GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Methyltransf_3 - O-methyltransferase
Pfam: PF01596 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0063
Length: 205
Sequences: 3507
Seq/Len: 17.11
HH_delta: 0.157 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
72_K100_E0.805333.281
76_I109_V0.757583.087
142_L188_F0.64362.622
91_R96_D0.631992.575
54_T75_T0.63072.570
180_E184_N0.626962.554
125_V145_L0.617132.514
145_L149_G0.603892.460
123_D146_R0.600752.448
74_T122_F0.572052.331
48_R72_K0.522292.128
140_K143_P0.503572.052
49_V63_L0.500682.040
50_L122_F0.480671.958
153_A178_F0.480111.956
77_E83_A0.477431.945
74_T102_I0.473021.927
47_K70_D0.457921.866
83_A101_V0.449491.831
135_L181_Y0.436471.778
138_F188_F0.43331.765
111_P140_K0.424381.729
105_D108_E0.420711.714
107_L136_E0.413071.683
80_P84_E0.405831.653
124_F152_I0.404061.646
127_I137_Y0.394961.609
67_L71_G0.388771.584
129_A137_Y0.382211.557
90_F99_I0.378121.541
34_G62_W0.376791.535
139_E181_Y0.376421.534
130_D133_N0.367551.497
41_V63_L0.356781.454
83_A103_E0.356491.452
47_K124_F0.35131.431
80_P103_E0.350341.427
27_M55_F0.349221.423
125_V141_A0.346351.411
133_N136_E0.345741.409
88_E92_K0.34271.396
38_Q66_A0.337261.374
54_T86_A0.327941.336
60_A73_I0.315111.284
122_F125_V0.31491.283
177_E180_E0.314071.280
41_V124_F0.309741.262
60_A75_T0.302461.232
63_L73_I0.291441.187
79_D82_R0.287261.170
104_G109_V0.28611.166
139_E143_P0.285751.164
102_I109_V0.281361.146
61_L93_A0.280241.142
69_E98_R0.279121.137
40_L152_I0.278951.136
181_Y185_D0.269441.098
42_R189_E0.267151.088
52_I76_I0.266441.086
48_R74_T0.264461.077
64_A95_L0.263511.074
153_A182_I0.260611.062
67_L73_I0.257221.048
77_E101_V0.25531.040
145_L151_I0.252961.031
178_F190_T0.250951.022
142_L185_D0.250171.019
135_L177_E0.249951.018
90_F101_V0.247741.009
61_L90_F0.245991.002
158_W172_T0.244980.998
48_R121_Q0.242810.989
107_L137_Y0.240120.978
50_L125_V0.238640.972
84_E87_R0.23740.967
106_A137_Y0.2370.966
45_R146_R0.235820.961
178_F182_I0.234980.957
182_I190_T0.234580.956
179_N183_A0.234230.954
64_A99_I0.233720.952
135_L139_E0.2330.949
74_T100_E0.232550.947
102_I112_E0.232380.947
85_I88_E0.231630.944
130_D137_Y0.231230.942
84_E88_E0.229420.935
135_L180_E0.226960.925
48_R122_F0.225320.918
38_Q62_W0.222820.908
76_I104_G0.222040.905
131_K155_N0.220770.899
127_I153_A0.218070.888
88_E91_R0.217370.886
87_R91_R0.216460.882
62_W66_A0.216080.880
29_I34_G0.215380.877
131_K197_D0.214290.873
61_L89_N0.213470.870
50_L76_I0.213350.869
55_F82_R0.211680.862
49_V67_L0.211320.861
176_R180_E0.211320.861
136_E139_E0.210830.859
49_V73_I0.210410.857
68_P98_R0.210320.857
52_I106_A0.210110.856
59_S128_D0.210.856
51_E73_I0.208410.849
89_N92_K0.206940.843
32_E36_L0.206910.843
146_R149_G0.205620.838
104_G108_E0.205590.838
37_L41_V0.205270.836
139_E185_D0.20320.828
46_P71_G0.202930.827
39_M43_L0.202860.826
142_L187_R0.202580.825
90_F95_L0.200510.817
173_V177_E0.200220.816
41_V44_T0.200030.815
126_F154_D0.199830.814
40_L43_L0.198320.808
81_E84_E0.196840.802
76_I102_I0.194970.794
78_I105_D0.19420.791
38_Q42_R0.194160.791
157_L179_N0.193790.790
34_G58_Y0.193470.788
54_T60_A0.192590.785
60_A63_L0.191360.780
132_R174_A0.190750.777
87_R103_E0.190730.777
69_E97_D0.190190.775
78_I103_E0.18970.773
29_I59_S0.18740.763
28_S55_F0.187150.762
113_L122_F0.187020.762
61_L95_L0.186240.759
77_E86_A0.185350.755
46_P123_D0.184910.753
114_A144_L0.184650.752
60_A90_F0.183970.750
182_I188_F0.183480.748
125_V149_G0.183320.747
64_A71_G0.183210.746
124_F149_G0.183130.746
70_D98_R0.181470.739
159_R175_I0.181040.738
34_G37_L0.179590.732
139_E184_N0.178650.728
54_T101_V0.178170.726
81_E85_I0.1780.725
192_L196_G0.177590.724
40_L193_L0.177040.721
158_W197_D0.176570.719
95_L98_R0.176330.718
47_K123_D0.176010.717
72_K97_D0.175910.717
185_D188_F0.174670.712
129_A155_N0.174580.711
33_T156_V0.174560.711
49_V124_F0.174190.710
131_K154_D0.173870.708
33_T199_L0.172010.701
26_Q55_F0.17180.700
77_E82_R0.170480.695
52_I141_A0.17020.693
70_D112_E0.170180.693
42_R45_R0.169970.692
138_F182_I0.169830.692
97_D121_Q0.169640.691
191_V196_G0.169470.690
100_E103_E0.169180.689
83_A86_A0.168940.688
138_F153_A0.168440.686
56_T157_L0.167420.682
131_K160_G0.167420.682
128_D155_N0.167140.681
51_E59_S0.167110.681
141_A144_L0.166870.680
35_Q38_Q0.166430.678
114_A143_P0.16620.677
108_E112_E0.165260.673
43_L46_P0.164840.672
83_A87_R0.164090.669
77_E89_N0.163640.667
143_P147_P0.163630.667
30_S33_T0.163570.666
127_I138_F0.16310.664
26_Q159_R0.163030.664
155_N197_D0.162870.664
39_M150_V0.162750.663
34_G66_A0.162030.660
41_V66_A0.161860.659
58_Y155_N0.160840.655
76_I106_A0.160680.655
126_F155_N0.160620.654
63_L126_F0.160350.653
27_M56_T0.160280.653
112_E121_Q0.160130.652
37_L152_I0.159510.650
132_R173_V0.158680.646
105_D133_N0.158620.646
79_D105_D0.15820.645
110_L140_K0.157430.641
131_K134_Y0.156910.639
107_L140_K0.156460.637
28_S56_T0.155260.633
53_G59_S0.155260.633
191_V195_I0.1550.631
138_F181_Y0.154990.631
156_V160_G0.154780.631
51_E58_Y0.154180.628
63_L75_T0.153810.627
44_T124_F0.152950.623
107_L133_N0.152860.623
75_T90_F0.152590.622
135_L178_F0.151190.616
133_N137_Y0.150970.615
152_I199_L0.150340.613
109_V112_E0.150340.613
175_I178_F0.150310.612
51_E154_D0.150250.612
183_A190_T0.150090.611
65_E93_A0.149920.611
121_Q146_R0.149760.610
70_D97_D0.149490.609
41_V65_E0.149390.609
33_T55_F0.149380.609
63_L124_F0.149210.608
33_T196_G0.149050.607
39_M193_L0.1490.607
59_S126_F0.148630.606
180_E183_A0.148120.603
76_I103_E0.147540.601
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3r3hA0.99511000.157
3dr5A0.96591000.175
3c3yA0.99511000.21
1suiA0.99511000.211
3cbgA0.99511000.226
3tr6A0.99511000.235
3tfwA0.98051000.237
3duwA0.99021000.24
3ntvA0.95611000.243
2avdA0.99511000.248

Page generated in 0.0147 seconds.