GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
CobS - Cobalamin-5-phosphate synthase
Pfam: PF02654 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 235
Sequences: 1263
Seq/Len: 5.37
HH_delta: 0.969 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
90_R93_E0.505844.437
91_R211_R0.38283.358
84_S94_I0.342453.004
79_A107_A0.326732.866
92_L216_T0.314032.755
76_A108_L0.304192.668
75_L111_V0.298152.615
8_L28_F0.293022.570
142_M224_I0.292282.564
60_L116_Y0.272722.392
69_G106_L0.270892.376
76_A104_G0.26442.319
39_A63_W0.262752.305
5_L34_L0.260642.286
208_A219_V0.257422.258
152_R216_T0.250262.195
42_V62_L0.244462.144
64_V110_L0.239482.101
134_A231_F0.233612.049
81_G95_M0.233482.048
138_A224_I0.226181.984
100_I105_V0.213091.869
115_K225_E0.206661.813
111_V229_L0.201961.772
78_T219_V0.200981.763
100_I104_G0.1991.746
55_A59_A0.196861.727
2_R14_P0.193811.700
86_R90_R0.192471.688
82_L212_L0.191621.681
61_A110_L0.191621.681
95_M216_T0.18881.656
82_L91_R0.188451.653
113_L116_Y0.185211.625
9_T35_I0.184961.622
35_I66_L0.183651.611
39_A59_A0.182621.602
57_V113_L0.179281.573
72_L225_E0.17891.569
92_L152_R0.178091.562
7_F70_L0.175351.538
78_T82_L0.172631.514
75_L107_A0.171021.500
115_K228_E0.165861.455
111_V225_E0.164921.447
57_V114_L0.163971.438
75_L79_A0.159751.401
146_A220_L0.158561.391
43_A59_A0.158061.386
6_S13_V0.154011.351
53_P116_Y0.151931.333
200_L230_A0.150861.323
135_P225_E0.150661.322
109_V112_L0.148351.301
102_A106_L0.147971.298
145_L223_T0.147831.297
76_A100_I0.146871.288
165_K168_Q0.14641.284
215_I219_V0.143311.257
58_L233_L0.143111.255
81_G98_S0.143061.255
158_A162_G0.142571.251
196_V234_A0.142521.250
88_R91_R0.136871.201
4_A24_S0.136061.193
84_S103_F0.135281.187
99_R102_A0.135241.186
8_L31_V0.134391.179
84_S91_R0.13341.170
103_F215_I0.133231.169
140_L173_L0.132791.165
36_G40_A0.131731.156
75_L226_L0.131451.153
63_W220_L0.130631.146
54_L118_A0.130111.141
135_P228_E0.129541.136
35_I135_P0.129411.135
149_S220_L0.128441.127
149_S209_R0.128051.123
134_A232_L0.127871.122
8_L142_M0.127081.115
82_L219_V0.126811.112
24_S28_F0.126081.106
72_L84_S0.125591.102
7_F68_G0.123861.086
100_I108_L0.123561.084
25_L146_A0.123341.082
58_L114_L0.123221.081
83_F103_F0.123131.080
98_S102_A0.123021.079
72_L108_L0.122561.075
115_K229_L0.122461.074
206_R209_R0.118971.044
215_I220_L0.117651.032
70_L86_R0.117631.032
9_T13_V0.117611.032
106_L112_L0.117541.031
204_L223_T0.11731.029
3_S6_S0.117211.028
204_L208_A0.116371.021
88_R92_L0.11631.020
102_A105_V0.114981.009
72_L157_G0.114081.001
7_F97_D0.114041.000
4_A8_L0.113460.995
32_G36_G0.112760.989
86_R94_I0.112150.984
63_W135_P0.111850.981
196_V199_L0.111560.979
91_R212_L0.111360.977
38_L195_L0.111080.974
153_P158_A0.110980.973
149_S205_A0.110540.970
157_G225_E0.110210.967
57_V116_Y0.110190.967
115_K139_R0.109750.963
8_L24_S0.109710.962
139_R224_I0.108270.950
66_L195_L0.108240.949
200_L204_L0.107390.942
152_R155_G0.107260.941
155_G225_E0.106090.931
69_G103_F0.104740.919
205_A209_R0.103830.911
64_V106_L0.103530.908
68_G115_K0.10350.908
51_P54_L0.103330.906
138_A228_E0.103070.904
86_R91_R0.102820.902
84_S87_D0.102790.902
146_A157_G0.102510.899
9_T135_P0.102410.898
3_S24_S0.102380.898
153_P157_G0.102360.898
151_P208_A0.101940.894
8_L85_G0.10140.889
111_V115_K0.101110.887
173_L195_L0.1010.886
4_A139_R0.100980.886
143_L172_A0.100610.883
77_D217_G0.100390.881
109_V113_L0.099790.875
64_V112_L0.099670.874
118_A229_L0.099630.874
96_K152_R0.098420.863
38_L62_L0.097990.860
7_F21_F0.097840.858
207_Y212_L0.097750.857
156_L159_L0.097720.857
35_I67_T0.097240.853
68_G97_D0.097180.852
5_L145_L0.096690.848
53_P120_S0.096480.846
138_A141_S0.096290.845
138_A227_G0.096270.844
227_G231_F0.096020.842
64_V69_G0.096010.842
149_S215_I0.095740.840
84_S98_S0.095350.836
105_V109_V0.095250.836
35_I63_W0.094760.831
69_G108_L0.094550.829
174_I178_L0.094470.829
3_S21_F0.094460.829
56_A116_Y0.094260.827
55_A154_E0.094250.827
133_I231_F0.094120.826
34_L136_V0.093990.824
68_G146_A0.093820.823
98_S228_E0.093740.822
76_A220_L0.093670.822
10_R107_A0.093530.820
2_R5_L0.093360.819
192_L199_L0.092440.811
133_I192_L0.0920.807
83_F91_R0.091890.806
27_F30_L0.091590.803
78_T139_R0.09130.801
56_A60_L0.091270.801
35_I39_A0.091150.800
58_L226_L0.091110.799
114_L117_A0.091070.799
9_T22_A0.091030.798
181_L198_L0.090880.797
125_H128_A0.090770.796
116_Y120_S0.090480.794
40_A135_P0.090140.791
191_L199_L0.090020.790
220_L224_I0.089960.789
65_L229_L0.089850.788
176_L179_L0.089820.788
185_G210_R0.089790.788
59_A135_P0.089570.786
167_R181_L0.089130.782
97_D102_A0.089070.781
2_R6_S0.08830.775
72_L224_I0.088230.774
61_A213_G0.088150.773
82_L208_A0.088150.773
91_R219_V0.087840.771
84_S99_R0.087790.770
42_V46_L0.087760.770
43_A55_A0.087670.769
33_L136_V0.087430.767
157_G215_I0.08740.767
184_G202_L0.087350.766
69_G102_A0.087180.765
87_D90_R0.087150.764
114_L229_L0.0870.763
142_M223_T0.086710.761
10_R103_F0.086670.760
92_L95_M0.086670.760
10_R85_G0.086630.760
28_F142_M0.086630.760
135_P224_I0.086620.760
42_V120_S0.086170.756
7_F156_L0.085560.751
51_P202_L0.085540.750
33_L45_L0.085530.750
79_A222_A0.085450.750
56_A88_R0.085390.749
156_L162_G0.085310.748
83_F94_I0.085220.748
63_W228_E0.085210.747
132_L192_L0.08520.747
81_G224_I0.084910.745
40_A132_L0.084870.744
83_F86_R0.084650.743
53_P117_A0.084610.742
122_L174_I0.084610.742
60_L63_W0.084440.741
41_L125_H0.08440.740
39_A135_P0.084370.740
84_S135_P0.084180.738
84_S93_E0.084140.738
76_A105_V0.084040.737
4_A31_V0.084010.737
14_P28_F0.083860.736
91_R208_A0.083720.734
53_P179_L0.083720.734
144_L227_G0.083140.729
7_F90_R0.083080.729
3_S7_F0.083060.729
105_V108_L0.082860.727
115_K135_P0.08270.725
76_A91_R0.082620.725
37_L234_A0.082510.724
146_A149_S0.08240.723
61_A109_V0.081950.719
78_T102_A0.081940.719
146_A161_V0.081640.716
201_A205_A0.081340.713
208_A215_I0.08130.713
57_V112_L0.081150.712
174_I181_L0.080810.709
120_S196_V0.080620.707
91_R103_F0.080610.707
11_I34_L0.080530.706
97_D228_E0.080420.705
76_A102_A0.080360.705
156_L160_F0.080310.704
4_A28_F0.080090.703
82_L211_R0.080060.702
6_S160_F0.079920.701
83_F211_R0.079560.698
132_L223_T0.079450.697
36_G146_A0.079330.696
2_R13_V0.079310.696
18_E90_R0.079160.694
78_T216_T0.079140.694
72_L232_L0.079130.694
94_I137_L0.079120.694
9_T108_L0.078920.692
72_L112_L0.078830.691
98_S146_A0.078740.691
78_T208_A0.078680.690
135_P139_R0.078660.690
40_A61_A0.078610.690
70_L74_G0.078540.689
132_L136_V0.078450.688
155_G160_F0.078390.688
95_M225_E0.078230.686
166_K171_I0.078070.685
85_G103_F0.078050.685
134_A138_A0.078050.685
124_S202_L0.0780.684
36_G114_L0.077940.684
167_R171_I0.077840.683
81_G172_A0.077780.682
63_W115_K0.07770.682
31_V34_L0.07770.682
94_I98_S0.077410.679
145_L226_L0.077230.677
8_L143_L0.07720.677
206_R210_R0.077190.677
7_F99_R0.07710.676
9_T67_T0.077030.676
95_M219_V0.076980.675
94_I103_F0.076930.675
156_L161_V0.076910.675
8_L70_L0.076780.673
200_L203_L0.076690.673
51_P121_S0.076680.673
38_L206_R0.076620.672
173_L193_A0.076580.672
70_L228_E0.076470.671
59_A119_L0.076470.671
178_L206_R0.076310.669
4_A36_G0.076170.668
22_A27_F0.076160.668
79_A103_F0.076150.668
127_L195_L0.076120.668
35_I220_L0.0760.667
13_V206_R0.0760.667
90_R222_A0.075980.666
67_T88_R0.075910.666
78_T83_F0.075880.666
224_I227_G0.075790.665
10_R68_G0.075770.665
138_A219_V0.075470.662
37_L210_R0.075350.661
181_L184_G0.07530.661
88_R213_G0.075230.660
95_M152_R0.075140.659
167_R192_L0.075070.658
150_K161_V0.075010.658
117_A120_S0.074990.658
5_L11_I0.074890.657
79_A215_I0.074770.656
42_V178_L0.074760.656
191_L195_L0.074750.656
183_L189_I0.074650.655
6_S10_R0.074570.654
223_T227_G0.074450.653
123_P126_G0.074380.652
133_I193_A0.074350.652
117_A229_L0.074290.652
11_I88_R0.073830.648
81_G215_I0.073760.647
6_S9_T0.073740.647
36_G132_L0.073720.647
11_I169_V0.073680.646
33_L219_V0.073460.644
65_L107_A0.073430.644
83_F104_G0.073240.642
4_A228_E0.073220.642
86_R98_S0.073010.640
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2jttC0.14893.30.969
2imlA0.25532.30.971
3l1lA0.34472.10.971
3mp7B0.212820.972
4j5uA0.25111.90.972
2wwbB0.22981.80.972
2akhX0.32771.80.973
3b4rA0.34891.70.973
1btqA0.11061.70.973
2lomA0.13191.60.973
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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