GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Maf - Maf-like protein
Pfam: PF02545 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0269
Length: 195
Sequences: 2622
Seq/Len: 13.45
HH_delta: 0.046 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
95_K134_D1.154943.714
87_E142_E1.051773.382
77_D100_K1.013223.258
79_E96_S1.010213.249
101_T128_K1.002833.225
13_R17_K0.948513.050
91_R138_E0.868622.793
89_E92_E0.833812.681
49_A109_C0.801372.577
126_K167_E0.740762.382
30_I51_A0.719672.314
125_T173_V0.70742.275
103_Q126_K0.672052.161
128_K164_E0.66172.128
103_Q124_V0.65122.094
91_R141_V0.638632.054
50_E54_E0.638272.053
125_T172_N0.638252.053
141_V147_L0.624642.009
98_S132_L0.607651.954
133_S136_E0.597451.921
159_G162_L0.588411.892
87_E141_V0.577811.858
123_E172_N0.560461.802
128_K165_R0.555451.786
85_K89_E0.550321.770
101_T126_K0.549731.768
13_R23_F0.54721.760
176_L181_L0.545161.753
91_R137_I0.516651.662
132_L137_I0.516171.660
3_I68_I0.504821.623
8_S27_P0.490611.578
46_Q122_V0.486381.564
87_E91_R0.485321.561
98_S134_D0.482461.552
145_E157_G0.478261.538
44_Y73_V0.470211.512
123_E180_E0.468751.507
98_S131_P0.466361.500
102_H153_Y0.463931.492
14_E18_Q0.461631.485
91_R95_K0.457721.472
68_I110_L0.454651.462
90_A146_P0.453731.459
155_I174_V0.442731.424
87_E147_L0.442671.424
93_M152_G0.432591.391
53_A69_G0.431731.388
105_Y124_V0.430551.385
6_A69_G0.428021.376
76_C100_K0.425981.370
110_L184_L0.419281.348
75_V105_Y0.417661.343
170_Y174_V0.397531.278
86_D89_E0.396661.276
81_L93_M0.392761.263
90_A152_G0.386431.243
17_K23_F0.381391.227
134_D138_E0.37831.217
44_Y48_L0.377571.214
50_E109_C0.375841.209
149_K154_G0.368231.184
130_R136_E0.367931.183
13_R25_V0.358051.151
29_D55_A0.356261.146
135_E139_A0.353031.135
11_R148_D0.351731.131
130_R179_E0.349241.123
125_T166_I0.348341.120
30_I48_L0.348291.120
38_E47_R0.3471.116
141_V146_P0.344311.107
92_E96_S0.343771.106
15_L176_L0.340111.094
76_C96_S0.337951.087
119_F187_E0.336981.084
45_V107_G0.33681.083
68_I181_L0.336131.081
47_R51_A0.332351.069
108_V181_L0.331541.066
95_K137_I0.330781.064
161_Q182_C0.330141.062
97_L153_Y0.329921.061
66_I110_L0.323451.040
105_Y122_V0.322341.037
4_I26_I0.317971.023
138_E142_E0.31571.015
98_S137_I0.312451.005
97_L102_H0.31241.005
53_A111_I0.312361.005
87_E138_E0.310240.998
75_V78_G0.308370.992
128_K167_E0.308070.991
11_R156_Q0.302850.974
18_Q160_G0.301590.970
182_C186_R0.301340.969
89_E93_M0.300780.967
130_R183_K0.299810.964
8_S28_S0.299740.964
75_V103_Q0.298390.960
130_R164_E0.296070.952
42_E124_V0.293670.944
91_R134_D0.293560.944
112_N188_L0.291780.938
138_E141_V0.290760.935
70_A106_T0.290630.935
44_Y80_I0.289280.930
107_G172_N0.287640.925
14_E17_K0.287140.923
164_E183_K0.286070.920
143_S158_L0.284690.916
136_E186_R0.28450.915
72_T104_V0.28430.914
50_E120_Y0.280990.904
35_I51_A0.280390.902
145_E158_L0.280220.901
180_E184_L0.27820.895
81_L96_S0.274270.882
30_I55_A0.27090.871
45_V105_Y0.269620.867
72_T156_Q0.266790.858
43_E46_Q0.262130.843
73_V80_I0.261320.840
149_K156_Q0.259340.834
46_Q50_E0.258370.831
79_E92_E0.258340.831
119_F184_L0.257880.829
34_A44_Y0.254780.819
110_L181_L0.254660.819
166_I173_V0.253510.815
74_V104_V0.253250.814
67_V111_I0.251070.807
144_G147_L0.250920.807
184_L187_E0.250730.806
169_D179_E0.248890.800
41_P45_V0.247890.797
62_P65_A0.247160.795
108_V177_P0.247050.794
90_A141_V0.24610.791
111_I116_G0.245410.789
86_D92_E0.243370.783
51_A55_A0.241930.778
75_V80_I0.241760.777
41_P75_V0.237630.764
112_N115_K0.237470.764
11_R14_E0.236220.760
50_E118_I0.235290.757
169_D172_N0.232650.748
42_E46_Q0.23250.748
137_I141_V0.232330.747
68_I176_L0.231540.745
109_C120_Y0.230510.741
45_V73_V0.230340.741
74_V81_L0.22940.738
108_V184_L0.229040.737
132_L162_L0.2290.736
54_E118_I0.227370.731
15_L178_L0.226710.729
69_G111_I0.226280.728
39_S43_E0.224820.723
16_L68_I0.223270.718
181_L184_L0.222910.717
16_L23_F0.222180.715
5_L9_S0.219470.706
9_S12_R0.218990.704
11_R149_K0.218630.703
184_L188_L0.218320.702
26_I60_L0.218260.702
4_I65_A0.218260.702
94_L152_G0.217840.701
45_V80_I0.217760.700
153_Y163_I0.216930.698
69_G109_C0.216810.697
134_D137_I0.215750.694
82_G150_A0.214860.691
127_V163_I0.213840.688
109_C118_I0.212790.684
72_T149_K0.212410.683
34_A80_I0.209820.675
15_L18_Q0.209140.673
160_G179_E0.206860.665
139_A142_E0.206440.664
104_V156_Q0.206020.663
35_I47_R0.20420.657
50_E111_I0.203640.655
34_A51_A0.202710.652
73_V82_G0.202310.651
171_S179_E0.200510.645
48_L51_A0.200060.643
63_D114_D0.199230.641
5_L12_R0.198250.638
19_L182_C0.198250.638
149_K153_Y0.19770.636
144_G157_G0.197190.634
11_R72_T0.196880.633
82_G93_M0.196530.632
49_A69_G0.195310.628
82_G152_G0.194860.627
31_D48_L0.194090.624
51_A54_E0.193790.623
4_I57_V0.192670.620
48_L69_G0.192280.618
104_V149_K0.191950.617
88_E92_E0.190920.614
113_P116_G0.190820.614
34_A47_R0.190530.613
116_G119_F0.189310.609
110_L188_L0.18890.607
160_G163_I0.188740.607
17_K22_N0.188730.607
3_I21_I0.18770.604
44_Y47_R0.186370.599
171_S174_V0.186020.598
125_T168_G0.185070.595
7_S12_R0.184870.595
85_K148_D0.184820.594
8_S30_I0.183830.591
99_G131_P0.183750.591
88_E91_R0.183670.591
171_S178_L0.182910.588
11_R104_V0.182650.587
74_V94_L0.182320.586
28_S55_A0.182110.586
26_I61_Y0.18150.584
28_S48_L0.181480.584
125_T174_V0.181140.583
155_I173_V0.180880.582
15_L174_V0.180650.581
68_I108_V0.18010.579
54_E111_I0.179880.578
76_C97_L0.178930.575
107_G122_V0.178130.573
154_G163_I0.177510.571
31_D35_I0.17640.567
20_G143_S0.176290.567
57_V111_I0.175490.564
77_D96_S0.175340.564
54_E116_G0.175040.563
160_G178_L0.174850.562
135_E138_E0.173630.558
129_F159_G0.172590.555
139_A143_S0.172530.555
46_Q120_Y0.172490.555
8_S29_D0.172280.554
61_Y65_A0.171180.551
153_Y156_Q0.170850.549
42_E103_Q0.169420.545
158_L161_Q0.169370.545
11_R74_V0.168440.542
142_E147_L0.168310.541
117_Q184_L0.167940.540
41_P80_I0.167310.538
119_F188_L0.167040.537
169_D180_E0.166440.535
113_P118_I0.166290.535
16_L178_L0.165880.533
74_V102_H0.165710.533
70_A108_V0.165220.531
104_V127_V0.164590.529
70_A172_N0.16430.528
84_P93_M0.163680.526
154_G162_L0.163570.526
3_I66_I0.163570.526
74_V93_M0.162790.524
18_Q171_S0.161820.520
84_P146_P0.16160.520
145_E159_G0.160490.516
44_Y82_G0.160470.516
55_A59_K0.159750.514
53_A109_C0.159230.512
98_S129_F0.159170.512
72_T154_G0.157920.508
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2p5xA0.99491000.046
1ex2A0.9591000.049
2amhA0.9591000.06
4jhcA0.97951000.085
4bnqA0.871890.70.927
1v7rA0.846289.30.929
3tquA0.866784.10.934
1vp2A0.856481.60.936
2z0fA0.907778.60.938
1b78A0.84178.30.938

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