GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
MoaC - MoaC family
Pfam: PF01967 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 136
Sequences: 1424
Seq/Len: 10.47
HH_delta: -0.025 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
54_K57_E1.676815.385
85_V109_A1.048643.368
87_A104_A1.012283.251
29_L119_V0.900782.893
18_G105_V0.877322.817
18_G128_I0.849722.729
17_S131_L0.824942.649
17_S84_E0.809042.598
28_E32_D0.752582.417
21_R126_T0.746722.398
9_V94_K0.720232.313
17_S129_R0.64232.063
11_Y90_K0.630112.024
48_G108_A0.600131.927
20_I109_A0.559391.796
52_A104_A0.555951.785
106_S128_I0.54571.752
22_L26_T0.535911.721
76_L83_V0.520131.670
13_T88_T0.514521.652
113_Y130_L0.503251.616
15_I88_T0.498821.602
19_R84_E0.486121.561
77_D80_E0.48011.542
58_L107_V0.473481.521
116_C123_M0.45171.451
23_S26_T0.450031.445
18_G109_A0.449681.444
74_F83_V0.448421.440
24_P28_E0.44771.438
31_R78_E0.447011.436
27_I76_L0.445081.429
46_I61_L0.440491.415
42_A45_R0.438011.407
39_D42_A0.43631.401
31_R76_L0.431041.384
66_P93_G0.41981.348
58_L103_T0.41931.347
66_P91_T0.41751.341
75_E84_E0.416461.337
48_G72_V0.412681.325
77_D84_E0.402121.291
3_D90_K0.401661.290
21_R124_V0.401371.289
19_R127_D0.401281.289
69_H90_K0.400951.288
30_I116_C0.388681.248
19_R82_S0.387321.244
15_I132_E0.387271.244
109_A125_I0.387241.244
29_L35_V0.383321.231
13_T134_S0.382451.228
67_L89_V0.376351.209
5_S68_T0.375341.205
102_L110_L0.368751.184
5_S90_K0.367371.180
17_S86_R0.358961.153
106_S125_I0.3571.146
20_I123_M0.35471.139
9_V92_T0.354611.139
52_A67_L0.351461.129
13_T90_K0.350091.124
39_D43_V0.348051.118
67_L97_V0.343471.103
124_V127_D0.339951.092
43_V46_I0.336011.079
10_T135_G0.335341.077
48_G87_A0.330711.062
105_V128_I0.321021.031
87_A105_V0.320051.028
29_L34_E0.318831.024
25_E28_E0.317121.018
36_P112_I0.311231.000
49_I61_L0.309260.993
75_E86_R0.308410.990
15_I86_R0.306920.986
73_D86_R0.304780.979
23_S120_D0.303140.974
22_L123_M0.302430.971
45_R73_D0.30060.965
35_V116_C0.300030.964
46_I50_M0.299650.962
20_I112_I0.299470.962
65_I89_V0.299410.962
47_A111_T0.297430.955
120_D123_M0.297080.954
106_S109_A0.289960.931
85_V108_A0.288350.926
35_V40_V0.284310.913
72_V108_A0.281340.904
9_V93_G0.277190.890
65_I91_T0.272550.875
68_T94_K0.270450.869
44_A111_T0.267930.860
8_P94_K0.267290.858
35_V119_V0.266920.857
5_S11_Y0.263440.846
11_Y92_T0.262960.844
125_I128_I0.258830.831
30_I40_V0.258750.831
41_L83_V0.258590.830
13_T132_E0.244410.785
113_Y116_C0.244190.784
56_S64_P0.242680.779
86_R131_L0.241880.777
19_R126_T0.238440.766
17_S127_D0.236750.760
83_V112_I0.235970.758
52_A70_V0.234150.752
23_S122_D0.234080.752
85_V105_V0.232420.746
19_R80_E0.232410.746
26_T120_D0.231760.744
89_V130_L0.229980.739
113_Y123_M0.226410.727
66_P94_K0.225640.725
59_I118_A0.225080.723
74_F112_I0.223610.718
89_V97_V0.222780.715
56_S66_P0.221670.712
20_I85_V0.220620.709
39_D45_R0.212440.682
28_E31_R0.211820.680
61_L71_D0.210460.676
27_I30_I0.210070.675
52_A87_A0.209280.672
2_V118_A0.208630.670
74_F85_V0.207060.665
4_V65_I0.205610.660
36_P45_R0.201850.648
51_A107_V0.198830.639
45_R69_H0.197940.636
124_V129_R0.195340.627
59_I111_T0.194120.623
40_V116_C0.193720.622
33_G42_A0.192060.617
30_I83_V0.191360.615
21_R82_S0.19060.612
10_T136_G0.189640.609
67_L70_V0.189220.608
40_V93_G0.18870.606
6_D9_V0.188040.604
72_V87_A0.187380.602
54_K58_L0.18640.599
77_D82_S0.186190.598
45_R71_D0.184510.593
11_Y15_I0.183240.588
40_V112_I0.181880.584
41_L74_F0.181230.582
73_D88_T0.180770.581
23_S27_I0.180260.579
56_S65_I0.179880.578
36_P119_V0.179680.577
63_H95_T0.178770.574
28_E78_E0.178350.573
63_H96_G0.176720.568
43_V61_L0.175910.565
68_T92_T0.175440.563
11_Y68_T0.175250.563
6_D11_Y0.172260.553
71_D88_T0.171730.552
50_M55_T0.171720.551
123_M130_L0.170910.549
26_T30_I0.170710.548
112_I121_K0.170430.547
22_L27_I0.168950.543
67_L132_E0.167410.538
26_T29_L0.166750.536
52_A89_V0.165650.532
22_L40_V0.164410.528
19_R77_D0.163650.526
130_L134_S0.162880.523
82_S116_C0.162050.520
116_C119_V0.161760.519
42_A64_P0.16150.519
7_K12_R0.161260.518
7_K98_E0.161150.518
122_D134_S0.160480.515
20_I125_I0.160040.514
91_T106_S0.15880.510
8_P61_L0.158440.509
122_D130_L0.157730.507
55_T89_V0.15770.506
103_T107_V0.157590.506
15_I87_A0.157130.505
31_R34_E0.156360.502
11_Y134_S0.155950.501
51_A62_C0.155910.501
27_I31_R0.155860.501
35_V42_A0.155560.500
3_D69_H0.155540.500
51_A105_V0.155170.498
22_L120_D0.155020.498
20_I113_Y0.154970.498
5_S13_T0.153190.492
26_T116_C0.15260.490
28_E75_E0.150450.483
68_T93_G0.150390.483
6_D92_T0.149220.479
74_F116_C0.148760.478
48_G109_A0.148640.477
8_P32_D0.148580.477
74_F82_S0.148580.477
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1ekrA1100-0.025
2iihA1100-0.021
2eeyA1100-0.021
4fdfA0.9853100-0.019
4fdfA0.9853100-0.019
2eknA0.9853100-0.005
2ohdA0.9853100-0.002
1fa2A0.639764.10.937
1wdpA0.632438.70.945
2xfrA0.617630.40.948

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