GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
BtpA - BtpA family
Pfam: PF03437 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0036
Length: 254
Sequences: 4336
Seq/Len: 17.07
HH_delta: 0.52 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
37_A41_G1.104143.840
36_E78_E0.907023.154
194_R197_E0.807642.809
168_V201_V0.78552.732
100_A139_A0.723612.516
36_E40_E0.699682.433
166_D170_R0.663212.306
97_A136_R0.651992.267
76_R105_D0.625892.177
34_E37_A0.618522.151
196_R222_D0.60952.120
97_A101_A0.607072.111
218_L224_A0.587072.042
124_E132_R0.586072.038
143_I167_A0.573831.996
39_E81_V0.569261.980
209_V217_Y0.541281.882
212_E216_E0.531321.848
96_L133_Y0.51951.807
145_A164_A0.509711.773
214_I227_G0.503111.750
100_A137_L0.498221.733
126_C132_R0.494991.721
215_A219_S0.494471.720
190_E194_R0.486911.693
33_R36_E0.486791.693
163_A166_D0.484691.686
70_R73_R0.483661.682
98_I101_A0.470761.637
166_D171_G0.466991.624
74_E77_R0.459121.597
62_P94_A0.455321.583
210_T213_N0.448981.561
68_M71_I0.441431.535
133_Y137_L0.433981.509
214_I229_Y0.409091.423
35_A46_I0.408421.420
32_V36_E0.405681.411
168_V200_P0.403411.403
144_L179_T0.401581.397
165_K198_A0.396451.379
214_I224_A0.389541.355
225_I229_Y0.387221.347
35_A75_V0.380651.324
163_A167_A0.378781.317
165_K170_R0.375161.305
70_R74_E0.366171.273
85_V99_A0.364991.269
165_K168_V0.363731.265
196_R203_V0.3621.259
133_Y141_V0.36151.257
65_V69_A0.361251.256
216_E220_Y0.360661.254
106_F142_K0.350691.220
192_L196_R0.349611.216
159_D162_E0.348051.210
189_P217_Y0.347711.209
134_R139_A0.343791.196
68_M72_A0.342911.193
151_H154_P0.342741.192
213_N216_E0.340891.186
73_R77_R0.340731.185
39_E80_S0.340091.183
164_A167_A0.339221.180
193_K197_E0.33671.171
161_E198_A0.335481.167
63_E66_A0.330851.151
226_V229_Y0.330161.148
193_K220_Y0.328341.142
161_E194_R0.324631.129
45_G106_F0.323621.125
32_V74_E0.322671.122
180_G185_E0.320861.116
69_A98_I0.319091.110
46_I81_V0.318721.108
37_A40_E0.318621.108
164_A201_V0.313411.090
164_A199_V0.313241.089
211_P214_I0.30911.075
36_E79_V0.307561.070
162_E166_D0.307121.068
66_A98_I0.305261.062
32_V35_A0.304341.058
194_R198_A0.303881.057
69_A73_R0.300281.044
97_A137_L0.298021.036
72_A85_V0.295621.028
123_I154_P0.295491.028
39_E79_V0.29351.021
160_L195_V0.293461.021
212_E215_A0.292541.017
140_D177_I0.290571.011
160_L164_A0.285420.993
189_P193_K0.283630.986
124_E127_A0.283030.984
98_I102_T0.282240.982
35_A79_V0.281480.979
181_K209_V0.28090.977
181_K205_V0.280460.975
76_R83_V0.280050.974
216_E219_S0.279940.974
44_D82_P0.275840.959
94_A98_I0.275460.958
65_V95_A0.272280.947
132_R135_K0.271860.945
120_E127_A0.269050.936
107_I134_R0.267110.929
32_V71_I0.266990.929
215_A218_L0.266810.928
144_L177_I0.262940.914
69_A102_T0.260490.906
178_V195_V0.259790.903
189_P192_L0.259360.902
154_P157_T0.2570.894
96_L127_A0.255970.890
66_A69_A0.254550.885
160_L191_K0.254530.885
79_V82_P0.253710.882
64_T67_A0.253530.882
53_D110_N0.251170.873
181_K213_N0.250520.871
215_A224_A0.250410.871
121_G141_V0.249480.868
73_R101_A0.248580.864
190_E193_K0.24570.854
138_G175_A0.245230.853
73_R102_T0.243450.847
34_E38_L0.243210.846
97_A133_Y0.241980.842
148_H152_S0.239490.833
52_G179_T0.238770.830
62_P65_V0.23730.825
161_E164_A0.235880.820
93_K96_L0.235650.820
121_G143_I0.23480.817
149_V152_S0.234610.816
199_V203_V0.233890.813
110_N146_D0.233160.811
75_V83_V0.23270.809
48_V83_V0.2320.807
67_A72_A0.231870.806
186_P216_E0.231590.805
197_E200_P0.231350.805
39_E83_V0.230970.803
62_P153_S0.230250.801
121_G124_E0.228310.794
140_D175_A0.227630.792
120_E124_E0.227010.789
48_V75_V0.226210.787
204_L223_G0.224330.780
168_V199_V0.223250.776
120_E183_T0.222530.774
211_P215_A0.221490.770
36_E39_E0.219250.762
150_K154_P0.216640.753
162_E165_K0.215370.749
176_V201_V0.215220.748
180_G183_T0.214760.747
141_V167_A0.214670.747
155_L159_D0.214320.745
217_Y224_A0.21290.740
138_G174_D0.212460.739
189_P213_N0.211940.737
75_V79_V0.209880.730
93_K124_E0.208580.725
94_A97_A0.206330.718
192_L205_V0.205870.716
158_R166_D0.205610.715
65_V98_I0.205250.714
224_A229_Y0.205150.713
33_R37_A0.204470.711
149_V210_T0.204310.711
82_P105_D0.204130.710
96_L141_V0.202170.703
72_A99_A0.20170.701
222_D225_I0.201050.699
192_L209_V0.200560.697
79_V83_V0.200290.697
164_A176_V0.200240.696
74_E78_E0.199110.692
89_R99_A0.19870.691
146_D167_A0.197020.685
42_G81_V0.196570.684
193_K196_R0.194460.676
157_T194_R0.194370.676
196_R199_V0.192590.670
99_A104_A0.192170.668
159_D163_A0.191840.667
146_D174_D0.191620.666
147_V159_D0.189970.661
127_A133_Y0.188180.654
120_E123_I0.188180.654
158_R162_E0.187690.653
35_A83_V0.186840.650
147_V160_L0.186740.649
96_L109_V0.186510.649
214_I226_V0.18650.649
192_L198_A0.185730.646
100_A133_Y0.185030.643
177_I204_L0.185010.643
35_A42_G0.183720.639
64_T68_M0.183480.638
38_L43_V0.183010.636
164_A198_A0.182680.635
32_V78_E0.181530.631
46_I75_V0.181470.631
146_D152_S0.181340.631
93_K133_Y0.180620.628
70_R75_V0.180360.627
213_N217_Y0.179970.626
190_E220_Y0.179160.623
85_V104_A0.178680.621
52_G177_I0.178070.619
71_I74_E0.177660.618
106_F140_D0.177440.617
54_V179_T0.177330.617
71_I75_V0.177130.616
89_R121_G0.176210.613
178_V191_K0.176090.612
88_L120_E0.173320.603
167_A173_A0.172560.600
146_D163_A0.17180.597
109_V143_I0.171540.597
192_L203_V0.17140.596
87_V96_L0.171060.595
147_V152_S0.170610.593
150_K184_G0.169570.590
105_D140_D0.168390.586
62_P89_R0.167480.582
59_R153_S0.167020.581
146_D185_E0.166920.580
192_L213_N0.166830.580
178_V201_V0.166180.578
121_G159_D0.165120.574
84_G104_A0.164330.571
95_A98_I0.164330.571
101_A137_L0.163740.569
134_R173_A0.163570.569
141_V176_V0.16340.568
109_V127_A0.162820.566
205_V208_G0.162520.565
32_V75_V0.162430.565
195_V198_A0.16160.562
135_K170_R0.161560.562
164_A168_V0.159090.553
32_V102_T0.159040.553
60_V65_V0.158420.551
73_R98_I0.15680.545
211_P229_Y0.156160.543
149_V190_E0.156010.543
110_N120_E0.154280.537
148_H155_L0.153940.535
64_T211_P0.153020.532
123_I183_T0.152830.531
197_E219_S0.152210.529
47_I108_R0.152080.529
145_A179_T0.151690.528
162_E168_V0.151110.526
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1twdA0.830799.90.52
3iwpA0.885899.90.553
2bdqA0.791399.90.556
1nsjA0.767799.80.584
1v5xA0.759899.80.587
4aajA0.846599.80.6
1ujpA0.830799.80.606
2ekcA0.854399.80.606
1piiA0.834699.70.613
3navA0.866199.70.617
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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