GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
MarC - MarC family integral membrane protein
Pfam: PF01914 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0292
Length: 203
Sequences: 7899
Seq/Len: 38.91
HH_delta: 0.92 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
84_A188_A1.230683.865
178_V181_R0.867462.724
70_P73_R0.848932.666
85_L89_F0.817762.568
74_I78_I0.794922.497
81_F191_A0.784832.465
77_G195_I0.744332.338
84_A184_G0.72982.292
81_F188_A0.711192.234
177_Q181_R0.695692.185
50_I116_L0.690212.168
77_G191_A0.657542.065
88_L184_G0.655872.060
185_L189_A0.61871.943
178_V182_I0.614691.931
74_I195_I0.581211.825
74_I77_G0.563341.769
30_G38_R0.561931.765
70_P74_I0.545061.712
43_A112_A0.539681.695
88_L181_R0.538661.692
82_L85_L0.537641.689
116_L121_L0.532861.674
81_F85_L0.526391.653
154_A158_Y0.502091.577
48_F120_L0.483241.518
144_L147_L0.48211.514
143_L147_L0.481891.513
82_L86_E0.479431.506
86_E89_F0.476191.496
113_I117_A0.474561.490
67_I70_P0.469761.475
69_L73_R0.466441.465
30_G162_R0.462721.453
47_A121_L0.461161.448
29_K33_P0.454641.428
166_K169_R0.453131.423
166_K170_R0.45181.419
181_R185_L0.440521.384
140_L143_L0.430511.352
38_R42_R0.429391.349
130_V150_I0.426571.340
48_F154_A0.426331.339
158_Y162_R0.424941.335
79_I82_L0.419151.316
79_I83_I0.417331.311
84_A191_A0.41691.309
53_I57_F0.41331.298
141_Q144_L0.4121.294
109_E113_I0.411351.292
67_I71_A0.410581.290
112_A116_L0.407221.279
175_G178_V0.400251.257
168_M172_G0.398681.252
142_S147_L0.39041.226
71_A74_I0.378981.190
29_K41_R0.376231.182
88_L188_A0.373431.173
184_G188_A0.369551.161
157_T161_L0.36741.154
51_L126_T0.367391.154
68_S71_A0.367021.153
71_A75_A0.366871.152
159_L163_F0.366181.150
48_F51_L0.355471.116
81_F195_I0.353491.110
154_A161_L0.350841.102
146_V149_A0.350541.101
167_I171_L0.347931.093
52_L147_L0.347321.091
33_P37_R0.345221.084
32_S35_E0.345131.084
60_L64_F0.340191.068
110_D113_I0.33951.066
123_G128_T0.338011.062
51_L120_L0.33571.054
188_A192_V0.333441.047
45_I48_F0.324551.019
193_Q196_L0.324231.018
118_I122_A0.322921.014
52_L130_V0.322071.012
107_D110_D0.321721.010
78_I82_L0.318681.001
179_I183_M0.316880.995
49_I151_L0.312010.980
51_L55_A0.308120.968
152_L156_I0.307850.967
65_F69_L0.307050.964
29_K114_V0.30540.959
41_R115_P0.304970.958
24_F28_T0.302660.951
188_A191_A0.301930.948
129_T135_A0.301690.948
36_R40_A0.301670.947
25_L41_R0.299190.940
143_L146_V0.299030.939
79_I125_G0.296050.930
142_S146_V0.295830.929
37_R111_I0.295360.928
48_F130_V0.29490.926
40_A111_I0.293990.923
172_G175_G0.292650.919
62_L65_F0.292240.918
193_Q197_S0.289680.910
35_E163_F0.287270.902
91_S181_R0.286470.900
183_M187_L0.286070.898
90_G180_T0.284120.892
122_A131_I0.282410.887
37_R40_A0.28160.884
34_K38_R0.281550.884
51_L127_I0.28120.883
41_R118_I0.280470.881
155_L159_L0.279910.879
114_V117_A0.279420.878
89_F92_P0.27710.870
143_L148_I0.274660.863
78_I81_F0.273250.858
60_L63_N0.273090.858
42_R162_R0.273060.858
50_I54_F0.270510.850
145_I148_I0.27040.849
164_A167_I0.268890.845
87_M181_R0.266160.836
48_F158_Y0.265870.835
59_Q63_N0.265450.834
48_F126_T0.264680.831
65_F68_S0.264610.831
65_F70_P0.26460.831
163_F166_K0.263550.828
58_G62_L0.263540.828
55_A130_V0.26290.826
116_L120_L0.261620.822
87_M183_M0.261460.821
192_V196_L0.259630.815
170_R173_K0.259490.815
190_I193_Q0.258090.811
177_Q180_T0.257170.808
189_A193_Q0.255460.802
132_V135_A0.254650.800
77_G81_F0.253390.796
38_R162_R0.253330.796
154_A157_T0.253250.795
23_I48_F0.25270.794
115_P120_L0.251710.791
62_L68_S0.251240.789
55_A127_I0.249620.784
27_L164_A0.249350.783
42_R46_I0.248540.781
134_S146_V0.247520.777
51_L131_I0.24720.776
144_L148_I0.246910.775
48_F151_L0.246440.774
28_T31_M0.24540.771
84_A89_F0.245390.771
51_L122_A0.244240.767
174_T178_V0.240990.757
158_Y161_L0.239020.751
142_S145_I0.23880.750
37_R41_R0.236560.743
71_A193_Q0.236240.742
48_F115_P0.232990.732
45_I126_T0.232850.731
134_S137_A0.232270.729
95_E100_D0.229480.721
93_S99_P0.228790.719
41_R45_I0.228520.718
44_S112_A0.22850.718
151_L158_Y0.227850.716
51_L130_V0.227730.715
132_V136_E0.227430.714
28_T32_S0.226850.712
87_M180_T0.22610.710
94_S101_E0.224550.705
157_T160_I0.224160.704
151_L155_L0.22410.704
83_I125_G0.22250.699
129_T133_L0.222180.698
73_R197_S0.221890.697
174_T177_Q0.221770.697
175_G179_I0.220930.694
156_I160_I0.220660.693
52_L112_A0.219750.690
43_A46_I0.217250.682
99_P106_K0.217250.682
80_L194_M0.216540.680
150_I154_A0.216090.679
92_P95_E0.215960.678
111_I115_P0.215520.677
130_V154_A0.214870.675
29_K32_S0.214490.674
61_I65_F0.214410.673
153_V157_T0.213720.671
46_I151_L0.212860.669
140_L144_L0.212520.667
151_L154_A0.21220.666
182_I185_L0.212050.666
56_F147_L0.211640.665
122_A127_I0.211330.664
52_L158_Y0.210730.662
139_S142_S0.210370.661
112_A115_P0.210310.661
129_T132_V0.210040.660
51_L115_P0.209550.658
126_T158_Y0.20910.657
184_G187_L0.208420.655
92_P181_R0.208320.654
31_M35_E0.207570.652
120_L123_G0.206720.649
39_I42_R0.206010.647
148_I152_L0.205630.646
62_L72_F0.205280.645
132_V191_A0.204220.641
54_F57_F0.204170.641
35_E39_I0.20350.639
41_R111_I0.203410.639
42_R159_L0.203220.638
127_I131_I0.202910.637
41_R158_Y0.202670.637
27_L161_L0.202250.635
94_S100_D0.202170.635
59_Q62_L0.202050.635
70_P196_L0.201860.634
44_S47_A0.201420.633
157_T162_R0.201240.632
80_L190_I0.201170.632
126_T131_I0.201020.631
129_T134_S0.200970.631
164_A172_G0.200950.631
180_T187_L0.200530.630
95_E101_E0.200370.629
47_A51_L0.199940.628
46_I155_L0.199930.628
179_I187_L0.198950.625
78_I195_I0.197680.621
81_F84_A0.197680.621
47_A125_G0.197670.621
32_S180_T0.197060.619
183_M190_I0.196910.618
176_L180_T0.196220.616
35_E159_L0.195590.614
128_T131_I0.195250.613
145_I149_A0.195180.613
72_F76_G0.195030.613
153_V156_I0.194520.611
23_I120_L0.194120.610
111_I114_V0.193640.608
45_I120_L0.193470.608
94_S99_P0.193370.607
106_K109_E0.19330.607
80_L125_G0.19320.607
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4dveA0.827618.20.92
3o7qA0.926118.70.92
1pw4A0.502512.70.925
3j1zP0.50259.10.93
4j05A0.56657.60.932
2gfpA0.9366.40.934
2wswA0.46315.10.937
3h90A0.46840.94
3l1lA0.4683.70.941
2nq2A0.41873.30.942
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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