GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
EcKinase - Ecdysteroid kinase
Pfam: PF02958 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0016
Length: 294
Sequences: 1542
Seq/Len: 5.24
HH_delta: 0.569 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
11_R97_D0.346244.296
31_V94_V0.340574.226
113_D116_H0.303413.765
131_S216_V0.298853.708
121_L257_L0.255623.172
122_K280_H0.253233.142
279_R283_E0.223372.772
81_C84_A0.188772.342
116_H231_Y0.187932.332
120_V222_F0.179252.224
118_E280_H0.172652.142
81_C95_L0.169152.099
125_A284_S0.165582.055
114_L273_H0.160691.994
284_S287_E0.158241.964
14_V29_L0.15511.925
280_H284_S0.153071.899
128_H281_Y0.149971.861
56_F61_L0.141191.752
120_V227_I0.138651.720
53_E57_Y0.137681.708
96_E101_K0.135851.686
114_L118_E0.135421.680
115_E118_E0.132421.643
230_K239_D0.129211.603
282_H286_V0.129041.601
122_K284_S0.128811.598
55_F59_E0.127151.578
60_L64_L0.121961.513
117_A277_L0.121511.508
246_Q264_S0.120921.500
6_L9_M0.11991.488
273_H276_E0.118251.467
105_M225_N0.117671.460
279_R282_H0.117071.453
12_V31_V0.116291.443
13_T28_S0.116261.443
11_R28_S0.11531.431
121_L280_H0.114751.424
4_N108_R0.114251.418
15_T26_P0.113751.411
123_K126_K0.112361.394
28_S97_D0.111851.388
121_L277_L0.111291.381
228_L243_I0.11121.380
113_D231_Y0.110981.377
282_H285_L0.110531.372
116_H229_F0.109651.361
121_L125_A0.107731.337
56_F248_A0.10491.302
11_R30_I0.104841.301
14_V277_L0.103941.290
201_E205_E0.102281.269
38_P42_E0.10131.257
125_A129_A0.101061.254
117_A265_L0.100321.245
114_L277_L0.100041.241
222_F242_L0.099521.235
119_L240_V0.099341.233
118_E276_E0.098681.224
50_F246_Q0.098271.219
5_Y108_R0.09761.211
117_A260_F0.096881.202
61_L78_F0.096851.202
267_P271_R0.096721.200
218_C251_G0.096041.192
265_L270_R0.094891.177
174_F178_L0.093741.163
64_L130_A0.093671.162
216_V253_P0.09341.159
9_M30_I0.093061.155
124_L222_F0.092481.148
202_R205_E0.091321.133
251_G256_D0.091211.132
4_N7_S0.09121.132
268_E272_E0.091141.131
260_F264_S0.090941.128
126_K284_S0.090751.126
98_L241_V0.08991.116
4_N12_V0.089721.113
5_Y225_N0.08931.108
54_I84_A0.087891.091
64_L127_F0.08781.089
229_F259_Y0.087341.084
63_E138_D0.086671.075
11_R99_S0.086321.071
78_F245_F0.086231.070
246_Q270_R0.086211.070
217_L250_Y0.085841.065
4_N8_D0.085731.064
127_F245_F0.085571.062
274_E278_L0.084841.053
52_R150_F0.084541.049
107_D111_G0.084471.048
223_W228_L0.083951.042
219_H243_I0.08351.036
256_D260_F0.083171.032
12_V94_V0.082571.025
85_D117_A0.082481.023
98_L129_A0.082321.021
120_V229_F0.081881.016
43_F94_V0.081841.016
97_D246_Q0.080661.001
249_R255_I0.08040.998
31_V92_V0.080370.997
52_R56_F0.080160.995
265_L269_L0.080120.994
168_E201_E0.079830.991
259_Y263_T0.079790.990
269_L273_H0.079640.988
132_W285_L0.079560.987
284_S288_T0.0790.980
94_V288_T0.078560.975
218_C254_A0.078250.971
112_L224_T0.077840.966
272_E279_R0.077790.965
112_L116_H0.077730.965
38_P227_I0.077570.963
106_G111_G0.077490.962
220_G277_L0.07740.960
119_L287_E0.077180.958
133_A137_K0.076870.954
135_E215_N0.076770.953
222_F259_Y0.076690.952
252_S255_I0.076690.952
223_W242_L0.076480.949
205_E232_D0.076470.949
32_K53_E0.075910.942
271_R285_L0.07590.942
270_R274_E0.075670.939
269_L277_L0.075210.933
145_L220_G0.075150.933
135_E250_Y0.075130.932
34_P60_L0.075110.932
209_P215_N0.074810.928
266_D269_L0.074660.926
29_L94_V0.074310.922
135_E212_E0.073930.917
57_Y93_L0.073720.915
210_S283_E0.073530.912
221_D226_N0.07350.912
4_N223_W0.073460.912
67_L274_E0.072840.904
193_E197_D0.072780.903
107_D127_F0.072630.901
221_D244_D0.072590.901
82_Y96_E0.072430.899
134_L138_D0.072430.899
227_I242_L0.072320.897
266_D278_L0.072240.896
132_W214_F0.072150.895
170_G183_P0.072110.895
249_R265_L0.071550.888
219_H281_Y0.071280.884
28_S184_E0.071230.884
247_L259_Y0.070970.881
6_L43_F0.070860.879
114_L280_H0.070850.879
128_H220_G0.070740.878
31_V86_E0.07070.877
31_V84_A0.070660.877
14_V27_L0.070650.877
108_R245_F0.070480.875
246_Q282_H0.070410.874
101_K276_E0.07040.874
7_S123_K0.07040.874
54_I58_R0.070350.873
40_R87_D0.070310.872
134_L137_K0.070230.871
271_R274_E0.070160.871
223_W259_Y0.070040.869
152_E156_R0.069880.867
62_P80_K0.069790.866
64_L134_L0.069790.866
270_R273_H0.069780.866
64_L131_S0.069690.865
63_E66_E0.069670.865
190_E272_E0.069660.864
12_V29_L0.069630.864
52_R245_F0.069530.863
132_W223_W0.069480.862
56_F132_W0.069250.859
273_H277_L0.069170.858
95_L123_K0.069140.858
258_A274_E0.068850.854
261_L274_E0.068810.854
5_Y223_W0.068720.853
6_L45_R0.068580.851
12_V189_S0.068570.851
132_W274_E0.06850.850
51_R63_E0.068410.849
33_S36_T0.068410.849
5_Y31_V0.068290.847
101_K260_F0.068040.844
15_T24_N0.067970.843
26_P178_L0.067930.843
117_A257_L0.067910.843
4_N225_N0.067770.841
122_K234_D0.067420.837
220_G259_Y0.067320.835
216_V262_Y0.06720.834
232_D287_E0.067180.834
127_F131_S0.067160.833
190_E199_F0.067130.833
120_V206_L0.067110.833
103_Y108_R0.067010.832
81_C192_L0.066910.830
7_S259_Y0.066890.830
253_P257_L0.066890.830
86_E118_E0.066770.829
7_S277_L0.066730.828
63_E173_A0.066350.823
51_R242_L0.066340.823
173_A177_S0.066290.823
5_Y8_D0.066270.822
42_E122_K0.066260.822
11_R14_V0.066160.821
56_F78_F0.066020.819
38_P43_F0.065990.819
61_L184_E0.065920.818
104_R231_Y0.065880.817
127_F134_L0.065740.816
52_R57_Y0.065630.814
276_E283_E0.065230.809
86_E96_E0.065150.808
80_K94_V0.0650.807
223_W246_Q0.064970.806
13_T100_E0.064910.805
114_L117_A0.064680.803
77_F241_V0.064530.801
54_I57_Y0.064420.799
175_I195_L0.064420.799
38_P93_L0.06440.799
114_L269_L0.063960.794
66_E115_E0.063870.793
175_I288_T0.063780.791
128_H255_I0.063770.791
169_Q176_E0.063730.791
16_Y27_L0.063630.790
120_V263_T0.063510.788
13_T26_P0.063480.788
66_E80_K0.063420.787
82_Y85_D0.063290.785
121_L124_L0.063270.785
29_L213_P0.063190.784
176_E183_P0.063150.784
108_R223_W0.063090.783
51_R86_E0.062950.781
177_S251_G0.062940.781
66_E172_K0.062870.780
125_A128_H0.062410.774
32_K57_Y0.062260.773
64_L78_F0.062140.771
111_G225_N0.061950.769
6_L49_S0.061760.766
132_W173_A0.061730.766
77_F96_E0.061550.764
123_K239_D0.061540.764
100_E240_V0.061510.763
119_L275_D0.061450.763
276_E279_R0.061150.759
178_L181_E0.061090.758
228_L242_L0.060960.756
114_L211_K0.060930.756
175_I197_D0.060910.756
95_L253_P0.060840.755
13_T23_K0.060820.755
15_T29_L0.060770.754
145_L258_A0.060710.753
13_T31_V0.060530.751
50_F223_W0.060510.751
244_D256_D0.060480.750
143_E272_E0.060460.750
64_L254_A0.060390.749
190_E283_E0.060390.749
223_W263_T0.060370.749
128_H218_C0.060310.748
127_F288_T0.060210.747
80_K232_D0.06020.747
29_L217_L0.060150.746
166_F169_Q0.060130.746
163_F242_L0.060090.746
108_R252_S0.060070.745
225_N264_S0.060060.745
85_D269_L0.059990.744
79_P279_R0.059970.744
51_R98_L0.059930.744
98_L145_L0.059930.744
108_R111_G0.059920.744
200_F217_L0.059740.741
107_D110_D0.059730.741
59_E138_D0.05950.738
172_K176_E0.05950.738
26_P82_Y0.05940.737
7_S260_F0.059390.737
4_N9_M0.059220.735
47_M285_L0.059040.733
115_E217_L0.059030.732
57_Y81_C0.058910.731
217_L251_G0.058720.729
94_V191_K0.058690.728
49_S246_Q0.058670.728
38_P87_D0.058620.727
14_V33_S0.058590.727
205_E230_K0.058550.727
25_E51_R0.058460.725
49_S223_W0.05830.723
267_P277_L0.058270.723
45_R174_F0.05820.722
245_F256_D0.058020.720
103_Y112_L0.057930.719
6_L259_Y0.057930.719
135_E217_L0.057880.718
268_E276_E0.057760.717
264_S270_R0.057730.716
25_E239_D0.05770.716
62_P252_S0.057670.716
223_W226_N0.057610.715
82_Y197_D0.05760.715
53_E219_H0.057490.713
97_D131_S0.057440.713
67_L133_A0.057270.711
79_P126_K0.057170.709
175_I204_Q0.057140.709
276_E280_H0.057090.708
93_L211_K0.057050.708
6_L123_K0.0570.707
223_W253_P0.0570.707
41_R222_F0.056970.707
57_Y246_Q0.056890.706
46_E192_L0.056750.704
121_L173_A0.056720.704
168_E205_E0.05670.704
181_E213_P0.056670.703
215_N250_Y0.056660.703
78_F278_L0.056580.702
32_K285_L0.056530.701
210_S215_N0.056520.701
127_F243_I0.05650.701
264_S269_L0.056480.701
267_P270_R0.056480.701
247_L256_D0.056480.701
5_Y246_Q0.056450.700
7_S224_T0.056430.700
82_Y231_Y0.05640.700
37_N242_L0.056390.700
243_I263_T0.056280.698
40_R249_R0.056270.698
38_P60_L0.056210.697
56_F258_A0.056210.697
6_L44_L0.05620.697
52_R276_E0.056170.697
148_G192_L0.056170.697
135_E261_L0.056160.697
96_E129_A0.056080.696
112_L281_Y0.056070.696
45_R49_S0.056010.695
118_E121_L0.055980.695
123_K240_V0.055960.694
255_I264_S0.055950.694
257_L261_L0.055920.694
118_E277_L0.05590.694
14_V212_E0.055880.693
145_L267_P0.055770.692
223_W243_I0.055760.692
39_S257_L0.055750.692
56_F273_H0.055680.691
268_E278_L0.055640.690
78_F93_L0.055590.690
121_L152_E0.055590.690
29_L88_P0.055560.689
55_F94_V0.055420.688
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2olcA0.863999.90.569
2pywA0.850399.90.628
3dxpA0.809599.80.641
3csvA0.782399.80.653
3atsA0.850399.80.655
3d1uA0.785799.80.665
3ovcA0.799399.80.666
3jr1A0.775599.70.679
3tm0A0.789199.70.683
3f7wA0.775599.70.683
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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