GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
MVIN - MviN-like protein
Pfam: PF03023 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0222
Length: 451
Sequences: 13525
Seq/Len: 29.99
HH_delta: 0.265 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
48_G51_E1.312874.202
270_D273_E1.197573.833
126_R129_I1.008723.228
77_F80_P1.007723.225
198_K202_K0.973663.116
110_F169_I0.906272.900
299_L302_P0.877832.809
304_V321_T0.814732.607
98_V102_R0.808722.588
79_P98_V0.745212.385
377_G380_G0.728332.331
99_Q158_Y0.715742.291
300_A326_R0.696182.228
350_D353_T0.688142.202
300_A322_A0.685922.195
265_L273_E0.647352.072
334_F390_I0.631592.021
322_A326_R0.630232.017
301_E305_R0.623661.996
323_S379_A0.604031.933
79_P83_R0.601211.924
297_I326_R0.594151.901
74_G105_A0.587871.881
37_F59_L0.58011.857
235_A320_L0.579991.856
138_N141_I0.57541.841
42_S263_S0.572671.833
278_L344_V0.561521.797
106_P109_L0.561141.796
137_F141_I0.556391.781
352_K356_R0.551561.765
128_L132_L0.549071.757
133_S174_I0.548581.756
278_L341_L0.548581.756
380_G384_A0.542851.737
44_A51_E0.542551.736
113_L172_F0.541161.732
279_R283_R0.539451.726
103_I158_Y0.537421.720
262_L274_F0.536151.716
301_E322_A0.535451.714
350_D399_L0.533811.708
54_R193_R0.532191.703
194_D198_K0.52661.685
266_A348_L0.510651.634
276_K280_K0.509251.630
258_V281_A0.509241.630
75_I102_R0.507981.626
103_I161_A0.504111.613
107_S165_L0.498371.595
78_A102_R0.497951.594
271_W275_R0.497931.594
78_A98_V0.492481.576
56_I120_I0.48581.555
266_A274_F0.48531.553
133_S175_Q0.483331.547
110_F172_F0.482871.545
361_S392_S0.481531.541
209_L355_V0.480691.538
327_I383_L0.479031.533
94_I98_V0.468051.498
315_A319_Q0.466771.494
95_E99_Q0.460551.474
144_S163_G0.459941.472
265_L270_D0.457721.465
394_L398_I0.456531.461
63_L116_I0.45431.454
96_L99_Q0.453831.452
41_F123_A0.453381.451
193_R196_N0.453131.450
125_R264_R0.45251.448
275_R279_R0.452231.447
264_R268_E0.450581.442
138_N142_I0.447011.431
384_A388_S0.442351.416
302_P305_R0.440941.411
376_F383_L0.438351.403
293_S297_I0.437931.402
146_L149_S0.433781.388
283_R287_L0.432371.384
356_R360_I0.430061.376
158_Y162_W0.429141.373
83_R94_I0.427491.368
229_G232_S0.425091.360
43_K46_E0.422461.352
357_I395_L0.42181.350
117_F175_Q0.420791.347
316_E319_Q0.420751.347
276_K279_R0.419661.343
45_R52_A0.419611.343
272_E276_K0.41341.323
51_E54_R0.412471.320
334_F393_A0.410641.314
373_V381_L0.410321.313
173_L177_P0.409931.312
145_L150_N0.40961.311
80_P83_R0.405751.299
368_L384_A0.405511.298
43_K349_G0.400631.282
62_I197_L0.400251.281
318_T321_T0.39911.277
261_K277_T0.398591.276
221_D236_L0.395091.264
103_I162_W0.390261.249
224_L369_S0.387971.242
92_E95_E0.387091.239
369_S373_V0.382111.223
295_G299_L0.378671.212
71_T109_L0.37751.208
221_D224_L0.376221.204
364_L391_I0.375791.203
289_L336_A0.37541.201
80_P84_L0.374151.197
40_V203_L0.372951.194
140_S170_I0.372191.191
297_I329_A0.371281.188
44_A48_G0.370841.187
324_A378_V0.370431.186
365_N388_S0.367631.177
222_R226_S0.367581.176
37_F41_F0.366411.173
132_L136_L0.366151.172
90_S230_E0.366071.172
129_I178_Y0.363431.163
398_I401_R0.362581.160
114_S171_Q0.361671.157
103_I165_L0.360221.153
213_I359_V0.359631.151
39_P43_K0.358741.148
91_P95_E0.357961.146
139_L143_L0.357591.144
82_V97_A0.356231.140
82_V94_I0.356161.140
225_A381_L0.355131.137
364_L368_L0.353481.131
137_F171_Q0.35211.127
376_F380_G0.350921.123
159_A163_G0.35031.121
50_E54_R0.35021.121
55_F196_N0.349251.118
213_I355_V0.34861.116
285_I340_L0.347681.113
274_F348_L0.345851.107
49_E53_R0.345581.106
320_L323_S0.343641.100
206_P355_V0.343311.099
327_I379_A0.34181.094
285_I336_A0.341061.092
205_I209_L0.340861.091
327_I386_S0.338921.085
372_L384_A0.337951.082
177_P181_R0.337571.080
319_Q323_S0.333751.068
372_L376_F0.330791.059
287_L291_P0.330181.057
265_L277_T0.329631.055
353_T399_L0.328491.051
357_I399_L0.328451.051
145_L148_L0.328081.050
324_A382_A0.326661.045
106_P165_L0.326641.045
58_T197_L0.326541.045
79_P102_R0.32561.042
294_I298_V0.325281.041
221_D385_T0.323881.037
357_I396_L0.321611.029
302_P306_L0.320921.027
239_A324_A0.320421.025
365_N385_T0.319491.022
273_E276_K0.31921.022
221_D225_A0.319091.021
101_L105_A0.318941.021
146_L150_N0.318811.020
71_T75_I0.317711.017
206_P351_T0.31771.017
109_L112_G0.31761.016
120_I124_H0.317171.015
40_V55_F0.316781.014
265_L268_E0.316321.012
343_R347_A0.315151.009
203_L351_T0.314641.007
365_N369_S0.312561.000
345_F399_L0.312170.999
199_R349_G0.311710.998
145_L149_S0.311450.997
102_R106_P0.311390.997
137_F142_I0.310210.993
371_L374_P0.309850.992
297_I301_E0.309490.990
367_I371_L0.30850.987
195_P198_K0.308140.986
323_S326_R0.308060.986
291_P294_I0.307580.984
262_L347_A0.304620.975
72_L76_L0.304430.974
272_E275_R0.30380.972
341_L396_L0.303790.972
363_V367_I0.303180.970
395_L398_I0.301670.965
65_I69_L0.300370.961
383_L386_S0.300260.961
76_L80_P0.300180.961
44_A55_F0.299130.957
215_Q219_L0.297410.952
338_N389_A0.297340.952
299_L303_I0.297170.951
174_I177_P0.296550.949
43_K199_R0.296180.948
232_S235_A0.294230.942
73_L77_F0.293840.940
79_P95_E0.29380.940
63_L112_G0.293680.940
368_L387_L0.291930.934
61_T65_I0.291630.933
51_E196_N0.291510.933
221_D369_S0.290920.931
136_L174_I0.290460.930
83_R91_P0.290180.929
133_S178_Y0.288930.925
45_R49_E0.288750.924
75_I79_P0.288630.924
261_K265_L0.288370.923
368_L372_L0.288260.923
397_Y401_R0.287960.922
341_L397_Y0.287950.922
54_R58_T0.285360.913
125_R261_K0.285290.913
288_I292_A0.284940.912
304_V322_A0.284310.910
78_A101_L0.283280.907
235_A321_T0.282370.904
69_L73_L0.281930.902
280_K283_R0.281720.902
82_V101_L0.279280.894
301_E326_R0.279110.893
337_L393_A0.278940.893
77_F81_I0.278880.893
319_Q322_A0.27850.891
371_L375_F0.278010.890
153_G159_A0.277660.889
158_Y161_A0.277630.889
273_E277_T0.277040.887
228_L232_S0.275990.883
59_L200_F0.275630.882
296_L329_A0.275270.881
236_L240_Q0.275210.881
140_S143_L0.275190.881
280_K284_L0.27510.880
43_K266_A0.274740.879
126_R182_F0.273210.874
152_W162_W0.273180.874
212_S216_I0.2720.870
259_F263_S0.271850.870
169_I173_L0.271280.868
117_F172_F0.271160.868
242_L303_I0.269850.864
278_L340_L0.268830.860
318_T322_A0.268260.859
383_L387_L0.267490.856
207_L351_T0.26740.856
69_L72_L0.266980.854
79_P94_I0.266880.854
300_A325_L0.266310.852
192_W197_L0.266030.851
286_L337_L0.265770.851
232_S378_V0.264830.848
263_S267_A0.264770.847
353_T357_I0.264090.845
379_A383_L0.263540.843
370_I374_P0.263070.842
39_P263_S0.262550.840
293_S333_P0.262120.839
301_E319_Q0.260540.834
107_S168_A0.258910.829
388_S392_S0.258760.828
71_T74_G0.25780.825
45_R124_H0.256750.822
276_K283_R0.25660.821
223_A227_F0.256580.821
274_F344_V0.256450.821
344_V400_L0.256330.820
205_I208_L0.255760.819
225_A236_L0.255740.818
38_I42_S0.254220.814
225_A378_V0.254120.813
265_L274_F0.254080.813
54_R57_S0.253890.813
291_P295_G0.253730.812
201_L205_I0.253610.812
224_L373_V0.25320.810
38_I41_F0.253090.810
99_Q102_R0.252840.809
253_S257_V0.252630.809
121_L129_I0.251950.806
231_G316_E0.251790.806
163_G167_G0.25140.805
71_T106_P0.251120.804
45_R264_R0.250650.802
78_A105_A0.25060.802
199_R202_K0.250530.802
72_L75_I0.250450.802
126_R130_P0.250390.801
162_W166_I0.250040.800
40_V44_A0.249680.799
224_L370_I0.249080.797
272_E279_R0.248980.797
297_I300_A0.248690.796
36_A203_L0.248540.795
127_F257_V0.248360.795
36_A42_S0.248290.795
39_P42_S0.247770.793
196_N199_R0.247670.793
176_L180_R0.247590.792
170_I174_I0.246960.790
316_E320_L0.246880.790
121_L179_L0.246870.790
147_L160_L0.246830.790
281_A340_L0.24650.789
372_L380_G0.246080.788
262_L344_V0.246040.787
290_I294_I0.245660.786
67_S71_T0.245550.786
369_S381_L0.244780.783
201_L204_A0.244440.782
100_L161_A0.244350.782
331_G386_S0.243520.779
53_R57_S0.243240.778
141_I144_S0.243110.778
225_A228_L0.242960.778
76_L102_R0.242520.776
117_F179_L0.242390.776
372_L375_F0.241320.772
91_P94_I0.240580.770
331_G334_F0.240360.769
122_N130_P0.240160.769
315_A318_T0.239980.768
122_N127_F0.239720.767
64_L113_L0.239290.766
217_N221_D0.238990.765
117_F176_L0.238930.765
296_L300_A0.238730.764
202_K352_K0.23830.763
121_L175_Q0.238220.762
42_S123_A0.238140.762
254_I281_A0.238030.762
206_P352_K0.237630.761
146_L152_W0.237440.760
345_F354_P0.237180.759
105_A108_I0.236770.758
57_S61_T0.236610.757
367_I374_P0.23630.756
119_A122_N0.236220.756
364_L367_I0.235580.754
144_S148_L0.235390.753
266_A271_W0.234550.751
141_I164_V0.234360.750
243_Y328_Y0.234110.749
391_I395_L0.233980.749
298_V302_P0.233980.749
325_L329_A0.233940.749
228_L378_V0.233710.748
239_A328_Y0.233590.748
259_F343_R0.23340.747
103_I106_P0.232990.746
110_F165_L0.232920.745
282_L337_L0.23290.745
259_F347_A0.232620.744
57_S189_K0.232060.743
243_Y332_L0.232050.743
331_G389_A0.232010.743
219_L226_S0.231810.742
330_L386_S0.231120.740
338_N342_S0.231030.739
98_V101_L0.230890.739
58_T62_I0.230870.739
149_S152_W0.230330.737
274_F278_L0.230180.737
296_L325_L0.230090.736
283_R286_L0.230050.736
42_S45_R0.229940.736
92_E230_E0.229550.735
341_L400_L0.229020.733
119_A123_A0.228890.733
68_L109_L0.228810.732
99_Q103_I0.228810.732
344_V348_L0.22880.732
297_I330_L0.228540.731
118_S122_N0.228320.731
38_I119_A0.227750.729
359_V363_V0.225660.722
241_R245_L0.224830.720
64_L67_S0.224590.719
364_L388_S0.224350.718
368_L371_L0.223920.717
136_L139_L0.223420.715
132_L135_L0.222810.713
150_N153_G0.222660.713
237_N240_Q0.222350.712
59_L116_I0.222250.711
380_G383_L0.221950.710
140_S144_S0.221570.709
354_P396_L0.221340.708
327_I382_A0.221270.708
177_P180_R0.221140.708
287_L290_I0.220860.707
40_V200_F0.22050.706
92_E96_L0.22010.704
68_L72_L0.21950.702
330_L333_P0.219480.702
76_L79_P0.218280.699
259_F346_Y0.217310.695
238_Y241_R0.217060.695
234_S237_N0.216670.693
321_T324_A0.216380.692
242_L296_L0.216270.692
369_S385_T0.216220.692
235_A317_D0.215690.690
278_L400_L0.215650.690
106_P110_F0.215520.690
174_I178_Y0.21550.690
162_W165_L0.215240.689
384_A387_L0.214920.688
217_N365_N0.214330.686
95_E98_V0.214220.686
296_L303_I0.214150.685
54_R196_N0.214090.685
178_Y182_F0.214080.685
304_V318_T0.214070.685
67_S112_G0.213470.683
147_L150_N0.21340.683
375_F379_A0.213160.682
346_Y354_P0.212870.681
61_T192_W0.212410.680
222_R225_A0.211990.678
152_W159_A0.211850.678
40_V43_K0.211730.678
219_L223_A0.21170.678
58_T192_W0.211580.677
351_T354_P0.211280.676
165_L168_A0.211030.675
338_N392_S0.210220.673
203_L207_L0.209910.672
223_A226_S0.209760.671
240_Q243_Y0.209740.671
37_F55_F0.209740.671
67_S105_A0.209620.671
214_S218_I0.209610.671
241_R244_Q0.209370.670
236_L241_R0.208820.668
292_A295_G0.208710.668
262_L278_L0.208170.666
175_Q178_Y0.207370.664
228_L373_V0.206490.661
255_S343_R0.206370.660
290_I333_P0.20560.658
68_L71_T0.205090.656
360_I363_V0.204970.656
237_N241_R0.204850.656
218_I221_D0.204410.654
366_I370_I0.203950.653
326_R330_L0.203920.653
134_P138_N0.203650.652
254_I285_I0.203650.652
234_S238_Y0.203310.651
338_N396_L0.203270.651
82_V98_V0.203230.650
52_A124_H0.203170.650
160_L163_G0.202860.649
144_S147_L0.202540.648
365_N368_L0.201490.645
51_E55_F0.201280.644
161_A165_L0.201270.644
323_S327_I0.201070.643
75_I106_P0.201070.643
180_R183_G0.200960.643
220_V223_A0.200830.643
140_S167_G0.200670.642
55_F59_L0.200660.642
202_K206_P0.200630.642
141_I167_G0.200310.641
300_A329_A0.200280.641
239_A325_L0.199970.640
379_A382_A0.199910.640
305_R318_T0.199890.640
221_D365_N0.199830.640
78_A82_V0.199460.638
46_E267_A0.198560.635
141_I163_G0.198330.635
271_W348_L0.198140.634
294_I297_I0.197940.633
118_S130_P0.197920.633
165_L169_I0.19790.633
329_A333_P0.197390.632
342_S354_P0.197360.632
239_A243_Y0.197320.631
286_L290_I0.196990.630
328_Y335_Y0.195530.626
146_L166_I0.195490.626
322_A325_L0.195370.625
271_W274_F0.194830.624
167_G171_Q0.194650.623
55_F200_F0.194070.621
356_R359_V0.19320.618
235_A324_A0.192870.617
308_F317_D0.192820.617
341_L344_V0.192720.617
252_V255_S0.192150.615
36_A39_P0.191710.614
40_V199_R0.191310.612
386_S390_I0.19060.610
225_A233_V0.190150.609
229_G233_V0.189910.608
268_E273_E0.18960.607
52_A56_I0.188940.605
365_N384_A0.188840.604
41_F124_H0.188560.603
60_L117_F0.188440.603
60_L63_L0.188370.603
36_A204_A0.188350.603
136_L140_S0.188260.603
293_S329_A0.188080.602
246_P251_A0.1880.602
335_Y389_A0.187970.602
171_Q175_Q0.187680.601
63_L67_S0.186940.598
127_F131_A0.186940.598
54_R191_D0.18610.596
207_L346_Y0.185980.595
39_P203_L0.185840.595
390_I394_L0.184520.591
61_T190_F0.184430.590
47_K268_E0.184380.590
243_Y246_P0.184340.590
109_L113_L0.18420.590
329_A332_L0.183990.589
149_S153_G0.183790.588
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3w4tA0.8981000.265
3mktA0.8981000.272
4humA0.90471000.355
3w4tA0.585499.80.624
3mktA0.569899.80.627
4humA0.576599.80.635
2gfpA0.756118.60.953
1pw4A0.789417.70.953
3o7qA0.753914.30.955
3qnqA0.425711.30.957

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