GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
MNHE - NaH ion antiporter subunit
Pfam: PF01899 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 156
Sequences: 954
Seq/Len: 6.12
HH_delta: 0.941 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
59_Y108_S0.41323.493
73_D77_R0.349842.958
6_F28_A0.326482.760
95_R145_K0.286482.422
63_F67_I0.271252.293
138_E142_R0.256382.167
65_W69_K0.238592.017
63_F108_S0.232531.966
109_I112_T0.224631.899
88_G134_A0.216611.831
105_L144_I0.201871.707
106_A117_T0.199381.686
86_N135_S0.188111.590
16_F21_L0.186381.576
91_R126_V0.180371.525
91_R128_Y0.178151.506
89_I128_Y0.174391.474
76_R80_R0.171311.448
66_E147_R0.171041.446
92_V129_V0.168831.427
146_G150_R0.16651.408
53_P57_L0.165351.398
74_V132_L0.161391.364
96_L101_A0.161181.363
6_F21_L0.15811.337
58_R151_R0.15811.337
75_A78_V0.157151.329
23_L27_V0.1561.319
148_F152_L0.155311.313
77_R132_L0.152071.286
13_S20_N0.151851.284
10_L21_L0.15021.270
131_A134_A0.150141.269
96_L105_L0.150061.269
142_R146_G0.148181.253
20_N23_L0.148121.252
6_F25_L0.148061.252
17_S20_N0.145461.230
95_R153_L0.14541.229
61_G65_W0.144691.223
58_R154_R0.142581.205
136_D139_A0.142471.204
105_L152_L0.138691.172
107_N112_T0.13861.172
80_R84_P0.13781.165
2_F6_F0.135311.144
96_L153_L0.134231.135
69_K73_D0.133551.129
105_L110_T0.13241.119
2_F32_S0.132011.116
67_I108_S0.131351.110
59_Y155_V0.130951.107
24_G56_L0.130781.106
60_I72_L0.130761.105
56_L103_T0.13041.102
119_D128_Y0.129451.094
109_I115_T0.128211.084
138_E141_I0.127681.079
66_E148_F0.127371.077
98_S101_A0.127241.076
15_S20_N0.126541.070
110_T117_T0.125561.061
55_A151_R0.125181.058
86_N133_D0.12471.054
92_V145_K0.124041.049
57_L61_G0.123241.042
80_R83_M0.122351.034
6_F10_L0.121971.031
108_S152_L0.121491.027
9_W12_L0.121411.026
71_N85_I0.121391.026
76_R133_D0.119521.010
88_G128_Y0.117550.994
19_G23_L0.117440.993
55_A154_R0.11650.985
8_L97_R0.115990.981
26_V139_A0.11590.980
107_N111_L0.115640.978
4_L60_I0.114470.968
147_R150_R0.1140.964
117_T127_L0.113820.962
119_D134_A0.113260.958
33_L72_L0.112660.952
141_I145_K0.11260.952
25_L49_Y0.111420.942
6_F16_F0.111080.939
63_F103_T0.110880.937
2_F49_Y0.110730.936
21_L25_L0.110380.933
78_V111_L0.110.930
89_I148_F0.109940.929
28_A103_T0.109680.927
52_R59_Y0.109260.924
30_L33_L0.109250.924
5_L9_W0.108880.920
102_R120_I0.108520.917
2_F25_L0.108210.915
19_G27_V0.108090.914
139_A143_E0.107750.911
13_S31_V0.106890.904
118_V132_L0.106840.903
145_K149_E0.106260.898
89_I151_R0.105650.893
54_W57_L0.105320.890
107_N117_T0.105180.889
106_A112_T0.104690.885
110_T116_L0.104640.885
58_R62_W0.104440.883
66_E69_K0.104180.881
109_I144_I0.103980.879
9_W24_G0.103440.874
87_P116_L0.103140.872
96_L100_L0.101830.861
59_Y62_W0.101570.859
94_L106_A0.101550.859
111_L131_A0.101460.858
67_I112_T0.100530.850
64_L138_E0.100280.848
59_Y122_D0.099290.839
111_L140_A0.099080.838
51_R72_L0.098520.833
59_Y63_F0.098390.832
107_N129_V0.098070.829
30_L34_F0.097830.827
83_M116_L0.096910.819
94_L127_L0.096870.819
67_I110_T0.096850.819
77_R133_D0.096640.817
89_I118_V0.096560.816
91_R120_I0.096540.816
67_I71_N0.096430.815
117_T120_I0.096150.813
52_R132_L0.096080.812
94_L105_L0.096030.812
68_V71_N0.0960.812
60_I68_V0.095790.810
7_A135_S0.09570.809
149_E156_F0.095520.808
81_P130_H0.095460.807
70_A110_T0.095360.806
100_L103_T0.095260.805
18_P29_L0.095190.805
62_W151_R0.094760.801
6_F24_G0.094550.799
105_L148_F0.094410.798
79_L128_Y0.094260.797
81_P87_P0.093530.791
76_R79_L0.092790.784
41_P53_P0.092650.783
10_L20_N0.092350.781
9_W20_N0.091590.774
18_P150_R0.091520.774
55_A58_R0.09140.773
53_P56_L0.091170.771
99_D124_R0.091160.771
5_L155_V0.090910.769
95_R149_E0.090680.767
104_L152_L0.090660.766
74_V114_G0.090470.765
129_V135_S0.090430.765
153_L156_F0.090090.762
26_V76_R0.089770.759
34_F142_R0.089730.759
87_P112_T0.089650.758
60_I64_L0.089640.758
2_F128_Y0.089510.757
30_L57_L0.08930.755
68_V84_P0.08930.755
34_F52_R0.089120.753
12_L83_M0.08910.753
47_R100_L0.08890.752
33_L47_R0.088760.750
41_P122_D0.088650.749
25_L101_A0.088340.747
34_F73_D0.088260.746
81_P84_P0.08810.745
25_L72_L0.087470.739
5_L77_R0.087290.738
58_R119_D0.086920.735
102_R123_D0.086510.731
72_L76_R0.086240.729
54_W72_L0.086190.729
28_A32_S0.086010.727
69_K118_V0.085820.726
5_L92_V0.085740.725
53_P60_I0.08540.722
62_W147_R0.085090.719
87_P132_L0.085090.719
118_V148_F0.085010.719
119_D131_A0.084950.718
94_L149_E0.084910.718
131_A137_P0.084860.717
6_F70_A0.084620.715
70_A111_L0.084560.715
3_L7_A0.084540.715
10_L15_S0.084470.714
84_P132_L0.084320.713
19_G25_L0.084210.712
93_P141_I0.084040.710
15_S27_V0.083690.708
80_R132_L0.083690.708
64_L68_V0.083590.707
109_I116_L0.083470.706
49_Y129_V0.083420.705
57_L76_R0.083350.705
70_A91_R0.082920.701
32_S101_A0.082810.700
97_R102_R0.082690.699
111_L117_T0.082580.698
25_L61_G0.082470.697
13_S53_P0.082430.697
40_R78_V0.082380.696
71_N144_I0.082370.696
25_L29_L0.082230.695
112_T129_V0.082070.694
72_L115_T0.081950.693
89_I96_L0.08190.692
7_A54_W0.081890.692
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2d3mA0.3597.30.941
1ghhA0.21156.60.942
4hg6A0.90386.10.943
1nt2B0.6093.80.948
3cb4D0.55133.60.949
4ixqK0.10263.20.95
2d5mA0.52562.80.952
2hqvA0.33332.70.952
1ej6A0.67312.60.952
4a17E0.46152.20.954
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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