_P160_D0.326651.269
117_I130_F0.324741.261
135_L139_L0.324711.261
182_L190_R0.322561.253
47_Q50_F0.320731.246
177_G180_F0.317311.233
7_L11_F0.311361.209
126_D129_S0.3111.208
118_I122_L0.310691.207
185_L193_S0.306821.192
132_L204_A0.303991.181
53_P58_G0.302121.174
178_V202_V0.299741.164
203_E207_A0.298231.158
131_F134_L0.294311.143
136_I201_A0.293741.141
88_S96_Y0.293431.140
18_P21_G0.291921.134
138_L142_L0.281941.095
74_S78_E0.281431.093
95_A99_A0.27981.087
133_F205_L0.279791.087
53_P206_R0.278731.083
76_E100_K0.278361.081
30_L118_I0.278041.080
134_L138_L0.277311.077
55_L123_F0.276371.074
5_A9_R0.275631.071
14_F107_I0.275351.070
155_F161_A0.274431.066
144_S148_G0.271581.055
130_F134_L0.270991.053
186_P190_R0.270511.051
55_L59_S0.269371.046
140_S205_L0.268571.043
147_L168_I0.265391.031
146_G153_A0.264331.027
24_W28_F0.263581.024
114_I117_I0.262991.022
75_F78_E0.262921.021
41_G44_G0.261911.017
76_E81_T0.259831.009
10_E103_S0.25831.003
83_E87_A0.257521.000
23_I27_I0.255370.992
183_S190_R0.254220.987
7_L103_S0.253830.986
181_P184_S0.253570.985
121_L127_F0.252850.982
48_D51_N0.252260.980
200_Y203_E0.249140.968
201_A204_A0.248340.965
11_F106_L0.247380.961
28_F32_L0.246410.957
35_I38_F0.244120.948
69_S165_S0.242520.942
55_L58_G0.241980.940
185_L190_R0.241480.938
143_C201_A0.240660.935
45_N48_D0.240170.933
186_P189_L0.240160.933
76_E80_G0.238820.928
106_L109_L0.235910.916
54_G57_F0.234940.913
189_L193_S0.23410.909
166_S170_L0.232540.903
94_F98_L0.232430.903
24_W27_I0.231780.900
25_S29_P0.23150.899
116_L133_F0.231440.899
102_L106_L0.231030.897
34_L37_G0.230480.895
172_L198_L0.229120.890
199_T203_E0.228930.889
109_L113_L0.228150.886
112_S138_L0.228120.886
182_L199_T0.224060.870
85_E90_L0.223570.868
33_L37_G0.223270.867
162_S166_S0.222790.865
177_G182_L0.222710.865
143_C146_G0.222660.865
75_F79_R0.222630.865
119_A123_F0.22240.864
120_Y125_L0.22210.863
167_L171_L0.220030.855
151_L161_A0.218240.848
203_E206_R0.217370.844
116_L134_L0.216260.840
150_L153_A0.215580.837
86_R93_P0.213170.828
54_G62_F0.211720.822
194_Y203_E0.20590.800
81_T84_R0.205670.799
61_I65_F0.205530.798
45_N124_G0.205460.798
117_I134_L0.205250.797
164_I168_I0.204560.795
155_F164_I0.204510.794
172_L196_N0.203950.792
161_A165_S0.203810.792
176_S202_V0.20350.790
56_I59_S0.203460.790
26_L110_I0.202250.786
105_F138_L0.202190.785
40_F43_L0.20210.785
42_K127_F0.201210.782
148_G152_A0.200210.778
9_R13_R0.199530.775
151_L155_F0.19920.774
28_F43_L0.199180.774
129_S132_L0.198280.770
204_A207_A0.198120.770
46_S51_N0.198090.769
40_F84_R0.197930.769
78_E100_K0.197670.768
6_L90_L0.197660.768
87_A90_L0.197440.767
98_L102_L0.197170.766
53_P57_F0.196030.761
128_E131_F0.195340.759
101_V146_G0.194530.756
117_I120_Y0.194320.755
112_S115_V0.194290.755
33_L118_I0.193820.753
15_W19_F0.193020.750
84_R87_A0.192820.749
136_I139_L0.192170.746
177_G199_T0.192110.746
95_A98_L0.191990.746
108_S112_S0.190980.742
37_G41_G0.190880.741
36_F40_F0.190760.741
29_P37_G0.190270.739
149_L152_A0.189010.734
57_F140_S0.188850.734
51_N55_L0.18810.731
34_L38_F0.186020.723
194_Y199_T0.185740.721
81_T85_E0.185540.721
137_L205_L0.184590.717
195_L200_Y0.184360.716
96_Y200_Y0.184260.716
76_E152_A0.183840.714
82_L86_R0.183230.712
65_F69_S0.183040.711
96_Y100_K0.182640.709
60_I64_F0.182290.708
29_P33_L0.181360.704
9_R12_K0.18130.704
105_F109_L0.180830.702
73_I76_E0.180620.702
41_G122_L0.180590.701
173_F178_V0.179930.699
85_E88_S0.179530.697
51_N57_F0.179510.697
180_F185_L0.179450.697
149_L153_A0.178770.694
73_I82_L0.176720.686
127_F130_F0.176630.686
64_F68_I0.176620.686
111_I115_V0.176550.686
173_F179_F0.176230.685
19_F23_I0.176230.685
81_T86_R0.175410.681
146_G149_L0.174940.680
176_S198_L0.174910.679
193_S197_P0.17460.678
27_I34_L0.174340.677
44_G52_R0.173290.673
26_L29_P0.17310.672
73_I149_L0.172950.672
17_N21_G0.17250.670
176_S196_N0.172460.670
140_S198_L0.17210.669
192_I196_N0.171420.666
15_W21_G0.171030.664
158_F162_S0.170870.664
35_I39_I0.170190.661
43_L185_L0.170060.661
147_L150_L0.169850.660
141_I145_S0.169760.659
14_F18_P0.169660.659
163_A166_S0.169590.659
43_L52_R0.169250.657
45_N49_G0.169210.657
113_L117_I0.169170.657
16_R34_L0.169170.657
166_S169_L0.168980.656
76_E85_E0.168320.654
36_F58_G0.167990.653
155_F162_S0.16790.652
58_G62_F0.167810.652
45_N50_F0.167750.652
25_S32_L0.166860.648
8_R15_W0.166490.647
73_I80_G0.16590.644
139_L142_L0.165890.644
136_I205_L0.165720.644
182_L185_L0.165410.643
124_G187_S0.1650.641
149_L166_S0.164950.641
40_F44_G0.164750.640
55_L119_A0.164060.637
192_I195_L0.164010.637
136_I140_S0.163440.635
20_L24_W0.163310.634
89_P92_S0.163290.634
74_S116_L0.163290.634
112_S134_L0.162910.633
10_E82_L0.162880.633
17_N20_L0.162390.631
93_P97_L0.162240.630
75_F158_F0.161680.628
38_F42_K0.16140.627
76_E83_E0.161220.626
15_W20_L0.160620.624
176_S203_E0.160550.624
74_S77_R0.160490.623
124_G127_F0.159910.621
151_L154_L0.159170.618
189_L192_I0.159030.618
52_R58_G0.158910.617
57_F205_L0.158690.616
78_E96_Y0.158450.615
166_S171_L0.157870.613
59_S63_S0.157330.611
6_L9_R0.157260.611
28_F174_F0.157230.611
156_P159_R0.156650.608
160_D163_A0.156010.606
17_N157_S0.155650.605
14_F103_S0.155520.604
28_F31_L0.15540.604
9_R104_A0.155240.603
104_A108_S0.154730.601
155_F158_F0.154450.600
116_L128_E0.154230.599
6_L10_E0.153980.598
100_K104_A0.153840.598
154_L166_S0.153360.596
184_S187_S0.153120.595
59_S133_F0.152070.591
175_L196_N0.15160.589
3_I94_F0.151170.587
108_S145_S0.151080.587
90_L94_F0.150980.586
60_I63_S0.150970.586
65_F144_S0.150360.584
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2a65A0.423860.924
4ev6A0.35244.20.929
4humA0.95714.10.929
2iubA0.35243.90.93
4i0uA0.35242.50.936
3mktA0.96671.30.944
1pi7A0.08571.30.944
4he8H0.37141.10.947
3n2fG0.071410.948
2kv5A0.157110.949
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