GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
PHO4 - Phosphate transporter family
Pfam: PF01384 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 326
Sequences: 1630
Seq/Len: 5
HH_delta: 0.968 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
20_T23_Q0.29693.261
42_A278_G0.245342.695
124_L128_I0.211672.325
68_G103_A0.195032.142
123_V127_V0.174121.913
19_L180_I0.166061.824
105_L110_F0.165631.819
1_N92_T0.162811.788
101_I119_L0.15651.719
25_L238_L0.153891.690
75_A325_L0.151531.664
82_I86_L0.151141.660
4_N84_T0.146961.614
281_V286_A0.146941.614
33_F234_A0.146061.604
142_R146_R0.145681.600
45_E49_K0.144891.592
235_L239_T0.144481.587
80_L92_T0.144061.582
32_N190_H0.142451.565
248_V288_V0.142221.562
26_I30_I0.141681.556
27_L184_A0.140281.541
17_R250_E0.138841.525
178_L261_F0.138711.524
244_V247_T0.13791.515
34_L188_F0.137881.515
223_W227_L0.137561.511
80_L84_T0.136661.501
84_T90_V0.136431.499
9_S186_V0.135841.492
274_A281_V0.135791.492
139_I143_L0.135471.488
144_I262_S0.135271.486
195_V233_I0.134771.480
4_N80_L0.134441.477
37_L227_L0.133121.462
5_D8_N0.13261.457
97_V122_I0.13251.455
94_H285_H0.132051.451
28_A187_S0.130911.438
83_A90_V0.129591.423
313_L317_L0.127911.405
43_V46_T0.127861.404
35_G230_G0.127081.396
4_N83_A0.126821.393
78_I82_I0.126711.392
84_T244_V0.126261.387
120_L124_L0.125671.380
33_F231_L0.124341.366
13_A183_A0.123561.357
128_I132_I0.122521.346
321_I325_L0.121351.333
37_L223_W0.120581.325
206_L225_I0.119511.313
228_L322_A0.119171.309
4_N244_V0.11881.305
140_L262_S0.118081.297
186_V255_L0.117521.291
104_G262_S0.117451.290
4_N90_V0.116961.285
33_F37_L0.116431.279
194_D284_T0.116281.277
179_Q264_Q0.116251.277
256_D298_R0.115011.263
146_R149_L0.114441.257
131_L316_I0.11411.253
52_V104_G0.113421.246
188_F265_L0.112581.237
30_I227_L0.110911.218
178_L181_L0.110821.217
125_S129_S0.110051.209
140_L269_L0.109981.208
189_A271_V0.109831.206
134_F289_G0.109751.206
138_Y142_R0.109741.205
31_F184_A0.108671.194
37_L230_G0.108361.190
18_A264_Q0.108341.190
145_R298_R0.107461.180
179_Q257_P0.107031.176
203_A221_I0.106531.170
12_T264_Q0.106111.166
228_L235_L0.105981.164
32_N237_T0.105291.157
99_A103_A0.104251.145
10_F14_V0.103941.142
13_A27_L0.10381.140
263_A287_I0.103681.139
34_L38_L0.103371.135
47_I200_G0.103221.134
179_Q260_G0.103011.132
138_Y297_A0.101961.120
137_A290_A0.10191.119
79_W318_T0.101451.114
266_S289_G0.101311.113
92_T196_A0.101221.112
175_F261_F0.101181.111
42_A122_I0.101121.111
309_R313_L0.100881.108
189_A275_S0.100441.103
40_G203_A0.100431.103
9_S260_G0.099521.093
228_L232_A0.099261.090
88_L322_A0.099181.089
80_L197_N0.099091.088
66_M205_I0.099071.088
231_L235_L0.099071.088
134_F296_L0.098631.083
234_A237_T0.097831.075
19_L264_Q0.097811.074
143_L147_I0.097751.074
185_F268_A0.097721.073
264_Q287_I0.097581.072
29_A234_A0.097521.071
30_I34_L0.09721.068
27_L35_G0.096741.063
1_N196_A0.096411.059
283_T286_A0.09641.059
45_E48_G0.096321.058
267_S287_I0.096291.058
30_I220_E0.096281.058
174_I178_L0.096251.057
227_L235_L0.096171.056
119_L267_S0.095841.053
71_A75_A0.095771.052
315_W318_T0.095681.051
75_A322_A0.095641.051
6_A237_T0.095591.050
322_A325_L0.095461.049
136_L266_S0.095231.046
275_S278_G0.095171.045
194_D283_T0.095021.044
52_V214_V0.094951.043
78_I325_L0.094921.043
25_L29_A0.094831.042
4_N92_T0.094811.041
18_A127_V0.094661.040
227_L312_V0.094651.040
78_I111_S0.094351.036
146_R324_L0.094291.036
260_G264_Q0.09391.031
247_T311_I0.093691.029
177_F181_L0.093541.027
8_N190_H0.093511.027
225_I230_G0.093141.023
182_S264_Q0.093061.022
71_A273_I0.093011.022
18_A176_R0.092461.016
48_G95_A0.092111.012
140_L181_L0.091981.010
193_N271_V0.091761.008
137_A148_F0.091261.002
3_A84_T0.091141.001
83_A92_T0.090950.999
285_H319_L0.090940.999
23_Q26_I0.090690.996
242_W246_R0.090520.994
94_H190_H0.09020.991
251_K264_Q0.090040.989
3_A92_T0.08990.988
131_L306_K0.089890.987
26_I152_K0.089810.987
8_N32_N0.089450.983
127_V316_I0.089430.982
230_G233_I0.089030.978
235_L313_L0.088650.974
273_I277_L0.088640.974
246_R251_K0.088310.970
134_F233_I0.088250.969
125_S192_A0.088030.967
105_L108_G0.087350.960
12_T287_I0.087160.957
80_L90_V0.08710.957
101_I113_V0.086990.956
183_A188_F0.086870.954
128_I139_I0.086710.952
246_R324_L0.08670.952
78_I131_L0.086620.951
319_L322_A0.086380.949
95_A219_A0.086240.947
183_A292_V0.085940.944
34_L213_S0.085930.944
271_V286_A0.085890.943
35_G126_W0.085850.943
53_D104_G0.085610.940
271_V275_S0.085510.939
99_A239_T0.085310.937
98_G102_G0.085180.936
111_S213_S0.085120.935
184_A187_S0.084980.933
24_A295_G0.08490.933
303_V308_V0.084720.931
321_I324_L0.084590.929
285_H314_G0.084540.929
290_A326_S0.084340.926
94_H98_G0.084050.923
36_A271_V0.083850.921
50_G53_D0.083840.921
78_I85_W0.083780.920
191_G236_G0.083650.919
6_A233_I0.083510.917
30_I324_L0.083250.914
86_L214_V0.083180.914
12_T263_A0.083150.913
49_K114_N0.083150.913
197_N204_A0.082960.911
248_V291_I0.082870.910
312_V316_I0.082690.908
306_K312_V0.082680.908
106_A326_S0.082660.908
263_A291_I0.082490.906
20_T173_K0.082480.906
139_I324_L0.08240.905
250_E254_K0.08240.905
88_L97_V0.082280.904
14_V24_A0.082250.903
286_A290_A0.082140.902
43_V278_G0.082110.902
5_D318_T0.082020.901
13_A36_A0.082020.901
8_N318_T0.081930.900
273_I321_I0.081880.899
8_N283_T0.081880.899
84_T197_N0.081810.899
131_L135_I0.081750.898
51_I200_G0.081750.898
192_A292_V0.081310.893
267_S275_S0.08130.893
207_I219_A0.081110.891
195_V232_A0.081070.891
17_R243_R0.080990.890
80_L96_L0.080950.889
75_A321_I0.080880.888
253_T302_S0.080870.888
183_A225_I0.080870.888
87_G293_G0.080860.888
110_F116_S0.080790.887
199_I229_G0.080790.887
8_N28_A0.080740.887
74_L132_I0.080670.886
26_I273_I0.080250.882
189_A272_L0.08020.881
109_G235_L0.080070.880
190_H224_W0.079960.878
36_A40_G0.079930.878
195_V229_G0.079820.877
19_L31_F0.079820.877
192_A275_S0.079780.876
197_N201_P0.079710.876
78_I235_L0.079680.875
132_I273_I0.079460.873
6_A180_I0.079420.872
111_S231_L0.079330.871
81_L242_W0.079170.870
120_L148_F0.079140.869
180_I230_G0.079110.869
185_F269_L0.079050.868
82_I235_L0.078760.865
131_L239_T0.078750.865
104_G112_A0.078590.863
256_D259_R0.078520.863
19_L23_Q0.078460.862
48_G204_A0.078420.861
145_R150_R0.07840.861
29_A68_G0.078340.861
75_A99_A0.078090.858
84_T243_R0.078040.857
68_G88_L0.077980.857
90_V244_V0.07790.856
73_L188_F0.07790.856
127_V131_L0.077840.855
40_G104_G0.07780.855
13_A264_Q0.077780.854
87_G243_R0.077740.854
195_V270_T0.077730.854
179_Q241_G0.077530.852
55_S324_L0.077510.851
182_S260_G0.077440.851
203_A207_I0.077410.850
110_F135_I0.077330.849
83_A244_V0.077280.849
95_A318_T0.077210.848
82_I146_R0.077090.847
27_L31_F0.077080.847
247_T307_T0.077010.846
313_L324_L0.076920.845
266_S270_T0.076870.844
82_I170_R0.076720.843
6_A32_N0.076570.841
48_G93_T0.076510.840
6_A271_V0.07650.840
13_A253_T0.076410.839
86_L105_L0.076390.839
97_V291_I0.076220.837
141_Y292_V0.076150.836
5_D283_T0.076120.836
141_Y145_R0.076080.836
5_D284_T0.075930.834
271_V281_V0.07590.834
51_I313_L0.075790.833
181_L269_L0.075750.832
188_F191_G0.075720.832
86_L235_L0.075690.831
243_R252_I0.075630.831
125_S284_T0.075630.831
21_P86_L0.075620.831
119_L123_V0.075390.828
3_A16_S0.075370.828
268_A275_S0.07530.827
79_W90_V0.075240.826
131_L144_I0.07520.826
16_S32_N0.075130.825
76_A271_V0.075110.825
223_W231_L0.075020.824
72_A76_A0.075010.824
188_F202_L0.07480.822
55_S140_L0.074680.820
169_P173_K0.074670.820
194_D197_N0.074610.820
145_R256_D0.074450.818
43_V198_A0.074290.816
5_D12_T0.074060.814
4_N8_N0.073940.812
252_I311_I0.073730.810
37_L269_L0.07370.810
255_L263_A0.073640.809
16_S93_T0.073620.809
284_T318_T0.073510.807
36_A46_T0.07350.807
192_A286_A0.073410.806
239_T245_I0.07340.806
86_L128_I0.073310.805
250_E253_T0.07330.805
56_Y273_I0.073240.805
78_I326_S0.073190.804
111_S215_N0.07310.803
266_S286_A0.073030.802
48_G52_V0.073020.802
50_G278_G0.073010.802
19_L234_A0.072910.801
123_V128_I0.072890.801
98_G125_S0.072770.799
116_S139_I0.07270.799
269_L273_I0.072650.798
144_I175_F0.072640.798
3_A240_G0.07260.797
27_L245_I0.07250.796
196_A203_A0.072480.796
137_A275_S0.072460.796
58_T68_G0.072340.795
114_N124_L0.072330.795
80_L83_A0.072320.794
142_R145_R0.072280.794
48_G219_A0.07220.793
173_K231_L0.072080.792
16_S80_L0.072020.791
19_L127_V0.072010.791
281_V314_G0.071990.791
139_I171_V0.071990.791
111_S135_I0.071970.791
124_L127_V0.07190.790
92_T197_N0.071870.789
221_I226_L0.071870.789
282_S318_T0.071860.789
122_I125_S0.071660.787
88_L314_G0.07150.785
38_L312_V0.071460.785
38_L42_A0.071440.785
29_A187_S0.071380.784
3_A83_A0.071360.784
112_A316_I0.071340.784
7_A193_N0.071330.784
121_K135_I0.07130.783
190_H194_D0.071260.783
285_H323_A0.071260.783
93_T259_R0.071190.782
43_V267_S0.071160.782
17_R240_G0.071130.781
94_H284_T0.071120.781
252_I289_G0.071120.781
22_R151_R0.071080.781
240_G243_R0.071060.781
133_A310_K0.071030.780
120_L123_V0.07090.779
110_F119_L0.070870.778
79_W94_H0.070860.778
113_V231_L0.070810.778
28_A237_T0.07080.778
143_L173_K0.070750.777
306_K309_R0.07070.777
317_L320_P0.070640.776
119_L184_A0.070590.775
78_I173_K0.070530.775
214_V222_P0.070450.774
10_F186_V0.070350.773
31_F248_V0.070340.773
31_F182_S0.070330.773
27_L187_S0.070310.772
318_T323_A0.070280.772
53_D147_I0.070260.772
72_A100_L0.070210.771
111_S146_R0.070150.771
5_D14_V0.070030.769
137_A186_V0.070.769
9_S190_H0.069950.768
36_A189_A0.069950.768
138_Y250_E0.069910.768
52_V75_A0.069870.767
5_D190_H0.069830.767
242_W285_H0.06980.767
308_V312_V0.069670.765
133_A286_A0.069650.765
5_D194_D0.06960.765
143_L146_R0.06960.765
299_G304_N0.069580.764
23_Q201_P0.069570.764
26_I82_I0.069470.763
195_V201_P0.069420.763
142_R310_K0.069360.762
71_A254_K0.069330.762
254_K298_R0.069230.760
306_K310_K0.069190.760
302_S310_K0.06910.759
126_W196_A0.069030.758
50_G113_V0.068960.757
79_W190_H0.068950.757
139_I317_L0.068910.757
196_A284_T0.068840.756
107_S180_I0.068830.756
98_G322_A0.068760.755
37_L85_W0.068720.755
277_L321_I0.068720.755
27_L34_L0.068650.754
34_L131_L0.068590.753
181_L188_F0.068590.753
169_P321_I0.068570.753
283_T318_T0.068540.753
132_I279_L0.068490.752
78_I177_F0.068470.752
198_A201_P0.068460.752
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3zojA0.472427.60.968
2w2eA0.472425.40.968
3c02A0.47557.10.975
2f2bA0.44175.80.976
3lw5I0.0925.40.976
1d4oA0.22095.20.976
1djlA0.22095.20.976
2wscI0.12274.90.976
1jb0I0.11664.70.977
2b6oA0.53994.30.977
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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