GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
TB2_DP1_HVA22 - TB2DP1 HVA22 family
Pfam: PF03134 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 94
Sequences: 658
Seq/Len: 7
HH_delta: 0.934 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
50_E59_W0.387982.894
73_W81_G0.328692.452
35_Q82_A0.318032.372
26_K91_R0.287862.147
26_K86_Y0.234881.752
21_S24_A0.233441.741
36_W39_Y0.220191.643
22_F94_L0.216871.618
89_F93_F0.207891.551
27_S33_L0.201671.504
46_F52_F0.196541.466
46_F54_D0.187751.401
65_E69_L0.182271.360
9_C71_L0.181681.355
21_S27_S0.165971.238
21_S40_W0.16421.225
24_A33_L0.159231.188
49_F58_S0.157911.178
21_S37_L0.157761.177
16_Y20_K0.156881.170
24_A27_S0.156821.170
33_L37_L0.156471.167
9_C43_Y0.156031.164
8_L27_S0.154871.155
43_Y73_W0.15271.139
74_L79_F0.152491.138
70_F80_Q0.152221.136
54_D59_W0.148161.105
44_G54_D0.14661.094
6_R64_Y0.145471.085
40_W43_Y0.144551.078
42_V46_F0.142611.064
49_F55_F0.140821.050
18_A75_Q0.140811.050
69_L78_Q0.139691.042
54_D57_L0.138361.032
51_S66_F0.137141.023
50_E63_Y0.136561.019
11_L15_L0.13651.018
11_L53_L0.135741.013
76_L88_K0.135071.008
73_W84_Y0.134751.005
12_I91_R0.133540.996
22_F93_F0.132220.986
54_D58_S0.131970.984
13_G71_L0.131710.983
10_N14_I0.131620.982
48_L82_A0.130760.975
21_S33_L0.129790.968
60_I84_Y0.129370.965
43_Y46_F0.128740.960
21_S62_F0.127130.948
16_Y21_S0.126970.947
38_T41_I0.12520.934
8_L88_K0.124980.932
14_I44_G0.124540.929
21_S32_D0.123120.918
46_F55_F0.122750.916
33_L38_T0.122560.914
58_S66_F0.122370.913
77_P81_G0.122270.912
13_G31_K0.121470.906
15_L80_Q0.121220.904
64_Y91_R0.12110.903
45_L49_F0.120330.898
68_L75_Q0.120020.895
47_T67_K0.119590.892
6_R9_C0.118950.887
66_F84_Y0.118560.884
23_K86_Y0.11850.884
7_L74_L0.117830.879
18_A85_I0.117590.877
71_L78_Q0.117440.876
6_R85_I0.117130.874
74_L80_Q0.1170.873
7_L41_I0.116520.869
32_D38_T0.116290.867
21_S38_T0.115650.863
67_K71_L0.115460.861
91_R94_L0.115370.861
16_Y39_Y0.115310.860
61_P73_W0.115210.859
13_G18_A0.114660.855
44_G94_L0.114070.851
84_Y89_F0.114020.851
39_Y43_Y0.112710.841
38_T43_Y0.112490.839
31_K41_I0.112410.839
35_Q38_T0.111540.832
69_L83_E0.110980.828
20_K90_I0.110910.827
9_C47_T0.11070.826
65_E74_L0.110660.825
7_L14_I0.110410.824
51_S85_I0.110320.823
15_L65_E0.110160.822
40_W44_G0.109430.816
10_N30_K0.109190.815
22_F60_I0.108880.812
29_D85_I0.108490.809
31_K91_R0.108170.807
20_K48_L0.107660.803
26_K41_I0.107630.803
8_L57_L0.107490.802
85_I90_I0.106840.797
11_L88_K0.106390.794
48_L77_P0.106310.793
29_D49_F0.106210.792
53_L71_L0.105990.791
26_K74_L0.105690.788
73_W82_A0.105540.787
44_G59_W0.105490.787
56_I87_D0.105430.786
12_I82_A0.105010.783
11_L14_I0.105010.783
19_Y67_K0.1050.783
12_I28_K0.104370.779
36_W60_I0.104120.777
61_P81_G0.103990.776
83_E87_D0.103840.775
41_I68_L0.103710.774
52_F55_F0.103650.773
70_F74_L0.103150.769
23_K29_D0.103010.768
20_K24_A0.102980.768
30_K33_L0.102060.761
22_F26_K0.100510.750
68_L87_D0.100330.748
6_R65_E0.100110.747
62_F84_Y0.099350.741
13_G78_Q0.099240.740
13_G67_K0.099220.740
86_Y91_R0.0990.739
47_T51_S0.09850.735
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3gfaA0.372320.934
2wscI0.39361.80.935
1jb0I0.34041.80.935
3hzqA0.34041.40.939
3ge6A0.3831.40.939
3gbhA0.3831.10.942
2ipbA0.41491.10.942
3eo8A0.393610.943
2yadA0.691510.944
3w4tA0.372310.944
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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