GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
LGT - Prolipoprotein diacylglyceryl transferase
Pfam: PF01790 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 256
Sequences: 2029
Seq/Len: 7.93
HH_delta: 0.966 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
79_Q85_D0.575123.143
171_H176_Y0.572713.129
147_L155_W0.520842.846
185_L211_L0.503922.754
145_T156_G0.489912.677
17_G21_A0.484822.649
79_Q82_A0.483072.640
218_F222_F0.464132.536
76_D79_Q0.410612.244
7_S12_A0.397892.174
132_I178_A0.39582.163
72_Y76_D0.395152.159
103_W107_R0.393112.148
6_F13_I0.391492.139
112_F116_L0.389612.129
148_P155_W0.364851.994
91_Y237_A0.357231.952
70_W74_S0.356421.948
206_G248_G0.353891.934
147_L156_G0.351171.919
180_F215_F0.350691.916
82_A85_D0.349481.910
210_I248_G0.345731.889
5_L13_I0.337461.844
250_I254_Y0.336571.839
213_G245_I0.334771.829
55_G100_A0.327241.788
72_Y79_Q0.319661.747
55_G96_G0.318491.740
44_Q108_R0.318381.740
5_L18_L0.314411.718
217_F238_Q0.305641.670
41_D44_Q0.303331.657
35_A45_L0.300211.640
105_A115_L0.299571.637
210_I245_I0.297241.624
186_F190_W0.296061.618
7_S10_P0.295991.617
36_R42_P0.294641.610
74_S77_P0.293521.604
134_C139_C0.290171.586
162_G166_P0.282631.544
217_F221_F0.281351.537
144_P168_V0.280821.534
187_L191_W0.280421.532
102_I106_R0.280041.530
206_G251_L0.27621.509
180_F219_I0.270251.477
59_G96_G0.266251.455
78_W81_L0.264781.447
96_G100_A0.263721.441
19_M133_G0.262311.433
77_P81_L0.262281.433
203_Q252_L0.260741.425
210_I249_L0.258661.413
104_Y108_R0.258341.412
127_Q208_Y0.257481.407
34_R193_R0.255051.394
83_I86_G0.253041.383
131_R216_R0.252591.380
117_D202_G0.251231.373
159_F174_Q0.250841.371
207_L252_L0.250041.366
116_L205_F0.246021.344
24_F56_G0.243781.332
101_G116_L0.236061.290
24_F53_L0.235131.285
113_W202_G0.234961.284
65_V80_I0.234441.281
125_L186_F0.233221.274
56_G97_G0.232731.272
48_L115_L0.232491.270
215_F219_I0.230451.259
66_L70_W0.230331.259
135_F175_L0.229321.253
135_F157_V0.221721.212
221_F238_Q0.217611.189
54_L58_L0.21761.189
69_N72_Y0.215631.178
162_G167_G0.214211.171
28_L49_L0.214081.170
58_L62_L0.211851.158
32_L46_E0.211821.157
146_D156_G0.211761.157
29_L33_R0.211081.153
114_K201_P0.210961.153
5_L14_P0.21031.149
27_A52_A0.210181.148
141_Y170_R0.209471.145
3_P14_P0.20861.140
5_L15_W0.208581.140
31_A122_G0.208161.137
210_I252_L0.207351.133
178_A183_L0.207271.133
200_F203_Q0.206141.126
102_I112_F0.206031.126
73_Y80_I0.205781.124
34_R37_R0.204071.115
192_L207_L0.203031.109
90_F127_Q0.202861.108
183_L187_L0.202681.108
34_R121_P0.202611.107
134_C140_C0.202461.106
134_C137_N0.201571.101
177_E219_I0.201011.098
124_A186_F0.20031.095
158_V169_P0.200061.093
99_L103_W0.198591.085
246_L250_I0.198511.085
156_G169_P0.198261.083
214_I218_F0.195421.068
30_L190_W0.194751.064
186_F189_L0.194591.063
173_T219_I0.194061.060
209_L248_G0.190981.044
214_I245_I0.190691.042
155_W171_H0.188751.031
125_L128_A0.187861.027
207_L211_L0.187721.026
73_Y79_Q0.186681.020
205_F209_L0.186261.018
76_D82_A0.186151.017
33_R36_R0.185681.015
124_A185_L0.185281.012
72_Y75_A0.184181.006
33_R37_R0.184071.006
89_S140_C0.183661.004
43_D46_E0.18331.002
217_F245_I0.182310.996
129_I178_A0.181710.993
128_A178_A0.181690.993
132_I136_L0.179880.983
242_L246_L0.179520.981
94_L123_L0.178470.975
170_R224_G0.178360.975
16_Y134_C0.177440.970
143_R224_G0.177220.968
247_A250_I0.176850.966
249_L253_I0.176230.963
234_L239_W0.175850.961
175_L179_L0.175470.959
139_C174_Q0.174050.951
121_P124_A0.173950.951
234_L242_L0.172370.942
148_P156_G0.171990.940
8_I11_L0.170760.933
51_W55_G0.168910.923
155_W172_P0.167770.917
70_W75_A0.166660.911
78_W82_A0.166330.909
111_P114_K0.165140.902
48_L52_A0.165090.902
65_V73_Y0.165050.902
69_N73_Y0.164920.901
144_P169_P0.16340.893
62_L80_I0.162820.890
48_L104_Y0.162810.890
14_P84_W0.162450.888
26_L129_I0.162330.887
237_A240_L0.161850.884
22_L26_L0.161560.883
51_W108_R0.161380.882
206_G252_L0.160750.878
110_L115_L0.160510.877
19_M22_L0.160370.876
2_D15_W0.160370.876
98_I112_F0.160170.875
161_N166_P0.15870.867
155_W176_Y0.157930.863
16_Y137_N0.15540.849
22_L129_I0.154520.844
247_A254_Y0.154280.843
128_A186_F0.152660.834
44_Q110_L0.152490.833
250_I253_I0.152270.832
239_W242_L0.151830.830
47_D108_R0.150590.823
99_L246_L0.150480.822
4_V14_P0.149920.819
113_W206_G0.149710.818
127_Q181_N0.149390.816
68_Y237_A0.149310.816
32_L36_R0.148060.809
31_A123_L0.147680.807
15_W134_C0.147550.806
62_L88_L0.147140.804
206_G255_L0.146830.802
20_M23_G0.146410.800
188_L215_F0.146110.798
72_Y82_A0.14570.796
126_G130_G0.144790.791
72_Y80_I0.143950.787
184_I218_F0.143590.785
35_A40_L0.143130.782
227_R235_S0.142510.779
177_E184_I0.142050.776
29_L32_L0.142040.776
26_L125_L0.141590.774
50_L54_L0.141340.772
93_G101_G0.141110.771
147_L171_H0.140950.770
213_G244_L0.139420.762
16_Y139_C0.139080.760
192_L199_R0.138640.758
102_I107_R0.138390.756
27_A122_G0.138140.755
63_F89_S0.138110.755
190_W193_R0.137890.753
88_L93_G0.137770.753
120_A205_F0.137430.751
91_Y134_C0.137320.750
49_L53_L0.137290.750
192_L203_Q0.137250.750
122_G125_L0.137210.750
188_L192_L0.136830.748
127_Q130_G0.136720.747
51_W100_A0.136520.746
173_T225_D0.13630.745
139_C177_E0.136230.744
144_P170_R0.135340.740
128_A183_L0.135160.739
90_F208_Y0.135080.738
91_Y241_S0.135020.738
216_R220_E0.13480.737
212_Y223_R0.134710.736
31_A118_A0.134440.735
188_L191_W0.13440.734
140_C223_R0.134280.734
140_C237_A0.134110.733
161_N167_G0.133980.732
187_L190_W0.133850.731
189_L207_L0.133660.730
63_F91_Y0.133640.730
61_R88_L0.133460.729
232_F239_W0.133420.729
60_A88_L0.13220.722
124_A181_N0.131560.719
23_G26_L0.131310.718
64_Y69_N0.131220.717
113_W251_L0.131020.716
228_R236_T0.130880.715
89_S139_C0.130610.714
61_R137_N0.130370.712
4_V7_S0.129930.710
91_Y213_G0.129750.709
181_N208_Y0.129730.709
105_A112_F0.129650.708
140_C226_P0.129230.706
113_W205_F0.12920.706
145_T171_H0.128970.705
34_R38_R0.128950.705
179_L184_I0.128830.704
69_N75_A0.128660.703
20_M134_C0.128410.702
29_L36_R0.12840.702
130_G212_Y0.12830.701
77_P80_I0.128110.700
19_M132_I0.128020.700
110_L114_K0.127840.699
40_L110_L0.127620.697
30_L122_G0.12760.697
103_W106_R0.127440.696
5_L8_I0.126970.694
130_G223_R0.126520.691
111_P201_P0.12640.691
17_G57_I0.126080.689
145_T148_P0.125590.686
94_L120_A0.125410.685
89_S134_C0.125290.685
189_L204_V0.124930.683
19_M26_L0.124890.682
187_L246_L0.124010.678
64_Y228_R0.123910.677
214_I242_L0.123770.676
185_L189_L0.123680.676
251_L255_L0.123570.675
134_C177_E0.123250.673
15_W91_Y0.123150.673
131_R134_C0.123090.673
209_L244_L0.123050.672
47_D104_Y0.122940.672
127_Q140_C0.122910.672
27_A126_G0.122810.671
248_G251_L0.12270.670
52_A101_G0.122450.669
236_T240_L0.122320.668
217_F222_F0.122260.668
2_D5_L0.121820.666
213_G248_G0.12170.665
98_I116_L0.121390.663
241_S247_A0.120840.660
140_C173_T0.120580.659
81_L85_D0.120330.658
211_L215_F0.120130.656
138_G174_Q0.120090.656
127_Q225_D0.120050.656
55_G103_W0.119860.655
63_F240_L0.119840.655
9_G12_A0.119710.654
193_R199_R0.119430.653
213_G223_R0.119070.651
139_C220_E0.119020.650
34_R118_A0.118840.649
206_G209_L0.118770.649
102_I105_A0.118750.649
140_C225_D0.118490.647
143_R171_H0.118480.647
70_W228_R0.118220.646
5_L12_A0.117710.643
234_L238_Q0.117650.643
241_S244_L0.117220.641
40_L45_L0.11640.636
235_S239_W0.116340.636
64_Y89_S0.11620.635
26_L30_L0.115820.633
210_I214_I0.11570.632
91_Y236_T0.115650.632
132_I174_Q0.115430.631
93_G97_G0.115230.630
20_M88_L0.115080.629
44_Q104_Y0.115070.629
143_R170_R0.114550.626
20_M90_F0.114320.625
15_W139_C0.114110.624
32_L42_P0.11410.623
141_Y173_T0.114030.623
55_G59_G0.113820.622
130_G208_Y0.113610.621
26_L29_L0.113530.620
239_W243_A0.113450.620
63_F174_Q0.112810.616
16_Y131_R0.112490.615
51_W103_W0.11240.614
103_W108_R0.112290.614
140_C227_R0.112190.613
118_A122_G0.111750.611
33_R39_G0.111520.609
204_V207_L0.111360.609
159_F169_P0.111210.608
143_R222_F0.110980.606
91_Y139_C0.110930.606
191_W204_V0.110740.605
48_L101_G0.110670.605
89_S241_S0.110660.605
212_Y216_R0.110630.605
41_D45_L0.110380.603
218_F249_L0.11020.602
19_M136_L0.110160.602
200_F255_L0.110030.601
158_V162_G0.109870.600
15_W136_L0.109770.600
223_R226_P0.109670.599
2_D136_L0.109580.599
24_F51_W0.109520.598
70_W77_P0.109460.598
180_F184_I0.109450.598
2_D7_S0.109370.598
68_Y89_S0.109290.597
166_P170_R0.109240.597
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2l2tA0.14458.90.966
2xfcB0.22666.60.968
2ks1B0.14455.60.969
2kixA0.09384.50.97
2k9yA0.13673.70.971
2looA0.42193.30.972
2jwaA0.17193.10.972
1jb0M0.12112.80.973
2yewC0.22662.60.973
3j0cB0.22662.20.974
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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