GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
2HCT - 2-hydroxycarboxylate transporter family
Pfam: PF03390 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 414
Sequences: 2678
Seq/Len: 6.47
HH_delta: 0.727 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
137_L345_G0.275333.447
142_G152_A0.211752.651
140_L144_L0.206462.585
136_L140_L0.195362.446
141_V341_A0.19352.423
108_I314_L0.173042.166
46_E50_R0.168952.115
351_F369_G0.166112.080
345_G349_G0.158011.978
139_G143_M0.157771.975
333_P337_V0.152331.907
336_V340_L0.150111.879
148_S151_D0.139051.741
169_A172_L0.132391.657
64_L68_V0.132361.657
347_V351_F0.131861.651
133_G349_G0.129611.623
353_V357_V0.126221.580
374_N377_G0.122651.536
185_E188_F0.121341.519
352_L356_L0.121271.518
125_P357_V0.120391.507
44_L48_G0.118451.483
40_L44_L0.117611.472
264_L268_L0.117421.470
153_I156_I0.117031.465
361_P364_S0.116971.464
350_A368_A0.115761.449
191_L371_C0.115511.446
65_C69_P0.114431.433
371_C374_N0.113691.423
174_Q178_E0.113211.417
328_I332_T0.113011.415
145_F334_Q0.112781.412
37_M315_V0.112731.411
355_K362_V0.112341.406
105_V281_V0.112041.403
36_V72_L0.111121.391
114_K117_I0.111081.391
106_G112_N0.110181.379
138_G142_G0.11011.378
129_G353_V0.109851.375
258_F280_L0.109551.372
131_V201_F0.109061.365
129_G349_G0.108621.360
127_I131_V0.108351.357
66_I70_S0.10761.347
325_N329_A0.107161.342
302_Y310_T0.106961.339
351_F355_K0.105141.316
355_K358_G0.105031.315
349_G353_V0.104531.309
348_I352_L0.104511.308
39_V327_L0.104071.303
65_C68_V0.103811.300
371_C375_M0.103651.298
354_G365_A0.10311.291
342_T375_M0.102761.287
112_N118_K0.102741.286
143_M152_A0.102481.283
122_R357_V0.100791.262
71_A75_F0.100671.260
47_I51_I0.100341.256
208_L212_L0.099811.250
69_P73_V0.099711.248
272_H378_T0.099421.245
175_I369_G0.098671.235
66_I194_A0.097771.224
358_G361_P0.09581.199
142_G151_D0.095571.197
40_L43_L0.094811.187
347_V369_G0.093961.176
242_P337_V0.093511.171
176_Y191_L0.09311.166
279_I353_V0.092961.164
143_M149_F0.092461.158
130_G350_A0.092061.153
119_A123_F0.0921.152
200_I324_L0.091621.147
108_I278_I0.090891.138
176_Y188_F0.090881.138
70_S323_D0.09081.137
138_G338_I0.090711.136
165_M379_G0.090681.135
129_G310_T0.090371.131
108_I281_V0.090241.130
375_M379_G0.09021.129
195_L200_I0.09021.129
111_M171_P0.090181.129
377_G380_D0.089991.127
346_A350_A0.089651.122
152_A156_I0.089541.121
124_I128_L0.089291.118
166_G169_A0.089261.118
274_Y378_T0.089191.117
316_G321_Y0.088711.111
115_L118_K0.088681.110
75_F352_L0.088331.106
134_A349_G0.088131.103
144_L351_F0.088121.103
337_V344_L0.087881.100
103_L285_K0.087441.095
128_L201_F0.087151.091
109_L284_V0.086811.087
99_F276_W0.086121.078
143_M147_Y0.085941.076
133_G205_F0.085631.072
323_D326_D0.085571.071
215_K218_K0.085531.071
219_L223_G0.085431.070
99_F102_A0.084811.062
199_N314_L0.084641.060
265_L269_I0.084421.057
195_L342_T0.084291.055
129_G356_L0.084141.053
275_A279_I0.083921.051
68_V71_A0.083791.049
65_C206_A0.08371.048
99_F277_M0.083531.046
46_E52_P0.083381.044
212_L219_L0.082691.035
111_M272_H0.082491.033
264_L369_G0.082431.032
182_Q187_Y0.082221.029
351_F362_V0.082141.028
213_G322_T0.082051.027
251_G254_L0.0821.027
136_L139_G0.081671.022
105_V276_W0.081591.021
46_E49_D0.081451.020
134_A345_G0.081441.020
147_Y152_A0.081431.019
347_V350_A0.081411.019
167_A171_P0.08131.018
117_I267_K0.081271.017
177_A200_I0.081231.017
37_M295_E0.081141.016
225_L229_G0.080961.014
107_S310_T0.08091.013
148_S361_P0.080771.011
137_L140_L0.080631.009
256_C284_V0.080151.003
199_N278_I0.080061.002
37_M312_P0.080011.002
120_F124_I0.080011.002
133_G137_L0.079760.999
130_G198_G0.079640.997
117_I265_L0.079560.996
355_K365_A0.07950.995
34_F38_M0.079380.994
277_M281_V0.079290.993
130_G134_A0.079210.992
357_V366_I0.079120.991
49_D178_E0.079070.990
251_G255_A0.078950.988
334_Q337_V0.07890.988
128_L131_V0.07880.987
341_A345_G0.078590.984
176_Y371_C0.078560.984
100_I381_V0.078480.983
254_L261_L0.078470.982
169_A195_L0.078270.980
314_L318_G0.078190.979
105_V188_F0.078170.979
246_S250_A0.078040.977
95_F124_I0.0780.977
198_G371_C0.077960.976
248_M284_V0.077930.976
49_D264_L0.077450.970
346_A372_M0.077350.968
70_S302_Y0.077310.968
39_V255_A0.07730.968
266_S310_T0.077220.967
140_L143_M0.077060.965
348_I355_K0.076960.964
114_K118_K0.076860.962
64_L311_W0.076820.962
334_Q338_I0.07680.962
254_L280_L0.076760.961
132_I136_L0.076760.961
149_F344_L0.07660.959
120_F378_T0.076590.959
102_A309_L0.076590.959
103_L378_T0.076460.957
99_F199_N0.076260.955
145_F337_V0.075920.951
188_F346_A0.075890.950
133_G340_L0.075810.949
43_L146_G0.07580.949
133_G348_I0.075750.948
130_G372_M0.075750.948
53_I296_E0.075740.948
117_I121_A0.075690.948
101_A155_Y0.075670.947
151_D344_L0.07540.944
187_Y368_A0.075350.943
123_F127_I0.075350.943
373_A377_G0.075120.940
118_K121_A0.075110.940
103_L310_T0.075090.940
102_A211_K0.075020.939
235_E238_K0.074910.938
110_G278_I0.07490.938
167_A378_T0.074680.935
182_Q188_F0.074620.934
276_W281_V0.074470.932
131_V198_G0.074430.932
111_M278_I0.07420.929
372_M378_T0.074190.929
196_T199_N0.074180.929
317_I377_G0.074110.928
278_I338_I0.073830.924
70_S272_H0.073760.923
252_L257_S0.073560.921
261_L265_L0.073330.918
66_I311_W0.073260.917
95_F312_P0.073190.916
108_I199_N0.073060.915
342_T345_G0.073060.915
195_L204_I0.072840.912
199_N318_G0.072760.911
136_L149_F0.072680.910
191_L350_A0.072610.909
338_I351_F0.072540.908
343_V373_A0.072460.907
62_A69_P0.072450.907
274_Y380_D0.072350.906
199_N313_L0.072340.906
168_G199_N0.072280.905
104_I171_P0.072140.903
267_K341_A0.071990.901
169_A375_M0.071890.900
37_M362_V0.071870.900
71_A356_L0.071820.899
154_F158_L0.071810.899
139_G142_G0.071780.899
176_Y276_W0.071770.899
375_M378_T0.071750.898
198_G378_T0.071720.898
226_L348_I0.071690.898
76_G80_E0.071680.897
70_S73_V0.071670.897
45_G48_G0.071650.897
112_N286_A0.071460.895
131_V271_I0.071410.894
286_A323_D0.071390.894
340_L344_L0.071380.894
271_I369_G0.071310.893
180_L200_I0.071210.892
277_M313_L0.071040.889
238_K356_L0.070880.887
351_F361_P0.070870.887
206_A211_K0.070780.886
35_A98_F0.070680.885
107_S367_T0.070610.884
98_F279_I0.070580.884
122_R126_P0.070440.882
211_K215_K0.070360.881
123_F193_P0.070350.881
316_G379_G0.070310.880
263_V267_K0.070230.879
333_P336_V0.070230.879
216_K219_L0.070130.878
134_A198_G0.070060.877
132_I352_L0.069910.875
224_Q232_E0.069840.874
103_L198_G0.06980.874
274_Y368_A0.069710.873
203_I317_I0.069540.871
144_L265_L0.069420.869
337_V352_L0.069370.868
64_L69_P0.069340.868
73_V195_L0.06930.868
68_V72_L0.06920.866
104_I274_Y0.069170.866
168_G229_G0.069170.866
266_S270_G0.069160.866
261_L327_L0.069140.866
374_N380_D0.069140.866
44_L122_R0.069120.865
199_N281_V0.069050.864
372_M380_D0.069050.864
139_G149_F0.0690.864
175_I324_L0.068890.862
188_F276_W0.068860.862
110_G346_A0.068850.862
377_G381_V0.068790.861
124_I132_I0.068770.861
68_V73_V0.068710.860
75_F344_L0.068690.860
356_L361_P0.068680.860
301_W324_L0.068680.860
250_A254_L0.06860.859
171_P378_T0.068570.858
171_P377_G0.068570.858
69_P311_W0.06840.856
95_F141_V0.068360.856
218_K221_G0.068280.855
337_V340_L0.068280.855
37_M43_L0.068250.854
98_F176_Y0.068180.854
167_A349_G0.068080.852
67_F290_V0.068020.852
41_G267_K0.068010.851
132_I135_F0.068010.851
78_I205_F0.0680.851
167_A374_N0.067880.850
43_L292_E0.067870.850
321_Y380_D0.067790.849
47_I230_D0.067780.849
122_R125_P0.06770.848
195_L199_N0.067670.847
338_I376_G0.067630.847
105_V372_M0.06760.846
234_E261_L0.06750.845
329_A337_V0.067490.845
239_K242_P0.067480.845
228_G231_D0.067420.844
292_E296_E0.067370.843
168_G196_T0.067290.842
121_A356_L0.067250.842
339_V343_V0.067250.842
132_I144_L0.067220.842
236_A261_L0.067120.840
169_A235_E0.067070.840
158_L370_L0.067010.839
123_F181_G0.066840.837
154_F208_L0.06680.836
198_G202_A0.066770.836
39_V355_K0.066690.835
135_F291_P0.066670.835
132_I149_F0.066590.834
96_L99_F0.066560.833
43_L220_T0.066320.830
166_G272_H0.066320.830
195_L368_A0.066320.830
350_A367_T0.066230.829
157_V202_A0.066210.829
100_I376_G0.066170.828
167_A274_Y0.066160.828
144_L148_S0.066130.828
264_L344_L0.066120.828
74_Y178_E0.066110.828
334_Q340_L0.066110.828
124_I208_L0.066090.827
354_G359_F0.066020.827
105_V108_I0.065980.826
131_V346_A0.065960.826
222_N356_L0.065930.825
96_L318_G0.065750.823
288_G358_G0.065730.823
39_V136_L0.065650.822
317_I326_D0.065640.822
230_D233_E0.06560.821
312_P323_D0.065570.821
220_T257_S0.065570.821
218_K344_L0.065520.820
114_K147_Y0.065490.820
167_A311_W0.065460.820
172_L176_Y0.065460.820
33_G154_F0.065450.819
49_D353_V0.065440.819
137_L152_A0.065390.819
103_L116_L0.065380.819
130_G374_N0.065230.817
52_P218_K0.065180.816
168_G235_E0.065180.816
284_V334_Q0.065160.816
199_N276_W0.065130.815
113_R264_L0.065120.815
167_A321_Y0.065110.815
96_L100_I0.065050.814
49_D118_K0.064990.814
191_L342_T0.064810.811
157_V309_L0.064780.811
78_I224_Q0.064730.810
209_L212_L0.064640.809
172_L232_E0.064620.809
47_I114_K0.064620.809
99_F313_L0.064550.808
142_G155_Y0.064520.808
263_V276_W0.064520.808
37_M154_F0.064510.808
236_A279_I0.06450.808
140_L337_V0.064420.807
171_P373_A0.064410.806
286_A314_L0.064390.806
146_G254_L0.064310.805
276_W313_L0.064290.805
244_D282_A0.064260.805
140_L336_V0.064130.803
218_K223_G0.064130.803
104_I378_T0.06410.803
269_I341_A0.064080.802
41_G152_A0.064070.802
177_A183_D0.064060.802
168_G189_S0.063990.801
361_P365_A0.063950.801
33_G37_M0.063940.801
218_K343_V0.063920.800
351_F356_L0.063860.800
181_G185_E0.063730.798
139_G152_A0.063690.797
205_F322_T0.063680.797
128_L147_Y0.063610.796
105_V199_N0.063590.796
115_L119_A0.063580.796
315_V357_V0.063510.795
129_G220_T0.063440.794
194_A302_Y0.063420.794
67_F71_A0.063340.793
252_L365_A0.063320.793
244_D356_L0.063260.792
79_P233_E0.063230.792
34_F208_L0.063220.792
65_C374_N0.063140.790
122_R353_V0.063050.789
99_F281_V0.063040.789
135_F265_L0.063020.789
66_I372_M0.063010.789
35_A42_F0.0630.789
83_V370_L0.062980.788
191_L339_V0.062880.787
43_L333_P0.062870.787
190_Q371_C0.062770.786
206_A372_M0.062750.786
128_L265_L0.062740.785
175_I180_L0.062680.785
237_K247_D0.062620.784
75_F84_E0.062590.784
109_L323_D0.062570.783
99_F103_L0.062560.783
288_G291_P0.062540.783
124_I225_L0.062520.783
35_A94_N0.06250.782
134_A167_A0.062470.782
44_L53_I0.062430.782
165_M172_L0.062410.781
126_P271_I0.062390.781
97_Y323_D0.062360.781
120_F372_M0.062340.780
167_A314_L0.062270.780
134_A375_M0.062230.779
189_S206_A0.062210.779
372_M377_G0.062180.778
229_G232_E0.062180.778
293_S297_G0.062140.778
96_L199_N0.062110.778
133_G141_V0.062090.777
138_G274_Y0.062020.776
178_E261_L0.061970.776
72_L239_K0.061950.776
183_D186_E0.061910.775
374_N378_T0.061890.775
78_I321_Y0.061850.774
139_G376_G0.06180.774
198_G346_A0.061690.772
172_L175_I0.061680.772
117_I192_I0.061590.771
34_F312_P0.061580.771
195_L374_N0.061530.770
73_V78_I0.061520.770
202_A343_V0.061480.770
104_I273_A0.061420.769
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1zcdA0.84399.80.727
3zuxA0.727197.60.896
2k3cA0.079790.968
2zy9A0.44936.80.969
2p2wA0.14255.20.971
1ifpA0.08213.10.974
1wazA0.11113.20.974
2nwlA0.65222.30.975
3tqfA0.144920.976
2l34A0.07971.80.977
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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