GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
MARVEL - Membrane-associating domain
Pfam: PF01284 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0396
Length: 144
Sequences: 1953
Seq/Len: 13.56
HH_delta: 0.924 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
10_R83_D0.418852.557
13_Q141_S0.409112.497
139_I143_V0.385322.352
47_F51_L0.384092.344
92_A96_A0.344932.105
52_S90_W0.334872.044
84_A88_I0.315771.927
21_F53_F0.308911.886
95_I99_A0.303541.853
94_F132_F0.301561.841
21_F25_A0.299381.827
98_A128_A0.274711.677
18_L22_G0.274531.676
58_I62_L0.271921.660
91_L95_I0.268521.639
98_A132_F0.260021.587
87_A139_I0.255361.559
125_K129_A0.255121.557
94_F131_G0.254691.555
128_A132_F0.252921.544
84_A142_A0.250131.527
24_V127_A0.249041.520
16_F130_F0.243421.486
10_R13_Q0.241711.475
45_A131_G0.228881.397
83_D141_S0.228381.394
43_G47_F0.224351.369
22_G26_S0.222921.361
51_L89_L0.22251.358
10_R141_S0.212181.295
46_L50_V0.20471.249
45_A93_A0.199081.215
26_S123_A0.198241.210
91_L135_W0.197791.207
20_I49_A0.197121.203
126_A130_F0.194381.186
135_W139_I0.192871.177
80_F84_A0.190941.165
77_L81_I0.187761.146
87_A142_A0.183521.120
55_Y82_F0.18341.119
11_I15_V0.182831.116
20_I130_F0.182181.112
20_I45_A0.180881.104
55_Y86_F0.180261.100
23_L126_A0.179831.098
19_I22_G0.179381.095
6_S10_R0.178121.087
13_Q137_L0.17721.082
16_F133_L0.175961.074
18_L50_V0.174111.063
126_A133_L0.174031.062
52_S86_F0.172831.055
82_F86_F0.170271.039
25_A50_V0.168771.030
25_A46_L0.167191.021
47_F89_L0.166091.014
122_G126_A0.16591.013
20_I90_W0.165021.007
17_A90_W0.16451.004
90_W94_F0.162930.995
49_A90_W0.162820.994
7_G10_R0.161520.986
17_A52_S0.16110.983
8_I12_L0.160.977
52_S138_F0.159880.976
81_I85_V0.159730.975
19_I130_F0.157390.961
104_H120_R0.157370.961
22_G27_S0.157010.958
38_S133_L0.156740.957
12_L15_V0.154870.945
125_K138_F0.153630.938
79_E83_D0.153530.937
90_W138_F0.152410.930
42_C127_A0.151980.928
40_S43_G0.150610.919
25_A122_G0.150310.917
7_G13_Q0.146810.896
57_L118_C0.146130.892
103_D120_R0.146050.891
95_I132_F0.1460.891
41_A96_A0.14570.889
26_S50_V0.144870.884
44_F92_A0.141840.866
87_A135_W0.140770.859
22_G25_A0.140350.857
24_V27_S0.139470.851
95_I102_S0.137960.842
92_A95_I0.137060.837
91_L127_A0.135720.828
23_L26_S0.135630.828
58_I81_I0.134940.824
28_I46_L0.134730.822
121_C125_K0.134610.822
94_F101_L0.133870.817
61_L118_C0.133730.816
55_Y58_I0.133680.816
48_V89_L0.132880.811
14_L55_Y0.132880.811
57_L65_F0.132810.811
9_L13_Q0.132430.808
65_F98_A0.13180.804
56_T138_F0.130240.795
20_I131_G0.130210.795
6_S141_S0.129880.793
14_L57_L0.129750.792
97_L138_F0.129620.791
13_Q83_D0.128930.787
42_C97_L0.128750.786
60_L102_S0.128570.785
9_L14_L0.128230.783
87_A138_F0.128230.783
20_I100_Y0.128150.782
6_S79_E0.126820.774
48_V93_A0.126670.773
23_L123_A0.126630.773
8_I11_I0.126150.770
27_S123_A0.125780.768
57_L72_R0.125680.767
14_L56_T0.124860.762
36_G49_A0.124740.761
44_F48_V0.124490.760
91_L94_F0.123880.756
61_L74_P0.123830.756
99_A102_S0.123090.751
104_H117_G0.122590.748
78_V82_F0.121860.744
44_F93_A0.121750.743
12_L123_A0.121310.740
90_W134_N0.12090.738
88_I136_L0.120890.738
7_G63_Y0.120630.736
15_V69_Y0.120430.735
16_F137_L0.120350.735
89_L133_L0.120270.734
51_L86_F0.11990.732
64_L81_I0.119760.731
134_N138_F0.119420.729
105_S116_S0.119310.728
117_G120_R0.11930.728
9_L17_A0.118750.725
28_I50_V0.117580.718
132_F136_L0.117180.715
54_L57_L0.117160.715
69_Y76_P0.117020.714
124_W128_A0.116830.713
74_P79_E0.116750.713
47_F86_F0.116590.712
64_L89_L0.116060.708
22_G28_I0.116050.708
18_L53_F0.115970.708
12_L80_F0.11580.707
19_I126_A0.114960.702
62_L75_W0.11380.695
129_A133_L0.113690.694
94_F130_F0.113490.693
127_A131_G0.113440.692
75_W78_V0.112410.686
45_A94_F0.112150.685
61_L136_L0.112040.684
16_F19_I0.110990.677
15_V23_L0.110320.673
99_A103_D0.110270.673
42_C46_L0.110170.672
79_E123_A0.109820.670
15_V74_P0.109810.670
7_G81_I0.109620.669
98_A131_G0.109480.668
13_Q17_A0.109430.668
59_F142_A0.109310.667
37_G117_G0.1090.665
122_G125_K0.108740.664
12_L137_L0.108360.661
90_W131_G0.108340.661
22_G85_V0.107850.658
39_P93_A0.107560.657
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3rhwA0.76392.30.924
2k1aA0.29172.10.925
2l2tA0.30561.80.927
2ks1B0.30561.80.927
2kihA0.20831.60.929
2z73A0.94441.40.931
2ljbA0.20831.20.934
3j01B0.54171.10.935
2jwaA0.229210.937
2iubA0.46530.90.939
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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