GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
NMT_C - Myristoyl-CoAprotein N-myristoyltransferase C-terminal domain
Pfam: PF02799 (v26) Consensus Sequence
Length: 190
Sequences: 1979
Seq/Len: 10.42
HH_delta: 0.316 (11Mar13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
32_R38_D0.792634.750
145_A155_L0.753194.513
132_L160_F0.490752.941
156_E162_P0.436772.617
40_P61_E0.403222.416
125_K157_D0.373912.241
153_S156_E0.34932.093
91_F131_A0.348392.088
162_P165_G0.329381.974
155_L160_F0.316851.899
135_A143_F0.314091.882
32_R81_E0.312541.873
142_V163_G0.305161.829
133_I137_N0.297381.782
147_D155_L0.292761.754
93_F135_A0.292541.753
44_K48_K0.292261.751
163_G167_L0.279071.672
41_Q86_K0.273361.638
88_T122_T0.271031.624
34_M42_V0.270671.622
39_V61_E0.266081.594
132_L143_F0.265471.591
127_L136_K0.258411.548
45_L87_I0.252481.513
79_V87_I0.250521.501
124_L127_L0.248551.489
147_D151_N0.248451.489
44_K86_K0.248351.488
48_K119_A0.246441.477
130_D133_I0.239891.438
61_E65_E0.238231.428
48_K120_T0.236921.420
86_K121_S0.23221.391
135_A140_F0.228421.369
89_D118_V0.228221.368
41_Q87_I0.225451.351
49_Y52_K0.224641.346
28_T126_Q0.224091.343
60_S63_E0.221711.329
43_T61_E0.207171.241
124_L154_F0.202031.211
30_G85_G0.199651.196
86_K122_T0.194621.166
153_S157_D0.194231.164
126_Q130_D0.191741.149
126_Q136_K0.190361.141
127_L130_D0.190131.139
164_D167_L0.189341.135
77_S80_V0.188261.128
112_A117_Y0.187381.123
125_K129_N0.186511.118
90_F117_Y0.18391.102
36_E65_E0.183051.097
40_P44_K0.180691.083
112_A155_L0.180681.083
64_V67_W0.177651.065
126_Q129_N0.174311.045
154_F160_F0.17431.044
142_V164_D0.173571.040
42_V64_V0.171851.030
119_A123_R0.169271.014
82_D86_K0.169091.013
39_V68_F0.169021.013
81_E87_I0.167541.004
125_K158_L0.166010.995
149_M165_G0.164760.987
82_D88_T0.162650.975
118_V123_R0.161980.971
86_K119_A0.161690.969
81_E85_G0.161590.968
128_M158_L0.160860.964
152_K156_E0.159090.953
77_S81_E0.156910.940
36_E69_L0.156480.938
145_A160_F0.155010.929
120_T123_R0.1550.929
49_Y123_R0.15450.926
95_S140_F0.152910.916
144_N163_G0.152820.916
28_T130_D0.152750.915
127_L134_L0.152030.911
60_S65_E0.151480.908
78_Y81_E0.151390.907
166_Q169_Y0.151060.905
85_G139_G0.150250.900
53_F146_L0.148920.892
26_P29_P0.147910.886
62_E65_E0.147620.885
154_F158_L0.14710.881
65_E69_L0.146190.876
118_V124_L0.145520.872
93_F143_F0.145130.870
80_V127_L0.144360.865
119_A122_T0.14390.862
147_D160_F0.143560.860
154_F157_D0.141850.850
128_M154_F0.138290.829
156_E161_G0.138180.828
132_L158_L0.137220.822
34_M90_F0.137160.822
51_K54_D0.137160.822
161_G165_G0.135570.812
42_V148_L0.135390.811
51_K55_L0.135310.811
45_L93_F0.133650.801
43_T63_E0.133290.799
124_L155_L0.132110.792
39_V43_T0.131140.786
130_D134_L0.131060.785
38_D42_V0.130670.783
93_F140_F0.130010.779
112_A154_F0.129850.778
31_L130_D0.129740.777
48_K121_S0.129610.777
127_L131_A0.128060.767
171_L174_W0.1280.767
34_M38_D0.127520.764
66_H69_L0.125120.750
148_L151_N0.125120.750
30_G69_L0.124770.748
46_L90_F0.12460.747
76_Y80_V0.124160.744
134_L138_E0.123620.741
49_Y111_A0.122790.736
41_Q44_K0.122430.734
110_K140_F0.122190.732
64_V112_A0.122090.732
32_R35_E0.120870.724
69_L139_G0.120460.722
50_L53_F0.119540.716
58_V64_V0.119350.715
142_V167_L0.119280.715
89_D124_L0.119050.713
143_F147_D0.118950.713
52_K57_P0.118470.710
73_N139_G0.118110.708
141_D168_N0.117840.706
34_M84_E0.117230.702
39_V147_D0.116470.698
129_N132_L0.115630.693
145_A148_L0.115530.692
72_E161_G0.115140.690
61_E156_E0.113030.677
166_Q172_Y0.112970.677
59_F63_E0.11280.676
49_Y53_F0.111920.671
64_V79_V0.111770.670
93_F110_K0.111260.667
29_P89_D0.111250.667
30_G66_H0.11090.665
52_K55_L0.110450.662
128_M160_F0.110420.662
30_G35_E0.110270.661
40_P43_T0.109810.658
138_E143_F0.108660.651
33_P36_E0.10840.650
43_T60_S0.108280.649
27_K71_R0.108220.648
72_E75_I0.107830.646
37_K86_K0.107570.645
39_V64_V0.107440.644
85_G105_K0.106650.639
43_T64_V0.106260.637
143_F160_F0.106250.637
142_V170_Y0.106150.636
26_P70_P0.105750.634
94_Y117_Y0.105640.633
58_V74_V0.105010.629
138_E153_S0.1050.629
39_V42_V0.104410.626
129_N133_I0.104070.624
84_E129_N0.103770.622
45_L77_S0.103750.622
40_P121_S0.10370.621
123_R157_D0.1030.617
134_L137_N0.102910.617
35_E44_K0.102840.616
65_E81_E0.10270.615
55_L67_W0.10250.614
27_K154_F0.102210.612
85_G138_E0.10220.612
128_M155_L0.102040.611
125_K128_M0.101650.609
126_Q135_A0.101550.609
142_V169_Y0.101510.608
126_Q134_L0.101360.607
49_Y117_Y0.1010.605
141_D163_G0.100940.605
126_Q132_L0.100560.603
129_N139_G0.100320.601
78_Y130_D0.099920.599
40_P152_K0.099680.597
67_W74_V0.099560.597
110_K117_Y0.099510.596
79_V146_L0.099420.596
27_K139_G0.099330.595
139_G171_L0.099310.595
75_I79_V0.09890.593
53_F57_P0.098870.592
44_K138_E0.098250.589
28_T133_I0.09820.588
64_V148_L0.098190.588
111_A117_Y0.098190.588
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1rxtA0.989599.80.316
3iu1A0.989599.80.328
1iicA199.80.337
2wuuA0.984299.80.342
4b14A0.984299.80.342
1iykA199.80.346
1vhsA0.805399.60.449
2jlmA0.847499.60.452
3i9sA0.905399.60.457
3r9fA0.889599.60.458

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