GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
HlyIII - Haemolysin-III related
Pfam: PF03006 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 222
Sequences: 1838
Seq/Len: 8.28
HH_delta: 0.969 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
55_F218_A0.53373.365
179_L220_C0.480333.028
6_E9_N0.427752.697
16_G215_V0.375532.368
108_W112_A0.375152.365
50_S90_G0.372182.346
148_W181_L0.371272.341
17_A52_I0.340342.146
112_A116_I0.335532.115
163_G171_W0.323372.039
212_I216_L0.314181.981
179_L216_L0.310911.960
179_L217_A0.309681.952
109_F113_F0.301521.901
24_L48_L0.299941.891
125_S139_R0.298871.884
171_W175_L0.297881.878
9_N12_T0.296571.870
144_L181_L0.293921.853
17_A56_L0.287641.813
187_Y190_R0.284121.791
10_I63_L0.281641.776
175_L179_L0.275951.740
38_P42_I0.275041.734
144_L184_A0.273721.726
108_W111_L0.26761.687
57_C79_L0.264941.670
184_A210_W0.256491.617
198_G206_S0.24561.548
89_A118_A0.243811.537
4_H7_T0.24261.529
41_Y45_L0.241591.523
75_I79_L0.234841.481
172_L220_C0.233371.471
61_Y77_L0.232761.467
25_I29_S0.230051.450
51_A218_A0.227571.435
62_H207_H0.227361.433
45_L49_L0.223231.407
52_I56_L0.220121.388
8_V208_Q0.219991.387
50_S86_L0.219821.386
189_T198_G0.219271.382
6_E12_T0.218851.380
80_D84_I0.218691.379
23_L27_L0.215011.356
50_S87_L0.212491.340
147_G177_G0.207951.311
207_H211_H0.206851.304
106_L109_F0.206851.304
105_W109_F0.205491.296
6_E207_H0.200611.265
153_P156_H0.194531.226
51_A87_L0.194341.225
47_Y51_A0.194231.225
117_L146_L0.193981.223
123_V127_F0.192451.213
12_T208_Q0.191651.208
93_T115_W0.190991.204
88_I180_Y0.190451.201
12_T212_I0.187821.184
9_N207_H0.187771.184
104_P107_G0.18721.180
100_F103_H0.186281.174
7_T11_W0.185081.167
42_I46_I0.183341.156
199_K206_S0.183321.156
39_W103_H0.182521.151
11_W15_L0.181881.147
121_G142_F0.180111.136
89_A115_W0.179571.132
83_G86_L0.179421.131
11_W14_L0.177711.120
56_L60_L0.176441.112
110_Y156_H0.176311.112
81_Y187_Y0.176271.111
158_I163_G0.175451.106
110_Y153_P0.175131.104
5_N8_V0.174951.103
21_L52_I0.174951.103
5_N208_Q0.17461.101
18_I22_A0.174081.098
109_F112_A0.173931.097
42_I45_L0.172921.090
114_I146_L0.172131.085
28_L45_L0.171841.083
43_P97_Y0.171221.079
87_L91_S0.170221.073
106_L152_I0.165591.044
174_I178_V0.164641.038
86_L122_I0.162571.025
58_S80_D0.162451.024
104_P108_W0.162141.022
189_T206_S0.160651.013
117_L142_F0.160631.013
4_H8_V0.160031.009
14_L59_T0.160021.009
47_Y180_Y0.158781.001
5_N9_N0.157480.993
103_H107_G0.157190.991
200_F208_Q0.154680.975
40_D98_Y0.153910.970
140_T210_W0.153580.968
23_L222_Y0.153460.968
9_N62_H0.153010.965
136_R206_S0.151610.956
210_W221_H0.151270.954
24_L52_I0.151160.953
175_L220_C0.150610.950
113_F149_S0.150360.948
198_G208_Q0.150090.946
129_C133_P0.149710.944
214_V217_A0.149330.941
29_S33_S0.148460.936
216_L220_C0.147690.931
75_I78_R0.147040.927
178_V182_L0.14660.924
151_I158_I0.146540.924
180_Y218_A0.146210.922
148_W177_G0.145920.920
14_L60_L0.145270.916
155_F159_F0.144790.913
26_F30_L0.144680.912
47_Y55_F0.142320.897
7_T14_L0.141860.894
78_R82_A0.140630.887
10_I14_L0.140360.885
134_R186_F0.140050.883
6_E62_H0.139450.879
22_A26_F0.139190.878
136_R187_Y0.138760.875
170_L174_I0.13780.869
5_N14_L0.137250.865
12_T62_H0.137170.865
137_W141_I0.137150.865
97_Y107_G0.136760.862
161_L170_L0.135990.857
82_A122_I0.135740.856
85_F121_G0.135440.854
14_L68_S0.135380.854
12_T207_H0.135340.853
119_L123_V0.135110.852
107_G150_G0.133810.844
37_S40_D0.13380.844
54_C87_L0.133610.842
160_F163_G0.133120.839
173_L180_Y0.132920.838
20_F23_L0.132620.836
218_A221_H0.132430.835
72_V75_I0.132280.834
180_Y183_G0.132180.833
114_I118_A0.131540.829
92_Y114_I0.131520.829
19_L219_L0.131420.829
32_S41_Y0.13080.825
155_F158_I0.130690.824
39_W43_P0.128850.812
106_L156_H0.128450.810
117_L149_S0.127990.807
190_R206_S0.127890.806
21_L25_I0.127820.806
141_I145_L0.127490.804
43_P98_Y0.127420.803
94_P177_G0.126770.799
88_I177_G0.126670.799
91_S180_Y0.126480.797
19_L22_A0.12640.797
10_I59_T0.125430.791
48_L51_A0.125120.789
5_N200_F0.12490.787
57_C83_G0.124580.785
91_S221_H0.124540.785
140_T184_A0.124470.785
128_P135_F0.124350.784
96_I110_Y0.124280.784
159_F164_W0.123950.781
200_F206_S0.123730.780
4_H200_F0.122780.774
13_H58_S0.122530.773
109_F152_I0.122360.771
89_A146_L0.122170.770
139_R143_F0.121270.765
151_I154_I0.120950.763
197_P206_S0.120470.760
180_Y217_A0.120280.758
14_L18_I0.120210.758
20_F48_L0.119990.756
8_V17_A0.119910.756
78_R126_L0.119550.754
96_I100_F0.119480.753
104_P156_H0.119430.753
88_I92_Y0.119340.752
40_D43_P0.118760.749
136_R190_R0.118230.745
30_L33_S0.118110.745
91_S176_G0.117320.740
185_V189_T0.117280.739
177_G180_Y0.117210.739
206_S209_I0.117120.738
34_P37_S0.116990.738
144_L147_G0.116810.736
117_L217_A0.116450.734
184_A188_A0.116290.733
82_A126_L0.116070.732
4_H12_T0.115610.729
125_S140_T0.115520.728
74_H78_R0.115230.726
93_T176_G0.115020.725
210_W214_V0.11490.724
60_L76_F0.114660.723
32_S37_S0.114630.723
186_F200_F0.114510.722
62_H187_Y0.113910.718
64_F76_F0.113780.717
144_L148_W0.113560.716
93_T111_L0.113530.716
61_Y92_Y0.113250.714
47_Y87_L0.113210.714
20_F51_A0.113180.714
77_L136_R0.112980.712
125_S200_F0.112930.712
26_F32_S0.111950.706
89_A93_T0.111790.705
12_T215_V0.111750.705
87_L218_A0.111730.704
171_W174_I0.11170.704
17_A21_L0.111630.704
144_L186_F0.111290.702
60_L64_F0.11120.701
49_L53_L0.111120.701
139_R206_S0.110740.698
128_P134_R0.11060.697
46_I93_T0.110580.697
118_A146_L0.110320.696
56_L59_T0.10970.692
39_W97_Y0.109690.692
154_I171_W0.109660.691
105_W112_A0.109480.690
64_F97_Y0.109240.689
99_G160_F0.108960.687
88_I91_S0.108870.686
8_V12_T0.10850.684
44_F91_S0.108480.684
88_I183_G0.108420.684
111_L146_L0.108420.684
100_F157_R0.10820.682
177_G181_L0.108080.681
31_A71_K0.108040.681
71_K75_I0.107980.681
109_F116_I0.107970.681
88_I147_G0.107910.680
93_T121_G0.107860.680
12_T17_A0.107660.679
75_I129_C0.107610.678
53_L86_L0.107520.678
156_H159_F0.107450.677
8_V212_I0.107350.677
177_G184_A0.107250.676
136_R140_T0.107010.675
97_Y111_L0.106620.672
73_Y186_F0.106320.670
62_H80_D0.106160.669
103_H113_F0.106120.669
90_G147_G0.106110.669
82_A125_S0.106050.669
74_H133_P0.105870.667
96_I107_G0.105590.666
6_E187_Y0.10550.665
24_L222_Y0.105420.665
29_S32_S0.105380.664
96_I150_G0.105210.663
213_F216_L0.105080.662
150_G157_R0.104790.661
135_F210_W0.104650.660
58_S62_H0.104050.656
172_L177_G0.104030.656
114_I200_F0.103960.655
89_A92_Y0.103840.655
164_W171_W0.103730.654
181_L185_V0.103580.653
53_L56_L0.103480.652
107_G111_L0.103410.652
95_F221_H0.103310.651
4_H11_W0.102960.649
37_S103_H0.102950.649
40_D57_C0.102650.647
10_I78_R0.10260.647
84_I88_I0.102570.647
161_L165_G0.102550.647
84_I143_F0.102530.646
53_L60_L0.102530.646
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3ddlA0.27031.90.969
4hfiA0.42341.80.97
4knfA0.33331.70.97
2hueA0.26131.40.971
3dwwA0.29281.40.972
3rlfF0.37841.20.973
2rmnA0.26581.10.973
2latA0.16671.10.973
2h8aA0.288310.973
3tpfA0.265810.974
If you are interested in a protein containing this domain,
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