GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
GST_N - Glutathione S-transferase N-terminal domain
Pfam: PF02798 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0172
Length: 76
Sequences: 14253
Seq/Len: 187.54
HH_delta: -0.064 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
57_E63_V2.267552.738
4_T29_V2.262992.733
19_L26_Y2.240282.705
20_A26_Y1.82172.200
44_L51_G1.808112.183
22_K75_A1.723522.081
58_D73_Y1.599191.931
4_T27_E1.577881.905
7_N12_S1.556361.879
58_D62_F1.475961.782
18_L71_L1.43611.734
41_P45_A1.35911.641
15_I71_L1.316781.590
7_N28_D1.200291.449
4_T57_E1.197521.446
18_L22_K1.195731.444
16_R28_D1.17821.423
43_F46_I1.175991.420
42_E45_A1.168761.411
11_R14_R1.148031.386
16_R20_A1.122061.355
57_E61_G1.105941.335
52_K66_E1.041821.258
14_R67_S1.027471.241
49_M65_T1.011561.221
46_I55_A0.99391.200
69_A72_R0.991361.197
46_I57_E0.960181.159
6_Y31_V0.954331.152
32_D35_K0.943551.139
41_P44_L0.930661.124
18_L75_A0.911551.101
3_L56_L0.905981.094
3_L24_V0.893191.079
49_M52_K0.879461.062
17_L21_E0.865781.045
43_F55_A0.862981.042
39_K51_G0.851841.029
43_F47_N0.843581.019
14_R71_L0.842561.017
46_I63_V0.841131.016
55_A63_V0.826270.998
47_N55_A0.813740.983
15_I67_S0.803430.970
7_N16_R0.763030.921
13_E17_L0.751060.907
6_Y57_E0.718010.867
14_R68_N0.716420.865
56_L70_I0.702350.848
15_I70_I0.701860.847
59_G62_F0.68390.826
72_R75_A0.674390.814
55_A65_T0.670790.810
32_D38_H0.666890.805
5_L16_R0.664440.802
4_T9_R0.662730.800
5_L19_L0.662470.800
22_K74_L0.650540.786
42_E46_I0.64620.780
31_V53_V0.644040.778
13_E16_R0.642890.776
14_R17_L0.641560.775
12_S53_V0.620060.749
64_L73_Y0.614980.743
9_R30_R0.613510.741
5_L28_D0.609860.736
64_L70_I0.593350.716
34_E38_H0.592790.716
11_R52_K0.589170.711
10_G13_E0.584230.705
12_S16_R0.578920.699
71_L75_A0.570670.689
19_L74_L0.569320.687
35_K38_H0.567890.686
11_R67_S0.558490.674
68_N71_L0.53350.644
17_L20_A0.533150.644
40_S44_L0.528330.638
8_G30_R0.51420.621
19_L24_V0.513560.620
56_L74_L0.51160.618
7_N30_R0.508330.614
4_T7_N0.498040.601
8_G33_F0.47170.570
39_K42_E0.468850.566
11_R15_I0.464590.561
16_R26_Y0.456680.551
68_N72_R0.452020.546
47_N65_T0.448550.542
18_L74_L0.448090.541
5_L12_S0.440280.532
48_P51_G0.437790.529
8_G32_D0.437650.528
8_G53_V0.434430.525
5_L9_R0.430030.519
40_S51_G0.429450.519
15_I19_L0.429140.518
66_E69_A0.423240.511
35_K40_S0.414910.501
30_R34_E0.414130.500
33_F39_K0.408320.493
8_G34_E0.40710.492
12_S28_D0.405430.490
23_G27_E0.405130.489
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4gltA0.947499.4-0.064
3vk9A0.973799.4-0.04
4jbbA0.973799.4-0.034
4igjA0.986899.4-0.023
4akgA0.973799.3-0.012
4hi7A0.973799.3-0.003
4hojA0.934299.3-0.001
3f6dA0.986899.30.001
4gf0A0.973799.30.001
3m8nA0.986899.30.008

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