GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
6PF2K - 6-phosphofructo-2-kinase
Pfam: PF01591 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0023
Length: 222
Sequences: 2646
Seq/Len: 11.92
HH_delta: 0.202 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
162_E166_K0.754834.187
67_P82_E0.588323.263
139_E143_R0.587043.256
17_M29_A0.572493.176
113_M156_D0.561493.115
142_I167_R0.52762.927
165_K187_S0.501552.782
63_E96_G0.495462.748
78_Q82_E0.482572.677
75_L78_Q0.441362.448
34_R38_W0.440952.446
29_A100_I0.434452.410
137_I140_R0.420332.332
30_R198_V0.416782.312
195_G200_V0.391792.173
65_F82_E0.38442.132
101_F148_N0.349541.939
36_L98_V0.342811.902
41_V98_V0.34241.899
78_Q81_K0.335181.859
46_F83_A0.334971.858
178_L192_I0.33351.850
156_D159_E0.331441.838
163_D167_R0.329891.830
35_Y39_L0.32421.798
42_K96_G0.312431.733
205_G209_S0.29691.647
169_E187_S0.279461.550
48_V80_A0.271721.507
44_K96_G0.269421.494
68_D71_E0.267711.485
175_Y185_D0.262781.458
33_C62_A0.260771.446
34_R199_I0.257931.431
29_A45_V0.257891.430
60_Q198_V0.250881.392
81_K85_E0.246991.370
46_F99_A0.24341.350
14_V84_L0.23761.318
163_D166_K0.231321.283
14_V101_F0.230151.277
50_D79_I0.230021.276
178_L207_L0.229971.276
34_R37_N0.225021.248
113_M160_A0.221481.229
51_Y79_I0.22011.221
75_L143_R0.219731.219
16_V101_F0.21941.217
193_N196_E0.218281.211
19_G25_K0.216821.203
77_E81_K0.212811.180
199_I202_N0.211521.173
37_N61_D0.210911.170
17_M32_L0.210651.168
37_N62_A0.209631.163
34_R201_N0.207651.152
44_K63_E0.205271.139
17_M28_I0.204371.134
204_S208_Q0.20331.128
178_L194_V0.201491.118
136_E139_E0.200981.115
43_T96_G0.200891.114
152_Y190_K0.194421.078
19_G24_G0.193651.074
45_V64_F0.192221.066
160_A163_D0.191431.062
15_I100_I0.187351.039
140_R150_P0.186561.035
112_K116_E0.185621.030
43_T63_E0.184331.022
159_E162_E0.183351.017
139_E142_I0.180421.001
42_K97_Q0.178860.992
55_L58_A0.178070.988
17_M193_N0.177310.984
84_L99_A0.175540.974
162_E165_K0.174550.968
144_E147_Q0.17280.958
140_R144_E0.172550.957
47_N56_S0.169410.940
169_E172_E0.168560.935
49_G53_R0.167860.931
206_Y210_R0.167170.927
47_N64_F0.166210.922
11_G41_V0.16590.920
113_M163_D0.165070.916
18_V28_I0.164820.914
30_R59_P0.164230.911
23_R29_A0.163930.909
156_D160_A0.163880.909
142_I145_K0.162630.902
116_E167_R0.161070.893
66_D69_N0.160090.888
34_R198_V0.158480.879
59_P200_V0.156560.868
138_I141_N0.155670.863
28_I193_N0.155270.861
84_L101_F0.154070.855
83_A99_A0.153250.850
82_E85_E0.153160.850
143_R147_Q0.152440.846
50_D53_R0.152280.845
138_I142_I0.151690.841
51_Y76_R0.151080.838
196_E206_Y0.150760.836
170_H187_S0.150330.834
192_I207_L0.150290.834
67_P78_Q0.149540.829
41_V97_Q0.149330.828
56_S67_P0.148080.821
112_K115_V0.147690.819
71_E75_L0.147540.818
17_M20_L0.147410.818
141_N145_K0.14670.814
170_H173_K0.146340.812
21_P138_I0.145980.810
192_I198_V0.145910.809
85_E184_E0.144640.802
142_I146_K0.144560.802
28_I194_V0.144380.801
46_F80_A0.143970.799
140_R211_I0.141960.787
143_R150_P0.141670.786
104_T110_R0.141140.783
115_V185_D0.140720.781
82_E94_E0.140590.780
45_V100_I0.140580.780
23_R28_I0.140290.778
24_G27_Y0.139540.774
27_Y31_K0.139240.772
115_V186_L0.138880.770
13_L151_D0.136960.760
48_V96_G0.136770.759
59_P198_V0.136540.757
84_L163_D0.136010.754
137_I150_P0.135570.752
145_K167_R0.135430.751
60_Q63_E0.135420.751
20_L111_R0.135390.751
50_D76_R0.134930.748
60_Q64_F0.134660.747
164_F174_V0.13430.745
54_K114_L0.132730.736
71_E78_Q0.131640.730
44_K99_A0.131410.729
136_E144_E0.130950.726
166_K169_E0.130420.723
14_V18_V0.130380.723
169_E173_K0.130080.722
32_L174_V0.130070.721
34_R60_Q0.129590.719
80_A148_N0.129540.719
20_L164_F0.128960.715
28_I174_V0.128670.714
11_G97_Q0.128620.713
15_I197_K0.128570.713
138_I150_P0.128340.712
29_A102_D0.12830.712
165_K169_E0.128120.711
35_Y38_W0.126920.704
60_Q65_F0.126160.700
198_V209_S0.126060.699
139_E152_Y0.12530.695
23_R48_V0.125110.694
30_R208_Q0.124940.693
111_R114_L0.12480.692
35_Y208_Q0.124620.691
194_V202_N0.124060.688
32_L189_I0.123980.688
152_Y171_Y0.12360.686
160_A168_I0.123460.685
144_E148_N0.122880.682
49_G103_A0.122820.681
32_L191_I0.122430.679
17_M174_V0.122320.678
80_A84_L0.12220.678
31_K201_N0.121870.676
85_E94_E0.121570.674
59_P62_A0.121190.672
95_G194_V0.120830.670
76_R144_E0.120460.668
153_K158_E0.119720.664
59_P199_I0.119710.664
54_K71_E0.119660.664
57_G69_N0.119630.664
18_V23_R0.119590.663
81_K113_M0.119420.662
14_V151_D0.119060.660
208_Q212_V0.118810.659
22_A52_R0.118780.659
176_E202_N0.118540.658
137_I152_Y0.118390.657
28_I201_N0.117810.653
38_W199_I0.117790.653
143_R146_K0.117670.653
12_K99_A0.11750.652
32_L204_S0.11720.650
49_G52_R0.116330.645
13_L98_V0.11570.642
40_G43_T0.115670.642
35_Y200_V0.115550.641
96_G207_L0.115480.641
208_Q211_I0.115220.639
142_I163_D0.115140.639
112_K173_K0.114590.636
80_A101_F0.114590.636
33_C37_N0.114550.635
202_N208_Q0.114110.633
18_V160_A0.114080.633
141_N193_N0.11380.631
143_R148_N0.113620.630
35_Y191_I0.11360.630
190_K210_R0.113470.629
151_D163_D0.113410.629
171_Y187_S0.113410.629
174_V191_I0.113220.628
114_L197_K0.112870.626
77_E144_E0.112830.626
51_Y83_A0.112790.626
46_F67_P0.112430.624
110_R114_L0.112420.624
15_I98_V0.112230.623
153_K157_P0.112070.622
96_G167_R0.111930.621
70_E78_Q0.111240.617
140_R143_R0.111090.616
138_I152_Y0.11090.615
77_E103_A0.110670.614
31_K164_F0.11050.613
23_R98_V0.110410.612
170_H203_I0.110380.612
43_T151_D0.110310.612
42_K95_G0.110180.611
194_V199_I0.109730.609
58_A174_V0.109650.608
56_S68_D0.109290.606
150_P154_G0.108520.602
202_N211_I0.108110.600
141_N151_D0.1080.599
22_A25_K0.107750.598
23_R167_R0.107690.597
57_G95_G0.107660.597
81_K84_L0.107570.597
96_G100_I0.107490.596
206_Y212_V0.107230.595
198_V203_I0.106990.593
161_I164_F0.106880.593
16_V141_N0.106560.591
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2axnA11000.202
1bifA11000.247
3umfA0.900999.90.511
3sr0A0.846899.80.54
3gmtA0.887499.70.578
3tlxA0.900999.70.592
3be4A0.860499.70.599
3dl0A0.860499.70.602
2c95A0.878499.70.603
3fb4A0.860499.70.607

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