GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Folate_carrier - Reduced folate carrier
Pfam: PF01770 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0015
Length: 412
Sequences: 61590
Seq/Len: 149.49
HH_delta: 0.214 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
92_T96_A2.48534.031
87_L100_M2.133243.460
80_S107_A2.018423.273
84_T100_M1.721582.792
53_S102_F1.693892.747
95_L99_L1.680082.725
61_V110_A1.661622.695
70_Y120_S1.656462.686
89_L165_Y1.626912.638
93_S96_A1.604072.601
82_I171_V1.549812.513
94_V98_Q1.498492.430
38_T41_Q1.498192.430
122_V130_V1.486732.411
77_Q110_A1.47872.398
128_Q310_V1.473042.389
283_E286_Y1.458572.365
126_H129_K1.399972.270
84_T103_F1.399072.269
301_A352_S1.384472.245
57_F106_L1.357812.202
84_T107_A1.337532.169
123_D126_H1.298632.106
66_D375_A1.293912.098
71_K75_I1.285012.084
41_Q94_V1.249852.027
297_L348_I1.22891.993
370_S373_R1.226481.989
341_W345_A1.215621.971
91_G100_M1.17591.907
369_L377_V1.161781.884
91_G96_A1.140251.849
37_F94_V1.138291.846
241_K245_S1.131141.834
65_T113_A1.125811.826
69_R72_P1.097671.780
84_T104_Y1.082231.755
49_V102_F1.074081.742
282_N286_Y1.073281.741
46_I97_M1.065571.728
63_L67_Y1.063011.724
57_F109_A1.035961.680
49_V98_Q1.009691.637
53_S57_F0.992681.610
37_F41_Q0.970561.574
88_L100_M0.959681.556
307_Y311_N0.93991.524
96_A100_M0.937651.521
294_S351_R0.92881.506
313_D316_G0.92821.505
286_Y289_A0.925841.501
72_P76_L0.925821.501
124_K127_Y0.905271.468
75_I178_A0.902291.463
86_L168_L0.90061.461
158_V162_Q0.894361.450
88_L97_M0.891991.447
129_K310_V0.88451.434
339_N342_V0.880411.428
76_L80_S0.874261.418
388_L391_I0.871721.414
304_L307_Y0.868491.408
119_Y127_Y0.86131.397
242_S373_R0.859171.393
72_P75_I0.85851.392
314_R367_K0.841561.365
95_L98_Q0.840981.364
86_L90_F0.839831.362
159_S162_Q0.838931.361
87_L90_F0.838741.360
242_S245_S0.831961.349
80_S84_T0.827591.342
60_P63_L0.825621.339
297_L301_A0.82541.339
75_I175_L0.823461.335
64_L68_L0.820661.331
57_F60_P0.813311.319
64_L73_V0.812681.318
306_G310_V0.812221.317
68_L73_V0.807591.310
77_Q107_A0.802431.301
176_L180_F0.801051.299
308_V312_W0.772411.253
62_F66_D0.767391.245
275_D287_N0.76131.235
118_I134_T0.758331.230
341_W344_Y0.756541.227
315_W319_A0.755081.225
301_A304_L0.749071.215
249_L253_S0.74831.214
385_A388_L0.745221.209
50_W54_Y0.742921.205
324_S353_L0.742611.204
333_L346_G0.739191.199
31_T42_V0.736631.195
316_G319_A0.731341.186
305_A356_F0.730351.184
82_I168_L0.726631.178
165_Y169_A0.726451.178
244_Y250_L0.723151.173
169_A173_L0.721911.171
99_L103_F0.72161.170
275_D284_S0.719721.167
65_T70_Y0.718721.166
313_D317_E0.718671.166
68_L72_P0.71671.162
89_L168_L0.713791.158
285_V289_A0.713121.157
50_W108_T0.70991.151
326_L353_L0.707721.148
154_S285_V0.704271.142
73_V76_L0.702821.140
385_A389_Q0.701081.137
31_T39_E0.699781.135
89_L161_F0.696441.129
330_L346_G0.695171.127
83_I87_L0.691231.121
365_I381_N0.688071.116
69_R183_M0.68651.113
72_P183_M0.684541.110
53_S105_G0.68361.109
96_A99_L0.682191.106
120_S374_Y0.678291.100
329_G333_L0.676661.097
129_K133_Y0.675831.096
273_L277_V0.675581.096
388_L392_L0.668441.084
147_L151_L0.668291.084
162_Q165_Y0.667281.082
316_G320_L0.662671.075
296_L300_I0.660421.071
345_A349_I0.657461.066
45_E49_V0.654971.062
66_D376_L0.654821.062
247_P251_L0.652491.058
75_I79_L0.652071.058
69_R73_V0.65161.057
117_Y181_L0.648881.052
250_L254_L0.643531.044
151_L155_F0.642141.041
152_L162_Q0.639581.037
289_A293_A0.638671.036
272_S276_T0.638021.035
79_L175_L0.637631.034
307_Y310_V0.636741.033
176_L179_L0.633631.028
325_L329_G0.632621.026
82_I175_L0.632111.025
373_R376_L0.61971.005
256_W260_T0.619521.005
129_K307_Y0.615030.997
101_Q105_G0.61340.995
300_I304_L0.607450.985
371_E374_Y0.607350.985
330_L353_L0.6050.981
87_L96_A0.600010.973
345_A348_I0.59970.973
119_Y131_T0.59940.972
172_S176_L0.598940.971
303_L307_Y0.5970.968
50_W105_G0.596250.967
62_F375_A0.595650.966
274_W343_C0.591590.959
328_A332_F0.591480.959
363_F367_K0.590170.957
147_L292_A0.590050.957
71_K183_M0.590050.957
177_I180_F0.589790.957
317_E320_L0.589290.956
168_L172_S0.585390.949
300_I303_L0.584510.948
70_Y183_M0.583690.947
330_L333_L0.582460.945
340_I344_Y0.581340.943
298_G355_M0.580290.941
79_L83_I0.579010.939
238_K241_K0.578150.938
239_D242_S0.577720.937
41_Q98_Q0.576960.936
127_Y367_K0.567220.920
150_Q288_G0.565170.917
122_V126_H0.564490.915
43_N269_Y0.563740.914
92_T95_L0.556890.903
148_L151_L0.55610.902
246_N250_L0.55530.901
81_Y107_A0.553490.898
247_P250_L0.553420.898
112_V115_Y0.553260.897
274_W282_N0.55320.897
85_W167_S0.552140.895
99_L102_F0.551740.895
387_V390_T0.551370.894
76_L79_L0.550510.893
387_V391_I0.550490.893
304_L308_V0.550150.892
90_F165_Y0.549970.892
138_T142_R0.543770.882
179_L182_P0.543580.882
282_N290_V0.542630.880
184_P187_S0.542050.879
342_V345_A0.541440.878
386_L390_T0.537110.871
47_Y268_N0.536720.870
119_Y374_Y0.534540.867
162_Q166_I0.534510.867
169_A172_S0.534420.867
359_T363_F0.533980.866
285_V288_G0.533590.865
385_A392_L0.53320.865
49_V53_S0.532510.864
46_I98_Q0.531690.862
59_L63_L0.530840.861
259_A357_L0.530410.860
31_T37_F0.530370.860
312_W316_G0.530020.860
78_A175_L0.529960.859
142_R295_T0.526840.854
70_Y116_S0.52370.849
326_L330_L0.521060.845
261_C389_Q0.520890.845
136_A139_L0.52060.844
82_I86_L0.519710.843
85_W168_L0.517910.840
78_A174_A0.51730.839
74_I117_Y0.517080.839
389_Q392_L0.516790.838
143_F296_L0.514540.834
327_Q330_L0.513830.833
256_W381_N0.512850.832
342_V346_G0.510490.828
332_F336_F0.510470.828
66_D70_Y0.510370.828
118_I130_V0.510150.827
312_W317_E0.510140.827
88_L104_Y0.508790.825
144_I147_L0.507220.823
46_I94_V0.50670.822
270_V347_Y0.506530.821
56_A60_P0.506480.821
239_D373_R0.50530.819
309_K313_D0.504870.819
85_W104_Y0.502860.816
344_Y348_I0.502120.814
165_Y168_L0.499150.810
158_V161_F0.499140.809
257_A385_A0.496960.806
318_L321_G0.495040.803
79_L82_I0.494980.803
161_F165_Y0.494790.802
92_T161_F0.493290.800
272_S275_D0.490580.796
349_I353_L0.489650.794
81_Y108_T0.489510.794
85_W101_Q0.487920.791
155_F158_V0.487740.791
80_S103_F0.487670.791
50_W101_Q0.485570.787
90_F96_A0.485540.787
146_S292_A0.484970.787
37_F42_V0.484830.786
374_Y378_F0.483030.783
74_I114_Y0.482740.783
170_S173_L0.481910.782
292_A296_L0.481560.781
152_L163_L0.481480.781
45_E98_Q0.48110.780
88_L164_N0.479750.778
321_G356_F0.477780.775
86_L165_Y0.477770.775
128_Q306_G0.477360.774
120_S184_P0.477340.774
380_I383_F0.47680.773
48_P387_V0.476630.773
82_I172_S0.475070.770
137_A141_G0.473880.769
55_L383_F0.472750.767
39_E276_T0.471710.765
83_I86_L0.467120.758
175_L179_L0.463180.751
40_E45_E0.460650.747
151_L154_S0.459740.746
293_A344_Y0.459660.745
52_Y55_L0.458670.744
48_P52_Y0.457930.743
264_Y267_I0.457540.742
48_P51_T0.456710.741
117_Y121_V0.455670.739
43_N48_P0.455210.738
153_V163_L0.455080.738
121_V185_K0.454130.736
286_Y290_V0.453910.736
114_Y117_Y0.453320.735
115_Y134_T0.452910.735
344_Y347_Y0.452760.734
253_S384_V0.45230.734
125_E129_K0.452190.733
30_L35_K0.45140.732
134_T137_A0.450790.731
282_N285_V0.45050.731
304_L352_S0.450490.731
366_A378_F0.448680.728
114_Y134_T0.448320.727
249_L377_V0.448260.727
309_K360_I0.448020.727
142_R146_S0.447450.726
163_L167_S0.446750.725
139_L298_G0.446590.724
61_V109_A0.44590.723
248_R251_L0.444010.720
135_R139_L0.443530.719
254_L258_F0.443460.719
379_G383_F0.443240.719
290_V344_Y0.441840.717
101_Q104_Y0.441290.716
48_P391_I0.441130.715
56_A59_L0.440730.715
159_S163_L0.438940.712
88_L91_G0.438150.711
308_V311_N0.438090.710
65_T116_S0.438030.710
290_V293_A0.437050.709
305_A308_V0.436980.709
296_L299_A0.436740.708
164_N168_L0.43620.707
50_W53_S0.435190.706
112_V116_S0.434550.705
282_N340_I0.434470.705
308_V317_E0.434370.704
132_S306_G0.434190.704
110_A113_A0.431020.699
187_S193_K0.430870.699
151_L289_A0.429840.697
321_G353_L0.42880.695
45_E48_P0.428540.695
116_S120_S0.428170.694
364_Q367_K0.42570.690
268_N271_Q0.425620.690
329_G332_F0.422690.686
289_A292_A0.420980.683
364_Q368_N0.419350.680
41_Q95_L0.418450.679
136_A303_L0.418320.678
149_G163_L0.417240.677
325_L328_A0.416760.676
378_F382_T0.416550.676
253_S381_N0.416340.675
359_T362_S0.413850.671
327_Q331_L0.413760.671
246_N373_R0.413260.670
356_F360_I0.411010.667
167_S171_V0.410250.665
301_A355_M0.410070.665
293_A297_L0.40950.664
294_S350_F0.408520.663
321_G357_L0.408260.662
178_A182_P0.40760.661
75_I179_L0.40710.660
319_A323_F0.406880.660
126_H130_V0.406870.660
135_R302_A0.406680.660
141_G145_S0.406590.659
140_V144_I0.406520.659
136_A299_A0.406130.659
81_Y104_Y0.405250.657
116_S378_F0.404820.657
58_L379_G0.404120.655
151_L285_V0.403750.655
294_S347_Y0.403560.654
183_M187_S0.40350.654
109_A112_V0.403220.654
333_L336_F0.403030.654
297_L300_I0.402660.653
77_Q113_A0.402290.652
286_Y340_I0.402140.652
337_T342_V0.401550.651
330_L334_M0.400890.650
303_L306_G0.40040.649
143_F295_T0.399710.648
41_Q45_E0.3990.647
362_S366_A0.398480.646
330_L349_I0.398060.646
284_S288_G0.397480.645
269_Y273_L0.397380.644
129_K132_S0.397140.644
386_L389_Q0.397080.644
57_F61_V0.396950.644
135_R138_T0.396720.643
145_S149_G0.396450.643
131_T363_F0.395040.641
348_I352_S0.393660.638
62_F65_T0.393560.638
155_F159_S0.389850.632
170_S174_A0.389440.632
133_Y136_A0.389410.632
302_A355_M0.387910.629
136_A140_V0.387840.629
65_T73_V0.387540.629
149_G153_V0.387350.628
61_V112_V0.386450.627
131_T135_R0.386380.627
274_W277_V0.386140.626
250_L253_S0.384480.624
258_F262_G0.384250.623
246_N368_N0.38370.622
84_T87_L0.383350.622
90_F100_M0.382720.621
126_H310_V0.38250.620
130_V137_A0.381940.619
366_A374_Y0.381280.618
365_I368_N0.381270.618
35_K92_T0.37960.616
78_A82_I0.379330.615
175_L178_A0.37930.615
301_A305_A0.378710.614
324_S328_A0.378370.614
100_M103_F0.37820.613
261_C265_Q0.377930.613
119_Y366_A0.37770.613
266_V270_V0.376470.611
45_E52_Y0.375710.609
253_S380_I0.37540.609
51_T55_L0.37490.608
317_E321_G0.374390.607
238_K242_S0.373880.606
58_L382_T0.373440.606
380_I384_V0.373260.605
74_I113_A0.373020.605
132_S136_A0.372950.605
245_S248_R0.372880.605
320_L324_S0.37180.603
241_K244_Y0.371220.602
375_A379_G0.370870.601
274_W290_V0.370050.600
253_S257_A0.369230.599
283_E287_N0.368790.598
269_Y272_S0.368550.598
61_V73_V0.368540.598
46_I49_V0.36830.597
150_Q285_V0.367880.597
92_T100_M0.367710.596
61_V64_L0.367120.595
105_G109_A0.366790.595
81_Y85_W0.365990.594
139_L299_A0.365750.593
146_S291_E0.365750.593
30_L42_V0.36510.592
115_Y378_F0.364980.592
177_I181_L0.364630.591
257_A261_C0.364390.591
385_A391_I0.364250.591
128_Q132_S0.364190.591
260_T264_Y0.364090.590
321_G325_L0.363750.590
53_S56_A0.363180.589
148_L152_L0.362620.588
260_T358_I0.362580.588
48_P390_T0.362340.588
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4j05A0.97091000.214
1pw4A0.9321000.26
3o7qA0.88831000.294
2gfpA0.86651000.315
4iu9B0.86411000.341
4gc0A0.9661000.342
4jr9A0.86411000.343
4apsA0.96361000.363
2cfqA0.88831000.377
2xutA0.97091000.437

Page generated in 0.0621 seconds.