GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ANF_receptor - Receptor family ligand binding region
Pfam: PF01094 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0144
Length: 348
Sequences: 8828
Seq/Len: 25.37
HH_delta: 0.094 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
11_D258_S1.047943.534
287_H290_N0.922853.112
54_A285_L0.90183.041
13_I286_A0.877022.957
142_Q155_F0.851952.873
253_K257_E0.846862.856
75_N97_T0.837562.824
3_L7_Q0.807612.723
11_D15_N0.801472.703
123_R151_I0.799062.695
250_D254_K0.770242.597
55_V71_A0.742422.504
287_H291_R0.736852.485
12_E254_K0.732612.470
249_E253_K0.704132.374
322_E327_R0.69892.357
145_L150_G0.678692.289
320_S327_R0.652352.200
142_Q146_R0.639542.157
39_A63_S0.633882.138
157_S172_K0.621992.097
7_Q11_D0.621262.095
10_I282_V0.619832.090
286_A290_N0.619772.090
256_K270_E0.617312.082
33_C38_F0.607252.048
12_E279_Y0.60412.037
20_L23_I0.581751.962
282_V286_A0.56681.911
311_Q314_K0.564321.903
117_K148_R0.549451.853
122_T181_R0.545071.838
30_F45_C0.541071.825
125_S154_A0.530451.789
320_S329_S0.529861.787
154_A157_S0.52741.778
280_D323_G0.523681.766
12_E283_Y0.523451.765
114_D148_R0.508671.715
139_D143_D0.506571.708
144_L147_E0.505861.706
6_V282_V0.493161.663
109_A113_V0.491541.658
313_L317_R0.485731.638
315_Y318_N0.475881.605
13_I283_Y0.465861.571
12_E16_N0.462711.560
146_R151_I0.460221.552
128_Y158_V0.456661.540
250_D253_K0.451931.524
198_A201_E0.449951.517
143_D147_E0.449941.517
35_D38_F0.446991.507
84_T105_D0.443441.495
287_H319_V0.441321.488
4_A7_Q0.438141.477
10_I27_V0.435241.468
58_P67_V0.434111.464
199_A204_M0.419781.416
121_W181_R0.416211.403
123_R179_G0.414861.399
121_W182_V0.410921.386
99_F317_R0.410011.383
5_A278_A0.40961.381
254_K257_E0.408031.376
58_P64_A0.405141.366
228_F232_F0.404631.364
9_A286_A0.392821.325
9_A282_V0.391821.321
291_R315_Y0.391091.319
130_D135_N0.389671.314
310_S314_K0.387371.306
38_F42_A0.386981.305
116_L212_I0.386831.304
314_K318_N0.386691.304
170_L198_A0.386371.303
213_L217_D0.383561.293
45_C50_Q0.383121.292
79_I285_L0.382511.290
4_A255_W0.380611.283
292_A315_Y0.38061.283
110_R144_L0.379171.279
4_A269_Q0.376521.270
162_S191_D0.37641.269
112_L184_I0.375761.267
114_D118_H0.374311.262
124_V182_V0.372481.256
159_V187_S0.370511.249
125_S180_A0.37011.248
285_L289_L0.370081.248
72_S96_P0.367371.239
64_A83_S0.362081.221
75_N310_S0.361691.220
280_D325_T0.361091.218
58_P78_Q0.360261.215
69_S73_E0.359791.213
123_R181_R0.35941.212
130_D160_I0.358591.209
71_A78_Q0.356571.202
47_L76_I0.354831.197
44_I48_N0.354811.196
170_L202_L0.354481.195
128_Y138_A0.353291.191
140_S143_D0.351961.187
123_R153_V0.351761.186
125_S157_S0.34941.178
284_L330_F0.34311.157
6_V56_I0.342691.156
126_V138_A0.342451.155
138_A142_Q0.339461.145
244_S249_E0.338271.141
13_I282_V0.338151.140
124_V145_L0.337141.137
226_E229_R0.336561.135
284_L316_L0.332771.122
283_Y286_A0.331021.116
61_S85_S0.329461.111
30_F42_A0.326541.101
251_F275_A0.325191.097
5_A275_A0.322311.087
45_C49_K0.322221.087
278_A282_V0.320931.082
43_A71_A0.319681.078
247_E322_E0.319271.077
225_N229_R0.317391.070
48_N74_W0.316971.069
28_Q50_Q0.316061.066
172_K175_E0.315371.063
127_V169_L0.313971.059
251_F255_W0.313861.058
80_S83_S0.312731.055
42_A45_C0.310951.049
131_D134_G0.310631.047
198_A202_L0.308991.042
78_Q98_F0.308681.041
58_P71_A0.30851.040
8_L12_E0.30821.039
6_V278_A0.306351.033
114_D144_L0.305011.029
10_I14_N0.304521.027
144_L148_R0.304451.027
89_S100_R0.304331.026
171_K175_E0.303371.023
135_N139_D0.302811.021
86_P106_S0.302171.019
14_N18_D0.301831.018
9_A279_Y0.301041.015
80_S98_F0.300991.015
7_Q258_S0.298691.007
288_A292_A0.297851.004
253_K256_K0.296691.000
38_F41_Q0.294270.992
172_K178_S0.291780.984
25_L286_A0.291320.982
99_F313_L0.291140.982
137_L186_C0.290590.980
113_V145_L0.29020.979
291_R319_V0.290120.978
268_D271_P0.289790.977
115_L119_F0.289250.975
43_A55_V0.288660.973
115_L236_L0.288590.973
246_P250_D0.287890.971
249_E252_M0.286910.967
199_A211_W0.285680.963
131_D161_S0.283180.955
289_L312_L0.282820.954
125_S153_V0.282690.953
311_Q315_Y0.28190.951
42_A46_S0.281310.949
283_Y287_H0.281230.948
143_D146_R0.280120.945
312_L315_Y0.279340.942
5_A9_A0.278910.941
187_S195_F0.278270.938
54_A77_P0.276410.932
9_A13_I0.276310.932
223_Q226_E0.276150.931
7_Q29_V0.274820.927
321_F328_V0.274490.926
56_I79_I0.27410.924
88_L98_F0.272680.920
267_S271_P0.272540.919
8_L255_W0.272540.919
32_T63_S0.271490.915
173_L180_A0.271080.914
72_S95_Y0.270360.912
168_E171_K0.269590.909
113_V141_F0.269350.908
163_D169_L0.268710.906
252_M256_K0.265760.896
167_E198_A0.265190.894
12_E15_N0.264260.891
290_N293_L0.263780.889
153_V180_A0.263740.889
170_L174_K0.263730.889
46_S52_V0.263430.888
284_L321_F0.263230.888
109_A137_L0.262990.887
9_A283_Y0.262180.884
185_L195_F0.262050.884
8_L254_K0.261720.883
99_F330_F0.261540.882
204_M209_Y0.26030.878
10_I25_L0.260080.877
64_A78_Q0.259630.875
3_L29_V0.259580.875
135_N158_V0.258970.873
145_L152_C0.25730.868
110_R114_D0.256030.863
86_P136_S0.25580.863
139_D142_Q0.255720.862
113_V148_R0.254690.859
81_P278_A0.254520.858
141_F145_L0.254470.858
276_A324_L0.253680.855
4_A267_S0.252190.850
124_V150_G0.251370.848
195_F199_A0.250680.845
56_I281_A0.249650.842
127_V195_F0.247850.836
129_S134_G0.247390.834
8_L11_D0.246790.832
232_F235_V0.246710.832
283_Y321_F0.245530.828
128_Y135_N0.243240.820
315_Y319_V0.242770.819
287_H321_F0.242490.818
117_K150_G0.242150.817
52_V55_V0.241750.815
323_G326_G0.241430.814
230_E233_Q0.241310.814
228_F231_A0.240950.813
40_L70_L0.240750.812
247_E250_D0.240470.811
246_P249_E0.240310.810
60_C63_S0.240170.810
6_V27_V0.239870.809
130_D134_G0.23930.807
39_A43_A0.2390.806
84_T102_V0.238680.805
166_A170_L0.238560.804
170_L199_A0.238420.804
154_A178_S0.238320.804
80_S88_L0.237910.802
65_E88_L0.2370.799
114_D117_K0.236750.798
37_S41_Q0.236650.798
192_A217_D0.235980.796
154_A172_K0.235360.794
97_T313_L0.235250.793
23_I26_E0.235220.793
87_S90_D0.233780.788
30_F46_S0.233690.788
68_A98_F0.233020.786
99_F316_L0.23280.785
200_Y230_E0.232770.785
102_V277_Y0.232690.785
77_P312_L0.231930.782
43_A47_L0.231150.779
125_S173_L0.231130.779
224_N232_F0.230290.777
165_D168_E0.229340.773
254_K258_S0.229170.773
125_S178_S0.229090.773
22_N26_E0.229090.773
136_S139_D0.229060.772
64_A80_S0.227330.767
294_Q311_Q0.22690.765
160_I163_D0.226890.765
175_E178_S0.226220.763
117_K122_T0.225880.762
96_P313_L0.22530.760
245_S248_F0.224570.757
56_I285_L0.224230.756
183_V199_A0.223830.755
225_N228_F0.223490.754
166_A198_A0.22310.752
101_T284_L0.221990.749
40_L43_A0.221610.747
166_A169_L0.221590.747
229_R232_F0.220820.745
150_G153_V0.22070.744
248_F252_M0.22010.742
83_S88_L0.21950.740
291_R318_N0.218890.738
196_L211_W0.217680.734
44_I73_E0.217340.733
288_A316_L0.217260.733
7_Q27_V0.217080.732
182_V212_I0.216690.731
128_Y155_F0.216020.728
174_K204_M0.216020.728
40_L44_I0.215520.727
7_Q10_I0.21550.727
194_Q198_A0.215250.726
196_L224_N0.215230.726
53_V76_I0.215080.725
70_L74_W0.215080.725
101_T281_A0.214760.724
271_P275_A0.21430.723
124_V141_F0.2140.722
67_V71_A0.213790.721
280_D324_L0.213630.720
65_E87_S0.213570.720
36_D39_A0.213260.719
18_D23_I0.213150.719
196_L199_A0.213080.719
41_Q44_I0.212580.717
79_I101_T0.212330.716
163_D166_A0.211730.714
21_P24_T0.211220.712
196_L200_Y0.210910.711
44_I70_L0.210770.711
15_N18_D0.210380.709
26_E29_V0.210060.708
29_V32_T0.209770.707
197_E201_E0.209730.707
30_F33_C0.208470.703
256_K268_D0.208360.703
105_D108_Q0.207850.701
284_L319_V0.207550.700
223_Q227_D0.206920.698
116_L121_W0.206830.697
317_R332_S0.206630.697
30_F50_Q0.206490.696
170_L204_M0.206070.695
185_L192_A0.204340.689
26_E30_F0.204130.688
79_I281_A0.2040.688
16_N290_N0.203240.685
174_K202_L0.202640.683
314_K317_R0.202490.683
90_D94_R0.201440.679
13_I17_P0.201430.679
181_R209_Y0.201390.679
112_L116_L0.201250.679
138_A158_V0.20040.676
168_E172_K0.19990.674
64_A88_L0.199760.674
316_L319_V0.199090.671
117_K145_L0.198880.671
9_A12_E0.198790.670
182_V210_V0.197460.666
68_A95_Y0.196050.661
170_L173_L0.195530.659
23_I27_V0.195060.658
224_N228_F0.194820.657
56_I81_P0.194380.655
64_A68_A0.194340.655
66_A69_S0.194160.655
8_L258_S0.193780.653
5_A8_L0.193760.653
27_V31_D0.193680.653
119_F182_V0.193160.651
152_C155_F0.19310.651
32_T39_A0.191980.647
28_Q45_C0.191510.646
171_K202_L0.19140.645
126_V141_F0.190610.643
84_T215_D0.189960.641
6_V10_I0.189130.638
20_L29_V0.187830.633
153_V178_S0.187280.632
105_D136_S0.18690.630
20_L25_L0.18660.629
209_Y213_L0.185410.625
258_S267_S0.185270.625
267_S270_E0.185240.625
84_T108_Q0.184490.622
61_S100_R0.184230.621
23_I29_V0.184210.621
47_L70_L0.183780.620
70_L73_E0.182460.615
57_G61_S0.181950.614
27_V30_F0.181820.613
97_T310_S0.180920.610
247_E283_Y0.180610.609
141_F184_I0.180110.607
80_S101_T0.179990.607
61_S105_D0.179360.605
46_S50_Q0.179260.604
40_L66_A0.17920.604
112_L212_I0.179140.604
165_D170_L0.178240.601
167_E202_L0.178130.601
41_Q45_C0.17810.601
54_A312_L0.177710.599
12_E250_D0.177610.599
14_N24_T0.177310.598
77_P97_T0.176740.596
4_A8_L0.176030.594
130_D158_V0.175940.593
39_A46_S0.175870.593
313_L316_L0.174790.589
194_Q197_E0.174740.589
105_D140_S0.174720.589
138_A155_F0.174620.589
47_L55_V0.173940.587
43_A67_V0.173840.586
126_V152_C0.173830.586
174_K179_G0.173510.585
47_L74_W0.172930.583
325_T328_V0.172690.582
14_N286_A0.171870.580
78_Q88_L0.171770.579
96_P310_S0.171720.579
63_S67_V0.171620.579
165_D198_A0.170040.573
113_V144_L0.16950.572
284_L287_H0.169170.570
74_W77_P0.169090.570
183_V204_M0.169030.570
26_E31_D0.168950.570
61_S133_Y0.168420.568
113_V117_K0.167910.566
61_S83_S0.167560.565
54_A79_I0.167020.563
321_F330_F0.166620.562
20_L24_T0.166520.562
13_I25_L0.166340.561
257_E268_D0.166280.561
171_K174_K0.166240.561
159_V191_D0.16590.559
128_Y134_G0.165790.559
276_A280_D0.165630.559
169_L195_F0.16560.558
292_A311_Q0.165510.558
65_E132_D0.165480.558
277_Y325_T0.165290.557
126_V142_Q0.165220.557
83_S100_R0.165220.557
64_A98_F0.164810.556
44_I74_W0.164540.555
43_A74_W0.164390.554
245_S249_E0.164240.554
21_P25_L0.164160.554
105_D133_Y0.164160.554
35_D39_A0.163820.552
137_L214_T0.16370.552
118_H148_R0.16340.551
46_S49_K0.163050.550
224_N230_E0.163020.550
133_Y137_L0.162880.549
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4f11A0.94831000.094
3o21A0.95111000.098
3om0A0.96261000.11
3h6gA0.96841000.128
3hsyA0.93681000.129
3kg2A0.93681000.135
1jdpA0.95111000.138
2e4uA0.97411000.143
1dp4A0.9541000.144
3sajA0.93391000.147

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