GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
TauE - Sulfite exporter TauESafE
Pfam: PF01925 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0292
Length: 240
Sequences: 6025
Seq/Len: 25.1
HH_delta: 0.907 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
10_F216_L0.79223.438
224_V227_R0.681732.959
62_D165_K0.679982.951
223_K227_R0.675812.933
83_L138_F0.67182.915
97_G237_G0.619472.688
76_G133_G0.555772.412
62_D65_I0.486092.109
221_P224_V0.479982.083
6_F209_G0.476942.070
215_K219_K0.473092.053
64_K67_L0.455031.975
105_I109_L0.453781.969
4_I26_I0.438581.903
66_V172_F0.438231.902
41_L181_A0.412561.790
104_A234_L0.408931.775
162_D165_K0.404481.755
56_R63_W0.402211.745
101_L237_G0.391481.699
104_A237_G0.389511.690
6_F208_L0.389141.689
76_G80_G0.386761.678
50_I211_F0.383781.665
50_I207_F0.38211.658
46_F203_L0.377571.639
211_F215_K0.377561.638
98_L102_L0.370951.610
65_I161_L0.370871.609
71_I75_I0.37021.607
64_K68_P0.365571.586
205_G209_G0.361321.568
82_W86_L0.356411.547
53_L56_R0.355131.541
8_A22_I0.353071.532
70_I176_F0.353021.532
5_G202_L0.35211.528
42_F196_L0.351291.524
61_I169_T0.349891.518
104_A230_L0.346921.506
6_F212_L0.340311.477
72_G129_F0.334661.452
99_F143_F0.334211.450
54_R214_A0.331751.440
39_T196_L0.330441.434
91_I95_I0.330311.433
63_W67_L0.329431.430
88_P91_I0.323921.406
72_G76_G0.321431.395
231_I235_L0.319621.387
73_A177_S0.317081.376
35_Q38_A0.315671.370
192_D195_M0.31481.366
66_V169_T0.312841.358
10_F212_L0.312461.356
126_W130_L0.30581.327
55_H60_N0.302961.315
49_L53_L0.299341.299
136_I150_L0.298971.297
32_P35_Q0.296041.285
204_P208_L0.29151.265
72_G132_G0.286081.242
151_L173_F0.284451.234
234_L238_L0.283291.229
5_G205_G0.283231.229
78_V82_W0.280571.218
35_Q192_D0.278091.207
67_L71_I0.277811.206
55_H168_A0.276881.202
55_H217_A0.276491.200
77_V181_A0.275891.197
91_I94_L0.275751.197
101_L234_L0.275261.195
51_A171_A0.275181.194
227_R231_I0.273381.186
9_G19_G0.270011.172
78_V184_S0.269381.169
89_D93_K0.268371.165
207_F211_F0.267711.162
90_D93_K0.267511.161
108_L230_L0.266571.157
215_K218_R0.26591.154
75_I78_V0.265621.153
81_A184_S0.263611.144
52_A172_F0.263271.143
186_L193_W0.2631.141
101_L105_I0.262781.140
28_I33_P0.262671.140
74_L180_A0.262451.139
183_I187_I0.258511.122
197_L204_P0.256951.115
60_N218_R0.256671.114
39_T191_V0.255271.108
82_W85_S0.254141.103
12_S20_G0.253651.101
27_L202_L0.252511.096
38_A191_V0.250321.086
67_L70_I0.249371.082
9_G13_G0.248231.077
40_S44_N0.248121.077
194_P198_L0.248051.076
3_L7_L0.247341.073
19_G40_S0.245341.065
55_H214_A0.245281.064
87_L142_L0.244391.061
193_W196_L0.242431.052
21_L100_L0.241921.050
5_G9_G0.241611.049
60_N168_A0.241111.046
81_A180_A0.240381.043
51_A210_A0.238711.036
15_T228_I0.235711.023
33_P96_F0.234531.018
45_L182_L0.233831.015
90_D94_L0.233671.014
76_G138_F0.233151.012
49_L175_F0.232111.007
209_G212_L0.231671.005
61_I66_V0.23081.002
228_I232_L0.230731.001
56_R61_I0.22970.997
13_G214_A0.228470.991
185_F190_D0.228150.990
58_H218_R0.227080.985
124_K127_L0.225980.981
224_V228_I0.225730.980
156_L166_A0.225490.979
221_P225_F0.225060.977
130_L134_L0.223380.969
194_P197_L0.222660.966
68_P71_I0.220520.957
197_L203_L0.220510.957
69_L173_F0.220140.955
83_L86_L0.219590.953
97_G101_L0.219060.951
12_S174_F0.218790.949
136_I151_L0.218350.948
121_S124_K0.218270.947
50_I210_A0.217820.945
164_K217_A0.217410.943
144_G170_S0.216980.942
104_A108_L0.215510.935
24_V40_S0.214980.933
136_I139_L0.214940.933
102_L106_Y0.214850.932
107_M230_L0.213120.925
184_S188_L0.212480.922
172_F176_F0.212430.922
43_I202_L0.211820.919
14_I220_I0.211420.917
180_A184_S0.209610.910
21_L143_F0.208210.904
156_L163_P0.2080.903
163_P167_R0.207770.902
24_V37_V0.207720.901
69_L155_L0.207340.900
147_G151_L0.206970.898
105_I234_L0.206960.898
23_A202_L0.206360.896
190_D194_P0.206270.895
80_G138_F0.206130.895
131_L154_L0.205380.891
79_I82_W0.205010.890
6_F205_G0.203960.885
43_I206_A0.203520.883
53_L57_K0.203370.883
212_L215_K0.20160.875
81_A181_A0.201340.874
209_G213_G0.200940.872
35_Q39_T0.19810.860
79_I83_L0.196590.853
163_P222_Q0.196120.851
163_P225_F0.195460.848
147_G153_P0.19490.846
66_V173_F0.19470.845
63_W66_V0.194450.844
79_I138_F0.193170.838
31_L36_A0.192010.833
128_L131_L0.190150.825
28_I36_A0.189920.824
37_V185_F0.188710.819
44_N178_S0.188320.817
174_F177_S0.188290.817
59_G62_D0.187950.816
193_W197_L0.187440.813
73_A173_F0.187110.812
12_S19_G0.186810.811
27_L43_I0.186520.809
220_I224_V0.186090.808
170_S174_F0.186020.807
226_R230_L0.1860.807
45_L179_V0.185980.807
131_L134_L0.185910.807
174_F178_S0.185680.806
109_L112_R0.185470.805
214_A218_R0.185330.804
235_L238_L0.185240.804
56_R59_G0.184350.800
208_L211_F0.184120.799
94_L97_G0.183650.797
108_L234_L0.183340.796
12_S44_N0.183260.795
17_F21_L0.182870.794
144_G147_G0.182790.793
107_M229_F0.182320.791
230_L234_L0.182320.791
167_R217_A0.182270.791
54_R211_F0.181480.788
145_I149_P0.180230.782
33_P37_V0.179810.780
37_V84_L0.179550.779
23_A40_S0.179350.778
62_D169_T0.17920.778
75_I79_I0.1790.777
127_L130_L0.178860.776
139_L143_F0.178250.774
40_S178_S0.17790.772
68_P129_F0.177060.768
221_P227_R0.176170.765
179_V183_I0.176090.764
166_A229_F0.175670.762
47_T144_G0.175350.761
15_T210_A0.174990.759
12_S140_S0.174760.758
140_S147_G0.17320.752
229_F233_L0.17320.752
96_F107_M0.172540.749
20_G167_R0.172530.749
152_V167_R0.171890.746
150_L154_L0.171310.743
104_A233_L0.171080.742
31_L195_M0.17080.741
20_G24_V0.17070.741
73_A210_A0.170660.741
54_R57_K0.170590.740
73_A151_L0.170310.739
76_G134_L0.169980.738
146_G178_S0.169570.736
152_V170_S0.169240.734
29_L239_K0.168430.731
13_G167_R0.168180.730
44_N147_G0.167450.727
78_V187_I0.167310.726
68_P72_G0.167190.726
151_L155_L0.166740.724
44_N174_F0.16650.723
103_L106_Y0.166250.721
24_V28_I0.166250.721
166_A170_S0.165820.720
127_L131_L0.165010.716
19_G24_V0.164250.713
106_Y157_Y0.164110.712
222_Q226_R0.162950.707
47_T206_A0.16270.706
31_L35_Q0.162310.704
10_F209_G0.162250.704
52_A56_R0.161790.702
150_L153_P0.161430.701
20_G44_N0.161160.699
12_S47_T0.161060.699
120_S123_P0.160890.698
149_P153_P0.16080.698
152_V166_A0.16060.697
216_L219_K0.160490.696
38_A190_D0.159670.693
228_I231_I0.159080.690
139_L150_L0.158790.689
155_L161_L0.15860.688
108_L231_I0.158420.687
217_A225_F0.1580.686
85_S188_L0.157870.685
5_G23_A0.157650.684
151_L174_F0.157410.683
61_I172_F0.156920.681
232_L236_S0.156840.681
22_I25_P0.15670.680
5_G148_G0.156590.680
8_A23_A0.156480.679
110_K113_R0.156330.678
12_S17_F0.156170.678
151_L154_L0.15590.677
75_I133_G0.155850.676
12_S48_S0.155790.676
10_F14_I0.155590.675
85_S190_D0.155220.674
12_S22_I0.154680.671
168_A217_A0.154320.670
48_S174_F0.154280.670
175_F179_V0.154140.669
14_I225_F0.154130.669
140_S145_I0.154090.669
100_L149_P0.153930.668
166_A225_F0.153790.667
12_S15_T0.153740.667
133_G138_F0.153740.667
103_L149_P0.153670.667
41_L144_G0.153290.665
104_A236_S0.152890.663
144_G177_S0.152870.663
155_L173_F0.152870.663
75_I185_F0.152540.662
34_K38_A0.152350.661
132_G154_L0.15220.661
18_G38_A0.152060.660
120_S125_R0.151630.658
54_R58_H0.151550.658
23_A26_I0.151540.658
32_P192_D0.150850.655
9_G206_A0.150680.654
225_F230_L0.150320.652
37_V144_G0.149970.651
12_S170_S0.149850.650
48_S178_S0.149830.650
48_S171_A0.149490.649
80_G84_L0.149310.648
44_N140_S0.149260.648
9_G44_N0.149080.647
136_I147_G0.148950.646
13_G210_A0.148930.646
66_V70_I0.148830.646
101_L104_A0.148460.644
121_S125_R0.146860.637
84_L185_F0.146390.635
9_G152_V0.146360.635
17_F229_F0.14590.633
12_S167_R0.145890.633
66_V159_F0.145860.633
208_L212_L0.145840.633
100_L233_L0.14580.633
12_S51_A0.14550.631
98_L114_K0.145220.630
55_H167_R0.14520.630
183_I186_L0.144430.627
21_L25_P0.144380.627
34_K84_L0.14420.626
39_T192_D0.144180.626
54_R215_K0.144140.626
223_K226_R0.143690.624
179_V184_S0.143650.623
18_G25_P0.143440.622
3_L120_S0.143250.622
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3l1lA0.495875.10.907
1pw4A0.854274.10.908
3o7qA0.858371.30.91
2gfpA0.841767.90.912
3llqA0.741762.10.915
4j05A0.916740.70.925
2a65A0.487524.60.932
4iu9B0.858319.50.935
4jr9A0.858314.90.938
2xutA0.395813.70.939
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