GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ATP-sulfurylase - ATP-sulfurylase
Pfam: PF01747 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0039
Length: 215
Sequences: 2535
Seq/Len: 11.79
HH_delta: 0.107 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
93_P97_R0.798943.856
50_G88_L0.795293.838
190_E194_E0.701033.383
53_L87_V0.620322.994
30_N65_I0.598182.887
44_L86_R0.58742.835
72_R75_E0.580742.803
136_E139_E0.54542.632
32_L74_Y0.544762.629
69_V210_I0.504222.433
73_C210_I0.479662.315
66_P69_V0.467832.258
198_P203_M0.466772.253
78_I89_L0.45622.202
76_A210_I0.452082.182
47_A153_V0.448342.164
140_I152_P0.444182.144
187_E191_L0.437122.110
209_A213_R0.410981.983
197_E200_E0.409151.975
69_V72_R0.394791.905
74_Y89_L0.386521.865
40_M53_L0.382311.845
129_G140_I0.378391.826
129_G132_Y0.373031.800
187_E190_E0.358651.731
82_F201_W0.354491.711
98_Y106_L0.352261.700
41_R82_F0.344791.664
52_L92_L0.338961.636
192_L198_P0.328961.588
208_A212_R0.328341.585
94_L109_I0.322041.554
71_V93_P0.321881.553
32_L77_L0.319341.541
72_R76_A0.318011.535
108_A139_E0.317311.531
71_V89_L0.314351.517
82_F86_R0.309911.496
76_A206_E0.304691.470
37_E204_R0.293071.414
30_N64_D0.288831.394
184_S189_R0.285121.376
188_I203_M0.284411.373
205_P209_A0.28251.363
198_P208_A0.278041.342
205_P208_A0.275961.332
191_L196_E0.275241.328
119_F152_P0.275131.328
74_Y78_I0.273141.318
108_A136_E0.271331.309
43_A120_I0.260921.259
79_D206_E0.260441.257
105_L108_A0.257121.241
200_E205_P0.254661.229
191_L198_P0.247021.192
65_I69_V0.242831.172
67_Y96_M0.240991.163
89_L93_P0.240371.160
118_H153_V0.240041.158
71_V75_E0.237751.147
105_L136_E0.236171.140
42_R46_K0.235261.135
34_R204_R0.228311.102
139_E142_D0.228131.101
207_V211_L0.224081.081
31_P70_R0.221541.069
41_R44_L0.220521.064
200_E208_A0.219151.058
59_P102_R0.218971.057
72_R210_I0.218161.053
105_L143_E0.217451.049
69_V73_C0.217451.049
30_N189_R0.21681.046
111_R143_E0.215851.042
38_Y181_I0.215381.039
52_L88_L0.214891.037
43_A176_G0.21161.021
192_L211_L0.211571.021
126_A154_P0.210451.016
151_E174_P0.209211.010
94_L98_Y0.205960.994
52_L114_Y0.204210.986
186_T189_R0.20360.983
200_E212_R0.202940.979
72_R213_R0.20270.978
60_T133_D0.202550.978
139_E143_E0.201360.972
80_N206_E0.201340.972
53_L78_I0.199050.961
54_H94_L0.19840.958
98_Y109_I0.197910.955
82_F87_V0.196610.949
73_C76_A0.195130.942
209_A212_R0.193820.935
94_L113_N0.193320.933
39_L155_F0.190990.922
30_N36_H0.190710.920
94_L110_I0.18990.916
57_V60_T0.188060.908
95_P102_R0.187320.904
124_D157_E0.186550.900
176_G179_H0.18440.890
48_G120_I0.183760.887
33_H188_I0.183510.886
134_P157_E0.183260.884
156_P177_K0.18120.874
133_D136_E0.180830.873
36_H124_D0.180660.872
76_A207_V0.180320.870
32_L73_C0.178520.862
51_L120_I0.178410.861
45_E196_E0.1780.859
124_D186_T0.177910.859
37_E201_W0.176850.854
164_C173_C0.17660.852
143_E150_I0.172840.834
26_F168_V0.168480.813
190_E193_R0.168070.811
36_H184_S0.166830.805
104_A119_F0.166520.804
61_K185_G0.165730.800
75_E93_P0.165720.800
197_E201_W0.165450.798
39_L43_A0.164360.793
37_E80_N0.16430.793
109_I112_K0.163790.790
68_E72_R0.163250.788
203_M208_A0.163170.787
161_C164_C0.162850.786
34_R201_W0.162570.785
43_A155_F0.161150.778
110_I114_Y0.16030.774
119_F150_I0.160260.773
77_L207_V0.15980.771
65_I73_C0.159330.769
78_I87_V0.157870.762
105_L135_Y0.157810.762
128_V137_A0.157550.760
73_C207_V0.157210.759
93_P96_M0.156950.757
36_H189_R0.156140.754
38_Y42_R0.155530.751
75_E79_D0.154830.747
37_E77_L0.154260.744
103_E107_H0.154210.744
76_A209_A0.153580.741
160_Y203_M0.153570.741
83_P86_R0.151860.733
191_L202_F0.151740.732
141_F173_C0.150590.727
108_A112_K0.149470.721
41_R45_E0.148910.719
37_E78_I0.14880.718
55_P74_Y0.148140.715
122_G184_S0.147940.714
98_Y102_R0.14770.713
29_R33_H0.147580.712
56_L59_P0.147440.712
27_Q167_Y0.146180.705
65_I70_R0.145460.702
58_G125_H0.145430.702
125_H128_V0.143980.695
28_T58_G0.143630.693
35_A38_Y0.143530.693
158_M180_H0.142170.686
141_F152_P0.141820.684
124_D189_R0.141370.682
34_R183_I0.140960.680
53_L71_V0.139010.671
54_H107_H0.138920.670
49_D117_T0.138250.667
75_E78_I0.137830.665
135_Y138_Q0.137580.664
168_V172_T0.137560.664
55_P58_G0.137490.664
49_D118_H0.13730.663
46_K177_K0.137110.662
41_R197_E0.13670.660
42_R201_W0.135810.655
109_I113_N0.13580.655
48_G118_H0.134470.649
55_P104_A0.13420.648
127_G132_Y0.134040.647
129_G152_P0.133650.645
183_I188_I0.133520.644
121_V125_H0.133090.642
210_I213_R0.133050.642
31_P36_H0.133010.642
28_T61_K0.132990.642
119_F129_G0.132950.642
201_W205_P0.132870.641
137_A141_F0.132840.641
192_L203_M0.132770.641
106_L135_Y0.132570.640
124_D184_S0.132450.639
41_R200_E0.131690.636
35_A157_E0.131130.633
121_V126_A0.131070.633
45_E86_R0.130750.631
32_L53_L0.130690.631
38_Y41_R0.129740.626
137_A140_I0.12960.625
71_V96_M0.129050.623
128_V133_D0.128820.622
30_N123_R0.128580.621
76_A79_D0.128420.620
26_F167_Y0.128130.618
33_H125_H0.127840.617
30_N63_G0.127830.617
111_R115_G0.127510.615
105_L119_F0.127250.614
30_N35_A0.126950.613
181_I187_E0.126410.610
61_K70_R0.126270.609
120_I153_V0.126130.609
118_H151_E0.125510.606
125_H137_A0.125270.605
188_I212_R0.12490.603
57_V67_Y0.124610.601
43_A153_V0.12450.601
127_G161_C0.124450.601
158_M182_S0.124360.600
71_V74_Y0.124340.600
132_Y137_A0.124240.600
123_R127_G0.123850.598
164_C167_Y0.123630.597
129_G141_F0.123560.596
53_L89_L0.1230.594
51_L87_V0.122960.593
200_E209_A0.12280.593
55_P153_V0.122620.592
104_A121_V0.122160.590
67_Y186_T0.12210.589
184_S187_E0.121830.588
60_T125_H0.121450.586
191_L197_E0.121280.585
119_F125_H0.120630.582
156_P180_H0.120540.582
52_L116_C0.120470.581
107_H134_P0.120280.580
40_M87_V0.120150.580
207_V210_I0.119950.579
26_F39_L0.119360.576
36_H157_E0.119290.576
187_E202_F0.119080.575
129_G137_A0.118970.574
44_L51_L0.118410.571
92_L185_G0.118210.570
119_F140_I0.117540.567
61_K124_D0.116820.564
57_V101_P0.116560.563
133_D193_R0.116280.561
121_V137_A0.116020.560
112_K138_Q0.115830.559
41_R201_W0.115790.559
46_K153_V0.115650.558
126_A137_A0.115460.557
190_E196_E0.11520.556
137_A192_L0.11510.555
29_R40_M0.11460.553
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1jhdA11000.107
1v47A0.99071000.115
1r6xA0.99071000.201
1g8fA0.99071000.232
1x6vB0.99071000.232
4dnxA11000.266
2gksA11000.296
3cr8A0.99071000.297
1m8pA0.99071000.325
3h05A0.74421000.359

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