GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
3Beta_HSD - 3-beta hydroxysteroid dehydrogenaseisomerase family
Pfam: PF01073 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0063
Length: 280
Sequences: 38202
Seq/Len: 136.44
HH_delta: 0.138 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
16_Q223_H2.483642.836
5_G28_V2.469592.820
90_K94_D2.293772.619
56_D59_S2.265732.587
224_A248_I2.259842.580
61_E105_K2.084452.380
110_R172_R2.06132.354
72_H113_Y2.017312.303
29_L52_G1.999952.284
52_G59_S1.938812.214
114_T225_H1.879842.146
16_Q226_V1.847882.110
151_A155_K1.797852.053
61_E102_A1.790182.044
16_Q20_R1.789392.043
69_V229_A1.779922.032
258_W262_R1.726251.971
86_E90_K1.638861.871
2_V14_V1.624161.855
27_R50_I1.617491.847
177_R245_A1.598431.825
57_P101_E1.597751.824
84_P87_E1.587621.813
97_R101_E1.5281.745
176_L225_H1.508161.722
16_Q19_E1.495621.708
13_I222_A1.474361.683
96_T153_A1.450421.656
20_R230_Q1.440381.645
59_S62_E1.428981.632
100_L160_A1.414441.615
57_P61_E1.408971.609
57_P98_N1.408151.608
97_R156_A1.398171.596
176_L228_A1.397021.595
255_P259_D1.382021.578
113_Y157_V1.377911.573
120_V247_F1.373011.568
68_D109_K1.370111.564
93_V152_L1.36121.554
27_R67_V1.352961.545
92_N149_S1.350941.543
223_H227_L1.350051.542
259_D262_R1.334481.524
20_R226_V1.330791.520
89_Y152_L1.307851.493
55_T90_K1.29421.478
71_F229_A1.291211.474
11_S15_R1.286331.469
3_T72_H1.283721.466
70_V103_A1.281011.463
9_L181_I1.260051.439
16_Q222_A1.255451.434
110_R174_C1.254131.432
86_E94_D1.249851.427
115_S154_E1.245661.422
195_K199_S1.243361.420
14_V28_V1.237881.413
157_V173_T1.235341.411
13_I71_F1.230661.405
13_I73_T1.219321.392
115_S119_V1.215211.388
1_L67_V1.186941.355
62_E65_E1.180511.348
61_E65_E1.161661.326
146_Y150_K1.158941.323
94_D98_N1.152671.316
5_G14_V1.143451.306
12_H219_E1.14211.304
102_A105_K1.138891.300
178_P225_H1.1341.295
15_R19_E1.125961.286
226_V230_Q1.125651.285
94_D97_R1.122091.281
13_I225_H1.110751.268
17_L226_V1.104761.261
155_K158_L1.103931.261
148_E152_L1.09721.253
178_P221_V1.09691.252
216_V221_V1.091681.247
101_E104_R1.086751.241
20_R24_Y1.079511.233
6_S30_D1.073721.226
89_Y93_V1.068161.220
70_V99_V1.062571.213
218_V222_A1.056281.206
62_E66_G1.046811.195
54_I95_G1.039931.187
154_E177_R1.039411.187
212_L253_P1.024621.170
65_E106_A1.014441.158
71_F225_H1.01431.158
227_L230_Q1.011881.155
16_Q219_E1.008521.152
58_E61_E1.006081.149
58_E62_E1.002761.145
54_I74_A0.983211.123
210_N258_W0.98151.121
12_H15_R0.977821.117
29_L63_A0.97761.116
214_D251_G0.96971.107
73_T114_T0.961631.098
102_A106_A0.948511.083
98_N101_E0.948131.083
3_T99_V0.943371.077
8_F183_G0.943131.077
177_R247_F0.939091.072
99_V111_L0.929661.062
262_R265_W0.928581.060
1_L29_L0.927871.059
32_S35_P0.92751.059
72_H96_T0.926631.058
156_A159_E0.925761.057
101_E105_K0.917811.048
91_V95_G0.916471.046
76_P91_V0.914511.044
172_R242_A0.914431.044
161_N173_T0.913431.043
182_Y217_Y0.906881.036
33_P51_Q0.906031.035
119_V154_E0.901771.030
113_Y153_A0.898151.026
60_L102_A0.896251.023
217_Y220_N0.895191.022
61_E106_A0.88621.012
100_L111_L0.886081.012
114_T178_P0.883911.009
32_S49_Y0.883671.009
158_L175_A0.877431.002
8_F218_V0.873480.997
98_N102_A0.870450.994
64_L70_V0.868320.991
3_T74_A0.86630.989
12_H222_A0.865840.989
210_N255_P0.858620.980
181_I221_V0.857970.980
175_A245_A0.849570.970
158_L173_T0.849480.970
103_A111_L0.848020.968
196_M201_L0.84760.968
155_K159_E0.844570.964
112_V176_L0.841440.961
59_S63_A0.840250.959
64_L103_A0.837770.957
220_N250_D0.834910.953
244_Q247_F0.834450.953
29_L59_S0.83060.948
88_Y149_S0.829360.947
12_H218_V0.826350.944
21_G24_Y0.823720.941
27_R66_G0.820970.937
113_Y175_A0.817060.933
57_P105_K0.816150.932
72_H99_V0.812540.928
192_R195_K0.812240.927
89_Y94_D0.795810.909
103_A108_V0.78680.898
111_L157_V0.781290.892
70_V111_L0.77860.889
259_D263_P0.775780.886
157_V175_A0.772290.882
255_P258_W0.769360.878
12_H16_Q0.769230.878
76_P87_E0.767360.876
101_E160_A0.766020.875
40_D44_S0.765550.874
195_K198_R0.760390.868
89_Y148_E0.753990.861
104_R171_L0.752860.860
158_L245_A0.75280.860
40_D43_K0.751250.858
28_V47_K0.742590.848
212_L255_P0.73690.841
18_L26_V0.735370.840
179_A249_T0.7310.835
69_V112_V0.726280.829
24_Y230_Q0.724570.827
100_L156_A0.723980.827
87_E90_K0.723030.826
64_L67_V0.718050.820
73_T225_H0.717720.820
55_T91_V0.713770.815
109_K172_R0.712930.814
60_L98_N0.7090.810
117_I179_A0.706350.807
261_M265_W0.706270.806
254_V259_D0.705670.806
241_V246_Y0.701330.801
153_A157_V0.700920.800
115_S175_A0.696540.795
24_Y69_V0.692030.790
152_L155_K0.69180.790
222_A226_V0.690460.788
13_I17_L0.687410.785
30_D49_Y0.685820.783
15_R185_G0.684780.782
31_R53_D0.681330.778
223_H226_V0.679190.776
14_V26_V0.675760.772
89_Y149_S0.675530.771
96_T100_L0.674810.771
33_P37_F0.667620.762
152_L156_A0.665830.760
197_V265_W0.665340.760
64_L102_A0.662570.757
192_R196_M0.660240.754
11_S40_D0.655080.748
72_H111_L0.648640.741
196_M200_G0.647680.740
241_V244_Q0.643020.734
50_I63_A0.641890.733
32_S51_Q0.638370.729
194_V198_R0.638010.729
176_L248_I0.637490.728
24_Y68_D0.636950.727
53_D56_D0.635460.726
254_V260_F0.63540.726
41_L45_G0.634310.724
178_P181_I0.6330.723
18_L46_V0.63010.719
25_E46_V0.627550.717
60_L64_L0.625950.715
156_A160_A0.622030.710
189_L193_L0.620660.709
41_L44_S0.618940.707
11_S185_G0.616890.704
209_G258_W0.612750.700
42_Q45_G0.610470.697
56_D60_L0.607250.693
158_L162_G0.60590.692
7_G184_P0.604520.690
15_R18_L0.603840.689
118_S147_A0.600180.685
100_L157_V0.599560.685
52_G63_A0.599020.684
158_L161_N0.598910.684
52_G60_L0.598060.683
55_T87_E0.594580.679
15_R219_E0.593080.677
60_L99_V0.5930.677
174_C228_A0.590070.674
191_P194_V0.589780.673
29_L60_L0.589440.673
18_L47_K0.587360.671
75_A92_N0.584140.667
181_I216_V0.583560.666
69_V110_R0.583070.666
254_V263_P0.581690.664
1_L70_V0.574790.656
57_P102_A0.574120.656
148_E159_E0.57180.653
2_V17_L0.570640.652
87_E91_V0.569290.650
104_R160_A0.568190.649
14_V21_G0.565220.645
214_D250_D0.565020.645
34_P37_F0.556020.635
146_Y149_S0.554170.633
1_L63_A0.552530.631
116_S119_V0.551490.630
1_L64_L0.549980.628
205_Q258_W0.54910.627
76_P88_Y0.548750.627
6_S31_R0.547190.625
112_V225_H0.545910.623
15_R44_S0.540890.618
56_D61_E0.540810.618
93_V149_S0.540790.618
25_E47_K0.537340.614
115_S177_R0.537270.613
92_N146_Y0.536960.613
96_T157_V0.536830.613
176_L224_A0.536560.613
148_E155_K0.535240.611
65_E105_K0.534920.611
17_L24_Y0.534490.610
154_E245_A0.533660.609
9_L221_V0.533540.609
219_E223_H0.532040.608
101_E156_A0.530720.606
63_A67_V0.530260.605
184_P217_Y0.529920.605
97_R160_A0.529340.604
93_V97_R0.529290.604
188_R191_P0.528630.604
220_N223_H0.528620.604
120_V177_R0.528170.603
14_V18_L0.527370.602
64_L99_V0.52730.602
21_G26_V0.526990.602
8_F12_H0.526260.601
81_G84_P0.521610.596
85_P145_P0.519010.593
96_T113_Y0.518570.592
144_D147_A0.518370.592
30_D51_Q0.51830.592
183_G218_V0.516460.590
69_V109_K0.516220.589
15_R43_K0.515970.589
25_E68_D0.515490.589
85_P148_E0.512130.585
43_K46_V0.51180.584
159_E162_G0.511410.584
7_G11_S0.510710.583
78_P81_G0.509330.582
191_P195_K0.508940.581
122_D143_L0.506850.579
20_R227_L0.504840.576
74_A95_G0.504660.576
153_A156_A0.498280.569
27_R47_K0.49820.569
116_S146_Y0.497490.568
24_Y27_R0.496940.567
85_P94_D0.496810.567
149_S152_L0.495850.566
37_F41_L0.495710.566
145_P148_E0.494480.565
32_S37_F0.493070.563
189_L192_R0.492560.562
214_D253_P0.492310.562
190_V193_L0.492190.562
160_A173_T0.491330.561
17_L21_G0.491130.561
37_F42_Q0.490510.560
112_V174_C0.490270.560
27_R63_A0.488230.557
54_I91_V0.483710.552
37_F40_D0.481670.550
19_E219_E0.478970.547
114_T176_L0.478460.546
148_E151_A0.47830.546
145_P149_S0.477080.545
64_L106_A0.476970.545
20_R223_H0.475380.543
142_P147_A0.474140.541
50_I66_G0.473650.541
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3rufA0.9251000.138
3slgA0.9251000.144
4egbA0.93211000.148
4id9A0.89291000.149
3m2pA0.88211000.152
3sxpA0.88931000.169
2c5aA0.9251000.17
2q1sA0.92141000.182
1i24A0.93211000.185
3enkA0.93211000.185

Page generated in 0.0255 seconds.