GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Pep_M12B_propep - Reprolysin family propeptide
Pfam: PF01562 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 131
Sequences: 1091
Seq/Len: 8.33
HH_delta: 0.93 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
79_C98_C0.388353.259
79_C100_G0.292012.450
115_E131_Y0.275282.310
45_D86_E0.251542.111
93_V105_I0.217261.823
42_F85_V0.212911.787
85_V107_T0.198591.666
8_R11_R0.191281.605
33_Y101_L0.185361.555
49_N52_L0.18331.538
82_Q97_L0.179561.507
120_Y127_P0.178881.501
2_E5_I0.177741.491
79_C96_S0.174641.465
81_Y96_S0.168351.413
49_N82_Q0.167341.404
95_L103_G0.163811.375
96_S100_G0.163211.370
112_Y115_E0.158091.327
79_C97_L0.157241.319
37_A42_F0.155621.306
83_G93_V0.155291.303
102_R119_R0.155231.303
92_S106_Q0.151091.268
62_R93_V0.149181.252
2_E6_P0.148361.245
79_C128_H0.147291.236
97_L101_L0.145581.222
93_V107_T0.144811.215
4_V130_V0.140991.183
97_L100_G0.140321.177
128_H131_Y0.139461.170
42_F107_T0.139431.170
87_G120_Y0.139181.168
85_V92_S0.139081.167
33_Y46_L0.136021.141
42_F105_I0.134641.130
69_E72_S0.133741.122
87_G91_S0.133431.120
31_L44_L0.133341.119
47_E66_G0.132121.109
66_G117_L0.131821.106
30_H40_R0.12971.088
33_Y113_F0.129521.087
93_V104_V0.128831.081
116_P128_H0.127611.071
4_V8_R0.125181.050
38_F42_F0.124111.041
103_G128_H0.123781.039
94_A100_G0.12331.035
98_C101_L0.122111.025
52_L98_C0.122041.024
36_R72_S0.121021.015
12_R25_Q0.119651.004
107_T111_T0.119571.003
32_S45_D0.118640.996
2_E12_R0.118190.992
62_R68_R0.117880.989
49_N80_H0.117720.988
98_C128_H0.117240.984
10_D72_S0.117150.983
88_D109_D0.11710.983
36_R41_E0.115840.972
58_V77_E0.115550.970
102_R109_D0.115130.966
110_E114_I0.114960.965
114_I118_P0.114020.957
57_F61_V0.113030.948
44_L105_I0.112690.946
9_V34_S0.112590.945
37_A44_L0.112470.944
100_G128_H0.112430.943
29_S41_E0.112070.940
60_E70_E0.112020.940
51_S54_S0.11190.939
31_L34_S0.111550.936
55_P112_Y0.110720.929
2_E9_V0.110530.927
101_L128_H0.109950.923
94_A98_C0.109670.920
42_F123_E0.109450.918
25_Q121_S0.108980.914
102_R107_T0.108250.908
40_R64_E0.108150.908
6_P9_V0.107530.902
52_L79_C0.107010.898
100_G103_G0.1070.898
34_S41_E0.106570.894
121_S131_Y0.106280.892
110_E115_E0.105650.887
64_E71_S0.105450.885
7_E11_R0.104580.878
96_S131_Y0.104570.877
44_L78_H0.104540.877
100_G127_P0.104220.875
59_V106_Q0.103720.870
3_V8_R0.103640.870
35_F113_F0.103470.868
75_H101_L0.103470.868
9_V97_L0.103360.867
35_F104_V0.103290.867
48_P57_F0.10320.866
12_R23_R0.103170.866
48_P104_V0.102790.863
33_Y105_I0.10270.862
76_Q86_E0.102480.860
63_N93_V0.101990.856
69_E78_H0.101740.854
56_G60_E0.101680.853
81_Y100_G0.100060.840
32_S86_E0.099590.836
61_V95_L0.099390.834
114_I128_H0.099020.831
47_E51_S0.098970.830
49_N65_D0.098820.829
3_V12_R0.098560.827
43_H107_T0.09850.827
95_L112_Y0.098350.825
3_V10_D0.098190.824
32_S91_S0.097920.822
79_C94_A0.096950.814
40_R92_S0.096620.811
95_L102_R0.096220.807
93_V97_L0.096080.806
49_N94_A0.095590.802
33_Y100_G0.095530.802
66_G71_S0.095510.801
41_E64_E0.095240.799
95_L128_H0.094870.796
2_E53_F0.094680.794
60_E101_L0.094570.794
87_G90_G0.094560.793
23_R26_D0.094560.793
100_G116_P0.094370.792
27_H57_F0.094370.792
33_Y112_Y0.093990.789
72_S85_V0.093230.782
4_V29_S0.093170.782
54_S77_E0.093070.781
23_R44_L0.093050.781
61_V69_E0.093040.781
51_S90_G0.092770.778
88_D107_T0.092770.778
41_E86_E0.092640.777
27_H45_D0.092540.777
9_V104_V0.091720.770
33_Y128_H0.091450.767
57_F64_E0.091120.765
119_R131_Y0.090940.763
72_S99_G0.089840.754
41_E109_D0.089790.753
93_V98_C0.089150.748
58_V90_G0.089130.748
30_H46_L0.08910.748
92_S131_Y0.089060.747
62_R91_S0.089010.747
48_P78_H0.088890.746
93_V100_G0.088880.746
23_R51_S0.088840.745
46_L54_S0.088790.745
6_P11_R0.088530.743
57_F78_H0.08850.743
59_V84_H0.088340.741
44_L91_S0.088050.739
64_E90_G0.087980.738
2_E11_R0.087820.737
8_R122_E0.087780.737
35_F112_Y0.087640.735
81_Y91_S0.087280.732
36_R76_Q0.087190.732
117_L129_V0.087110.731
83_G98_C0.086720.728
32_S43_H0.086540.726
33_Y37_A0.086490.726
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3lwtX0.67948.60.93
2hj8A0.66418.10.931
1m1hA0.80927.90.931
1szwA0.51157.60.932
3dbhI0.66416.70.933
1z2zA0.39696.70.933
1wggA0.72525.20.937
1v5tA0.65655.20.937
2ktsA0.58784.20.939
3g65A0.68740.94
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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