GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Peptidase_A8 - Signal peptidase (SPase) II
Pfam: PF01252 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 150
Sequences: 2057
Seq/Len: 13.71
HH_delta: 0.943 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
12_T112_F1.069424.165
5_L131_F0.88493.446
39_E108_Y0.754612.939
5_L94_G0.702152.734
6_L101_I0.672362.618
33_F113_I0.649682.530
16_I20_L0.641862.500
114_D121_H0.625012.434
10_Q101_I0.582872.270
94_G131_F0.510621.989
130_I134_I0.508251.979
9_D13_K0.506311.972
45_F123_P0.501071.951
38_V124_V0.496191.932
20_L26_I0.495331.929
17_L110_V0.490481.910
15_W19_H0.484271.886
12_T127_L0.46271.802
34_R114_D0.46241.801
90_A94_G0.453111.765
127_L130_I0.448031.745
122_F133_V0.445111.733
17_L39_E0.440441.715
133_V137_I0.439991.714
71_I93_L0.42081.639
127_L131_F0.404731.576
92_I135_G0.377941.472
20_L37_Y0.373871.456
8_I127_L0.369741.440
16_I37_Y0.356641.389
14_Y18_N0.342581.334
36_R124_V0.342091.332
41_T108_Y0.340441.326
34_R116_H0.338111.317
73_Y77_K0.336431.310
33_F115_F0.33431.302
69_L73_Y0.327241.274
11_L15_W0.32581.269
6_L97_L0.321711.253
25_P34_R0.321061.250
88_G138_L0.319751.245
113_I130_I0.317891.238
25_P36_R0.30691.195
83_K87_I0.304771.187
136_A140_V0.303371.181
134_I138_L0.302741.179
66_L70_F0.30011.169
106_Y110_V0.297111.157
68_I93_L0.296051.153
112_F127_L0.292811.140
41_T49_S0.292391.139
41_T46_G0.290531.131
17_L106_Y0.290391.131
16_I35_L0.289861.129
88_G142_S0.286931.117
35_L113_I0.284411.108
36_R114_D0.283351.103
37_Y108_Y0.283091.102
7_V11_L0.282131.099
61_L100_L0.265441.034
64_S100_L0.259371.010
84_L88_G0.255170.994
84_L138_L0.254640.992
44_A123_P0.254250.990
46_G49_S0.25260.984
99_N126_N0.250770.977
82_S85_L0.249350.971
46_G123_P0.246330.959
27_P30_G0.246020.958
21_E37_Y0.244450.952
12_T113_I0.241380.940
5_L91_L0.240860.938
10_Q105_F0.238940.931
115_F125_F0.238770.930
61_L64_S0.238450.929
114_D124_V0.236760.922
28_I35_L0.235060.915
130_I133_V0.230590.898
60_L63_I0.22970.895
88_G135_G0.228510.890
70_F73_Y0.227990.888
75_L89_L0.225210.877
37_Y110_V0.225140.877
88_G139_L0.223270.870
20_L24_E0.219340.854
70_F74_F0.219060.853
61_L104_L0.218720.852
75_L90_A0.217570.847
48_F60_L0.215510.839
109_V126_N0.21490.837
75_L86_K0.213680.832
32_F120_F0.212880.829
27_P34_R0.212410.827
64_S68_I0.210160.818
99_N109_V0.209770.817
101_I105_F0.209450.816
12_T15_W0.20860.812
85_L89_L0.20660.805
43_A60_L0.206160.803
59_F63_I0.205190.799
16_I25_P0.197040.767
48_F51_L0.196680.766
84_L142_S0.196680.766
60_L64_S0.196510.765
58_L61_L0.194690.758
12_T16_I0.194210.756
42_G99_N0.194140.756
45_F132_I0.194130.756
140_V143_I0.194120.756
42_G126_N0.193840.755
125_F130_I0.193470.753
42_G128_A0.193150.752
45_F122_F0.193080.752
16_I22_L0.192780.751
5_L127_L0.190970.744
26_I35_L0.190320.741
68_I96_A0.190170.741
32_F115_F0.188840.735
10_Q106_Y0.188510.734
5_L90_A0.187980.732
91_L131_F0.18660.727
117_F141_I0.186510.726
20_L35_L0.186350.726
34_R121_H0.186040.725
57_K61_L0.185130.721
113_I127_L0.18430.718
99_N128_A0.183270.714
79_R82_S0.183250.714
67_A96_A0.182860.712
116_H124_V0.18260.711
44_A122_F0.182040.709
64_S103_R0.181690.708
114_D117_F0.178850.697
10_Q13_K0.178280.694
103_R126_N0.17760.692
113_I124_V0.176550.688
37_Y89_L0.175410.683
39_E110_V0.174860.681
72_L76_F0.174390.679
73_Y76_F0.173530.676
32_F113_I0.171040.666
32_F116_H0.171030.666
116_H120_F0.170260.663
7_V18_N0.169560.660
72_L75_L0.169310.659
30_G34_R0.169260.659
99_N103_R0.168320.656
48_F116_H0.168260.655
61_L107_G0.167620.653
134_I137_I0.166880.650
92_I139_L0.166620.649
86_K90_A0.166310.648
97_L101_I0.166120.647
45_F103_R0.165770.646
15_W20_L0.165710.645
11_L19_H0.16560.645
63_I75_L0.165580.645
84_L87_I0.164760.642
25_P114_D0.164470.641
71_I96_A0.164170.639
84_L136_A0.163920.638
91_L135_G0.1630.635
71_I89_L0.162830.634
95_G135_G0.162670.634
39_E49_S0.162530.633
65_I69_L0.162250.632
137_I140_V0.160890.627
62_I66_L0.160540.625
109_V128_A0.160040.623
44_A110_V0.159760.622
43_A46_G0.159270.620
66_L69_L0.158850.619
5_L130_I0.157510.613
38_V114_D0.156870.611
17_L100_L0.156860.611
42_G135_G0.156560.610
37_Y44_A0.156120.608
22_L39_E0.15590.607
45_F112_F0.154670.602
41_T48_F0.154620.602
114_D122_F0.154450.601
98_G126_N0.153480.598
117_F122_F0.153150.596
141_I144_L0.152960.596
27_P31_G0.152610.594
76_F79_R0.152360.593
28_I31_G0.152350.593
116_H121_H0.152150.593
4_L7_V0.151730.591
113_I123_P0.15150.590
48_F59_F0.151070.588
21_E25_P0.15080.587
64_S96_A0.150750.587
37_Y46_G0.150710.587
92_I96_A0.150460.586
20_L25_P0.150410.586
39_E46_G0.149720.583
16_I19_H0.148850.580
133_V140_V0.148360.578
34_R140_V0.148330.578
7_V14_Y0.148210.577
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2iubA0.47338.50.943
4i0uA0.487.50.944
4ev6A0.47337.20.944
3zbqA0.45336.70.945
4g1uA0.91335.30.948
3hzqA0.62674.30.95
3qe7A0.944.20.95
2qi9A0.92674.10.95
2nq2A0.933340.95
1fftB0.466730.953
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