GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
FAT - FAT domain
Pfam: PF02259 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0020
Length: 352
Sequences: 30045
Seq/Len: 85.36
HH_delta: 0.104 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
273_S276_E2.700093.480
161_N164_L2.69223.470
86_E89_E2.669543.441
199_E202_E2.645223.409
44_D47_E2.638333.400
123_S126_E2.617773.374
307_E310_P2.484523.202
233_E236_E2.187072.819
78_L94_K1.656352.135
191_A207_L1.561912.013
153_A169_L1.502781.937
255_F280_Y1.450721.870
128_I132_R1.44121.857
115_L131_L1.434641.849
49_K53_E1.402931.808
32_S51_Y1.383051.782
74_A93_L1.372931.769
258_L280_Y1.368971.764
149_W168_A1.368961.764
190_Y206_K1.362141.756
36_A52_I1.341571.729
278_L282_K1.337541.724
204_I208_R1.337011.723
187_F206_K1.318181.699
282_K298_W1.317421.698
259_A281_Y1.308641.687
242_N258_L1.296271.671
35_R51_Y1.294271.668
152_F168_A1.293611.667
114_R130_S1.292851.666
111_W130_S1.282291.653
77_S93_L1.274791.643
91_I95_S1.265711.631
166_L170_N1.222071.575
238_I242_N1.197261.543
53_E77_S1.186581.529
156_A168_A1.16741.505
52_I76_P1.160531.496
225_A241_T1.156641.491
202_E205_Q1.153031.486
35_R39_A1.145131.476
95_S114_R1.132691.460
298_W302_N1.123361.448
47_E50_K1.112871.434
258_L262_L1.10831.428
114_R118_M1.100711.419
39_A51_Y1.100021.418
156_A164_L1.099851.417
81_L93_L1.09341.409
224_N240_S1.093141.409
194_L202_E1.08921.404
262_L276_E1.08141.394
89_E92_E1.075121.386
295_W331_G1.068551.377
126_E129_L1.026641.323
256_L297_S1.024861.321
164_L167_S1.023291.319
112_R148_T1.022331.318
152_F156_A1.02061.315
190_Y194_L1.015481.309
194_L206_K1.012491.305
77_S81_L1.007061.298
131_L151_K1.004631.295
224_N228_K0.986281.271
170_N190_Y0.984061.268
39_A47_E0.98291.267
132_R152_F0.980111.263
33_F73_R0.979431.262
262_L280_Y0.97471.256
39_A44_D0.973451.255
302_N307_E0.971811.252
329_I333_L0.964991.244
169_L189_E0.942841.215
302_N310_P0.942361.215
278_L302_N0.940171.212
81_L89_E0.938251.209
256_L294_A0.937351.208
118_M130_S0.934361.204
150_L186_V0.931161.200
118_M126_E0.930511.199
49_K84_L0.930261.199
156_A161_N0.92391.191
74_A96_N0.922771.189
75_Y110_R0.92271.189
208_R224_N0.920051.186
281_Y297_S0.919851.186
194_L199_E0.915471.180
222_I254_A0.896141.155
81_L86_E0.893631.152
241_T257_L0.888321.145
80_K84_L0.882931.138
278_L298_W0.882681.138
283_E286_K0.881921.137
90_I117_N0.881131.136
265_L273_S0.880341.135
38_L42_Q0.86721.118
118_M123_S0.863091.112
276_E279_K0.854081.101
94_K113_S0.852151.098
78_L97_L0.851761.098
171_R175_L0.847721.093
217_K220_D0.847311.092
278_L307_E0.847021.092
49_K81_L0.845711.090
260_K297_S0.839021.081
275_D305_L0.824311.062
262_L273_S0.821741.059
111_W134_L0.817711.054
236_E239_S0.816931.053
277_I301_F0.814371.050
79_V83_Q0.813281.048
187_F210_L0.812311.047
209_E213_C0.811671.046
37_L76_P0.811.044
119_Q155_L0.807921.041
128_I156_A0.806771.040
291_W294_A0.803971.036
228_K236_E0.796511.027
221_S240_S0.789591.018
259_A284_A0.789291.017
46_D84_L0.788261.016
255_F283_E0.782841.009
115_L134_L0.781171.007
78_L90_I0.777871.003
88_E121_D0.777271.002
134_L137_S0.776791.001
37_L41_R0.776361.001
166_L197_Q0.773460.997
111_W133_R0.771620.994
91_I121_D0.769240.991
188_L220_D0.766770.988
146_A172_L0.762870.983
74_A97_L0.762260.982
154_K189_E0.762090.982
149_W171_R0.761950.982
54_K58_L0.761610.982
278_L305_L0.760040.980
56_R74_A0.759040.978
187_F209_E0.758290.977
166_L194_L0.755790.974
296_H300_L0.750110.967
283_E287_L0.746290.962
260_K264_E0.745490.961
166_L190_Y0.745470.961
32_S55_A0.745380.961
108_L112_R0.744120.959
45_Y80_K0.739390.953
75_Y113_S0.737640.951
91_I118_M0.734190.946
243_L247_S0.73410.946
116_P120_D0.733330.945
55_A73_R0.7330.945
284_A294_A0.731420.943
278_L301_F0.730560.942
112_R151_K0.730250.941
238_I258_L0.729590.940
75_Y79_V0.722930.932
117_N121_D0.722360.931
238_I262_L0.722050.931
153_A172_L0.719610.927
238_I265_L0.718020.925
49_K80_K0.717780.925
87_L117_N0.717510.925
210_L220_D0.715450.922
82_Q117_N0.713630.920
217_K221_S0.71110.916
154_K158_K0.710120.915
298_W331_G0.707270.912
124_V155_L0.704970.909
188_L223_S0.70410.907
76_P79_V0.703890.907
256_L260_K0.703240.906
226_E230_G0.701740.904
33_F76_P0.696050.897
153_A165_A0.695750.897
128_I152_F0.694260.895
204_I224_N0.694110.895
184_P210_L0.693760.894
229_S261_W0.692240.892
71_Y75_Y0.689780.889
263_D301_F0.68890.888
49_K77_S0.688530.887
171_R174_Q0.687520.886
191_A210_L0.686230.884
54_K57_Q0.686120.884
193_L197_Q0.685490.883
244_D254_A0.68520.883
115_L127_P0.680530.877
45_Y49_K0.679230.875
263_D304_K0.678770.875
330_E334_K0.677850.874
107_L110_R0.675910.871
226_E257_L0.673130.868
36_A48_A0.673030.867
251_K254_A0.669730.863
191_A203_A0.668390.861
195_W207_L0.667540.860
192_K196_A0.667270.860
70_S73_R0.665950.858
163_Q197_Q0.665660.858
255_F284_A0.664550.856
172_L186_V0.66450.856
29_P55_A0.661820.853
149_W172_L0.66090.852
280_Y283_E0.658730.849
285_T294_A0.658520.849
234_S265_L0.651430.840
55_A58_L0.650980.839
92_E96_N0.648010.835
279_K283_E0.64780.835
155_L159_A0.647340.834
36_A55_A0.643620.830
40_L48_A0.643580.829
244_D247_S0.643090.829
133_R137_S0.641160.826
40_L52_I0.639310.824
53_E57_Q0.639050.824
228_K240_S0.638540.823
192_K223_S0.637270.821
150_L189_E0.636380.820
129_L133_R0.635990.820
79_V113_S0.635950.820
170_N173_F0.635670.819
90_I94_K0.635660.819
301_F305_L0.635630.819
157_R193_L0.634430.818
204_I228_K0.631480.814
33_F37_L0.629640.811
134_L148_T0.62810.810
170_N174_Q0.626380.807
166_L193_L0.626070.807
183_L186_V0.626030.807
259_A277_I0.624150.804
297_S300_L0.623930.804
243_L246_E0.62330.803
50_K54_K0.621420.801
257_L260_K0.62120.801
303_D308_S0.619910.799
103_D106_S0.615840.794
252_A284_A0.615010.793
206_K209_E0.613060.790
127_P131_L0.61280.790
288_D291_W0.611370.788
162_F166_L0.611260.788
51_Y54_K0.610290.787
108_L134_L0.609260.785
108_L145_L0.60920.785
261_W265_L0.607590.783
256_L291_W0.607230.783
133_R136_L0.605620.781
59_L70_S0.605360.780
207_L223_S0.605010.780
157_R162_F0.604610.779
225_A244_D0.601330.775
82_Q113_S0.599680.773
104_L107_L0.598480.771
51_Y55_A0.5980.771
205_Q209_E0.597520.770
55_A59_L0.597280.770
29_P33_F0.59670.769
184_P188_L0.595740.768
27_D32_S0.595490.767
214_R217_K0.595350.767
157_R169_L0.59520.767
157_R189_E0.594920.767
92_E95_S0.594410.766
285_T295_W0.593120.764
40_L80_K0.591880.763
130_S133_R0.590530.761
71_Y97_L0.590450.761
119_Q127_P0.588060.758
234_S261_W0.587710.757
82_Q94_K0.587640.757
31_Y34_Y0.586930.756
91_I114_R0.586490.756
125_W159_A0.585090.754
299_A332_Y0.584550.753
112_R116_P0.584360.753
295_W334_K0.583230.752
195_W203_A0.58060.748
328_A332_Y0.579490.747
195_W227_L0.579220.747
228_K233_E0.576690.743
300_L304_K0.57660.743
222_I257_L0.576340.743
209_E212_K0.576290.743
235_L265_L0.574170.740
30_E34_Y0.573520.739
119_Q151_K0.572980.738
263_D297_S0.572230.737
56_R96_N0.5720.737
45_Y83_Q0.571820.737
132_R136_L0.570830.736
167_S171_R0.569360.734
279_K282_K0.566390.730
238_I276_E0.566220.730
208_R212_K0.565280.729
204_I233_E0.564080.727
331_G334_K0.563590.726
195_W223_S0.56330.726
53_E56_R0.562170.725
28_S31_Y0.561990.724
91_I126_E0.561250.723
225_A237_V0.559830.722
145_L148_T0.559470.721
97_L110_R0.558060.719
98_S110_R0.557080.718
56_R73_R0.555580.716
119_Q124_V0.555090.715
200_Q204_I0.5550.715
32_S35_R0.553850.714
27_D31_Y0.552920.713
128_I159_A0.552070.712
245_K254_A0.551790.711
82_Q90_I0.55170.711
32_S54_K0.5490.708
34_Y37_L0.546290.704
142_P145_L0.544370.702
299_A303_D0.544330.702
248_K251_K0.543170.700
218_N221_S0.543170.700
48_A52_I0.542090.699
82_Q87_L0.540650.697
237_V241_T0.54020.696
32_S58_L0.540030.696
225_A228_K0.538910.695
253_K257_L0.538780.694
263_D281_Y0.53820.694
188_L192_K0.537960.693
157_R196_A0.537860.693
71_Y107_L0.537310.692
151_K154_K0.536280.691
204_I231_L0.536240.691
201_E231_L0.535160.690
93_L96_N0.535120.690
195_W200_Q0.534130.688
164_L168_A0.533970.688
254_A257_L0.533810.688
252_A291_W0.533440.688
274_S301_F0.533330.687
200_Q227_L0.532960.687
276_E280_Y0.532520.686
88_E92_E0.532090.686
242_N276_E0.531680.685
40_L45_Y0.531250.685
162_F193_L0.531140.685
192_K195_W0.530920.684
296_H299_A0.530190.683
31_Y35_R0.52990.683
202_E206_K0.529340.682
94_K114_R0.526960.679
260_K281_Y0.526650.679
239_S243_L0.526610.679
45_Y84_L0.526340.678
205_Q208_R0.52580.678
274_S305_L0.523930.675
223_S226_E0.523820.675
40_L76_P0.523540.675
240_S243_L0.522610.674
173_F187_F0.521780.672
128_I161_N0.520450.671
284_A287_L0.519610.670
172_L175_L0.51920.669
150_L172_L0.518820.669
281_Y298_W0.518250.668
146_A150_L0.516240.665
130_S134_L0.514490.663
300_L303_D0.511850.660
256_L284_A0.511140.659
162_F197_Q0.510510.658
238_I273_S0.510010.657
330_E333_L0.508890.656
184_P217_K0.50870.656
163_Q167_S0.50670.653
229_S241_T0.506620.653
87_L91_I0.506110.652
46_D50_K0.505780.652
157_R165_A0.504670.650
210_L213_C0.503380.649
204_I236_E0.501940.647
48_A80_K0.501710.647
215_L218_N0.500290.645
252_A256_L0.49950.644
96_N102_Q0.497380.641
281_Y285_T0.496260.640
47_E51_Y0.49540.638
112_R145_L0.495150.638
165_A169_L0.494860.638
167_S170_N0.49250.635
216_S221_S0.488060.629
229_S257_L0.487510.628
222_I226_E0.486130.627
203_A227_L0.485930.626
116_P151_K0.485840.626
227_L231_L0.485360.626
297_S301_F0.48410.624
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1w3bA0.9291000.104
1w3bA0.9291000.104
2xpiA0.88071000.145
2xpiA0.92611000.146
2y4tA0.88071000.166
3iegA0.88071000.183
3fp2A0.93181000.189
2gw1A0.89771000.196
2gw1A0.9461000.202
1fchA0.86931000.207

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