GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
GIDA - Glucose inhibited division protein A
Pfam: PF01134 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0063
Length: 392
Sequences: 5924
Seq/Len: 15.11
HH_delta: 0.314 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
347_L351_E1.000254.347
14_A145_V0.785783.415
335_A345_Q0.683692.971
141_A144_V0.662842.880
2_V18_A0.625692.719
245_E249_D0.621392.700
210_E233_P0.589662.562
3_I26_L0.553042.403
24_K112_T0.552362.400
3_I28_I0.550672.393
3_I139_I0.542552.358
26_L114_I0.5272.290
1_D24_K0.525552.284
1_D142_D0.509622.215
122_I127_K0.495362.153
4_V15_A0.47482.063
323_G326_N0.473052.056
183_L214_D0.472612.054
380_A384_A0.469012.038
5_V118_V0.468462.036
10_A361_A0.466952.029
146_L364_I0.463812.015
3_I141_A0.462772.011
204_D207_K0.455451.979
276_K291_E0.445621.936
248_R252_H0.440731.915
24_K110_N0.428951.864
1_D26_L0.426941.855
242_A245_E0.418271.818
238_Y285_Y0.414891.803
172_T175_G0.409281.778
69_E100_A0.403681.754
120_D179_S0.403391.753
377_G381_G0.403141.752
143_A359_F0.401891.746
203_I300_Y0.401841.746
26_L139_I0.400581.741
279_R289_F0.398111.730
234_C244_H0.39571.719
126_G357_G0.394871.716
7_G35_I0.383951.668
103_E107_S0.383181.665
28_I139_I0.382841.664
2_V145_V0.380071.652
185_F352_T0.375851.633
278_V291_E0.37141.614
100_A103_E0.368131.600
105_L113_I0.365231.587
243_T320_S0.364931.586
18_A23_A0.360731.568
185_F215_D0.357311.553
114_I139_I0.356531.549
341_V360_F0.354811.542
16_L62_L0.353841.538
188_G288_V0.353671.537
17_A382_I0.349591.519
121_L130_G0.348341.514
127_K138_E0.347871.512
5_V146_L0.33961.476
119_T130_G0.338041.469
21_M382_I0.329861.433
23_A385_A0.329271.431
241_E284_P0.328591.428
205_F300_Y0.327941.425
120_D144_V0.32791.425
132_V138_E0.327641.424
7_G27_L0.326541.419
18_A25_V0.324551.410
99_R103_E0.322991.404
122_I125_N0.322041.399
116_G135_D0.321541.397
251_L278_V0.317761.381
143_A357_G0.316951.377
120_D132_V0.316231.374
201_D298_N0.315971.373
28_I116_G0.315411.371
27_L105_L0.315051.369
258_F261_C0.311171.352
186_E215_D0.309551.345
351_E356_P0.30851.341
12_C36_G0.307651.337
355_I358_L0.306491.332
359_F383_N0.305981.330
122_I126_G0.304761.324
171_L180_L0.304041.321
102_R106_E0.302841.316
31_N113_I0.302261.313
360_F364_I0.301981.312
381_G385_A0.301631.311
127_K140_E0.301021.308
245_E248_R0.300781.307
1_D23_A0.300361.305
52_L375_A0.298451.297
143_A384_A0.296061.287
352_T360_F0.295551.284
347_L356_P0.293871.277
151_F319_R0.293451.275
106_E115_Q0.291731.268
278_V289_F0.290461.262
145_V384_A0.290161.261
26_L112_T0.286281.244
203_I222_Y0.282311.227
345_Q353_K0.280651.220
28_I118_V0.278031.208
281_P287_Q0.277671.207
233_P260_G0.275921.199
241_E245_E0.275491.197
25_V111_L0.273581.189
122_I138_E0.272651.185
30_H117_E0.272251.183
290_L324_L0.271571.180
246_I250_N0.270061.174
2_V23_A0.26881.168
379_I383_N0.268011.165
188_G340_F0.267511.162
14_A380_A0.26731.162
177_S187_L0.267211.161
144_V357_G0.266471.158
151_F306_S0.266021.156
133_T139_I0.26581.155
203_I251_L0.265671.154
203_I208_L0.264581.150
351_E357_G0.264111.148
18_A384_A0.263041.143
380_A383_N0.261791.138
186_E297_T0.261281.135
337_E340_F0.260581.132
116_G131_V0.259161.126
281_P289_F0.258031.121
361_A380_A0.257291.118
174_D177_S0.257261.118
56_I378_L0.253931.103
28_I131_V0.253861.103
119_T132_V0.253531.102
105_L111_L0.253221.100
18_A381_G0.253081.100
70_T100_A0.252691.098
52_L55_E0.252131.096
3_I144_V0.251941.095
13_E374_A0.251111.091
207_K325_E0.250081.087
349_T383_N0.249561.084
20_R109_P0.249141.083
121_L138_E0.24831.079
100_A104_K0.246091.069
130_G138_E0.245921.069
51_H55_E0.245631.067
145_V361_A0.243581.058
250_N253_R0.243081.056
179_S182_K0.242451.054
186_E345_Q0.241131.048
283_R287_Q0.24061.046
56_I374_A0.240011.043
21_M385_A0.238631.037
192_T235_F0.238431.036
120_D128_V0.237491.032
346_L365_N0.236891.029
117_E134_K0.234881.021
378_L382_I0.234621.020
28_I114_I0.233851.016
120_D182_K0.233281.014
70_T96_K0.232681.011
340_F345_Q0.232551.011
151_F308_S0.231781.007
14_A381_G0.23051.002
187_L209_E0.230061.000
54_R211_Q0.229410.997
319_R327_A0.229130.996
127_K356_P0.227680.989
3_I128_V0.226940.986
120_D146_L0.226460.984
133_T136_G0.226240.983
204_D326_N0.225540.980
48_A52_L0.224650.976
69_E104_K0.223790.972
258_F278_V0.223730.972
96_K100_A0.22290.969
16_L20_R0.222360.966
178_E182_K0.221070.961
45_G49_K0.220910.960
10_A373_A0.218930.951
14_A377_G0.21880.951
96_K99_R0.217620.946
350_L365_N0.216970.943
299_E304_G0.216030.939
19_A111_L0.215480.936
19_A110_N0.214570.932
119_T134_K0.213710.929
16_L109_P0.213570.928
287_Q296_N0.212780.925
35_I113_I0.212740.924
101_M105_L0.212670.924
3_I131_V0.212650.924
148_T364_I0.211860.921
327_A355_I0.211460.919
208_L290_L0.21120.918
43_S47_I0.210180.913
122_I140_E0.20940.910
101_M104_K0.208570.906
164_P174_D0.208210.905
114_I137_E0.207860.903
361_A384_A0.206430.897
43_S205_F0.206250.896
102_R115_Q0.205620.894
17_A20_R0.205370.892
12_C101_M0.205330.892
2_V381_G0.205260.892
144_V358_L0.20480.890
352_T355_I0.203940.886
181_R187_L0.203670.885
234_C241_E0.203580.885
49_K59_L0.203510.884
15_A25_V0.202960.882
147_A361_A0.20220.879
340_F366_G0.201750.877
176_L209_E0.200950.873
381_G384_A0.198890.864
7_G31_N0.19790.860
38_M174_D0.197750.859
145_V380_A0.196180.852
221_S258_F0.195010.847
324_L334_Y0.194140.844
187_L341_V0.193120.839
302_P305_F0.192870.838
351_E383_N0.192010.834
327_A336_H0.191960.834
302_P307_T0.190870.829
255_P259_E0.190490.828
128_V144_V0.190460.828
120_D141_A0.190350.827
17_A381_G0.190310.827
38_M92_V0.188580.819
258_F290_L0.18820.818
2_V384_A0.187710.816
351_E359_F0.18770.816
50_G211_Q0.18710.813
249_D252_H0.186870.812
299_E302_P0.186390.810
341_V352_T0.186230.809
222_Y257_L0.184010.800
120_D327_A0.183660.798
212_P233_P0.18330.797
341_V364_I0.183210.796
204_D325_E0.181860.790
62_L104_K0.181830.790
47_I208_L0.18170.790
280_F286_H0.181690.790
103_E106_E0.18140.788
116_G134_K0.181360.788
23_A142_D0.18130.788
210_E255_P0.181220.787
68_D71_G0.179850.782
280_F288_V0.179580.780
211_Q253_R0.179370.779
210_E215_D0.179290.779
359_F384_A0.178860.777
57_D68_D0.178820.777
178_E181_R0.178720.777
251_L255_P0.178470.776
246_I249_D0.176680.768
231_Q276_K0.175870.764
209_E214_D0.175350.762
157_H303_N0.174610.759
248_R257_L0.174140.757
62_L75_R0.173060.752
177_S181_R0.172510.750
7_G11_G0.171940.747
48_A51_H0.171590.746
187_L214_D0.171250.744
146_L360_F0.170210.740
350_L379_I0.169910.738
54_R57_D0.168320.731
337_E366_G0.167590.728
125_N138_E0.166910.725
251_L258_F0.166360.723
234_C237_T0.165480.719
304_G308_S0.164530.715
15_A111_L0.163990.713
52_L56_I0.16360.711
186_E214_D0.163140.709
334_Y358_L0.162320.705
164_P172_T0.161840.703
171_L175_G0.16140.701
352_T358_L0.161370.701
142_D357_G0.161150.700
104_K107_S0.160840.699
32_T113_I0.160170.696
133_T137_E0.160070.696
61_G76_M0.159920.695
93_D99_R0.159140.692
175_G178_E0.158930.691
44_I53_V0.158880.690
5_V148_T0.158730.690
234_C320_S0.15620.679
304_G307_T0.155690.677
14_A384_A0.155490.676
13_E17_A0.155480.676
205_F208_L0.155040.674
350_L383_N0.154910.673
235_F248_R0.154850.673
17_A21_M0.154570.672
157_H306_S0.154450.671
337_E345_Q0.154130.670
39_S47_I0.154050.669
190_F301_Y0.15380.668
349_T359_F0.15340.667
243_T246_I0.153130.665
31_N34_T0.152730.664
194_T239_T0.152210.661
34_T37_E0.152120.661
327_A334_Y0.152080.661
235_F259_E0.151740.659
202_S230_E0.15160.659
375_A378_L0.150810.655
99_R102_R0.15080.655
365_N376_Q0.150660.655
2_V143_A0.150620.655
281_P285_Y0.15050.654
246_I320_S0.150280.653
17_A378_L0.149890.651
53_V57_D0.149740.651
378_L381_G0.148790.647
32_T35_I0.14830.644
36_G101_M0.1480.643
4_V19_A0.147730.642
4_V11_G0.147730.642
29_T113_I0.147570.641
145_V381_G0.147520.641
323_G327_A0.147250.640
280_F299_E0.147150.639
131_V139_I0.147060.639
98_S102_R0.146420.636
367_T373_A0.146380.636
10_A147_A0.146060.635
157_H162_C0.145760.633
350_L376_Q0.145640.633
185_F345_Q0.145360.632
371_E376_Q0.145270.631
230_E233_P0.144730.629
248_R259_E0.144250.627
369_G372_E0.144210.627
53_V72_I0.144060.626
126_G356_P0.144030.626
8_G11_G0.143670.624
27_L113_I0.143290.623
35_I40_C0.143280.623
32_T115_Q0.143110.622
49_K371_E0.14310.622
62_L71_G0.142390.619
175_G180_L0.141590.615
190_F277_P0.141170.613
119_T320_S0.141020.613
207_K211_Q0.140730.612
232_Y295_L0.14020.609
46_G49_K0.140120.609
121_L326_N0.140070.609
300_Y304_G0.139880.608
141_A357_G0.139690.607
34_T98_S0.139420.606
374_A378_L0.139330.605
58_A61_G0.139080.604
37_E168_R0.138730.603
334_Y337_E0.138650.602
335_A353_K0.138640.602
341_V345_Q0.138620.602
307_T340_F0.138350.601
235_F300_Y0.138140.600
33_D115_Q0.138120.600
18_A145_V0.138040.600
44_I201_D0.137930.599
125_N356_P0.137860.599
320_S327_A0.137790.599
336_H341_V0.137690.598
231_Q237_T0.137510.598
11_G15_A0.137370.597
236_I247_I0.137320.597
122_I132_V0.13730.597
247_I255_P0.13730.597
12_C105_L0.137270.596
282_D285_Y0.136930.595
24_K142_D0.136930.595
4_V18_A0.136840.595
120_D323_G0.136840.595
20_R382_I0.136620.594
27_L111_L0.136540.593
203_I257_L0.136290.592
291_E294_G0.136220.592
106_E113_I0.135750.590
346_L350_L0.135080.587
15_A19_A0.134520.585
234_C248_R0.134330.584
299_E307_T0.133930.582
132_V179_S0.133740.581
121_L127_K0.133630.581
240_N244_H0.133590.581
54_R58_A0.133330.579
30_H38_M0.13310.578
16_L104_K0.132790.577
54_R253_R0.132730.577
169_G372_E0.13270.577
47_I205_F0.132540.576
118_V131_V0.132420.575
180_L214_D0.132090.574
365_N368_E0.132020.574
51_H54_R0.131860.573
277_P288_V0.131460.571
352_T356_P0.131170.570
22_G25_V0.130920.569
282_D286_H0.130910.569
254_S257_L0.130750.568
15_A105_L0.130660.568
2_V385_A0.130150.566
290_L300_Y0.129750.564
171_L176_L0.129680.564
120_D326_N0.129410.562
44_I191_K0.129240.562
9_H12_C0.129210.561
32_T102_R0.129140.561
13_E377_G0.129010.561
297_T300_Y0.128730.559
6_G11_G0.128650.559
294_G297_T0.128650.559
169_G282_D0.128510.558
363_Q373_A0.128190.557
280_F301_Y0.127950.556
202_S237_T0.127950.556
34_T47_I0.127910.556
21_M381_G0.127820.555
179_S183_L0.127780.555
34_T174_D0.12730.553
334_Y355_I0.126870.551
193_G202_S0.126860.551
208_L237_T0.126580.550
194_T334_Y0.126140.548
72_I91_Q0.125860.547
97_Y101_M0.125780.547
14_A18_A0.125590.546
145_V385_A0.12520.544
48_A55_E0.125090.544
37_E98_S0.124790.542
363_Q370_Y0.12470.542
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2zxiA0.99741000.314
3cesA0.99741000.321
3cp8A0.99741000.363
4b1bA0.8241000.399
3g5sA0.86221000.442
3dgzA0.81891000.464
3qfaA0.81891000.465
3dghA0.81891000.465
3ic9A0.82141000.466
4jdrA0.82141000.478

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