GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7tm_6 - 7tm Odorant receptor
Pfam: PF02949 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0176
Length: 313
Sequences: 1699
Seq/Len: 5.43
HH_delta: 0.946 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
111_S115_Y0.285714.083
112_P115_Y0.268353.835
151_D255_E0.228123.260
153_L185_L0.208792.984
182_H186_L0.203722.911
250_Q254_D0.203082.902
293_T296_G0.186492.665
21_K136_D0.184932.643
243_F305_F0.177742.540
79_F83_P0.163512.337
150_F290_V0.162672.325
136_D241_Q0.147332.105
273_R277_K0.146862.099
149_Q181_R0.145832.084
83_P87_P0.144232.061
157_L282_M0.144112.059
273_R276_R0.137481.965
105_F117_T0.136061.944
246_C249_G0.130791.869
235_L292_L0.123311.762
193_E293_T0.121381.735
309_L312_S0.118351.691
156_R181_R0.118081.687
31_K191_K0.11621.661
158_E265_S0.116131.660
203_Q207_S0.114681.639
263_I283_L0.114021.629
193_E212_C0.112731.611
286_S289_P0.111751.597
179_I278_L0.11081.583
56_K60_R0.109541.565
172_R278_L0.109431.564
308_I312_S0.108921.557
283_L287_Q0.105181.503
281_I284_M0.104091.488
180_K183_Q0.103241.475
260_A283_L0.102531.465
112_P116_I0.102331.462
98_P118_Y0.101991.458
157_L178_C0.101441.450
207_S211_I0.100641.438
201_L297_F0.099791.426
193_E296_G0.098051.401
146_I188_F0.097871.399
21_K203_Q0.097131.388
55_F59_Y0.096221.375
97_L121_Q0.095951.371
42_L145_H0.094871.356
150_F185_L0.094821.355
298_F304_T0.093921.342
271_W275_N0.093581.337
251_E254_D0.093291.333
172_R274_K0.093111.331
179_I182_H0.093011.329
305_F309_L0.092891.327
291_K299_P0.092751.325
143_L252_L0.092221.318
259_I282_M0.091871.313
51_D156_R0.091521.308
154_Q258_E0.090471.293
148_G152_I0.088531.265
190_E288_K0.088021.258
197_S212_C0.087791.255
146_I185_L0.087631.252
186_L285_R0.085781.226
208_S235_L0.085441.221
201_L295_G0.084981.214
67_F71_F0.084781.212
250_Q302_L0.083571.194
42_L149_Q0.083491.193
239_L305_F0.082761.183
175_L179_I0.082591.180
149_Q152_I0.082261.176
243_F247_Y0.082241.175
146_I189_V0.081831.169
304_T310_K0.081791.169
308_I311_T0.08171.168
34_E56_K0.081551.165
294_A298_F0.080621.152
259_I286_S0.080461.150
23_I27_L0.080361.148
43_Y145_H0.080321.148
256_S285_R0.080221.146
272_S276_R0.079711.139
176_K180_K0.079711.139
150_F256_S0.079631.138
256_S290_V0.079171.131
37_D71_F0.0791.129
277_K281_I0.078351.120
149_Q275_N0.07831.119
157_L262_A0.078171.117
6_I217_Q0.077611.109
52_R59_Y0.077231.104
31_K34_E0.076941.100
38_K187_R0.076911.099
156_R177_E0.076741.097
225_S228_I0.076481.093
154_Q255_E0.07631.090
52_R56_K0.075761.083
136_D234_Y0.07561.080
139_F196_F0.075321.076
97_L102_P0.07511.073
200_F217_Q0.074651.067
160_L173_E0.074041.058
253_I301_S0.073511.051
54_I57_I0.073331.048
149_Q153_L0.073271.047
200_F245_Y0.073131.045
256_S301_S0.073061.044
50_E159_N0.073021.044
274_K294_A0.072891.042
147_C255_E0.072871.041
38_K184_R0.07271.039
250_Q253_I0.072661.038
272_S275_N0.072261.033
136_D203_Q0.072141.031
14_T203_Q0.072021.029
246_C305_F0.071961.028
102_P106_D0.071881.027
242_L308_I0.071731.025
295_G300_L0.071721.025
54_I218_I0.07161.023
261_D264_Y0.071441.021
267_P270_N0.071391.020
181_R185_L0.070461.007
205_L213_F0.070351.005
122_V190_E0.070031.001
179_I282_M0.070011.001
300_L304_T0.069991.000
52_R57_I0.069880.999
247_Y251_E0.069850.998
306_T312_S0.069390.992
21_K241_Q0.069260.990
30_K280_L0.069220.989
201_L205_L0.069210.989
140_I300_L0.069070.987
146_I192_L0.068920.985
281_I287_Q0.068740.982
16_I23_I0.068640.981
149_Q185_L0.068620.981
176_K281_I0.06840.978
172_R176_K0.068360.977
212_C312_S0.068330.977
163_D174_E0.068060.973
299_P304_T0.0680.972
81_I233_M0.067850.970
46_C196_F0.067780.969
189_V256_S0.067590.966
71_F75_M0.067530.965
282_M285_R0.067530.965
199_I209_L0.067280.961
72_Y76_S0.067020.958
30_K168_D0.067020.958
117_T140_I0.066910.956
139_F301_S0.066910.956
174_E177_E0.06680.955
110_S115_Y0.066770.954
248_L251_E0.066160.945
157_L185_L0.066090.944
186_L290_V0.065550.937
54_I59_Y0.065520.936
9_L26_L0.065310.933
152_I156_R0.06530.933
263_I282_M0.065250.932
288_K291_K0.065240.932
36_I138_L0.06510.930
97_L203_Q0.064930.928
145_H249_G0.064810.926
281_I288_K0.064810.926
31_K194_D0.064650.924
274_K278_L0.064450.921
218_I234_Y0.064420.921
157_L263_I0.064380.920
34_E191_K0.064160.917
73_I76_S0.063910.913
177_E180_K0.063880.913
135_F263_I0.063760.911
71_F233_M0.063580.909
275_N294_A0.063540.908
238_M250_Q0.063520.908
34_E173_E0.063520.908
264_Y268_W0.06350.907
35_L307_S0.063450.907
258_E261_D0.063230.904
52_R55_F0.062950.900
306_T310_K0.062790.897
252_L296_G0.062580.894
71_F190_E0.062520.893
99_Y125_M0.062330.891
232_F237_A0.062310.890
106_D157_L0.062260.890
153_L290_V0.062230.889
259_I262_A0.062060.887
285_R288_K0.061880.884
278_L282_M0.061840.884
73_I204_F0.061830.884
30_K258_E0.061790.883
35_L130_F0.061780.883
284_M287_Q0.061570.880
175_L278_L0.061530.879
150_F259_I0.061530.879
159_N174_E0.061340.877
135_F215_L0.061330.876
113_P117_T0.061290.876
36_I190_E0.061160.874
38_K191_K0.060990.872
287_Q290_V0.060860.870
254_D277_K0.060830.869
302_L305_F0.060780.869
14_T125_M0.060780.869
14_T35_L0.060720.868
114_Y121_Q0.06070.867
217_Q294_A0.060690.867
241_Q248_L0.060570.866
13_L122_V0.060530.865
148_G295_G0.06050.865
84_L280_L0.060490.864
18_C281_I0.060490.864
181_R184_R0.060440.864
14_T234_Y0.060280.861
28_N31_K0.060220.861
42_L184_R0.060070.858
261_D265_S0.060.857
259_I302_L0.059810.855
260_A264_Y0.059770.854
217_Q239_L0.059740.854
158_E180_K0.05970.853
36_I196_F0.059670.853
260_A301_S0.059660.853
204_F241_Q0.059510.850
243_F246_C0.059450.850
101_I283_L0.059360.848
8_N11_M0.059360.848
129_V136_D0.059350.848
79_F87_P0.059330.848
35_L124_S0.059290.847
161_F267_P0.059280.847
298_F311_T0.059220.846
82_F153_L0.059140.845
295_G305_F0.059110.845
207_S241_Q0.059060.844
236_V239_L0.058910.842
155_R159_N0.058890.842
103_F107_W0.058840.841
264_Y279_L0.058780.840
30_K187_R0.058610.838
208_S308_I0.058590.837
203_Q234_Y0.058570.837
41_E78_F0.058470.836
97_L114_Y0.058420.835
12_L234_Y0.058380.834
39_L284_M0.058360.834
150_F189_V0.058280.833
301_S306_T0.058270.833
140_I248_L0.05820.832
6_I139_F0.058190.832
75_M78_F0.058170.831
118_Y122_V0.058150.831
193_E294_A0.05810.830
260_A286_S0.05810.830
70_I79_F0.0580.829
210_V215_L0.057950.828
194_D198_P0.057940.828
107_W209_L0.057890.827
121_Q149_Q0.057840.827
81_I122_V0.057830.826
255_E258_E0.057830.826
199_I311_T0.05780.826
76_S79_F0.057790.826
152_I301_S0.057760.825
148_G243_F0.057720.825
110_S191_K0.057570.823
155_R274_K0.057570.823
132_I242_L0.05750.822
138_L309_L0.057430.821
137_S300_L0.057370.820
185_L282_M0.057360.820
260_A287_Q0.057220.818
101_I150_F0.057210.818
156_R308_I0.05710.816
70_I78_F0.057090.816
146_I306_T0.057080.816
136_D294_A0.057030.815
29_R33_K0.057010.815
218_I254_D0.056940.814
211_I234_Y0.056890.813
56_K173_E0.056860.813
183_Q285_R0.056820.812
167_E179_I0.056630.809
257_E289_P0.056550.808
26_L123_Y0.056530.808
14_T238_M0.056480.807
34_E280_L0.056370.806
197_S293_T0.056330.805
153_L178_C0.056240.804
122_V162_E0.056190.803
5_L12_L0.056150.802
138_L214_L0.056120.802
49_E60_R0.056010.800
160_L178_C0.0560.800
37_D67_F0.055860.798
87_P118_Y0.055820.798
279_L285_R0.055810.798
119_L126_F0.055810.798
108_N277_K0.055730.796
139_F143_L0.055680.796
157_L259_I0.055580.794
97_L103_F0.055530.794
88_I190_E0.055470.793
121_Q185_L0.055260.790
137_S141_I0.055240.789
281_I285_R0.055160.788
54_I148_G0.055130.788
116_I119_L0.055120.788
34_E162_E0.055090.787
136_D196_F0.055080.787
98_P199_I0.055070.787
181_R300_L0.054990.786
10_C118_Y0.054990.786
52_R65_R0.054970.786
183_Q276_R0.054970.786
158_E262_A0.054950.785
32_L134_G0.054920.785
87_P90_S0.054880.784
98_P300_L0.054880.784
142_L191_K0.054840.784
272_S294_A0.05480.783
96_P106_D0.054780.783
17_L21_K0.054740.782
227_N230_F0.054630.781
83_P90_S0.054540.779
150_F192_L0.054450.778
292_L296_G0.054370.777
53_E57_I0.054370.777
83_P230_F0.054350.777
73_I119_L0.054280.776
291_K302_L0.054280.776
249_G308_I0.054250.775
285_R306_T0.054220.775
86_S90_S0.054210.775
76_S310_K0.054150.774
193_E197_S0.05410.773
227_N232_F0.054090.773
160_L250_Q0.054080.773
286_S306_T0.054060.773
23_I236_V0.054050.772
68_I123_Y0.054050.772
5_L15_C0.054030.772
51_D134_G0.054030.772
162_E267_P0.053970.771
163_D166_E0.053870.770
81_I92_E0.053820.769
125_M231_Y0.053720.768
98_P306_T0.05370.767
119_L265_S0.053660.767
201_L292_L0.053640.767
32_L56_K0.053620.766
193_E295_G0.053580.766
38_K41_E0.053470.764
154_Q262_A0.053430.764
263_I284_M0.053410.763
303_E308_I0.053390.763
39_L142_L0.053370.763
155_R158_E0.053360.763
33_K229_F0.053290.762
191_K195_I0.053290.762
29_R272_S0.053280.761
101_I121_Q0.053270.761
173_E194_D0.053250.761
131_I135_F0.053220.761
121_Q183_Q0.053190.760
30_K119_L0.053090.759
231_Y235_L0.053070.758
121_Q271_W0.053030.758
67_F72_Y0.052970.757
243_F261_D0.052950.757
235_L297_F0.052920.756
282_M286_S0.052890.756
125_M129_V0.052880.756
35_L155_R0.052870.756
186_L287_Q0.052850.755
97_L142_L0.052850.755
214_L249_G0.052830.755
21_K137_S0.052680.753
192_L206_S0.052660.753
53_E56_K0.052630.752
280_L287_Q0.052570.751
189_V290_V0.052570.751
21_K246_C0.052540.751
24_I123_Y0.05250.750
185_L256_S0.052470.750
21_K114_Y0.052460.750
22_L186_L0.052440.749
47_L209_L0.052390.749
98_P214_L0.052390.749
214_L255_E0.052350.748
34_E37_D0.052310.748
39_L215_L0.052290.747
159_N282_M0.052280.747
14_T312_S0.052260.747
7_E11_M0.052240.747
218_I295_G0.052190.746
37_D309_L0.052180.746
204_F304_T0.052170.746
197_S213_F0.052140.745
13_L309_L0.052070.744
273_R281_I0.052040.744
143_L295_G0.051960.743
7_E217_Q0.051870.741
242_L249_G0.051870.741
139_F200_F0.051860.741
262_A287_Q0.051840.741
40_E202_V0.051830.741
22_L126_F0.05180.740
238_M241_Q0.05180.740
185_L210_V0.051780.740
267_P291_K0.051780.740
41_E236_V0.051730.739
127_I133_I0.051710.739
197_S207_S0.051680.739
132_I197_S0.051650.738
73_I180_K0.051550.737
122_V255_E0.051540.737
264_Y302_L0.051480.736
145_H148_G0.051460.735
265_S287_Q0.051410.735
23_I254_D0.051340.734
178_C247_Y0.05120.732
8_N85_I0.051170.731
75_M79_F0.051170.731
23_I259_I0.051150.731
234_Y248_L0.05110.730
15_C189_V0.051090.730
165_S169_E0.051060.730
256_S277_K0.051030.729
293_T299_P0.051030.729
136_D242_L0.050990.729
252_L292_L0.050950.728
147_C252_L0.050950.728
78_F186_L0.05090.727
50_E53_E0.050880.727
203_Q241_Q0.050830.726
9_L12_L0.05080.726
200_F248_L0.050780.726
211_I238_M0.050770.726
280_L284_M0.050740.725
257_E261_D0.050720.725
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1hkqA0.194942.30.946
3ukmA0.6557.60.962
2kogA0.25244.10.966
4eiyA0.201340.966
3ahqA0.19173.90.966
3emlA0.20133.80.966
4aq5C0.35143.80.966
2bg9B0.30993.60.967
4aq5E0.32913.10.968
3vw7A0.194930.968
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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