GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
NAD_Gly3P_dh_N - NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
Pfam: PF01210 (v26) Consensus Sequence
Clan: CL0063
Length: 157
Sequences: 7543
Seq/Len: 48.04
HH_delta: 0.072 (11Mar13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
32_E36_E1.47323.430
1_K24_E1.4343.338
3_A70_A1.251252.913
84_D88_Q1.13982.653
62_D65_E1.109522.583
7_A27_L1.057272.461
36_E40_E0.990742.306
7_A29_G0.94012.189
29_G35_V0.86622.016
24_E58_K0.834881.944
33_E36_E0.804671.873
26_T69_D0.801161.865
76_A102_L0.800221.863
87_E121_I0.794221.849
39_N59_A0.755211.758
2_I18_L0.747071.739
64_E92_Y0.743811.732
94_K97_Q0.73221.705
36_E39_N0.707141.646
77_V85_V0.696981.623
35_V59_A0.653481.521
26_T60_T0.649871.513
32_E61_T0.648541.510
3_A67_L0.635761.480
3_A66_A0.629071.464
24_E56_N0.624261.453
28_W63_L0.623081.451
26_T58_K0.620111.444
60_T66_A0.612151.425
72_I98_I0.607291.414
93_L97_Q0.604011.406
1_K26_T0.603871.406
83_R113_L0.594621.384
16_A20_E0.584691.361
43_R50_G0.582961.357
15_A27_L0.57841.346
88_Q91_P0.57361.335
113_L116_E0.572221.332
69_D94_K0.566641.319
4_V15_A0.56341.312
19_A57_I0.56221.309
31_D34_V0.545741.270
33_E37_E0.544651.268
84_D87_E0.53921.255
83_R87_E0.532061.239
122_L125_H0.525921.224
5_I63_L0.522621.217
38_I59_A0.522531.216
83_R107_E0.504081.173
2_I23_H0.483791.126
16_A54_P0.48131.120
62_D66_A0.479841.117
29_G34_V0.477861.112
71_D94_K0.476021.108
37_E45_P0.472971.101
1_K69_D0.470921.096
64_E88_Q0.467831.089
60_T65_E0.460621.072
18_L74_I0.451321.051
73_I97_Q0.448311.044
115_S119_E0.442831.031
1_K71_D0.442761.031
35_V39_N0.440281.025
119_E123_P0.431121.004
37_E41_N0.426410.993
34_V37_E0.425310.990
5_I28_W0.421510.981
112_K120_E0.42060.979
81_A106_I0.418130.973
72_I100_I0.416450.969
67_L70_A0.413350.962
67_L73_I0.412530.960
17_V21_N0.41020.955
3_A73_I0.408220.950
81_A84_D0.407410.948
88_Q92_Y0.40420.941
68_E94_K0.402660.937
65_E68_E0.400940.933
20_E53_L0.39940.930
123_P126_R0.394440.918
71_D96_G0.392750.914
96_G128_V0.390640.909
131_S137_E0.389170.906
73_I93_L0.388020.903
28_W60_T0.386930.901
117_I120_E0.385540.898
52_K55_K0.383180.892
14_L102_L0.382510.890
79_S103_T0.382190.890
31_D35_V0.377950.880
58_K65_E0.375870.875
26_T70_A0.370760.863
70_A73_I0.370590.863
28_W88_Q0.365870.852
87_E117_I0.365830.852
83_R117_I0.362810.845
117_I121_I0.359750.837
87_E91_P0.359570.837
10_W14_L0.359520.837
43_R52_K0.357060.831
121_I125_H0.356150.829
45_P49_P0.352140.820
51_I55_K0.351920.819
75_I82_H0.351210.818
103_T106_I0.351090.817
90_K111_L0.349380.813
114_L117_I0.349240.813
101_S129_V0.348340.811
5_I89_I0.343080.799
42_R45_P0.34290.798
74_I102_L0.341150.794
39_N58_K0.337550.786
45_P48_L0.337150.785
64_E68_E0.336930.784
82_H103_T0.336850.784
86_L99_I0.335770.782
37_E40_E0.335580.781
112_K116_E0.335460.781
39_N42_R0.335030.780
4_V74_I0.334190.778
86_L117_I0.333680.777
10_W102_L0.332920.775
85_V88_Q0.332490.774
9_N12_T0.329810.768
114_L118_I0.327340.762
116_E119_E0.326240.759
58_K66_A0.325960.759
64_E91_P0.325720.758
116_E120_E0.325610.758
63_L88_Q0.324930.756
12_T41_N0.323610.753
27_L59_A0.322990.752
108_P111_L0.318250.741
41_N45_P0.318180.741
36_E61_T0.317870.740
7_A15_A0.316790.737
98_I101_S0.313450.730
4_V25_V0.313020.729
12_T27_L0.310370.723
5_I73_I0.30890.719
30_R84_D0.306550.714
82_H114_L0.306220.713
34_V38_I0.305850.712
35_V61_T0.305310.711
4_V14_L0.305210.711
46_K49_P0.303840.707
18_L23_H0.303160.706
5_I85_V0.302290.704
7_A38_I0.302040.703
120_E123_P0.301460.702
11_G29_G0.300120.699
63_L92_Y0.298810.696
22_G25_V0.298670.695
31_D46_K0.298010.694
2_I72_I0.296640.691
37_E42_R0.29650.690
37_E43_R0.295610.688
28_W66_A0.292180.680
118_I121_I0.288630.672
10_W76_A0.282140.657
86_L90_K0.281530.655
14_L18_L0.280530.653
46_K50_G0.279240.650
101_S118_I0.2780.647
80_Q108_P0.276930.645
107_E110_T0.272350.634
113_L117_I0.272350.634
16_A41_N0.272040.633
14_L76_A0.271890.633
87_E90_K0.271470.632
10_W13_A0.268960.626
89_I93_L0.268420.625
52_K56_N0.268160.624
26_T66_A0.268020.624
30_R34_V0.266730.621
9_N78_P0.2660.619
45_P50_G0.265860.619
127_I131_S0.264360.615
101_S108_P0.263390.613
34_V41_N0.26320.613
63_L67_L0.262950.612
79_S104_K0.262890.612
19_A56_N0.260990.608
83_R110_T0.260980.608
15_A25_V0.259740.605
14_L17_V0.259530.604
81_A85_V0.257360.599
42_R48_L0.257260.599
43_R46_K0.257230.599
128_V135_F0.256960.598
38_I53_L0.256110.596
38_I41_N0.255520.595
15_A19_A0.254320.592
15_A57_I0.253090.589
75_I79_S0.252850.589
75_I89_I0.252110.587
75_I99_I0.251280.585
66_A70_A0.24910.580
3_A28_W0.249050.580
42_R46_K0.248820.579
83_R121_I0.24850.578
114_L122_L0.247860.577
16_A53_L0.24580.572
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4fgwA0.993699.90.072
3k96A0.993699.90.078
4a7pA0.987399.80.206
1yj8A0.993699.80.213
1evyA199.80.222
1x0vA0.993699.80.239
3gg2A0.987399.80.253
1z82A0.94999.80.259
2y0cA0.987399.80.266
1txgA0.974599.70.299

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