GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Zip - ZIP Zinc transporter
Pfam: PF02535 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0184
Length: 317
Sequences: 1793
Seq/Len: 5.66
HH_delta: 0.946 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
40_L305_G0.189562.077
261_S265_V0.17351.901
54_F278_L0.17191.884
211_K215_G0.156591.716
234_L238_L0.153911.687
61_A271_A0.151271.658
249_I253_I0.148231.624
16_L237_L0.14811.623
8_I247_A0.143321.571
211_K214_E0.143041.568
153_H159_S0.141031.546
46_A285_L0.137941.512
228_S231_K0.137271.504
91_L272_F0.13561.486
303_F307_L0.135541.485
179_A187_E0.132891.456
152_S158_H0.132821.456
9_L13_I0.130591.431
81_A271_A0.130131.426
300_L304_L0.125661.377
162_D165_S0.123481.353
160_H164_K0.122781.346
62_I82_F0.122091.338
185_F249_I0.122051.338
94_F98_I0.121931.336
88_G272_F0.120081.316
189_L250_G0.119331.308
184_S239_F0.119181.306
215_G277_F0.118761.301
307_L311_L0.118371.297
114_S152_S0.117421.287
84_I268_I0.117041.283
180_L211_K0.116831.280
180_L215_G0.116491.277
153_H158_H0.116241.274
301_L305_G0.115891.270
56_H313_M0.115811.269
154_S158_H0.115741.268
40_L91_L0.115351.264
42_N289_E0.114911.259
89_F307_L0.114281.252
218_L222_L0.113991.249
180_L187_E0.113741.246
161_H164_K0.113661.246
214_E239_F0.112411.232
88_G94_F0.112411.232
177_L235_L0.112291.231
154_S160_H0.111981.227
311_L315_L0.111641.223
60_E63_E0.111481.222
215_G219_G0.111351.220
81_A85_F0.11111.218
78_Y83_L0.110981.216
152_S159_S0.110581.212
204_F208_I0.110361.209
114_S308_I0.110231.208
39_S302_K0.109951.205
153_H160_H0.109351.198
211_K218_L0.10931.198
304_L315_L0.109071.195
14_V212_I0.108861.193
49_L277_F0.108851.193
154_S159_S0.10831.187
58_L85_F0.107691.180
78_Y314_A0.107221.175
45_A280_V0.107081.173
80_L87_V0.106841.171
10_A195_F0.106791.170
184_S213_P0.106581.168
96_E300_L0.106551.168
58_L250_G0.106141.163
45_A52_T0.105681.158
56_H210_H0.105541.157
185_F246_G0.105411.155
51_G58_L0.105091.152
187_E211_K0.104971.150
203_L214_E0.104331.143
209_L219_G0.104271.143
158_H161_H0.104261.143
214_E218_L0.104151.141
264_I268_I0.103371.133
201_W205_I0.103291.132
158_H163_D0.102791.126
93_F279_Y0.102741.126
191_I207_I0.102651.125
223_V229_K0.102281.121
270_L276_T0.10221.120
113_H152_S0.10171.115
42_N46_A0.101691.114
158_H166_G0.101441.112
154_S161_H0.100281.099
158_H162_D0.100211.098
84_I88_G0.100161.098
180_L218_L0.100051.096
229_K233_L0.09931.088
15_S190_A0.099241.088
8_I251_I0.098981.085
203_L219_G0.098961.084
153_H164_K0.098821.083
60_E274_A0.098781.083
10_A16_L0.09851.079
16_L278_L0.098221.076
183_H188_G0.098161.076
180_L183_H0.098141.075
89_F95_I0.097841.072
211_K219_G0.097681.070
95_I99_L0.097331.067
215_G244_P0.096981.063
15_S19_G0.096891.062
179_A189_L0.096891.062
58_L82_F0.096731.060
44_F174_L0.096511.058
44_F312_L0.095981.052
180_L302_K0.095551.047
211_K277_F0.095521.047
215_G218_L0.095261.044
153_H161_H0.095261.044
211_K239_F0.095141.043
305_G308_I0.095091.042
96_E171_I0.094411.035
159_S162_D0.094351.034
59_P63_E0.093911.029
184_S211_K0.093831.028
51_G314_A0.09351.025
98_I241_L0.093491.025
180_L214_E0.093341.023
174_L225_A0.093131.021
206_A209_L0.093121.020
189_L246_G0.092521.014
41_L60_E0.092491.014
40_L301_L0.092381.012
193_A269_L0.092121.010
52_T243_T0.091951.008
193_A217_A0.091881.007
218_L239_F0.091881.007
38_L48_V0.09171.005
43_A53_A0.091641.004
48_V313_M0.091431.002
53_A191_I0.091130.999
54_F292_N0.091110.998
96_E281_A0.091070.998
152_S160_H0.0910.997
88_G92_F0.090840.995
200_G219_G0.090670.994
211_K276_T0.090570.993
187_E243_T0.09050.992
158_H165_S0.090350.990
281_A284_E0.090270.989
20_L23_L0.090120.988
12_F244_P0.089980.986
89_F278_L0.089940.986
63_E91_L0.089930.986
183_H187_E0.089740.983
93_F97_R0.089310.979
187_E193_A0.089260.978
76_H88_G0.089110.977
22_P239_F0.088880.974
69_G205_I0.088430.969
289_E302_K0.088380.969
42_N209_L0.088280.967
95_I178_I0.087820.962
266_S272_F0.087720.961
16_L240_S0.08760.960
90_L294_H0.087570.960
163_D166_G0.087570.960
49_L59_P0.087540.959
14_V17_L0.08740.958
94_F303_F0.087360.957
91_L268_I0.087330.957
304_L311_L0.087270.956
105_H111_H0.087250.956
200_G213_P0.087130.955
44_F47_G0.087080.954
112_D158_H0.087050.954
61_A267_G0.087040.954
96_E279_Y0.08670.950
240_S265_V0.086610.949
183_H210_H0.086490.948
85_F88_G0.086440.947
213_P219_G0.086430.947
87_V94_F0.085790.940
59_P82_F0.085780.940
33_L50_L0.085630.938
52_T203_L0.085510.937
162_D166_G0.085480.937
111_H160_H0.085420.936
20_L233_L0.085240.934
159_S165_S0.085150.933
165_S304_L0.08490.930
90_L306_F0.084760.929
182_I286_L0.08470.928
8_I248_L0.084470.926
184_S215_G0.084430.925
153_H163_D0.084360.924
48_V52_T0.08430.924
56_H277_F0.084070.921
15_S45_A0.084050.921
186_F272_F0.083810.918
16_L61_A0.08370.917
192_G196_S0.083660.917
46_A179_A0.08350.915
248_L252_A0.083470.915
172_R222_L0.083460.915
10_A20_L0.083380.914
152_S164_K0.083370.914
89_F282_F0.083220.912
112_D161_H0.083150.911
308_I315_L0.083110.911
299_R303_F0.083080.910
49_L187_E0.0830.910
52_T277_F0.082840.908
215_G221_I0.082840.908
214_E244_P0.082820.908
211_K221_I0.082810.907
78_Y93_F0.082790.907
93_F217_A0.082640.906
52_T280_V0.082580.905
48_V273_A0.082570.905
167_V315_L0.082510.904
178_I312_L0.082480.904
99_L191_I0.082470.904
65_L68_S0.082430.903
17_L229_K0.082370.903
186_F193_A0.08220.901
176_L218_L0.082180.901
290_F299_R0.082130.900
10_A103_F0.08210.900
184_S200_G0.081810.897
53_A96_E0.081380.892
90_L95_I0.081370.892
214_E277_F0.081320.891
67_S70_C0.081010.888
32_R163_D0.080930.887
53_A56_H0.080920.887
205_I253_I0.080620.883
7_A204_F0.080460.882
65_L267_G0.080320.880
14_V18_G0.080240.879
64_A245_I0.080130.878
163_D311_L0.080090.878
154_S165_S0.079910.876
154_S162_D0.07990.876
238_L241_L0.079850.875
163_D205_I0.079710.874
44_F285_L0.079570.872
206_A278_L0.079510.871
178_I229_K0.079250.868
9_L18_G0.07920.868
208_I277_F0.079170.868
52_T65_L0.079150.867
217_A221_I0.079070.867
113_H154_S0.079030.866
200_G221_I0.078870.864
85_F307_L0.078870.864
177_L227_F0.078820.864
252_A315_L0.07880.864
154_S272_F0.078740.863
241_L253_I0.078670.862
187_E273_A0.078660.862
304_L307_L0.078630.862
89_F308_I0.078590.861
89_F284_E0.078470.860
159_S167_V0.078430.859
203_L206_A0.078350.859
266_S316_L0.078340.859
239_F243_T0.078320.858
175_I280_V0.07830.858
306_F309_G0.078150.856
86_L90_L0.078010.855
177_L218_L0.077990.855
83_L87_V0.077980.855
184_S204_F0.077970.854
159_S164_K0.077910.854
100_H103_F0.077910.854
294_H301_L0.077820.853
174_L315_L0.077760.852
112_D152_S0.077730.852
38_L236_L0.077720.852
112_D154_S0.077650.851
113_H164_K0.077590.850
203_L218_L0.077560.850
206_A313_M0.077440.849
270_L277_F0.077410.848
215_G239_F0.077320.847
190_A207_I0.077220.846
175_I285_L0.07720.846
160_H304_L0.077090.845
113_H160_H0.076930.843
231_K235_L0.076610.840
85_F92_F0.076490.838
17_L24_L0.076470.838
276_T285_L0.076360.837
52_T56_H0.076150.835
159_S166_G0.07610.834
11_I15_S0.076060.834
61_A316_L0.0760.833
215_G236_L0.075770.830
101_S190_A0.075630.829
187_E214_E0.075590.828
90_L93_F0.075520.828
186_F211_K0.075290.825
50_L177_L0.075140.823
286_L306_F0.075130.823
83_L93_F0.075060.823
152_S162_D0.075040.822
112_D162_D0.0750.822
91_L158_H0.074940.821
114_S163_D0.074870.820
306_F310_F0.074860.820
91_L94_F0.074830.820
177_L222_L0.074730.819
14_V26_R0.074650.818
51_G261_S0.074580.817
87_V308_I0.074560.817
309_G313_M0.074330.815
19_G219_G0.074290.814
48_V228_S0.074270.814
166_G231_K0.074240.814
160_H252_A0.074130.812
11_I22_P0.073950.810
173_A178_I0.07390.810
111_H154_S0.073890.810
89_F194_A0.073840.809
77_S153_H0.073730.808
41_L280_V0.073680.807
98_I240_S0.073670.807
18_G26_R0.073640.807
234_L237_L0.073590.806
184_S218_L0.073580.806
277_F302_K0.073370.804
176_L184_S0.073330.804
180_L184_S0.073180.802
253_I303_F0.073140.802
226_G231_K0.073040.800
88_G91_L0.072810.798
7_A11_I0.07280.798
114_S198_D0.07270.797
213_P217_A0.072690.797
112_D160_H0.072540.795
80_L294_H0.072540.795
42_N218_L0.072540.795
57_L177_L0.072530.795
230_R234_L0.072450.794
264_I304_L0.072140.791
111_H114_S0.072090.790
165_S230_R0.0720.789
253_I312_L0.071960.789
13_I252_A0.071910.788
58_L81_A0.071790.787
113_H159_S0.071760.786
152_S165_S0.071450.783
36_R260_S0.071430.783
90_L315_L0.071250.781
55_L314_A0.071250.781
15_S49_L0.071230.781
218_L240_S0.071210.780
158_H164_K0.071140.780
177_L277_F0.071110.779
35_K111_H0.07110.779
154_S164_K0.071040.779
34_N92_F0.071040.779
52_T210_H0.070890.777
223_V226_G0.070880.777
114_S160_H0.070820.776
234_L301_L0.070820.776
7_A34_N0.07080.776
43_A239_F0.070610.774
191_I235_L0.070580.773
42_N211_K0.070540.773
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4j05A0.955861.60.946
4g1uA0.48960.60.946
3b9wA0.447937.20.953
2jlnA0.410135.90.953
4djkA0.432222.60.958
2v50A0.271322.40.958
2zy9A0.189320.10.959
2xq2A0.359615.90.96
3effK0.268114.90.961
4gc0A0.451114.50.961
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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