GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Creatinase_N - CreatinaseProlidase N-terminal domain
Pfam: PF01321 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0356
Length: 132
Sequences: 4395
Seq/Len: 33.3
HH_delta: 0.156 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
14_I96_G1.019243.058
8_A11_E0.984552.954
10_A46_A0.919362.759
94_R118_E0.73132.194
5_L28_L0.685312.056
16_A45_T0.685252.056
8_A12_A0.669672.009
15_D93_K0.666121.999
52_F84_A0.651921.956
54_P57_E0.627821.884
9_M14_I0.622661.868
108_Q111_Q0.574881.725
15_D46_A0.566841.701
61_A65_S0.560841.683
104_A108_Q0.54991.650
7_A11_E0.546331.639
80_A83_E0.530951.593
90_P93_K0.529281.588
25_I39_P0.514171.543
6_R45_T0.51091.533
24_N98_E0.509511.529
107_Y111_Q0.491581.475
94_R120_V0.491191.474
29_T41_L0.487091.462
5_L17_L0.476881.431
2_L6_R0.473761.422
6_R9_M0.47161.415
9_M16_A0.463021.389
50_V84_A0.45161.355
15_D94_R0.444051.332
99_P108_Q0.443931.332
14_I120_V0.439441.319
60_R64_E0.434191.303
23_E26_R0.432081.296
19_L28_L0.427611.283
36_G41_L0.424271.273
96_G122_A0.419721.259
2_L44_I0.419671.259
7_A10_A0.41621.249
4_R7_A0.414361.243
18_L95_I0.40881.227
5_L44_I0.405061.215
60_R63_E0.404141.213
58_Y62_A0.402221.207
17_L122_A0.400251.201
51_L62_A0.398641.196
9_M17_L0.395141.186
3_E7_A0.394391.183
99_P121_D0.391211.174
108_Q112_E0.381851.146
48_G88_L0.375261.126
71_V74_Y0.368171.105
31_F37_E0.368011.104
97_V107_Y0.352411.057
36_G39_P0.336961.011
52_F74_Y0.333161.000
105_A109_R0.331840.996
6_R49_A0.331060.993
103_S106_E0.329820.990
84_A88_L0.328610.986
13_G94_R0.326260.979
20_T101_S0.321720.965
25_I38_R0.321070.963
83_E86_K0.320250.961
22_P25_I0.318730.956
21_S25_I0.315820.948
125_L128_E0.31530.946
5_L129_L0.315120.946
81_I89_G0.31510.945
54_P58_Y0.312180.937
36_G40_V0.311790.936
89_G93_K0.309870.930
97_V102_L0.306980.921
42_L50_V0.305610.917
45_T48_G0.305130.916
67_P71_V0.303660.911
35_P40_V0.301170.904
35_P61_A0.299860.900
50_V70_E0.298840.897
19_L44_I0.294290.883
122_A125_L0.293450.881
97_V121_D0.292570.878
97_V104_A0.290510.872
6_R46_A0.286980.861
18_L41_L0.282560.848
19_L126_I0.282460.848
106_E110_L0.281880.846
1_R28_L0.27970.839
6_R47_D0.279020.837
38_R54_P0.276380.829
24_N27_Y0.276360.829
8_A128_E0.276160.829
104_A107_Y0.27520.826
10_A47_D0.274080.822
21_S103_S0.273440.820
14_I94_R0.272690.818
26_R35_P0.271830.816
37_E54_P0.268780.806
38_R56_G0.266850.801
16_A95_I0.26670.800
1_R4_R0.2660.798
95_I98_E0.265690.797
84_A87_K0.263270.790
36_G61_A0.262480.788
42_L81_I0.261740.785
8_A125_L0.261730.785
4_R8_A0.261310.784
59_E73_E0.259950.780
25_I51_L0.259420.778
27_Y129_L0.259370.778
28_L129_L0.258810.777
100_D123_S0.25610.768
6_R10_A0.251340.754
2_L49_A0.250670.752
57_E62_A0.250230.751
96_G120_V0.24990.750
82_A86_K0.249550.749
78_Y89_G0.24890.747
57_E65_S0.248380.745
31_F61_A0.24790.744
56_G60_R0.246690.740
29_T51_L0.245520.737
57_E61_A0.245470.737
25_I41_L0.241820.726
10_A13_G0.240640.722
45_T50_V0.240540.722
85_L90_P0.240410.721
125_L129_L0.238910.717
36_G54_P0.23890.717
86_K116_G0.237870.714
8_A129_L0.237480.713
35_P65_S0.237040.711
49_A70_E0.236970.711
79_E113_A0.235620.707
39_P54_P0.234840.705
79_E83_E0.232610.698
25_I37_E0.230190.691
24_N124_P0.230150.691
57_E60_R0.229230.688
50_V74_Y0.228590.686
78_Y81_I0.227840.684
109_R113_A0.226520.680
97_V119_F0.22650.680
50_V88_L0.226110.678
28_L126_I0.225930.678
83_E87_K0.225450.676
109_R112_E0.223030.669
20_T102_L0.223020.669
35_P38_R0.222890.669
82_A109_R0.222270.667
50_V72_V0.221350.664
53_V58_Y0.22110.663
79_E82_A0.220090.660
20_T25_I0.219960.660
50_V75_E0.219260.658
124_P127_E0.217190.652
9_M12_A0.21550.647
36_G57_E0.215350.646
26_R30_G0.213540.641
24_N127_E0.213190.640
102_L106_E0.213110.639
4_R129_L0.212970.639
17_L96_G0.212960.639
6_R48_G0.21260.638
24_N101_S0.212590.638
45_T49_A0.212090.636
40_V68_D0.211950.636
82_A89_G0.210040.630
37_E51_L0.209450.628
100_D105_A0.208340.625
21_S24_N0.207310.622
27_Y52_F0.205350.616
3_E6_R0.204230.613
75_E80_A0.204190.613
97_V110_L0.203840.612
53_V57_E0.203710.611
17_L28_L0.201340.604
18_L81_I0.200920.603
54_P61_A0.198670.596
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3i7mA0.992499.80.156
3il0A0.939499.80.169
3pn9A0.969799.70.177
3oooA0.94799.70.183
3o5vA0.94799.70.188
3ovkA0.924299.70.205
3q6dA0.939499.70.235
3qocA0.916799.70.236
4egeA0.962199.60.267
4fkcA0.977399.60.271

Page generated in 0.0175 seconds.